EKS-CAF-00418

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00418

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	436.2	4.7E-131	35	293	259

Status

Unreviewed

Ensembl Protein

ENSCAFP00000015677

UniProt Accession

E2R573;

Protein Name

Protein Synonyms/Alias

Gene Name

STK17B

Gene Synonyms/Alias

STK17B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000010652	ENSCAFP00000015677	ENSCAFT00000016946

Organism

Canis familiaris

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MSRRRFDCRS ISGLLTTIPQ TPMKMENFNN FYTLTSKELG RGKFAVVRQC ISKSTGQEYA 60

AKFLKKRRRG QDCRAEILHE IAILELAKSC PHVINLHEVY ENTSEIILIL EYAAGGEIFN 120

LCLPELAEMV SENDIIRLIK QILEGVCYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF 180

GMSRKIGNAC ELREIMGTPE YLAPEILNYD PITTATDMWN VGIIAYMLLT HTSPFVGEDN 240

QETYLNISQV NVDYSEETFS SVSQLATDFI QRLLVKNPEK RPTAEICLSH SWLQQWDFGN 300

LFHPEETSSS SQSQDHSLRS SEDKTSKSSC NGTCSDREDK ENIPEDSSMV SKRFRFDNSL 360

PNPHELVSDL LC 372

Nucleotide Sequence
(FASTA)

ATGTCGAGGA GAAGATTTGA TTGCCGAAGT ATTTCAGGCT TGCTAACTAC AATTCCTCAA 60

ACTCCAATGA AAATGGAAAA CTTTAATAAT TTTTATACAC TTACATCTAA AGAGCTGGGA 120

AGAGGAAAGT TTGCTGTGGT TAGACAGTGT ATATCAAAAT CTACTGGCCA AGAATATGCT 180

GCAAAATTTC TAAAAAAGAG AAGAAGAGGG CAGGATTGTC GAGCAGAGAT TCTACATGAG 240

ATTGCCATAC TTGAATTGGC AAAGTCTTGT CCTCATGTAA TTAATCTTCA TGAAGTCTAT 300

GAAAATACCA GTGAAATCAT TTTGATACTG GAGTATGCTG CGGGTGGAGA AATTTTCAAC 360

TTGTGTTTGC CTGAGCTGGC TGAAATGGTT TCTGAAAATG ATATTATCAG GCTCATTAAA 420

CAAATACTTG AAGGAGTTTG TTATCTACAT CAGAATAACA TTGTACACCT TGATTTAAAG 480

CCACAGAATA TATTATTGAG CAGCATATAT CCTCTTGGAG ATATAAAAAT TGTAGATTTT 540

GGAATGTCTC GAAAAATAGG AAATGCATGT GAACTTCGGG AAATCATGGG AACACCAGAA 600

TACTTAGCTC CAGAAATCCT GAACTATGAT CCTATTACCA CAGCAACAGA TATGTGGAAT 660

GTTGGTATAA TAGCATATAT GTTGTTAACT CATACATCTC CATTTGTGGG AGAAGATAAC 720

CAAGAAACAT ACCTCAATAT TTCTCAAGTT AATGTAGATT ATTCAGAAGA AACTTTTTCG 780

TCAGTTTCAC AGCTGGCCAC AGACTTTATC CAGAGGCTTC TAGTAAAAAA TCCAGAGAAA 840

AGACCAACAG CAGAAATCTG CCTGTCTCAT TCTTGGCTAC AGCAGTGGGA CTTTGGAAAC 900

TTATTTCATC CTGAAGAAAC CTCCAGTTCC TCTCAAAGTC AAGATCATTC ATTAAGGTCC 960

TCTGAAGACA AAACTTCTAA ATCCTCTTGT AATGGAACCT GTAGTGATCG AGAAGACAAA 1020

GAGAATATTC CAGAGGACAG CAGCATGGTT TCCAAAAGAT TTCGCTTTGA TAACTCATTG 1080

CCCAATCCCC ATGAACTTGT TTCAGATTTG CTGTGTTAG 1119

Domain Profile

S: 3     tgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirse  62

         t+kelg+Gkfavvr+c++kstG+eyaakflkkrr    r++++r+ei +e+a+l++++s+

Q: 35    TSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR----RGQDCRAEILHEIAILELAKSC  90

         789*******************************....**********************

S: 63    pnvinlhevyenksdvililelvaGGelfd..llaekeslseeeatellkqilegvkylh  120

         p+vinlhevyen+s++ilile++aGGe+f+  l + +e++se+++++l+kqilegv ylh

Q: 91    PHVINLHEVYENTSEIILILEYAAGGEIFNlcLPELAEMVSENDIIRLIKQILEGVCYLH  150

         ******************************877899************************

S: 121   skkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivny  180

         +++ivhldlkP+nill++ + p gdik++dfG+srki +++el+ei+GtPe++aPei+ny

Q: 151   QNNIVHLDLKPQNILLSSIY-PLGDIKIVDFGMSRKIGNACELREIMGTPEYLAPEILNY  209

         ********************.***************************************

S: 181   eplsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdf  240

         +p++++tdmw++G+i+y+ll+++sPf+G+++qet+lnis+vn+d+see+fssvs+la+df

Q: 210   DPITTATDMWNVGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDF  269

         ************************************************************

S: 241   irrllvkdpekrltieeclehswl  264

         i+rllvk+pekr t+e cl+hswl

Q: 270   IQRLLVKNPEKRPTAEICLSHSWL  293

         ***********************7

Domain Sequence
(FASTA)

TSKELGRGKF AVVRQCISKS TGQEYAAKFL KKRRRGQDCR AEILHEIAIL ELAKSCPHVI 60

NLHEVYENTS EIILILEYAA GGEIFNLCLP ELAEMVSEND IIRLIKQILE GVCYLHQNNI 120

VHLDLKPQNI LLSSIYPLGD IKIVDFGMSR KIGNACELRE IMGTPEYLAP EILNYDPITT 180

ATDMWNVGII AYMLLTHTSP FVGEDNQETY LNISQVNVDY SEETFSSVSQ LATDFIQRLL 240

VKNPEKRPTA EICLSHSWL 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006917	; P:induction of apoptosis

KEGG

cfa:488453

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013