EKS-CAF-00373
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00373
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src421.99.7E-127262510249
StatusUnreviewed
Ensembl ProteinENSCAFP00000017792
UniProt AccessionE2RSN0;
Protein Name
Protein Synonyms/Alias
Gene NameFGR
Gene Synonyms/Alias FGR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000012070ENSCAFP00000017792ENSCAFT00000019186
OrganismCanis familiaris
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MGCVFCKKSE PGLKDDVGLE GEFRGSGAAD RYGPDPTQAR GVSSFAHIPN YNNFPTQSTN 60
PTFLDGGTIR GISGTGVTLF IALYDYEART EDDLTFTKGE KFHILNNTEG DWWEARSLSS 120
GRTGYIPSNY VAPVDSIQAE EWYFGKIGRK DAERQLLSPG NPRGAFLIRE SETTKGAYSL 180
SIRDWDQTRG DHVKHYKIRK LDTGGYYITT RAQFHSVQEL VQHYMEVNDG LCHLLSVACT 240
TMKPQTMGLA KDAWEISRSS IALERRLGTG CFGDVWLGMW NGSTKVAVKT LKPGTMSPKA 300
FLAEAQIMKL LRHDKLVQLY AVVSEEPIYI VTEFMCHGSL LDFLKDLKGQ DLILSQLGDW 360
AARVAEGMAY MERMNYIHRD LRAANILVGE RLVCKIADFG LARLIEDDEY NPQQGAKFPI 420
KWTAPEAALF GKFTIKSDVW SFGILLTELI SKGRVPYPGM NNREVLEQVE HGYHMPCPPG 480
CPASLYEAME QTWRMDPEER PTFEYLQSFL EDYFTSTEPQ YQPGDQT 527
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGTTCTGCAA GAAGTCGGAG CCGGGGCTCA AGGACGATGT TGGCCTGGAA 60
GGGGAATTCA GGGGCAGTGG GGCTGCGGAC CGCTATGGCC CTGACCCTAC TCAGGCCCGG 120
GGCGTGTCCT CCTTTGCCCA TATCCCCAAC TACAACAACT TTCCCACTCA GTCCACCAAC 180
CCCACCTTCC TCGATGGGGG CACCATCAGG GGCATCTCAG GGACTGGGGT GACCCTGTTC 240
ATCGCCCTGT ATGACTATGA GGCCCGGACA GAGGATGACC TCACCTTCAC CAAGGGTGAG 300
AAGTTCCACA TCCTGAACAA CACTGAGGGT GACTGGTGGG AAGCTCGGTC TCTCAGCTCC 360
GGACGAACTG GCTATATTCC CAGCAACTAT GTGGCCCCTG TGGACTCTAT CCAGGCTGAA 420
GAGTGGTACT TTGGAAAGAT CGGGAGGAAG GATGCTGAGA GGCAGCTGCT CTCCCCTGGG 480
AACCCCCGGG GGGCCTTTCT TATTCGTGAG AGTGAGACTA CCAAAGGTGC CTACTCCCTG 540
TCCATCCGGG ATTGGGACCA GACCAGAGGC GACCATGTGA AGCATTACAA AATTCGCAAA 600
CTGGACACGG GCGGCTACTA CATCACCACA CGGGCCCAGT TCCACTCGGT GCAGGAGCTG 660
GTACAGCATT ACATGGAGGT GAACGACGGG CTCTGCCACC TGCTCTCGGT GGCCTGCACC 720
ACCATGAAGC CGCAGACAAT GGGCCTGGCC AAGGATGCTT GGGAGATTAG CCGCAGCTCC 780
ATCGCGCTCG AGCGCCGGCT GGGCACCGGC TGCTTCGGGG ACGTGTGGCT GGGCATGTGG 840
AACGGCAGCA CGAAGGTGGC GGTGAAGACG CTGAAGCCGG GAACCATGTC CCCGAAGGCC 900
TTCCTGGCGG AGGCGCAGAT CATGAAGCTG CTGCGGCACG ACAAGCTGGT GCAGCTGTAC 960
GCCGTGGTGT CGGAGGAGCC CATCTACATC GTGACCGAGT TCATGTGCCA CGGTAGCTTG 1020
CTGGACTTCC TCAAGGACCT GAAAGGCCAG GATTTGATCT TGTCCCAATT GGGGGATTGG 1080
GCCGCCCGGG TAGCTGAGGG CATGGCCTAC ATGGAACGTA TGAACTACAT CCACCGGGAC 1140
CTGAGAGCAG CCAACATCCT TGTTGGGGAA CGACTGGTGT GCAAGATAGC TGACTTCGGG 1200
CTGGCTCGTC TCATTGAGGA TGATGAGTAC AATCCCCAGC AAGGGGCCAA GTTCCCCATC 1260
AAGTGGACAG CCCCGGAGGC TGCTCTCTTT GGCAAATTCA CCATCAAGTC AGATGTGTGG 1320
TCCTTTGGGA TTCTGCTCAC TGAGCTCATC AGCAAGGGCC GAGTCCCCTA TCCAGGCATG 1380
