EKS-CAF-00249

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00249

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.5	2.9E-116	58	309	252

Status

Unreviewed

Ensembl Protein

ENSCAFP00000016655

UniProt Accession

F1Q1P8;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000011275	ENSCAFP00000040265	ENSCAFT00000043806
ENSCAFG00000011275	ENSCAFP00000016655	ENSCAFT00000017983

Organism

Canis familiaris

Functional Description

Protein Length

795

Protein Sequence
(FASTA)

LYSPPGKVSE SQVEIHTSVD GYTEPHIQPT KSSSRQNIPR CRNSITSATD EQPHIGNYRL 60

QKTIGKGNFA KVKLARHVLT GREVAVKIID KTQLNPTSLQ KLFREVRIMK ILNHPNIVKL 120

FEVIETEKTL YLVMEYASGG EVFDYLVAHG RMKEKEARAK FRQIVSAVQY CHQKCIVHRD 180

LKAENLLLDA DMNIKIADFG FSNEFTVGNK LDTFCGSPPY AAPELFQGKK YDGPEVDVWS 240

LGVILYTLVS GSLPFDGQNL KELRERVLRG KYRIPFYMST DCENLLKKLL VLNPIKRGSL 300

EQIMKDRWMN VGHEEEELKP YAEPEPDFND TKRIVLDIMV TMGFARDEIN DALINQKYDE 360

VMATYILLGR KPPEFEGGES LSSGSLCQRS RPSSDLNNSS LQSPAHLKVQ RSISANQKQR 420

RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWDKDLARK LGSTTVGSKS EMTASPLVGP 480

ERKKSSTIPS SNVYPGGSMA RRNTYVCERT TDRYAALQNG KDSSLTEMSA SSISSAGSAV 540

ASAVPSARPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGA TQRVPAASPS AHSISATTPD 600

RTRFPRGSSS RSTFHGEQLR ERRSAAYNGP PASPSHETGT FAHARRGTST GIISKITSKF 660

VRRDPSEGEA SGRTDTSRST SGEPKERDKE EGKDSKPRSL RFTWSMKTTS SMDPNDMMRE 720

IRKVLDANNC DYEQKERFLL FCVHGDARQD SLVQWEMEVC KLPRLSLNGV RFKRISGTSI 780

AFKNIASKIA NELKL 795

Nucleotide Sequence
(FASTA)

