EKS-CAF-00197
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00197
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LISK483.91.4E-145339604266
StatusUnreviewed
Ensembl ProteinENSCAFP00000018366
UniProt AccessionE2RQT0;
Protein Name
Protein Synonyms/Alias
Gene NameLIMK1
Gene Synonyms/Alias LIMK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000012073ENSCAFP00000018366ENSCAFT00000019799
OrganismCanis familiaris
Functional Description
Protein Length647
Protein Sequence
(FASTA)
MRLTLLCCTW REERMGEEGS ELPMCASCGQ RIYDGQYLQA LNADWHADCF RGCECNASLS 60
HPYYQKDGQL FCKRDYWARY GEACHGCSEH ITKGLVMVAG ELKYHPECFI CLTCGTFIGD 120
GDTYTLVEHS KLYCGHCYYQ TVVTPAIEQV LPDSPGSRLP HTVTLVSIPA SPHGKRGLSV 180
SIDPAHGPPG CSTEHSHTVR VQGVDPGCMS PDVKNSIHVG DRILEINGTP IRNVPLDEID 240
LLIQETSRLL QLTLEHDPHD TPGHGPGPEL SPLGSPTPTP SGEVGTSSRQ KPVLRSYSID 300
RSPGAGSLSS PASQRKDLGR SESLRVVCRP HRIFRPSDLI HGEVLGKGCF GQAIKVTHRE 360
TGEVMVMKEL IRFDEETQRT FLKEVKVMRC LEHPNVLKFI GVLYKDKRLN FITEYIKGGT 420
LRDIIKSMDS QYPWTQRVSF AKDIASGMAY LHSMNIIHRD LNSHNCLVRE NKNVVVADFG 480
LARLMVEEKT QPGGLRSIKK SDRKKRYTVV GNPYWMAPEM INGRSYDEKV DVFSFGIVLC 540
EIIGRVNADP DYLPRTMDFG LNVRGFLDRY CPPNCPPSFF PITVRCCDLD PEKRPSFMKL 600
EQWLETLRMH LASHLPLGLQ LEELDRSFWE TYRRGESGLP AHPEVPD 647
Nucleotide Sequence
(FASTA)
ATGAGGTTGA CGCTACTTTG TTGCACCTGG AGGGAAGAAC GTATGGGAGA AGAAGGAAGT 60
GAGTTGCCCA TGTGTGCGAG CTGCGGCCAG AGGATCTATG ATGGCCAGTA CCTCCAGGCC 120
CTGAATGCTG ACTGGCACGC AGACTGCTTC AGGGGTTGTG AATGCAATGC CTCCCTCTCA 180
CACCCATACT ACCAGAAGGA TGGACAGCTC TTCTGCAAGA GGGACTACTG GGCCCGCTAT 240
GGAGAGGCCT GCCACGGGTG CTCGGAGCAC ATCACCAAGG GGCTGGTCAT GGTGGCTGGG 300
GAGCTGAAAT ACCACCCCGA GTGCTTCATC TGCCTCACGT GCGGAACCTT CATCGGTGAC 360
GGAGACACCT ACACGCTGGT GGAGCACTCC AAGCTGTACT GCGGGCACTG CTACTACCAG 420
ACTGTGGTGA CCCCCGCCAT CGAGCAGGTC CTGCCCGACT CCCCCGGCTC CCGCCTGCCC 480
CACACAGTTA CCCTAGTATC CATCCCCGCC TCACCTCATG GCAAACGTGG CCTGTCGGTC 540
TCCATTGACC CCGCCCACGG CCCGCCAGGC TGCAGCACAG AGCACTCCCA CACCGTCCGC 600
GTCCAGGGAG TGGACCCAGG CTGCATGAGC CCAGATGTGA AGAATTCCAT CCACGTGGGA 660
GACCGGATCC TCGAAATCAA TGGCACACCC ATCCGGAACG TGCCCCTGGA TGAGATTGAT 720
CTGCTGATCC AGGAAACCAG CCGCCTGCTC CAGCTAACTC TTGAGCATGA CCCCCATGAC 780
ACCCCGGGTC ATGGGCCAGG GCCTGAGCTC AGCCCCCTGG GCTCCCCAAC CCCCACTCCC 840
AGTGGGGAGG TGGGCACCTC TTCCCGGCAG AAGCCTGTCC TGAGGAGCTA CAGCATTGAC 900
AGGTCTCCGG GTGCTGGCTC ACTAAGCTCC CCAGCCTCCC AGCGCAAGGA CCTGGGTCGC 960
