EKS-CAF-00074

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00074

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	336.8	1.2E-100	242	518	277

Status

Unreviewed

Ensembl Protein

ENSCAFP00000014825

UniProt Accession

F1PBY2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK18

Gene Synonyms/Alias

CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000010082	ENSCAFP00000014825	ENSCAFT00000016029

Organism

Canis familiaris

Functional Description

Protein Length

567

Protein Sequence
(FASTA)

MATTGRICAH KLLGCQVLGS RLRLRSSGCS FPGEPLTFPE WGSLPEPRAR TRRPAPRPQD 60

TRGSTAWPLL TMNKMKNFKR RLSLSVPRTE TIEESLTEFT EQFNQLHNRR NEDLQLGPLS 120

RDPQPETSTF SPTDSGEDPG QPSPGMQYRR QNQRRFSMEV RGSGLSPVGA AGHASHACPR 180

RAVAWHCPCD ISKRLSLPMD IRLPQEFLQK LQLESPDLPK PLSRMSRRAS LSDIGFGKLE 240

TYVKLDKLGE GTYATVFKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKNLKHANI 300

VTLHDLIHTE RSLTLVFEYL DSDLKQYLDH CGNLMSMHNV KIFMFQLLRG LAYCHRRKIL 360

HRDLKPQNLL ISERGELKLA DFGLARAKSV PTKTYSNEVV TLWYRPPDVL LGSTEYSTPI 420

DMWGVGCIHY EMATGRPLFP GTVKEELQLI ILTLCHCPEA PWGLLWAPRI SPSGQARPVP 480

APSSCRLDTD GLHLLSSLLL YESKSRMSAE AALSHPYFRS LGERVHQLED TASIFSLKEI 540

QLQKDPGYRG LAFQQPGRGK SRRQSIF 567

Nucleotide Sequence
(FASTA)

ATGGCCACAA CAGGGCGAAT CTGTGCGCAT AAGCTCCTGG GGTGCCAGGT GCTGGGATCC 60

AGGCTCAGAC TCAGAAGCTC AGGTTGCAGC TTCCCCGGGG AGCCGCTCAC CTTTCCGGAG 120

TGGGGGAGCC TCCCCGAGCC CCGGGCGCGG ACCCGGCGCC CAGCCCCGCG GCCCCAGGAC 180

ACGCGCGGCT CCACTGCCTG GCCCCTGCTG ACCATGAACA AGATGAAGAA CTTCAAGCGC 240

CGCCTCTCCC TGTCAGTGCC TCGCACCGAG ACTATCGAGG AGTCCTTGAC TGAGTTCACA 300

GAGCAGTTCA ACCAGCTACA CAATCGACGC AATGAGGATC TGCAGCTCGG GCCTCTCAGC 360

AGAGACCCCC AGCCAGAGAC CAGCACCTTC TCCCCGACAG ACAGCGGGGA GGACCCTGGG 420

CAGCCGTCCC CTGGCATGCA GTACCGGCGG CAGAACCAGC GCCGCTTCTC CATGGAGGTG 480

AGGGGCTCTG GGCTCTCCCC TGTGGGTGCA GCAGGACACG CCAGCCACGC GTGCCCAAGG 540

AGGGCGGTGG CCTGGCATTG CCCATGTGAC ATCAGTAAGA GGCTGTCTCT GCCCATGGAC 600

ATCCGCCTAC CCCAGGAATT CCTGCAGAAG CTACAGCTGG AGAGTCCAGA CCTGCCCAAA 660

CCACTCAGCC GCATGTCCCG CCGAGCATCC CTGTCAGATA TTGGCTTTGG GAAACTGGAA 720

ACATACGTGA AGCTGGACAA ACTGGGGGAG GGTACCTATG CCACAGTCTT CAAAGGGCGC 780

AGCAAACTGA CGGAGAACCT GGTGGCCCTA AAGGAGATCC GGCTGGAGCA TGAGGAGGGG 840

GCGCCTTGCA CTGCCATCCG AGAGGTGTCT CTACTGAAGA ACCTAAAGCA CGCCAATATT 900

GTGACTCTGC ATGACCTCAT CCATACGGAA CGGTCTCTTA CCCTGGTGTT TGAGTACCTG 960

GATAGTGACC TGAAGCAGTA TCTGGACCAC TGCGGAAACC TCATGAGCAT GCACAATGTC 1020

AAGATTTTCA TGTTCCAGCT GCTCCGGGGC CTTGCCTACT GCCACCGCCG CAAGATCCTG 1080

CACCGAGATC TGAAACCACA GAACCTGCTC ATTAGTGAGA GGGGGGAGCT GAAGCTGGCT 1140

GACTTTGGAC TGGCCCGGGC CAAGTCAGTA CCCACGAAGA CCTACTCCAA TGAGGTGGTG 1200

ACCCTGTGGT ACAGGCCCCC GGATGTGCTG TTGGGGTCCA CGGAGTACTC CACCCCCATT 1260

GACATGTGGG GCGTGGGCTG CATCCACTAC GAGATGGCCA CGGGGAGGCC CCTCTTCCCC 1320

GGAACGGTCA AGGAGGAGCT GCAACTCATC ATACTGACTC TCTGTCACTG CCCGGAAGCT 1380

CCATGGGGCT TACTATGGGC CCCACGCATC AGCCCCTCAG GTCAGGCCCG GCCTGTGCCA 1440

GCTCCTTCCT CCTGCAGGTT GGACACTGAC GGCCTCCACC TCCTGAGCAG CCTCCTCCTG 1500

TACGAATCCA AGAGTCGCAT GTCAGCCGAG GCGGCCCTGA GTCACCCCTA CTTCCGGTCT 1560

CTGGGAGAGC GTGTGCACCA GCTTGAAGAT ACGGCATCCA TCTTCTCCCT GAAGGAGATC 1620

CAGCTCCAGA AGGACCCAGG CTACCGGGGC CTGGCCTTCC AGCAGCCAGG ACGAGGGAAG 1680

AGCCGGAGGC AGAGCATCTT CTGA 1704

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 242   YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANI  300

         7899********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++++l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+glay+H++k

Q: 301   VTLHDLIH-TERSLTLVFEYLDSDLKQYLDHCGN-LMSMHNVKIFMFQLLRGLAYCHRRK  358

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 359   ILHRDLKPQNLLISERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  418

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfpk  240

          +D+W+vgci  e++t +plf+g+  +++l+ i+ +l +  e+ w  +   p+++ s +

Q: 419   PIDMWGVGCIHYEMATGRPLFPGTV-KEELQLIILTLCHCPEAPWGLL-WAPRISPSGQA  476

         ***********************86.5779999999988999999755.56777744444

S: 241   kkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

          ++    + + +l++++l+ll++ll ++ k+R+sa++al+h+yf

Q: 477   -RPVPAPSSC-RLDTDGLHLLSSLLLYESKSRMSAEAALSHPYF  518

         .344555555.78999***************************9

Domain Sequence
(FASTA)

YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKNLKHANIV 60

TLHDLIHTER SLTLVFEYLD SDLKQYLDHC GNLMSMHNVK IFMFQLLRGL AYCHRRKILH 120

RDLKPQNLLI SERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180

MWGVGCIHYE MATGRPLFPG TVKEELQLII LTLCHCPEAP WGLLWAPRIS PSGQARPVPA 240

PSSCRLDTDG LHLLSSLLLY ESKSRMSAEA ALSHPYF 277

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013