EKS-CAF-00163

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00163

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	362.9	1.4E-108	65	326	262

Status

Unreviewed

Ensembl Protein

ENSCAFP00000017035

UniProt Accession

E2R7K9;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000011590	ENSCAFP00000036722	ENSCAFT00000042823
ENSCAFG00000011590	ENSCAFP00000017035	ENSCAFT00000018392

Organism

Canis familiaris

Functional Description

Protein Length

482

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEPE FSPSDVCPLA ESRAAGPEPV GHCEEVELTE TSVNLGPERI 60

GPHCFELLRV LGKGGYGKVF QVRKVQGTNL GKIYAMKVLR KAKIVRNAKD TAHTRAERNI 120

LESVKHPFIV ELAYAFQTGG KLYLILECLS GGELFTHLER EGIFLEDTAC FYLAEITLAL 180

GHLHSQGIIY RDLKPENIML NSQGHIKLTD FGLCKESIHE GAVTHTFCGT IEYMAPEILV 240

RSGHNRAVDW WSLGALMYDM LTGSPPFTAE NRKKTMDKII KGKLTLPPYL TPDARDLVKK 300

FLKRNPSQRI GGGPGDSADV QRHPFFRHIN WDDLLARRID PPFRPCLQSE EDVSQFDTHF 360

TRQTPVDSPD DTALSESANQ AFLGFTYVAP SVLDSIKEGF SFQPKLRSPR RLNSSPRTPV 420

SPLKFSPFEG FRPSSGPPEP MEPPLPPLLP PPPPPPSSTA PLPIRPPSGT KKSKRGRGRP 480

GR 482

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTTTGACCT GGACTTGGAG ACGGAGGAAG GCAGCGAGGG CGAGCCAGAG 60

TTCAGCCCCT CGGACGTGTG TCCCCTTGCC GAGTCGAGGG CGGCTGGCCC GGAGCCTGTG 120

GGACACTGTG AGGAGGTGGA GCTGACTGAG ACCAGTGTGA ACCTGGGCCC TGAACGCATC 180

GGGCCCCACT GCTTTGAGCT GCTGCGTGTG CTGGGCAAGG GGGGCTATGG CAAGGTGTTC 240

CAAGTCCGGA AGGTGCAGGG CACCAACTTG GGCAAGATAT ATGCCATGAA AGTCCTGAGA 300

AAGGCCAAAA TTGTGCGCAA CGCCAAGGAC ACAGCACACA CGCGGGCTGA ACGGAACATT 360

CTAGAGTCAG TGAAGCACCC CTTCATTGTG GAACTGGCCT ATGCCTTCCA GACTGGTGGC 420

AAACTCTACC TCATCCTCGA GTGCCTCAGT GGCGGTGAGC TTTTCACGCA TCTGGAGCGA 480

GAGGGCATCT TCCTGGAAGA CACAGCCTGT TTCTACCTGG CAGAGATCAC CCTGGCCCTG 540

GGACATCTCC ACTCCCAAGG CATAATCTAC CGGGACCTCA AACCTGAGAA CATCATGCTC 600

AACAGTCAGG GCCACATCAA ACTGACAGAC TTTGGACTCT GCAAAGAGTC GATCCATGAG 660

GGCGCTGTCA CCCATACTTT CTGTGGCACC ATTGAATACA TGGCCCCTGA GATTCTGGTA 720

CGCAGTGGCC ACAACCGGGC TGTGGACTGG TGGAGCCTGG GGGCCCTGAT GTATGACATG 780

CTCACTGGAT CGCCACCCTT CACCGCAGAG AACCGGAAGA AAACCATGGA CAAGATCATC 840

AAAGGGAAAC TGACGCTGCC CCCCTACCTC ACCCCGGATG CCCGGGACCT TGTCAAAAAG 900

TTTCTGAAGC GGAATCCCAG CCAGCGGATC GGGGGTGGCC CAGGGGACTC TGCTGATGTG 960

CAGAGGCACC CCTTCTTCCG GCACATTAAT TGGGATGACC TCCTGGCTCG CCGCATAGAC 1020

CCCCCTTTCA GGCCCTGTCT GCAGTCAGAG GAGGACGTGA GCCAGTTTGA CACCCACTTC 1080

ACACGGCAGA CACCAGTGGA CAGTCCAGAT GATACGGCCC TCAGTGAGAG TGCCAACCAG 1140

GCCTTCCTGG GCTTCACATA CGTGGCACCT TCTGTCCTGG ACAGCATCAA GGAGGGCTTC 1200

TCATTCCAGC CCAAGCTACG CTCCCCCAGG CGTCTCAACA GTAGTCCCCG GACCCCGGTC 1260

AGCCCCCTGA AGTTCTCACC CTTTGAGGGA TTCCGGCCCA GCTCTGGCCC ACCGGAGCCC 1320

ATGGAGCCCC CTCTACCTCC TCTCCTGCCG CCGCCACCAC CACCACCATC GAGCACTGCC 1380

CCTCTCCCCA TCCGACCCCC CTCGGGGACC AAGAAGTCTA AGAGGGGCCG TGGGCGCCCT 1440

GGGCGCTAG 1449

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 65    FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  124

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 125   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  184

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 185   SQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  243

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l+lp +  l+++a+dlvk

Q: 244   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LTLPPY--LTPDARDLVK  299

         ****************************************..******..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    + +++++h+f+

Q: 300   KFLKRNPSQRIGGgpgDSADVQRHPFF  326

         ***********999999********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLNSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL TLPPYLTPDA RDLVKKFLKR 240

NPSQRIGGGP GDSADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045948	; P:positive regulation of translational initiation
GO:0043491	; P:protein kinase B signaling cascade

KEGG

cfa:610499

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013