EKS-CAF-00487

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00487

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	430.2	2.6E-129	18	273	256

Status

Unreviewed

Ensembl Protein

ENSCAFP00000016211

UniProt Accession

E2QXK2;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000010959	ENSCAFP00000016211	ENSCAFT00000017509

Organism

Canis familiaris

Functional Description

Protein Length

893

Protein Sequence
(FASTA)

MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERKPVSY SKVLCIAFEV LQGLQYMNKH GIVHRALSPH 120

NILLDRKGHV KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIFKTT DHVPSEKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLG CVDDTIIVLA EEHGCLDIIK 240

DLPENVINLL KKCLTFHPSK RPTADELMQD EVFSEVSPLY TPFTKPASLF SSSLRCADLT 300

LPEDISQLCK DINSDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420

SAAATLPLII RERDTEYQLN RIILFDRLLK AYPYKKNQIW KEARIDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKPT 720

SDSNGIRSST PFFSTECPDP PKTDLSRESI PLNDLKSEVS PRISAEDLID LCELTVTGHF 780

KTPTKKTKSS KPKLLVVDIR NSEDFIRGHI SGSINIPFSA AFTAEGELTQ GPFTTVLQSF 840

KGKVIVIVGH VAKHTAEFAA HLVKMKYPRI CILDGGINKI KPTGLLTVPS PQI 893

Nucleotide Sequence
(FASTA)