AATAACCGGG AAGTGTTGGA ACAGGTGGAG CATGGCTACC ACATGCCATG CCCCCCAGGC 1440
TGCCCAGCAT CCCTATATGA AGCCATGGAG CAGACCTGGC GTATGGACCC AGAGGAGAGG 1500
CCTACCTTCG AGTACCTGCA GTCCTTCCTT GAAGACTACT TCACTTCTAC AGAACCCCAG 1560
TACCAGCCTG GGGATCAGAC ATAG 1584
Domain Profile
S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61
          l+++lG+G+fG+vwlg+w+gs+kvavktlk+gt+sp+afl+eaqi+k lrh+klv+lya
Q: 262   ALERRLGTGCFGDVWLGMWNGSTKVAVKTLKPGTMSPKAFLAEAQIMKLLRHDKLVQLYA  321
         789*********************************************************
S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121
         vvse ePiyivte+m +Gslldflk+ +g+ l l++l d aa+vaeGmay+e++n+ihrd
Q: 322   VVSE-EPIYIVTEFMCHGSLLDFLKDLKGQDLILSQLGDWAARVAEGMAYMERMNYIHRD  380
         ***9.*******************************************************
S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181
         l+a+n+lvge+lv+k+adfGlarlieddey++++gak+PikWtaPea+ +gkftiksdvW
Q: 381   LRAANILVGERLVCKIADFGLARLIEDDEYNPQQGAKFPIKWTAPEAALFGKFTIKSDVW  440
         ************************************************************
S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241
         sfGillte+++kG+vPypGm+n+evleqve+gy++p+p  cp++lye+++++w+ dpeer
Q: 441   SFGILLTELISKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPASLYEAMEQTWRMDPEER  500
         ************************************************************
S: 242   Ptfetlqevl  251
         Ptfe+lq++l
Q: 501   PTFEYLQSFL  510
         *******986
Domain Sequence
(FASTA)
ALERRLGTGC FGDVWLGMWN GSTKVAVKTL KPGTMSPKAF LAEAQIMKLL RHDKLVQLYA 60
VVSEEPIYIV TEFMCHGSLL DFLKDLKGQD LILSQLGDWA ARVAEGMAYM ERMNYIHRDL 120
RAANILVGER LVCKIADFGL ARLIEDDEYN PQQGAKFPIK WTAPEAALFG KFTIKSDVWS 180
FGILLTELIS KGRVPYPGMN NREVLEQVEH GYHMPCPPGC PASLYEAMEQ TWRMDPEERP 240
TFEYLQSFL 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-AIM-00344
EKS-BOT-00371
EKS-CAJ-00374
EKS-CAP-00403
EKS-EQC-00362
EKS-FEC-00357
EKS-GOG-00361
EKS-HOS-00377
EKS-ICT-00349
EKS-LOA-00379
EKS-MAM-00370
EKS-MUM-00402
EKS-MUP-00364
EKS-NOL-00341
EKS-ORA-00323
EKS-ORC-00348
EKS-OTG-00373
EKS-PAT-00350
EKS-POA-00360
EKS-RAN-00385
EKS-SAH-00341
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0007229; P:integrin-mediated signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0030335; P:positive regulation of cell migration
GO:0050715; P:positive regulation of cytokine secretion
GO:0043306; P:positive regulation of mast cell degranulation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045088; P:regulation of innate immune response
GO:0050764; P:regulation of phagocytosis
GO:0045859; P:regulation of protein kinase activity
KEGG
cfa:487341;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013