EKS-CAF-00127

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00127

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	453.1	3.4E-136	1086	1344	259

Status

Unreviewed

Ensembl Protein

ENSCAFP00000031338

UniProt Accession

F6XRA9;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R

Gene Synonyms/Alias

MST1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000010974	ENSCAFP00000016175	ENSCAFT00000017469
ENSCAFG00000010974	ENSCAFP00000031338	ENSCAFT00000036013

Organism

Canis familiaris

Functional Description

Protein Length

1403

Protein Sequence
(FASTA)

MELLPPPSQP SLLLLLLLLL PPPSLLARGS WRCPRTPYAA LRNFDVEYQV PSFSAGGPVQ 60

AVTTYEGGED GSAVFVAIRN RLFVLGPGLQ PVESLVTGPV GDSGCQTCAA CGPGPHSPQG 120

DTDARVLVLE PALPALVSCG SSLHGRCFLH ELEPGGAALR LAPPLCLFSA HHNRPDECPD 180

CVASPLGTLV TVVEQGHASY FYTASSLDAT VAASFSPRSV SIRRLKADAS GFAPGFAALS 240

VLPEYLTSYS IEYVYTFRAG AFVYFLTVQR PSVTAAPGAL HTRLARLSAA EPELGDYREL 300

ILDCRLEPKR RRRAAPQGGQ SYPVLRAAHT APVGSQLAKE LSIPQGQEVL FGVFATRRDS 360

SPGVNPNSVV CAFPLDLVDT LIEQGVERCC EPPVSSGLRR GLDFFQLPSF CPNPPGLEAP 420

SLNTSCRHFP LLVTGSLSRV DLFNGLLGPV QVTALHVTRL NNVTVAHMGT ADGRILQVEL 480

VRSLNYLLFV SNFSLGNNGQ PTQRDVSRLG DHLFFASGDQ VFQVPIQGPG CHHFLTCGSC 540

LRAQRFMGCG WCGGMCGRQK ECPGSWQQDH CPPKLTEFYP QSGPLRGSTR LTLCGSNFHL 600

RPADLVHEGT HHVTVGQSPC RLLPKDSSNL SPVPQKDFVE ELECELQPSG KQPAGPANVS 660

LTVTNVPPGK HFRVDGTSML QGFSFMEPVL TAVKPHFGPR AGGTRLTLEG KGLSLGTSQT 720

VLVNGTECPL KQVSEQQLLC TTPPGAATAI VPIHLQVGGA VVPGSWNFHY REDPIVLGIS 780

PNCGYIGSHV TIHGQHLTSA WHLVLSFHDG LRVVENRCKG LSPEQHQCRL PDYVVRSPQR 840

WVIGNLSAWG DGAAGFTLPG FRFLPPPHPP STDLAPLKPE EHAIKFEYIG LGAVADCIDM 900

NVTVDGKVCQ HELRGDVVIC PLPPSLELDK EPLPLQVCVD DKCHILGRVV RPSRERVPQR 960

LLLGVLLALL VLVAVLATVL IFNYRRRRQL VLSLNSNDLA SLGQTTGAVP LPVLCSGSDY 1020

RSGQGLHDLD GLDSTTWGHK ASSSDSGDGS CVPLLRTASI QLGDLDSALL AEVKDVLIPH 1080

EQVVTHSDRV IGKGHFGVVY HGEYIDEDQN RIHCAVKSLS RITEVQEAEA FLREGLLMRG 1140

LHHPNVLALI GIVLPPEGLP RVLLPYMRHG DLLRFIRSPQ RNPTVKDLIS FGLQVARGME 1200

YLAEQKFVHR DLAARNCMLD ESFTVKVADF GLARDILDKE YYSVRQHRHA RLPVKWMALE 1260

SLQTYRFTTK SDVWSFGVLL WELLTRGAPP YPHIDPFDLI QFLAQGRRLP QPEYCPNSLY 1320

MVMQRCWAVD PAVRPTFTAL VEEVEHVAAR LLGDHYVQLP AAYVNLGAGA SEEANKPPEQ 1380

LQTTPVHRNT GRLRPFSEPS QPT 1403

Nucleotide Sequence
(FASTA)