ATGTTTCCCC TAAAGGATGC TGAAATGGGT GCCTTTACCT TCTTTGCCTC GGCTCTGCCA 60

CATGACGTTT GTGGAAGTAA TGGACTTCCT CTTACACCAA ATTCCATCAA AATTTTAGGG 120

CGATTTCAAA TCCTTAAGAC CATCACCCAT CCCAGACTTT GCCAGTATGT GGATATTTCT 180

AGAGGAAAGC ATGAAAGACT GGTGGTGGTA GCTGAACACT GTGAACGGAG TCTAGAAGAC 240

TTGCTTCGAG AAAGGAAACC CGTGAGCTAT TCAAAGGTTT TGTGCATAGC ATTTGAGGTA 300

CTTCAGGGTT TGCAGTATAT GAACAAGCAT GGTATAGTAC ATCGGGCCCT GTCTCCTCAT 360

AATATTCTTT TGGACCGAAA GGGACATGTT AAATTGGCTA AATTTGGACT TTATCACATG 420

ACAGCTCACG GTGATGATGT TGATTTCCCT ATTGGGTATC CATCATATTT GGCACCCGAG 480

GTAATTGCAC AAGGAATTTT CAAAACCACT GATCATGTGC CAAGTGAAAA ACCATTGCCT 540

TCTGGCCCCA AATCAGATGT GTGGTCTCTT GGAATCATTT TATTTGAGCT TTGTGTGGGA 600

AGAAAATTAT TTCAGAGCTT GGATATTTCT GAAAGACTAA AATTTTTGCT TACATTAGGT 660

TGTGTAGATG ACACTATAAT AGTTCTGGCT GAAGAACATG GTTGTCTGGA CATTATAAAG 720

GACCTTCCTG AAAATGTGAT AAATCTTTTG AAGAAGTGTC TCACCTTCCA CCCTTCCAAG 780

AGGCCAACTG CAGATGAATT AATGCAAGAC GAGGTATTTA GTGAAGTGTC TCCTTTGTAT 840

ACTCCCTTTA CCAAACCTGC CAGTCTGTTT TCATCTTCTC TGAGATGTGC TGATTTAACT 900

CTGCCTGAGG ATATCAGTCA GCTCTGTAAA GATATAAACA GTGATTACCT GGCAGAAAGA 960

TCTATTGAAG AAGTATATTA CCTTTGGTGT TTAGCTGGAG GTGACTTGGA GAAAGAACTT 1020

GTCAACAAGG AAATCATTCG ATCCAAACCA CCTATCTGCA CACTTCCCAA TTTTCTCTTT 1080

GAAGATGGTG AAAGCTTTGG ACAAGGTCGA GATAGAAGCT CACTATTAGA TGACACAACT 1140

GTGACATTGT CATTATGCCA GCTAAGAAAT AGATTAAAAG ATGTTGGTGG AGAAGCATTT 1200

TACCCATTAC TTGAAGATGA CCAGTCTAAT TTACCTCATT CAAACAGCAA TAATGAATTG 1260

TCTGCAGCTG CCACTCTCCC TTTAATCATC CGAGAGAGGG ACACAGAGTA CCAACTAAAC 1320

AGAATCATTC TCTTTGACAG ACTGCTAAAG GCTTATCCAT ATAAAAAAAA TCAAATCTGG 1380

AAAGAAGCGA GGATTGACAT TCCTCCTCTA ATGAGAGGTT TAACCTGGGC TGCCCTTCTG 1440

GGAGTTGAGG GGGCTATTCA TGCCAAGTAT GATGCAATTG ATAAAGATAC TCCAATTCCT 1500

ACAGATAGAC AAATTGAAGT GGACATTCCT CGGTGTCATC AGTATGATGA ACTATTATCA 1560

TCACCAGAAG GTCATGCAAA ATTTAGGCGT GTATTAAAAG CTTGGGTCGT GTCTCATCCT 1620

GATCTTGTAT ATTGGCAAGG TCTTGATTCA CTTTGTGCTC CATTCCTATA TTTAAATTTC 1680

AATAATGAAG CTTTGGCTTA TGCTTGTATG TCTGCCTTTA TCCCCAAATA CCTGTATAAC 1740

TTCTTCTTGA AAGACAACTC ACACGTAATA CAAGAGTATC TGACTGTGTT CTCACAGATG 1800

ATTGCATTCC ATGATCCAGA GTTGAGCAAT CATCTCAATG AGATTGGATT TATTCCAGAT 1860

CTCTATGCCA TACCTTGGTT TCTCACCATG TTTACTCATG TATTTCCACT GCACAAAATT 1920

TTCCACCTCT GGGATACCTT ACTCCTTGGG AATTCCTCTT TCCCATTCTG TATTGGAGTA 1980

GCAATTCTCC AGCAGCTACG GGACCGGCTT TTGGCTAATG GCTTTAACGA GTGCATTCTT 2040

CTCTTCTCTG ATTTACCAGA AATCGACATT GAACGCTGTG TGCGAGAATC AATCAACCTG 2100

TTCTGTTGGA CTCCTAAAAG TGCTACTTAC AGACAGCATG CTCAACCTCC AAAGCCAACT 2160

TCTGATAGCA ATGGTATCAG AAGTTCGACA CCTTTTTTCT CCACTGAGTG TCCAGATCCT 2220

CCAAAAACAG ATTTGTCAAG AGAATCCATC CCATTGAATG ACCTAAAGTC AGAAGTATCA 2280

CCCCGAATTT CAGCAGAGGA CCTCATTGAC TTGTGTGAAC TCACAGTGAC AGGCCATTTC 2340

AAAACACCTA CCAAGAAGAC AAAGTCCAGT AAACCAAAGC TCCTGGTAGT TGACATCCGG 2400

AATAGTGAAG ATTTTATTCG GGGTCATATT TCAGGCAGCA TCAACATTCC ATTCAGTGCT 2460

GCCTTCACTG CAGAAGGAGA GCTTACCCAG GGCCCTTTCA CTACTGTGCT CCAGAGCTTC 2520

AAAGGAAAGG TCATTGTCAT CGTGGGGCAT GTGGCAAAGC ACACAGCAGA GTTTGCAGCT 2580

CATCTTGTGA AGATGAAATA TCCAAGAATC TGCATTTTAG ATGGTGGCAT TAATAAGATC 2640

AAGCCAACAG GCCTCCTCAC TGTCCCATCT CCTCAAATAT GA 2682

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs s+vl+ia+evl+gl+y+nkh+ivhral+p++illdrkg+ vkLak+G

Q: 78    LEDLLRERKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGifkttdhvpSEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+t+i+laee++cldiik+l+e++++llkkCLt+

Q: 197   LCVGRKLFQSLDISERLKFLLTLGCVDDTIIVLAEEHGCLDIIKDLPENVINLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+ del++++vf

Q: 257   HPSKRPTADELMQDEVF  273

         **************997

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERKP VSYSKVLCIA FEVLQGLQYM NKHGIVHRAL SPHNILLDRK GHVKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIF KTTDHVPSEK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DISERLKFLL TLGCVDDTII VLAEEHGCLD IIKDLPENVI NLLKKCLTFH 240

PSKRPTADEL MQDEVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013