EKS-CAF-00285

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00285

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	451.4	1.6E-135	204	491	288

Status

Unreviewed

Ensembl Protein

ENSCAFP00000014864

UniProt Accession

E2RA74;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000010107	ENSCAFP00000014864	ENSCAFT00000016073

Organism

Canis familiaris

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MLLRSSGKLN VGTKKEDGES TVPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60

DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120

GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQESRPRYS IGLEQDETYI PPGESLRDLI 180

EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240

WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKS 300

MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360

TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420

EEYQLPYHDL VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM MECWAHNPAS 480

RLTALRVKKT LAKMSESQDI KL 502

Nucleotide Sequence
(FASTA)

ATGCTTTTGC GAAGTTCAGG AAAATTAAAT GTGGGCACCA AGAAAGAGGA TGGTGAGAGT 60

ACAGTCCCCA CCCCTCGTCC AAAGATCTTG CGTTGCAAAT GCCACCACCA TTGTCCAGAA 120

GACTCAGTCA ACAACATTTG CAGCACAGAT GGATATTGTT TCACAATGAT TGAAGAAGAT 180

GATTCTGGGA TGCCTGTGGT CACTTCTGGA TGTCTAGGAC TAGAAGGCTC AGATTTTCAG 240

TGCCGGGATA CCCCCATTCC TCATCAAAGA AGATCAATTG AGTGCTGCAC AGAACGGAAT 300

GAATGTAATA AAGATCTACA CCCTACATTG CCTCCACTGA AAAATAGAGA TTTTGTTGAC 360

GGACCTATAC ATCACAAGGC CTTACTTATA TCTGTAACTG TCTGTAGTTT GCTATTGGTC 420

CTTATTATTT TATTCTGTTA CTTCAGGTAT AAAAGACAAG AAAGCCGACC TCGGTACAGC 480

ATTGGGTTAG AACAGGACGA AACATACATT CCTCCTGGAG AATCCCTGAG AGACTTAATT 540

GAGCAGTCTC AAAGCTCAGG AAGTGGATCA GGCCTCCCTC TGCTGGTCCA AAGGACTATA 600

GCTAAGCAGA TTCAGATGGT GAAACAGATT GGAAAAGGTC GCTATGGGGA AGTTTGGATG 660

GGGAAGTGGC GTGGCGAAAA GGTAGCTGTG AAAGTGTTCT TCACCACAGA GGAAGCCAGC 720

TGGTTCCGAG AGACAGAAAT ATATCAGACA GTGTTGATGA GGCATGAAAA CATTCTGGGG 780

TTCATTGCTG CAGATATCAA AGGGACAGGG TCATGGACCC AGTTGTACCT AATCACAGAC 840

TATCATGAAA ATGGTTCCCT CTATGATTAT CTGAAGTCCA CCACCCTAGA TACAAAATCG 900

ATGCTGAAGT TAGCCTATTC TTCTGTCAGT GGCTTATGTC ATTTACACAC AGAAATCTTT 960

AGCACCCAAG GCAAACCAGC AATTGCCCAC CGAGATCTGA AAAGTAAGAA CATCCTGGTG 1020

AAGAAAAATG GAACTTGTTG TATAGCTGAC CTGGGCCTGG CTGTTAAATT TATTAGTGAT 1080

ACAAATGAAG TTGACATACC ACCCAACACC CGAGTTGGCA CCAAACGCTA TATGCCTCCG 1140

GAAGTGTTGG ATGAGAGCTT AAACAGAAAT CACTTTCAGT CTTACATTAT GGCCGACATG 1200

TATAGTTTTG GACTCATCCT CTGGGAGGTC GCTAGGAGAT GTGTATCCGG AGGTATAGTC 1260

GAAGAATACC AGCTTCCCTA TCATGACCTA GTGCCCAGTG ATCCTTCTTA TGAGGACATG 1320

AGAGAGATCG TTTGCATCAA AAAGCTACGT CCCTCGTTCC CCAACCGATG GAGTAGTGAT 1380

GAGTGTCTGA GGCAGATGGG AAAACTCATG ATGGAATGCT GGGCTCACAA TCCTGCATCA 1440

AGACTGACAG CCCTGCGTGT TAAGAAAACA CTAGCCAAGA TGTCCGAGTC CCAGGACATT 1500

AAACTCTAA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 204   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  263

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 264   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 324   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 382   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl+ ecW+++p++Rltalrvkk+l

Q: 441   REIVCIKKLRPSFPNRWSSDECLRQMGKLMMECWAHNPASRLTALRVKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMMEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0001502	; P:cartilage condensation
GO:0009953	; P:dorsal/ventral pattern formation
GO:0006954	; P:inflammatory response
GO:0035108	; P:limb morphogenesis
GO:0001550	; P:ovarian cumulus expansion
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0060041	; P:retina development in camera-type eye
GO:0031290	; P:retinal ganglion cell axon guidance
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013