EKS-CAF-00016

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00016

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	542.7	1.6E-163	999	1266	268

Status

Unreviewed

Ensembl Protein

ENSCAFP00000016006

UniProt Accession

F1PXU6;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

LOC100687483

Gene Synonyms/Alias

LOC100687483;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000010881	ENSCAFP00000016006	ENSCAFT00000017295

Organism

Canis familiaris

Functional Description

Protein Length

1367

Protein Sequence
(FASTA)

MKSGSGGGSP TSLWGLVFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGYLH 60

ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF 120

EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTVDWSLI LDAVSNNYIV GNKPPKECGD 180

LCPGTMEEKP LCEKTTINNE YNYRCWTTNR CQKMCPSACG KRACTENNEC CHPECLGSCS 240

APDNDTACVA CRHYYYAGVC VPTCPPNTYR FEGWRCVDRD FCANIPSAES SDSEGFVIHD 300

GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML QGCTIFKGNL 360

LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS FLKNLRQILG EEQLEGNYSF 420

YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF NPKLCVSEIY RMEEVTGTKG RQSKGDINTR 480

NNGERASCES DVLHFTSTTT WKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG 540

QDACGSNSWN MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE 600

ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR QPQDSYLYRH 660

NYCSKDKIPI RKYADGTIDV EEVTENPKTE VCGGEKGPCC ACPKTEAEKQ AEKEEAEYRK 720

VFENFLHNSI FVPRPERKRR DVTQVTNTTM SSRSRNTTVV DTYNITDPEE LETEYPFFES 780

RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW 840

ESRPENSIFL KWPEPENPNG LILMYEIKYG SQIEDQRECV SRQEYRKYGG AKLNRLNPGN 900

YTARIQATSL SGNGSWTDPV FFYVPAKITY ENFIHLIIAL PVAVLLIVGG LVIMLYVFHR 960

RRNNSRLGNG VLYASVNPEY FSAADVYVPD EWEVAREKIT MSRELGQGSF GMVYEGVAKG 1020

VVKDEPETRV AIKTVNEAAS MRERIEFLNE ASVMKEFNCH HVVRLLGVVS QGQPTLVIME 1080

LMTRGDLKSY LRSLRPEIEN NPVLAPPSLS KMIQMAGEIA DGMAYLNANK FVHRDLAARN 1140

CMVAEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT THSDVWSFGV 1200

VLWEIATLAE QPYQGLSNEQ VLRFVMEGGL LDKPDNCPDM LFELMRMCWQ YNPKMRPSFL 1260

EIISSIKDEM EPGFREVSFY YSEENKPPEP EELDLEPENM ESVPLDPSAS SSSLPLPDRL 1320

SGHKAENGPG PGVLVLRASF DERQPYAHMN GGRKNERALP LPQSSTC 1367

Nucleotide Sequence
(FASTA)