TTATATTCCC CCCCCGGCAA AGTGAGCGAA AGTCAAGTAG AAATTCACAC GTCTGTGGAT 60

GGATACACTG AACCGCACAT CCAGCCTACC AAATCGAGTA GCCGACAGAA CATTCCCCGG 120

TGCAGAAACT CCATTACGTC AGCAACAGAC GAGCAGCCTC ACATTGGAAA TTATCGTTTA 180

CAAAAAACAA TAGGGAAGGG AAACTTTGCC AAAGTGAAAT TGGCAAGACA TGTCCTAACT 240

GGTAGAGAGG TTGCTGTGAA AATAATAGAC AAAACTCAGC TAAATCCTAC CAGTCTACAA 300

AAGTTATTTC GAGAAGTACG AATAATGAAG ATATTGAATC ATCCTAACAT AGTAAAATTA 360

TTTGAAGTTA TTGAAACAGA GAAGACCCTC TATTTAGTCA TGGAATACGC GAGTGGGGGT 420

GAAGTATTTG ATTACTTAGT TGCCCATGGA AGAATGAAAG AAAAAGAGGC CCGTGCAAAA 480

TTTAGGCAGA TTGTATCTGC TGTGCAGTAT TGCCATCAAA AGTGCATTGT TCACCGTGAT 540

CTTAAGGCTG AAAACCTTCT CCTTGATGCT GATATGAATA TTAAAATTGC TGACTTTGGT 600

TTTAGTAATG AATTTACAGT TGGGAACAAA TTGGACACAT TTTGTGGAAG CCCGCCCTAT 660

GCTGCCCCTG AGCTTTTCCA AGGAAAGAAG TACGATGGGC CTGAAGTGGA CGTGTGGAGC 720

CTCGGCGTCA TTCTCTATAC ACTAGTCAGT GGCTCCTTGC CTTTTGATGG CCAGAATTTG 780

AAGGAACTAC GGGAGCGAGT CTTACGAGGG AAGTACCGTA TTCCTTTCTA TATGTCCACT 840

GACTGTGAAA ATCTTCTGAA GAAATTATTG GTGCTGAATC CAATAAAGAG AGGCAGCTTA 900

GAACAAATAA TGAAAGATCG GTGGATGAAT GTTGGTCATG AAGAGGAAGA ACTAAAGCCA 960

TATGCTGAGC CTGAACCGGA CTTCAATGAC ACGAAGAGAA TAGTTCTAGA CATCATGGTC 1020

ACCATGGGTT TTGCACGAGA TGAGATAAAT GACGCCTTAA TAAATCAGAA ATATGATGAA 1080

GTTATGGCTA CTTATATTCT TCTAGGTAGA AAACCACCTG AATTTGAAGG CGGTGAATCG 1140

TTGTCCAGCG GAAGCTTGTG TCAGAGGTCA CGGCCCAGCA GTGACCTGAA CAACAGCAGC 1200

CTCCAGTCCC CTGCTCACCT GAAGGTCCAG CGGAGCATCT CCGCAAACCA GAAGCAGCGG 1260

CGTTTCAGTG ATCATGCTGG TCCATCCATT CCCCCTGCTG TATCATATAC CAAAAGGCCT 1320

CAGGCTAATA GCGTGGAAAG TGAACAGAAA GAGGAATGGG ACAAAGACCT AGCTCGTAAG 1380

CTTGGCAGCA CAACAGTTGG TTCAAAAAGC GAGATGACTG CAAGCCCTCT TGTGGGGCCA 1440

GAGAGGAAGA AATCTTCAAC TATTCCAAGT AGCAATGTAT ATCCTGGAGG TAGCATGGCA 1500

AGAAGGAACA CATATGTCTG TGAAAGGACC ACAGATCGAT ATGCGGCATT GCAGAATGGA 1560

AAAGACAGCA GCCTTACGGA GATGTCCGCA AGTAGCATAT CTTCTGCAGG CTCTGCTGTG 1620

GCTTCTGCTG TCCCCTCAGC ACGACCCCGC CACCAGAAGT CCATGTCCAC TTCTGGCCAT 1680

CCTATTAAAG TTACACTGCC AACCATTAAA GACGGCTCTG AAGCTTACCG GCCCGGTGCA 1740

ACCCAGAGAG TGCCTGCTGC TTCCCCATCT GCTCACAGTA TCAGTGCCAC CACTCCAGAC 1800

CGAACCCGCT TCCCCCGGGG GAGCTCAAGC CGAAGCACTT TTCATGGTGA GCAGCTCCGG 1860

GAGCGTCGCA GCGCTGCTTA CAACGGGCCA CCCGCGTCGC CTTCCCACGA AACGGGCACG 1920

TTTGCACATG CCAGGAGGGG CACATCAACT GGTATAATAA GCAAAATAAC ATCCAAATTC 1980

GTTCGCAGGG ATCCAAGTGA AGGCGAAGCC AGTGGCAGAA CAGACACCTC AAGAAGTACA 2040

TCAGGGGAAC CAAAAGAAAG AGACAAGGAA GAGGGCAAAG ATTCTAAGCC ACGTTCTTTG 2100

CGATTCACGT GGAGTATGAA GACCACTAGT TCAATGGACC CCAATGACAT GATGCGAGAA 2160

ATCCGGAAAG TGTTAGATGC AAATAACTGT GATTATGAAC AAAAAGAGAG GTTTCTGCTT 2220

TTCTGTGTCC ACGGAGACGC TCGGCAGGAC AGCCTCGTGC AGTGGGAGAT GGAAGTCTGC 2280

AAGTTGCCAC GACTGTCACT GAACGGGGTC CGCTTCAAGC GGATCTCAGG GACGTCGATC 2340

GCCTTTAAGA ACATTGCATC TAAAATAGCA AATGAGCTTA AGCTGTAA 2388

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l+kt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 58    YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  117

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 118   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  177

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 178   HRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  237

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p kR

Q: 238   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR  297

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i+k++w+

Q: 298   GSLEQIMKDRWM  309

         ***********8

Domain Sequence
(FASTA)

YRLQKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KLLVLNPIKR 240

GSLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013