EKS-CAF-00239

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00239

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	426.6	4.1E-128	41	301	261

Status

Unreviewed

Ensembl Protein

ENSCAFP00000015096

UniProt Accession

F1PU32;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPKAPK3

Gene Synonyms/Alias

MAPKAPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000010281	ENSCAFP00000015096	ENSCAFT00000016320

Organism

Canis familiaris

Functional Description

Protein Length

380

Protein Sequence
(FASTA)

MDGETAKEPV PSPGAPCGTG SAGAPAGAGE PQKYAVTHYY QLSKQVLGLG VNGKVLECFH 60

RRTGQKCALK LLYDSPKARQ EVDHHWQASG GPHIVRILDV YENMHHSKRC LLIVMECMEG 120

GELFSRIQER GDLAFTEREA AEIMRDIGTA IQFLHSQNIA HRDVKPENLL YTSKEKDAVL 180

KLTDFGFAKE TTQNALQTPC YTPYYVAPEV LGPEKYDKSC DMWSLGVIMY ILLCGFPPFY 240

SNTGQAISPG MKRRIRLGQY GFPNPEWSEV SEDAKQLIRL LLKTDPTERL TITQFMNHPW 300

INQSMVVPQT PLHTARVLQE DRDHWDEVKE EMTSALATMR VDYDQVQIKD LKTSNNRLLN 360

KRRKKQAGSG SSASQGCNNQ 380

Nucleotide Sequence
(FASTA)

ATGGATGGTG AGACAGCAAA GGAGCCTGTG CCCTCTCCAG GAGCACCCTG CGGAACTGGC 60

TCAGCTGGCG CTCCTGCCGG GGCGGGGGAG CCCCAGAAGT ATGCAGTGAC CCATTATTAC 120

CAGTTGTCCA AGCAAGTGCT GGGCCTGGGT GTGAACGGCA AGGTGCTGGA GTGCTTCCAC 180

AGGCGCACTG GGCAGAAATG TGCCCTGAAG CTCCTGTACG ACAGCCCCAA GGCCCGGCAG 240

GAGGTGGACC ACCACTGGCA GGCCTCGGGT GGCCCTCACA TTGTGCGCAT CCTGGACGTG 300

TATGAGAACA TGCATCACAG CAAGCGCTGT CTCCTCATCG TCATGGAATG CATGGAAGGT 360

GGTGAGCTAT TCAGCCGGAT TCAGGAGCGT GGTGACCTGG CTTTCACCGA AAGAGAAGCT 420

GCAGAGATCA TGCGGGATAT CGGCACCGCC ATCCAGTTCC TGCACAGCCA GAACATTGCC 480

CACCGAGATG TCAAGCCTGA AAACTTGCTC TACACGTCCA AGGAGAAGGA TGCAGTACTC 540

AAGCTCACCG ACTTTGGCTT TGCCAAGGAG ACCACCCAAA ATGCCCTGCA GACACCCTGC 600

TACACTCCCT ATTATGTGGC TCCTGAGGTC TTGGGTCCAG AGAAGTACGA CAAATCGTGT 660

GACATGTGGT CCCTGGGCGT CATCATGTAC ATCCTCCTGT GTGGCTTCCC ACCCTTCTAC 720

TCCAACACGG GCCAGGCTAT CTCCCCAGGG ATGAAGAGGA GGATCCGCCT AGGCCAGTAT 780

GGCTTCCCCA ATCCTGAGTG GTCGGAGGTT TCTGAAGATG CCAAGCAGCT GATCCGTCTC 840

CTGCTGAAGA CTGACCCCAC AGAGAGGCTG ACCATCACAC AGTTCATGAA CCATCCCTGG 900

ATCAACCAAT CAATGGTGGT GCCCCAGACG CCTCTTCACA CGGCCCGAGT GCTGCAGGAA 960

GATAGAGACC ATTGGGATGA GGTCAAGGAG GAGATGACCA GTGCCCTGGC AACCATGCGT 1020

GTGGACTACG ACCAGGTGCA GATCAAGGAT CTGAAGACCT CTAACAACCG GCTGCTCAAC 1080

AAGCGGAGAA AGAAGCAAGC AGGCAGTGGC TCCTCAGCCT CACAGGGCTG CAACAACCAG 1140

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60

         +l+++vlG G++gkvlec++++tg+k+alk+l+d++k+r+ev++h+qasg ++iv+++dv

Q: 41    QLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVRILDV  100

         5789********************************************************

S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118

         +en+++ +++ll+v+e++eGGel+sriqer   afte+ea+e+++di++a++flhs+nia

Q: 101   YENMHHSKRCLLIVMECMEGGELFSRIQERgdLAFTEREAAEIMRDIGTAIQFLHSQNIA  160

         ******************************9889**************************

S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178

         hrD+kpenlLy+skek+a++kl+Dfg+ake +++++l+tpc+t++yvaPevl++ek

Q: 161   HRDVKPENLLYTSKEKDAVLKLTDFGFAKE-TTQNALQTPCYTPYYVAPEVLGPEK----  215

         *****************************7.7899*********************....

S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238

          ydksCD+WslGvi+yillcG+pPfys++g+ais+++k+ri+ g+y fP++eWsevse+a

Q: 216   -YDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDA  274

         .***********************************************************

S: 239   kdlirklLkrdpkerltieevlnhpwv  265

         k+lir lLk+dp+erlti++++nhpw+

Q: 275   KQLIRLLLKTDPTERLTITQFMNHPWI  301

         **************************8

Domain Sequence
(FASTA)

QLSKQVLGLG VNGKVLECFH RRTGQKCALK LLYDSPKARQ EVDHHWQASG GPHIVRILDV 60

YENMHHSKRC LLIVMECMEG GELFSRIQER GDLAFTEREA AEIMRDIGTA IQFLHSQNIA 120

HRDVKPENLL YTSKEKDAVL KLTDFGFAKE TTQNALQTPC YTPYYVAPEV LGPEKYDKSC 180

DMWSLGVIMY ILLCGFPPFY SNTGQAISPG MKRRIRLGQY GFPNPEWSEV SEDAKQLIRL 240

LLKTDPTERL TITQFMNHPW I 261

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013