ATGAAGTCTG GCTCCGGAGG AGGGTCCCCG ACCTCGCTGT GGGGGCTCGT GTTTCTCTCC 60

GCCGCGCTGT CGCTCTGGCC GACGAGTGGA GAAATCTGTG GGCCAGGCAT CGACATCCGC 120

AATGACTATC AGCAGCTGAA GCGCCTGGAG AACTGTACAG TGATCGAGGG CTACCTCCAC 180

ATCCTACTCA TCTCCAAGGC AGAGGACTAC CGCAGCTACC GCTTCCCCAA GCTCACGGTC 240

ATCACCGAGT ACCTGCTGCT GTTCCGTGTG GCCGGCCTTG AGAGCCTCGG GGATCTCTTC 300

CCCAACCTCA CAGTCATCCG CGGCTGGAAG CTCTTCTACA ACTACGCCCT GGTCATCTTT 360

GAGATGACCA ACCTCAAGGA TATTGGGCTT TACAATCTGA GGAACATTAC TCGGGGGGCC 420

ATCAGGATTG AGAAGAATGC TGACCTCTGT TACCTCTCCA CAGTGGACTG GTCCCTGATC 480

CTGGATGCAG TGTCCAACAA CTACATCGTG GGGAACAAAC CCCCTAAGGA ATGTGGGGAC 540

CTGTGTCCAG GGACAATGGA GGAGAAGCCC TTGTGTGAGA AGACTACCAT CAACAATGAA 600

TACAACTATC GCTGCTGGAC TACAAATCGC TGCCAGAAAA TGTGCCCGAG CGCTTGCGGG 660

AAGCGGGCGT GCACGGAGAA CAACGAGTGT TGTCACCCCG AGTGTCTGGG CAGCTGCAGC 720

GCGCCGGACA ACGATACGGC CTGTGTGGCC TGCAGGCATT ACTACTACGC AGGCGTCTGC 780

GTGCCCACCT GCCCGCCCAA CACCTACCGC TTTGAGGGCT GGCGCTGCGT GGACCGCGAC 840

TTCTGCGCCA ACATCCCCAG CGCCGAGAGC AGCGACTCCG AGGGGTTCGT GATCCATGAC 900

GGCGAGTGCA TGCAGGAGTG CCCCTCTGGG TTCATCCGCA ATGGCAGTCA GAGCATGTAC 960

TGCATCCCTT GTGAAGGTCC TTGTCCCAAG GTCTGTGAGG AAGAAAAGAA AACAAAGACC 1020

ATTGATTCTG TTACCTCTGC TCAAATGCTC CAAGGATGTA CCATCTTCAA GGGCAATTTG 1080

CTCATTAATA TCCGCCGAGG CAATAACATT GCCTCAGAGC TGGAGAACTT CATGGGGCTC 1140

ATCGAGGTGG TGACAGGCTA CGTGAAGATC CGCCATTCCC ATGCCTTGGT CTCCCTGTCC 1200

TTCCTAAAAA ACCTTCGCCA GATCTTAGGA GAGGAACAGC TGGAGGGGAA CTACTCCTTC 1260

TACGTCCTCG ACAACCAGAA CTTGCAGCAG CTTTGGGATT GGGACCACCG TAACCTGACC 1320

ATCAAAGCTG GGAAAATGTA TTTTGCTTTC AATCCCAAAT TGTGCGTCTC CGAAATTTAC 1380

CGCATGGAAG AAGTGACGGG GACCAAAGGA CGCCAGAGCA AAGGAGACAT AAATACCAGA 1440

AACAATGGAG AGCGAGCCTC CTGTGAAAGC GACGTCCTGC ACTTCACCTC TACGACCACA 1500

TGGAAGAATC GCATCATCAT CACGTGGCAC CGTTACCGGC CCCCTGACTA CAGGGACCTC 1560

ATCAGCTTTA CTGTCTACTA CAAGGAAGCA CCTTTTAAAA ACGTTACGGA GTATGATGGG 1620

CAGGATGCCT GTGGCTCCAA CAGCTGGAAT ATGGTAGATG TGGACCTCCC TCCCAACAAG 1680

GACGTTGAGC CTGGCATTTT ACTGCACGGA CTGAAGCCCT GGACGCAGTA TGCGGTTTAT 1740

GTCAAGGCGG TGACCCTCAC CATGGTGGAG AATGACCACA TCCGTGGGGC TAAGAGTGAA 1800

ATCTTGTACA TTCGCACCAA TGCTTCAGTT CCTTCCATTC CCCTGGATGT TCTTTCTGCA 1860

TCAAACTCCT CTTCTCAGCT CATTGTGAAG TGGAACCCAC CCTCTCTGCC CAACGGTAAC 1920

CTCAGTTACT ACATCGTGAG GTGGCAGCGG CAGCCCCAGG ACAGTTACCT TTACCGCCAC 1980

AACTACTGCT CCAAAGATAA AATCCCCATC AGGAAGTATG CTGATGGCAC TATCGATGTC 2040

GAAGAGGTGA CAGAGAATCC CAAGACCGAA GTATGTGGTG GAGAGAAGGG GCCTTGCTGT 2100

GCCTGCCCCA AAACTGAGGC CGAGAAGCAG GCTGAGAAGG AGGAGGCCGA GTACCGCAAA 2160

GTGTTCGAGA ATTTCCTGCA CAACTCCATC TTCGTGCCCA GACCTGAAAG GAAGCGTAGA 2220

GATGTTACAC AAGTCACCAA CACCACCATG TCCAGCCGAA GCAGGAACAC CACGGTGGTG 2280

GACACCTATA ATATCACAGA CCCAGAAGAG CTCGAGACAG AATACCCTTT CTTTGAGAGC 2340

AGAGTGGATA ACAAGGAGAG AACTGTAATC TCTAACCTCC GGCCTTTTAC CCTGTACCGC 2400

ATTGACATCC ACAGCTGTAA TCATGAGGCT GAGAAGCTGG GCTGCAGTGC CTCCAACTTT 2460

GTTTTTGCAA GAACCATGCC TGCAGAAGGA GCAGATGACA TTCCTGGGCC AGTGACCTGG 2520