ATGGAGCTTC TCCCGCCGCC TTCCCAGCCT TCACTGTTGC TGTTGCTGCT GCTGCTGTTG 60

CCGCCGCCGT CGCTGCTGGC CAGAGGGTCC TGGCGGTGCC CACGCACCCC CTATGCCGCC 120

TTGCGCAATT TTGACGTGGA GTACCAGGTG CCGAGCTTCT CTGCCGGAGG TCCGGTACAG 180

GCCGTAACGA CCTACGAGGG CGGCGAGGAC GGGAGTGCAG TGTTCGTAGC TATACGCAAT 240

CGCCTGTTTG TGCTGGGGCC TGGCCTGCAG CCAGTAGAGA GCCTGGTCAC GGGCCCTGTT 300

GGGGACTCCG GCTGCCAGAC ATGTGCGGCC TGTGGCCCGG GCCCCCACAG CCCACAGGGA 360

GACACAGATG CACGGGTGCT GGTGCTGGAG CCGGCGCTTC CCGCGCTGGT CAGCTGCGGC 420

TCTAGCCTGC ACGGCCGCTG CTTCCTGCAC GAACTTGAGC CGGGAGGCGC TGCCTTGCGC 480

CTGGCACCTC CGCTCTGCCT CTTCTCCGCC CACCACAACC GACCCGACGA GTGCCCTGAC 540

TGTGTGGCCA GCCCCCTGGG CACCCTGGTG ACCGTGGTGG AGCAGGGCCA TGCCTCCTAC 600

TTCTACACGG CATCCTCGCT GGACGCGACG GTGGCCGCGA GCTTCAGCCC CCGCTCGGTG 660

TCCATCCGGC GCCTCAAGGC CGATGCCTCC GGATTCGCAC CCGGCTTTGC GGCGCTGTCG 720

GTGCTGCCCG AGTACCTCAC TTCCTACTCC ATCGAGTACG TGTACACTTT CCGCGCCGGA 780

GCCTTCGTCT ACTTCCTGAC CGTGCAGCGG CCCAGCGTGA CAGCTGCCCC GGGCGCCTTG 840

CACACGCGCC TGGCACGGCT CAGCGCTGCC GAGCCCGAGC TGGGCGACTA CCGGGAGCTG 900

ATCCTCGACT GCCGTTTGGA GCCCAAACGC CGGCGCCGCG CAGCGCCCCA GGGAGGACAG 960

TCCTACCCAG TGCTGAGAGC GGCCCACACG GCGCCCGTGG GCAGCCAGTT GGCCAAGGAG 1020

CTGAGCATCC CCCAGGGCCA GGAAGTGCTA TTCGGAGTCT TCGCGACTAG GAGAGACAGC 1080

AGCCCCGGTG TGAATCCCAA TTCTGTCGTC TGTGCCTTTC CCCTCGACCT CGTGGACACT 1140

CTCATTGAGC AGGGTGTGGA ACGCTGTTGT GAGCCTCCTG TCTCCTCCGG CCTGCGGCGA 1200

GGCCTCGACT TCTTCCAGTT GCCTAGTTTT TGCCCCAACC CGCCTGGCCT GGAGGCCCCC 1260

AGCCTCAACA CCAGCTGCCG TCACTTCCCT CTACTGGTCA CTGGCAGCCT ATCACGTGTG 1320

GACCTCTTCA ATGGATTGTT AGGACCAGTG CAAGTCACTG CCCTGCACGT GACACGCCTC 1380

AACAATGTCA CAGTGGCCCA CATGGGCACA GCTGATGGGC GCATCCTGCA GGTGGAGCTG 1440

GTCAGATCTC TCAACTACTT GCTGTTTGTG TCCAACTTCT CACTGGGCAA CAATGGGCAG 1500

CCCACACAAC GAGATGTTAG TCGCCTTGGA GACCACCTGT TCTTTGCTTC CGGGGATCAG 1560

GTCTTCCAGG TACCTATCCA GGGCCCTGGC TGCCACCACT TCCTCACCTG TGGGAGTTGT 1620

CTGCGGGCAC AGCGTTTCAT GGGCTGTGGC TGGTGTGGGG GCATGTGTGG CCGGCAGAAA 1680

GAGTGTCCTG GCTCCTGGCA ACAGGATCAT TGCCCACCTA AGCTTACTGA GTTCTACCCT 1740

CAGAGTGGAC CCCTAAGGGG CAGCACAAGG TTGACCCTGT GTGGCTCCAA CTTCCACCTG 1800

