EKS-CAF-00371
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00371
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src433.62.7E-130245494250
StatusUnreviewed
Ensembl ProteinENSCAFP00000040453
UniProt AccessionE2R589;
Protein Name
Protein Synonyms/Alias
Gene NameLCK
Gene Synonyms/Alias LCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000010625ENSCAFP00000015667ENSCAFT00000016931
ENSCAFG00000010625ENSCAFP00000040453ENSCAFT00000043214
OrganismCanis familiaris
Functional Description
Protein Length509
Protein Sequence
(FASTA)
MGCSCSSNPE DDWMENIDVC ENCHYPIVPL DGKATLPMRN GSDVRDPLVI YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LERNGEWWKA QSLTTGQEGF IPFNFVAKAN 120
SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 180
YKIRNLDKGG FYISPRITFP GLHELVRHYT NSSDGLCTRL SRPCQTQKPQ KPWWEDEWEV 240
PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 300
VRLYAVVTQE PIYIITEYME NGSLVDFLKT PPGIKLTINK LLDMAAQIAE GMAFIEERNY 360
IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420
SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY QLMMLCWKER 480
PEDRPTFDYL RSVLEDFFTA TEGQYQPQP 509
Nucleotide Sequence
(FASTA)
ATGGGCTGTA GCTGCAGCTC AAACCCTGAA GATGACTGGA TGGAAAACAT CGATGTATGT 60
GAAAACTGCC ATTACCCCAT AGTCCCACTG GATGGCAAGG CCACGCTGCC CATGCGGAAT 120
GGCTCTGACG TGCGGGATCC ACTGGTTATC TATGAAGGCT CCAATCCCCC AGCCTCACCA 180
CTGCAAGACA ACCTGGTTAT CGCTCTGCAC AGCTATGAGC CCTCTCACGA TGGAGACTTG 240
GGTTTCGAGA AGGGTGAACA GCTCCGTATC CTGGAGCGGA ACGGTGAGTG GTGGAAGGCG 300
CAGTCCTTGA CCACGGGCCA GGAAGGCTTC ATCCCTTTCA ATTTCGTGGC CAAAGCGAAC 360
AGCCTGGAGC CCGAACCCTG GTTCTTCAAG AACCTGAGCC GCAAGGACGC GGAACGGCAG 420
CTCCTGGCGC CCGGGAACAC CCACGGCTCC TTCCTGATTC GGGAGAGCGA GAGCACCGCG 480
GGATCGTTTT CATTGTCTGT GCGGGACTTC GACCAGAACC AGGGAGAGGT GGTGAAACAT 540
TACAAGATCC GTAACCTGGA CAAAGGCGGC TTCTACATCT CCCCTCGCAT CACCTTCCCT 600
GGCCTGCACG AGCTGGTCCG CCATTACACC AATTCTTCAG ACGGGCTGTG CACGCGGTTG 660
AGTCGCCCCT GCCAGACCCA GAAGCCCCAG AAGCCTTGGT GGGAGGATGA GTGGGAGGTT 720
CCCAGGGAGA CGCTGAAGCT GGTGGAGCGG CTAGGGGCCG GCCAGTTCGG GGAGGTGTGG 780
ATGGGGTACT ACAACGGGCA CACAAAGGTG GCAGTGAAGA GCCTGAAGCA GGGCAGCATG 840
TCCCCTGACG CCTTCCTGGC CGAGGCTAAT CTCATGAAGC AGCTGCAGCA CCAGAGGCTG 900
GTCCGGCTCT ATGCGGTGGT CACCCAGGAG CCCATCTACA TCATCACGGA ATACATGGAG 960
AACGGGAGCC TGGTGGATTT CCTCAAGACC CCCCCAGGCA TCAAGCTGAC TATCAACAAA 1020
CTCTTGGACA TGGCAGCCCA AATTGCAGAG GGCATGGCAT TCATTGAAGA GCGGAATTAT 1080
ATCCACCGTG ACCTGAGGGC TGCCAATATC CTGGTGTCTG ACACCCTGAG CTGCAAGATC 1140
GCAGACTTTG GCCTGGCACG CCTCATCGAG GACAACGAGT ACACAGCGAG GGAGGGAGCC 1200
AAGTTTCCCA TTAAGTGGAC AGCACCAGAA GCCATTAACT ACGGGACATT CACCATCAAG 1260
TCGGACGTGT GGTCTTTTGG GATCCTGCTG ACAGAGATTG TCACCCATGG CCGCATCCCT 1320
TACCCAGGGA TGACCAATCC TGAGGTGATT CAGAACCTGG AACGAGGCTA CCGCATGGTG 1380
CGACCTGACA ACTGTCCAGA GGAGCTATAC CAACTCATGA TGCTGTGTTG GAAGGAGCGC 1440
CCAGAGGATC GGCCAACCTT TGACTACCTG CGTAGTGTGC TGGAGGACTT CTTCACAGCC 1500
ACAGAGGGCC AGTACCAGCC CCAGCCCTGA 1530
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv++lG+GqfGevw+g+++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly
Q: 245   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY  304
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+m++Gsl+dflk+  g kl+++kl+d+aaq+aeGma++ee+n+ihr
Q: 305   AVVTQ-EPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNYIHR  363
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+++l +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 364   DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  423
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGmtn ev++++ergyr+ rp++cpeely+l++ cwk++pe+
Q: 424   WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMMLCWKERPED  483
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++l++vl
Q: 484   RPTFDYLRSVL  494
         *******9876
Domain Sequence
(FASTA)
LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHQRLVRLY 60
AVVTQEPIYI ITEYMENGSL VDFLKTPPGI KLTINKLLDM AAQIAEGMAF IEERNYIHRD 120
LRAANILVSD TLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180
SFGILLTEIV THGRIPYPGM TNPEVIQNLE RGYRMVRPDN CPEELYQLMM LCWKERPEDR 240
PTFDYLRSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00347
EKS-BOT-00370
EKS-CAJ-00376
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-EQC-00361
EKS-ERE-00004
EKS-FEC-00358
EKS-GAM-00223
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MEG-00303
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MUP-00365
EKS-MYL-00368
EKS-OCP-00080
EKS-ORN-00480
EKS-ORC-00349
EKS-ORL-00441
EKS-OTG-00374
EKS-PAT-00349
EKS-PES-00333
EKS-POA-00359
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-SUS-00324
EKS-TAR-00475
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
cfa:478151;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013