GAGTCAAGGC CTGAAAACTC CATCTTTTTA AAGTGGCCAG AACCTGAGAA TCCCAATGGA 2580

TTGATTCTAA TGTATGAAAT AAAATATGGA TCCCAAATCG AGGATCAGCG GGAATGTGTA 2640

TCCAGACAGG AGTACAGGAA GTATGGAGGT GCCAAGCTTA ACCGGCTCAA CCCGGGGAAC 2700

TATACAGCCC GGATCCAGGC CACTTCTCTC TCTGGGAATG GGTCGTGGAC GGATCCTGTG 2760

TTCTTCTATG TCCCAGCCAA AATAACGTAT GAAAACTTCA TCCATCTGAT CATTGCTCTG 2820

CCCGTTGCTG TGCTATTGAT AGTGGGAGGG TTGGTTATAA TGCTGTACGT CTTCCACAGG 2880

AGAAGAAATA ACAGCAGGCT GGGGAATGGA GTGCTGTATG CTTCCGTGAA CCCAGAATAC 2940

TTCAGTGCTG CCGATGTGTA TGTACCTGAT GAGTGGGAGG TTGCTCGAGA GAAGATCACC 3000

ATGAGCCGAG AGCTGGGCCA GGGCTCGTTT GGGATGGTAT ATGAAGGAGT TGCCAAGGGT 3060

GTGGTTAAAG ATGAGCCTGA AACAAGGGTG GCCATTAAAA CAGTGAACGA GGCCGCCAGC 3120

ATGCGTGAAA GGATCGAATT TCTCAATGAG GCTTCAGTGA TGAAGGAGTT CAATTGTCAC 3180

CATGTGGTGC GGTTGCTGGG TGTGGTGTCC CAGGGCCAGC CGACGCTGGT CATCATGGAA 3240

CTGATGACAC GAGGGGATCT CAAAAGTTAT CTCAGGTCTC TGAGGCCAGA AATAGAGAAT 3300

AATCCAGTCC TCGCACCTCC AAGCCTAAGC AAGATGATCC AGATGGCTGG GGAGATTGCT 3360

GATGGCATGG CATACCTCAA TGCCAACAAG TTTGTCCACA GAGACCTTGC TGCCAGGAAC 3420

TGCATGGTGG CCGAAGATTT CACAGTCAAA ATTGGAGATT TCGGTATGAC AAGAGACATC 3480

TATGAGACAG ACTATTACCG GAAAGGAGGC AAGGGGCTGC TGCCTGTGCG CTGGATGTCA 3540

CCTGAGTCTC TCAAGGATGG AGTCTTCACC ACTCACTCTG ACGTCTGGTC CTTTGGGGTC 3600

GTTCTCTGGG AGATCGCCAC GCTGGCTGAG CAGCCATACC AGGGCTTGTC CAACGAGCAA 3660

GTCCTTCGCT TCGTTATGGA GGGCGGCCTT CTGGACAAGC CGGACAACTG CCCCGACATG 3720

CTGTTTGAGC TGATGCGCAT GTGCTGGCAG TACAACCCCA AGATGAGGCC TTCCTTCCTG 3780

GAGATCATCA GCAGCATCAA GGACGAGATG GAGCCCGGCT TCCGGGAGGT CTCCTTCTAC 3840

TACAGCGAGG AGAACAAGCC GCCCGAGCCG GAGGAGCTGG ACCTGGAGCC GGAGAACATG 3900

GAGAGTGTCC CCCTGGACCC GTCGGCCTCC TCGTCGTCCC TGCCTCTGCC TGACAGACTC 3960

TCAGGACACA AGGCCGAGAA CGGCCCAGGC CCTGGCGTGC TGGTCCTGCG AGCCAGCTTC 4020

GATGAGAGAC AGCCTTACGC GCACATGAAC GGGGGCCGCA AGAACGAGCG GGCCTTGCCT 4080

CTGCCCCAGT CTTCGACCTG CTGA 4104

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeGvak+vvk+e etrvaiktvneaas+reriefl+easvmkef+

Q: 999   ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFN  1058

         799*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrpe en+++lapp+l+k+iqma+e

Q: 1059  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEIENNPVLAPPSLSKMIQMAGE  1118

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1119  IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1178

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqGlsneqvl+fv++gg+l+kp+ncp

Q: 1179  MSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP  1238

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elmr+cwqynpk+rpsflei++++

Q: 1239  DMLFELMRMCWQYNPKMRPSFLEIISSI  1266

         *************************976

Domain Sequence
(FASTA)

ITMSRELGQG SFGMVYEGVA KGVVKDEPET RVAIKTVNEA ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPEI ENNPVLAPPS LSKMIQMAGE 120

IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTTHSDVWSF GVVLWEIATL AEQPYQGLSN EQVLRFVMEG GLLDKPDNCP 240

DMLFELMRMC WQYNPKMRPS FLEIISSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013