EKS-CAF-00273

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00273

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	464.3	2.6E-139	174	487	314

Status

Unreviewed

Ensembl Protein

ENSCAFP00000039513

UniProt Accession

E2R8C3;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK3

Gene Synonyms/Alias

DYRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000011429	ENSCAFP00000039513	ENSCAFT00000043274
ENSCAFG00000011429	ENSCAFP00000016800	ENSCAFT00000018140

Organism

Canis familiaris

Functional Description

Protein Length

552

Protein Sequence
(FASTA)

MMIDETKCPP CSNVLCNPSE LPLPRRLNIT AEQLTRDHTQ RFLNGGEVKV EQLFQEFSTR 60

RSDTLQSDGI NDSEKCSPTV SQGKSSDSLN AVKPSNSAKS SKVVPLTPEQ ALKQYKHHLT 120

AYEKLEIINY PEIYFVGPNA KKRHGVIGGP NNGGYDDADG AYIHVPRDHL AYRYEVLKII 180

GKGSFGQVAR VYDHKLRQYV ALKMVRNEKR FHRQAAEEIR ILEHLKKQDK TGSMNVIHML 240

ESFTFRNHVC MAFELLSIDL YELIKKNKFQ GFSVQLVRKF AQSILQSLDA LHKNKIIHCD 300

LKPENILLKH HGRSATKVID FGSSCFEYQK LYTYIQSRFY RAPEIILGSR YSTPIDIWSF 360

GCILAELLTG QPLFPGEDEG DQLACMMELL GMPPPKLLEQ SKRAKYFINS KGLPRYCSVT 420

TQADGRVVLV GGRSRRGKKR GPPGSKDWVT ALKGCDDYLF IEFLKRCLHW DPSARLTPAQ 480

ALRHPWISKS VPRPLTIEKV SGKRVVNPAN AFQGLGSKLP PVVGIANKLK ANLMSETNGG 540

IPLCSVLPKL IS 552

Nucleotide Sequence
(FASTA)

ATGATGATAG ATGAAACCAA ATGCCCACCC TGTTCAAATG TACTCTGCAA TCCTTCTGAA 60

CTGCCTCTAC CCAGAAGACT AAATATCACT GCTGAGCAGT TAACAAGAGA TCACACTCAG 120

CGCTTCCTGA ATGGAGGTGA GGTGAAAGTG GAACAGCTGT TTCAAGAATT TAGCACCAGA 180

AGATCCGATA CTCTTCAGTC AGATGGCATC AACGACTCTG AAAAATGCTC TCCTACCGTC 240

TCTCAGGGTA AAAGTTCAGA TAGCTTGAAT GCAGTAAAAC CCAGCAATTC AGCCAAATCA 300

TCCAAAGTGG TGCCACTGAC TCCAGAGCAA GCCCTGAAGC AATATAAACA CCACCTCACC 360

GCATATGAGA AGCTGGAAAT CATCAATTAT CCAGAAATCT ACTTTGTGGG CCCAAATGCC 420

AAAAAAAGAC ATGGAGTGAT CGGTGGTCCC AATAACGGGG GGTATGATGA TGCAGATGGG 480

GCCTATATTC ACGTACCTCG CGACCATCTA GCTTATCGAT ATGAGGTGCT GAAGATTATT 540

GGCAAGGGGA GTTTTGGGCA GGTGGCCCGG GTCTACGATC ACAAACTTCG ACAGTATGTG 600

GCCCTAAAGA TGGTGCGCAA TGAAAAGCGC TTCCATCGTC AAGCCGCTGA GGAGATCCGG 660

ATCTTGGAGC ATCTTAAAAA GCAGGACAAA ACCGGTAGCA TGAACGTCAT CCACATGCTG 720

GAAAGTTTCA CATTCCGGAA CCATGTTTGC ATGGCCTTCG AGTTGCTGAG CATAGACCTT 780

TACGAGCTAA TTAAAAAAAA CAAGTTTCAG GGTTTTAGCG TCCAGTTAGT TCGCAAGTTT 840

GCTCAATCCA TCTTGCAATC CTTGGATGCT CTCCACAAAA ATAAGATCAT TCACTGTGAC 900

CTGAAGCCAG AAAACATTCT CCTGAAACAC CATGGGCGCA GCGCGACCAA GGTCATTGAC 960

TTTGGGTCCA GCTGCTTCGA ATACCAGAAG CTTTACACGT ATATCCAGTC TCGGTTCTAC 1020

AGAGCTCCGG AGATCATCCT AGGAAGCCGC TACAGCACAC CTATAGACAT ATGGAGTTTT 1080

GGCTGCATCC TTGCAGAACT TTTAACAGGA CAGCCTCTCT TCCCGGGAGA GGATGAAGGG 1140

GACCAGTTGG CCTGTATGAT GGAGCTGCTA GGGATGCCAC CACCAAAACT TCTGGAACAA 1200

TCCAAACGTG CCAAGTACTT CATTAACTCT AAGGGCCTAC CTCGCTACTG TTCTGTGACT 1260

ACTCAGGCAG ATGGGAGAGT TGTGCTTGTG GGGGGTCGCT CACGTAGGGG TAAAAAGCGG 1320

GGCCCTCCAG GTAGCAAAGA CTGGGTGACA GCACTGAAGG GATGTGATGA CTACTTGTTT 1380

ATAGAGTTTC TGAAAAGGTG TCTTCACTGG GACCCCTCTG CCCGTTTGAC CCCAGCTCAA 1440

GCATTAAGAC ACCCTTGGAT TAGTAAGTCT GTGCCCAGAC CTCTTACCAT TGAAAAGGTG 1500

TCAGGCAAAC GGGTGGTAAA TCCTGCAAAT GCTTTCCAGG GACTGGGTTC CAAGCTGCCT 1560

CCAGTTGTCG GAATAGCCAA TAAGCTCAAA GCTAATTTAA TGTCAGAAAC CAACGGTGGT 1620

ATACCTCTGT GCAGTGTACT GCCAAAACTC ATTAGCTAA 1659

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqV++++d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 174   YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS  233

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c+ fells++Lyel+kknkf+g+s++lvrk+aq+il++L++L++

Q: 234   MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK  293

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs+ kviDFGss+++ qk +ytyiqsrfYraPEiilg +y+

Q: 294   NKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQK-LYTYIQSRFYRAPEIILGSRYS  352

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iD+WS+Gc+laEl+tG+pLfpGe+e dqla+++e+lg+pp+klle++k+ak+f+++k+

Q: 353   TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKG  412

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

          p+y+ +t+++d +++lv ++++++kkr +p+sk++++alk ++d+lf+++lkr+l++dp

Q: 413   LPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWVTALKGCDDYLFIEFLKRCLHWDP  472

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+tp++al+hp++

Q: 473   SARLTPAQALRHPWI  487

         **************7

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVARVYD HKLRQYVALK MVRNEKRFHR QAAEEIRILE HLKKQDKTGS 60

MNVIHMLESF TFRNHVCMAF ELLSIDLYEL IKKNKFQGFS VQLVRKFAQS ILQSLDALHK 120

NKIIHCDLKP ENILLKHHGR SATKVIDFGS SCFEYQKLYT YIQSRFYRAP EIILGSRYST 180

PIDIWSFGCI LAELLTGQPL FPGEDEGDQL ACMMELLGMP PPKLLEQSKR AKYFINSKGL 240

PRYCSVTTQA DGRVVLVGGR SRRGKKRGPP GSKDWVTALK GCDDYLFIEF LKRCLHWDPS 300

ARLTPAQALR HPWI 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

cfa:480010

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013