CGTCCTGCTG ATCTGGTGCA TGAGGGCACA CATCATGTCA CCGTGGGCCA AAGTCCCTGC 1860

CGACTGCTGC CCAAGGACAG TTCAAACCTC AGCCCAGTGC CCCAGAAAGA CTTTGTAGAG 1920

GAGCTTGAGT GTGAGCTACA GCCCTCGGGA AAGCAGCCAG CAGGGCCCGC CAATGTCAGC 1980

CTCACTGTGA CCAACGTGCC TCCAGGCAAG CACTTCCGGG TAGATGGCAC CTCCATGCTG 2040

CAAGGCTTCT CTTTCATGGA GCCGGTGCTG ACAGCAGTAA AACCCCACTT TGGCCCACGG 2100

GCAGGGGGTA CCCGCCTCAC CCTTGAAGGC AAGGGCCTGT CCTTAGGCAC CAGTCAGACT 2160

GTGCTGGTCA ATGGGACTGA GTGCCCACTG AAACAGGTCA GCGAGCAGCA GCTTTTATGT 2220

ACCACGCCCC CTGGGGCTGC TACGGCCATC GTTCCCATCC ACCTGCAGGT AGGGGGTGCT 2280

GTGGTGCCTG GCTCCTGGAA CTTTCACTAC CGGGAAGACC CCATTGTGCT GGGCATCAGC 2340

CCCAACTGTG GCTATATTGG CTCCCATGTC ACCATCCATG GCCAGCATCT GACTTCAGCA 2400

TGGCACCTAG TGCTGTCATT CCATGATGGA CTTAGGGTAG TGGAAAACAG GTGTAAGGGG 2460

CTGTCCCCGG AGCAGCACCA GTGCCGCCTG CCTGATTATG TGGTCCGAAG CCCCCAGAGG 2520

TGGGTGATAG GGAACCTGAG TGCCTGGGGG GATGGAGCTG CTGGCTTCAC ACTGCCTGGT 2580

TTTCGCTTCC TGCCCCCACC CCATCCACCC AGCACTGACC TAGCCCCGCT GAAGCCTGAG 2640

GAGCATGCCA TTAAGTTTGA GTATATTGGG CTGGGTGCTG TGGCTGATTG TATAGACATG 2700

AATGTGACCG TGGATGGTAA GGTCTGCCAG CATGAACTCC GGGGGGACGT GGTCATCTGC 2760

CCTCTGCCCC CCTCCCTGGA ACTTGACAAG GAACCACTAC CACTGCAGGT CTGTGTGGAT 2820

GATAAATGTC ACATCCTGGG GAGGGTGGTA CGGCCAAGCC GAGAGCGGGT CCCACAGAGG 2880

CTACTCCTTG GTGTCCTGCT GGCCCTGCTC GTGCTTGTAG CTGTGCTGGC CACTGTGCTG 2940

ATCTTCAACT ACCGGCGGAG GAGACAGCTA GTCCTCTCTC TAAACTCAAA TGACCTGGCA 3000

TCCTTGGGCC AGACGACTGG AGCTGTGCCC TTGCCTGTGC TCTGCTCAGG CTCTGACTAC 3060

AGAAGTGGCC AAGGTCTGCA TGATCTGGAT GGTCTGGATT CTACTACTTG GGGCCACAAA 3120

GCGTCCTCCT CAGACAGTGG GGATGGGTCC TGTGTCCCAC TGCTGCGGAC AGCGTCCATC 3180

CAGCTTGGGG ACTTGGACTC TGCACTCCTG GCCGAGGTCA AGGATGTGCT GATCCCCCAC 3240

GAGCAGGTGG TCACCCACAG TGACCGAGTC ATTGGCAAAG GCCACTTTGG AGTTGTCTAT 3300

CATGGAGAAT ACATAGACGA GGACCAGAAT CGAATCCACT GTGCTGTAAA GTCACTGAGT 3360

CGCATTACAG AGGTGCAGGA GGCAGAGGCC TTCCTGCGCG AGGGGTTGCT CATGCGTGGT 3420

CTGCACCACC CAAACGTACT GGCTCTCATC GGTATCGTGC TGCCACCTGA AGGCCTGCCC 3480

CGTGTGCTGC TGCCCTATAT GCGCCATGGA GACCTGCTTC GGTTCATCCG CTCACCCCAG 3540

CGGAATCCCA CGGTGAAGGA CCTCATCAGC TTCGGCCTTC AGGTAGCCCG TGGCATGGAG 3600

