EKS-CAF-00176
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00176
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC478.66.2E-144284542259
StatusUnreviewed
Ensembl ProteinENSCAFP00000016686
UniProt AccessionF1Q1D5;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCA
Gene Synonyms/Alias PRKCA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000011326ENSCAFP00000016686ENSCAFT00000018019
OrganismCanis familiaris
Functional Description
Protein Length617
Protein Sequence
(FASTA)
FFRGFGKQGF QCQVCCFVVH KRCHEFVTFS CPGADKGPDT DDPRSKHKFK IHTYGSPTFC 60
DHCGSLLYGL IHQGMKCDTC DMNVHKQCVI NVPSLCGMDH TEKRGRIYLK AEVTDEKLHV 120
TVRDAKNLIP MDPNGLSDPY VKLKLIPDPK NESKQKTKTI RSTLNPQWNE SFTFKLKPSD 180
KDRRLSVEIW DWDRTTRNDF MGSLSFGVSE LMKMPASGWY KLLNQEEGEY YNVPIPEGDE 240
EGNVELRQKF EKAKLGPAGN KVISPSEDRR QPSNNLDRVK LTDFNFLMVL GKGSFGKVML 300
ADRKGTEELY AIKILKKDVV IQDDDVECTM VEKRVLALLD KPPFLTQLHS CFQTVDRLYF 360
VMEYVNGGDL MYHIQQVGKF KEPQAVFYAA EISIGLFFLH KRGIIYRDLK LDNVMLDSEG 420
HIKIADFGMC KEHMMDGVTT RTFCGTPDYI APEIIAYQPY GKSVDWWAYG VLLYEMLAGQ 480
PPFDGEDEDE LFQSIMEHNV SYPKSLSKEA VSICKGLMTK HPGKRLGCGP EGERDVREHA 540
FFRRIDWEKL ENREIQPPFK PKVCGKGAEN FDKFFTRGQP VLTPPDQLVI ANIDQSDFEG 600
FSYVNPQFVH PILQSAV 617
Nucleotide Sequence
(FASTA)
TTTTTCAGGG GGTTTGGGAA ACAAGGCTTC CAGTGCCAAG TTTGCTGTTT TGTGGTTCAC 60
AAGAGGTGCC ATGAATTTGT CACTTTTTCT TGCCCGGGTG CGGATAAGGG ACCCGACACT 120
GATGACCCCA GAAGCAAGCA CAAGTTTAAA ATCCACACTT ATGGAAGCCC CACCTTCTGT 180
GATCACTGTG GGTCATTGCT GTATGGACTT ATCCATCAAG GAATGAAATG TGACACCTGT 240
GATATGAACG TGCACAAGCA GTGTGTAATA AATGTCCCCA GCCTCTGCGG GATGGACCAC 300
ACGGAGAAGA GGGGCCGGAT CTACCTGAAG GCTGAGGTCA CTGATGAGAA GCTCCACGTC 360
ACTGTACGAG ATGCAAAGAA TCTGATTCCT ATGGATCCAA ATGGGCTTTC AGATCCTTAT 420
GTGAAGCTGA AACTAATTCC TGATCCCAAG AATGAAAGCA AACAGAAAAC CAAAACCATC 480
CGCTCTACAC TGAATCCCCA GTGGAATGAG TCTTTTACAT TCAAATTAAA ACCTTCAGAT 540
AAAGACCGCC GGCTGTCCGT AGAGATCTGG GACTGGGATC GAACAACAAG GAATGATTTC 600
ATGGGCTCCC TTTCCTTCGG AGTCTCAGAG CTGATGAAGA TGCCAGCCAG TGGATGGTAC 660
AAGCTGCTTA ACCAAGAGGA AGGTGAGTAC TACAATGTAC CCATCCCAGA AGGGGACGAA 720
GAAGGAAACG TGGAGCTCAG ACAGAAATTC GAGAAAGCCA AGCTTGGCCC CGCTGGTAAC 780
AAAGTAATCA GTCCTTCAGA AGACAGGAGA CAACCTTCCA ACAACCTGGA CAGAGTGAAA 840
CTCACAGACT TCAATTTCCT CATGGTGCTG GGGAAGGGAA GTTTTGGAAA GGTAATGCTT 900
GCTGACAGGA AGGGCACAGA GGAACTGTAT GCTATCAAAA TCCTGAAGAA GGACGTGGTG 960
