EKS-CAF-00158

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00158

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	521.9	5.2E-157	90	383	294

Status

Unreviewed

Ensembl Protein

ENSCAFP00000016430

UniProt Accession

E2R001; E3TH09;

Protein Name

Protein Synonyms/Alias

Serine/threonine kinase 38-like protein;

Gene Name

STK38L

Gene Synonyms/Alias

STK38L;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000011145	ENSCAFP00000016430	ENSCAFT00000017749

Organism

Canis familiaris

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MAMTAGTTST FPMSNHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE VAMEEEGLAD 60

EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA FGEVRLVQKK DTGHIYAMKI 120

LRKADMLEKE QVAHIRAERD ILVEADGAWV VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM 180

KKDTLTEEET QFYISETVLA IDAIHQLGFI HRDIKPDNLL LDAKGHVKLS DFGLCTGLKK 240

AHRTEFYRNL THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY 300

NKLCDWWSLG VIMYEMLIGY PPFCSETPQE TYRKVMNWKE TLVFPPEVPI SEKAKDLILR 360

FCIDSENRIG NSGVEEIKSH PFFEGVDWGH IRERPAAIPI EIKSIDDTSN FDDFPESDIL 420

QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT QRGSIPTYMK AGKL 464

Nucleotide Sequence
(FASTA)

ATGGCAATGA CAGCAGGGAC CACAAGCACC TTTCCTATGA GCAACCATAC CCGGGAAAGA 60

GTGACCGTGG CCAAGCTCAC GTTGGAGAAT TTTTACAGCA ACCTAATTTT ACAGCATGAA 120

GAGAGAGAAA CCAGGCAGAA GAAATTAGAA GTGGCCATGG AAGAGGAAGG ATTAGCAGAT 180

GAAGAGAAAA AGTTACGCCG ATCACAACAT GCCCGAAAGG AAACAGAGTT CTTACGGCTC 240

AAGAGGACCA GACTTGGCTT GGATGACTTT GAGTCTCTGA AAGTTATAGG AAGAGGAGCA 300

TTTGGAGAGG TGCGGCTGGT CCAGAAGAAG GATACAGGGC ATATCTATGC AATGAAGATA 360

TTGAGAAAAG CTGATATGCT TGAAAAAGAG CAGGTGGCCC ATATCCGAGC AGAAAGAGAT 420

ATTTTGGTTG AAGCAGATGG TGCCTGGGTG GTGAAAATGT TTTACAGTTT TCAAGATAAG 480

AGAAATCTTT ATCTGATCAT GGAATTTCTC CCTGGAGGTG ACATGATGAC ATTGTTAATG 540

AAGAAAGATA CCTTGACAGA AGAGGAGACA CAATTCTACA TTTCAGAGAC TGTTCTGGCA 600

ATAGATGCAA TCCACCAGTT GGGTTTCATC CATCGGGATA TTAAACCAGA CAACCTTTTA 660

TTGGATGCCA AGGGTCATGT AAAATTATCT GATTTTGGTT TATGCACGGG ATTAAAGAAA 720

GCTCATAGGA CTGAATTCTA CAGAAACCTT ACACACAACC CTCCAAGTGA CTTCTCATTT 780

CAGAATATGA ACTCAAAGAG GAAAGCAGAA ACATGGAAGA AGAATAGGAG ACAGCTGGCA 840

TATTCTACAG TTGGGACACC AGATTATATT GCTCCAGAAG TATTCATGCA GACTGGTTAC 900

AATAAATTGT GTGACTGGTG GTCTTTGGGA GTGATTATGT ATGAAATGCT AATAGGGTAT 960

CCGCCTTTCT GCTCTGAAAC TCCTCAAGAA ACATATAGAA AAGTGATGAA CTGGAAAGAA 1020

ACTTTGGTAT TTCCCCCAGA GGTACCCATA TCTGAGAAAG CCAAGGACTT GATTCTTAGA 1080

TTTTGTATTG ATTCTGAAAA CAGAATTGGA AATAGCGGAG TAGAAGAAAT AAAAAGTCAT 1140

CCTTTTTTTG AAGGTGTAGA CTGGGGACAC ATCAGGGAAA GGCCAGCAGC GATCCCTATA 1200

GAAATCAAAA GCATTGATGA TACTTCAAAT TTCGATGACT TTCCCGAATC TGATATTTTA 1260

CAACCAGTGC CAAACACCAC AGAACCTGAC TACAAATCCA AAGACTGGGT TTTTCTCAAT 1320

TATACCTATA AAAGGTTTGA AGGGTTGACT CAACGTGGTT CTATCCCCAC CTACATGAAA 1380

GCTGGAAAAT TATGA 1395

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt+++ya+kilrk+d+l+k+qvah++aerdil+ead +w

Q: 90    FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEADGAW  149

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk+nlyl+me+lPGGd+mtll+kk++l+ee+++fyi+e+vla++++h+lGf

Q: 150   VVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGF  209

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+dakGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+++++  ++ +

Q: 210   IHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKA  269

         *************************************************65555555555

S: 181   rkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPflaetpq  240

            kknrr+lays+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++etpq

Q: 270   ETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQ  329

         555*********************************************************

S: 241   etykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         ety+kv+nwketl fp+ev++se+akdli r+++d+e+r+g++Gv+eik+hpff

Q: 330   ETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKSHPFF  383

         *****************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHIYAMK ILRKADMLEK EQVAHIRAER DILVEADGAW 60

VVKMFYSFQD KRNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYISETVL AIDAIHQLGF 120

IHRDIKPDNL LLDAKGHVKL SDFGLCTGLK KAHRTEFYRN LTHNPPSDFS FQNMNSKRKA 180

ETWKKNRRQL AYSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240

ETYRKVMNWK ETLVFPPEVP ISEKAKDLIL RFCIDSENRI GNSGVEEIKS HPFF 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0051128	; P:regulation of cellular component organization

KEGG

cfa:477663

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013