TACTTGGCAG AGCAGAAGTT TGTGCACAGG GACCTGGCTG CTCGGAACTG CATGCTGGAC 3660

GAATCATTCA CAGTTAAGGT GGCTGACTTT GGCCTGGCTC GTGATATCCT GGACAAGGAA 3720

TACTACAGTG TTCGACAGCA CCGCCACGCT CGCCTCCCTG TCAAATGGAT GGCACTGGAG 3780

AGCCTGCAGA CCTACAGATT CACCACCAAG TCTGACGTGT GGTCGTTTGG TGTGTTGCTA 3840

TGGGAGCTGC TGACACGGGG TGCCCCACCA TATCCCCACA TTGACCCTTT TGACCTCATT 3900

CAATTCCTGG CCCAGGGTCG GCGCCTGCCC CAGCCTGAAT ATTGTCCCAA TTCTCTGTAT 3960

ATGGTGATGC AACGCTGCTG GGCTGTGGAC CCCGCGGTGA GACCCACCTT CACGGCACTG 4020

GTGGAGGAAG TAGAGCACGT GGCGGCCAGG CTGCTTGGGG ACCACTATGT GCAGCTGCCG 4080

GCAGCCTATG TAAACCTGGG CGCTGGTGCC TCGGAGGAGG CAAACAAGCC CCCAGAGCAG 4140

TTGCAGACCA CACCTGTGCA CAGGAACACG GGTCGACTCC GGCCTTTCTC AGAGCCATCA 4200

CAGCCCACGT GA 4212

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         ++++viGkGhfGvvy+ge++d+++++i++avksl+rit++++ e+flregl+m++l+hpn

Q: 1086  HSDRVIGKGHFGVVYHGEYIDEDQNRIHCAVKSLSRITEVQEAEAFLREGLLMRGLHHPN  1145

         7899********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vl+l+Gi+l++eglp v+lpym++Gdl +fir+++rn+tvkdl++f+lqva+gmeyla++

Q: 1146  VLALIGIVLPPEGLPRVLLPYMRHGDLLRFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ  1205

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlard+ldke+y+v+++r+arlpvkw+aleslqt+

Q: 1206  KFVHRDLAARNCMLDESFTVKVADFGLARDILDKEYYSVRQHRHARLPVKWMALESLQTY  1265

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         + fttksdvwsfGvllwelltrga+py+++++fdl+++l++grrl++peycp++ly vm+

Q: 1266  R-FTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLIQFLAQGRRLPQPEYCPNSLYMVMQ  1324

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsii  261

         +cw  +pa rp+f+ lv  +

Q: 1325  RCWAVDPAVRPTFTALVEEV  1344

         **************999765

Domain Sequence
(FASTA)

HSDRVIGKGH FGVVYHGEYI DEDQNRIHCA VKSLSRITEV QEAEAFLREG LLMRGLHHPN 60

VLALIGIVLP PEGLPRVLLP YMRHGDLLRF IRSPQRNPTV KDLISFGLQV ARGMEYLAEQ 120

KFVHRDLAAR NCMLDESFTV KVADFGLARD ILDKEYYSVR QHRHARLPVK WMALESLQTY 180

RFTTKSDVWS FGVLLWELLT RGAPPYPHID PFDLIQFLAQ GRRLPQPEYC PNSLYMVMQR 240

CWAVDPAVRP TFTALVEEV 259

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013