ATTCAAGATG ATGACGTGGA GTGCACCATG GTAGAGAAGC GAGTCCTGGC CCTGCTTGAC 1020
AAGCCCCCAT TCCTGACACA GCTACACTCC TGCTTCCAGA CAGTGGATCG ACTGTACTTC 1080
GTCATGGAAT ACGTCAATGG TGGGGACCTC ATGTACCACA TTCAGCAAGT AGGAAAATTT 1140
AAGGAACCAC AAGCAGTATT TTATGCGGCA GAGATTTCCA TTGGATTGTT CTTTCTTCAT 1200
AAAAGAGGAA TCATTTACAG GGATCTGAAG TTAGACAATG TCATGCTGGA TTCGGAAGGG 1260
CATATCAAGA TTGCTGATTT TGGGATGTGC AAAGAACACA TGATGGATGG AGTCACAACC 1320
AGGACCTTCT GCGGGACTCC AGATTACATT GCCCCGGAGA TAATCGCTTA TCAGCCGTAT 1380
GGAAAATCCG TGGACTGGTG GGCCTATGGC GTCCTATTAT ATGAAATGCT AGCCGGACAG 1440
CCTCCCTTTG ATGGTGAAGA TGAAGACGAG CTGTTTCAGT CCATAATGGA GCATAACGTT 1500
TCTTATCCCA AATCCTTATC CAAGGAGGCC GTTTCCATCT GCAAAGGACT GATGACCAAA 1560
CACCCAGGCA AGCGGCTGGG TTGCGGGCCA GAGGGAGAGA GAGACGTTCG GGAGCACGCT 1620
TTCTTCCGGA GGATCGACTG GGAAAAACTC GAGAACAGGG AGATCCAGCC ACCCTTCAAG 1680
CCCAAAGTGT GTGGCAAAGG CGCAGAAAAC TTTGACAAGT TCTTCACACG AGGGCAGCCT 1740
GTCTTAACAC CACCTGATCA GTTGGTCATT GCTAACATAG ACCAGTCTGA TTTCGAGGGG 1800
TTCTCGTATG TCAACCCCCA ATTTGTGCAC CCCATCTTAC AGAGTGCGGT A 1851
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p
Q: 284   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  343
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g
Q: 344   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  403
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks
Q: 404   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS  463
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p 
Q: 464   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPG  523
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+d++ehaff
Q: 524   KRLGCGPEGERDVREHAFF  542
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPG 240
KRLGCGPEGE RDVREHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00161
EKS-ANC-00165
EKS-BOT-00169
EKS-CAE-00131
EKS-CAJ-00173
EKS-CAP-00169
EKS-CII-00114
EKS-DAR-00460
EKS-DRM-00084
EKS-EQC-00167
EKS-FEC-00159
EKS-GAM-00089
EKS-GAG-00145
EKS-GAA-00203
EKS-GOG-00167
EKS-HOS-00175
EKS-ICT-00164
EKS-LAC-00179
EKS-LOA-00168
EKS-MAM-00167
EKS-MEG-00134
EKS-MOD-00168
EKS-MUM-00174
EKS-MUP-00173
EKS-MYL-00178
EKS-NOL-00162
EKS-ORN-00213
EKS-ORA-00149
EKS-ORC-00155
EKS-ORL-00198
EKS-OTG-00175
EKS-PAT-00160
EKS-PES-00149
EKS-POA-00171
EKS-PRC-00045
EKS-RAN-00168
EKS-SAH-00163
EKS-TAG-00197
EKS-TAR-00221
EKS-TEN-00212
EKS-XIM-00207
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013