TCTGAATCCC TCCGTGTGGT CTGCCGGCCG CACCGCATCT TCCGGCCATC GGATCTCATC 1020
CATGGGGAGG TGTTGGGCAA AGGCTGCTTC GGCCAGGCCA TCAAGGTGAC ACACCGGGAG 1080
ACAGGCGAAG TGATGGTGAT GAAGGAACTG ATCCGGTTTG ATGAAGAGAC CCAGAGGACG 1140
TTCCTCAAGG AGGTAAAGGT CATGAGATGC CTGGAGCACC CTAACGTGCT CAAGTTCATC 1200
GGAGTGCTCT ACAAGGACAA GAGGCTCAAC TTCATCACAG AGTACATCAA GGGGGGTACC 1260
CTCCGGGACA TCATCAAGAG TATGGACAGC CAGTACCCGT GGACTCAGAG GGTGAGCTTT 1320
GCCAAGGATA TCGCTTCAGG GATGGCTTAC CTCCACTCCA TGAACATTAT CCACCGGGAC 1380
CTGAACTCAC ACAACTGCCT GGTCCGAGAG AACAAGAACG TGGTGGTGGC TGACTTTGGG 1440
CTGGCACGGC TCATGGTGGA AGAGAAGACA CAGCCCGGAG GCCTTCGAAG CATCAAGAAG 1500
TCAGATCGCA AGAAGCGATA CACGGTAGTG GGCAACCCAT ACTGGATGGC GCCTGAGATG 1560
ATCAATGGCC GCAGCTACGA TGAGAAGGTG GATGTGTTTT CCTTTGGAAT CGTCCTGTGC 1620
GAGATCATTG GGCGGGTGAA TGCGGACCCC GACTACCTGC CCCGCACCAT GGACTTTGGC 1680
CTCAATGTGC GGGGCTTCCT GGACCGTTAC TGCCCTCCAA ACTGCCCTCC GAGCTTTTTC 1740
CCCATAACTG TGCGCTGCTG TGATCTGGAC CCCGAGAAGA GGCCCTCCTT TATGAAGCTG 1800
GAGCAGTGGC TGGAGACCCT CCGCATGCAC TTGGCCAGCC ACCTGCCACT GGGCCTGCAG 1860
CTGGAAGAAC TGGACAGGAG CTTCTGGGAG ACCTACCGGC GAGGCGAGAG CGGACTGCCC 1920
GCTCACCCCG AGGTCCCCGA CTGA 1944
Domain Profile
S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60
         li+ge+lGkG+f++++kvthr++Gevmv+kelir+dee+++++lkevk++r+lehpnvlk
Q: 339   LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLK  398
         689*********************************************************
S: 61    fiGvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiih  119
         fiGvl+kdk+l+++teyi+gGtl++++ks++s +pwtqrv++akdiasG++ylhs++iih
Q: 399   FIGVLYKDKRLNFITEYIKGGTLRDIIKSMDSqYPWTQRVSFAKDIASGMAYLHSMNIIH  458
         ******************************999***************************
S: 120   rdlnsknclvredksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaP  179
         rdlns+nclvre+k+vvvadfGlarl+vee++++  lrs+kk+drkkr+tvvG+PywmaP
Q: 459   RDLNSHNCLVRENKNVVVADFGLARLMVEEKTQPGGLRSIKKSDRKKRYTVVGNPYWMAP  518
         ************************************************************
S: 180   evlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPea  239
         e+++g+sydekvdvfsfGivlceii+rv+adPdylPrt+dfgl+v+ f +++++ +cP++
Q: 519   EMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPS  578
         ************************************************************
S: 240   flklavvccdldpesrpsfeelekkl  265
         f++++v+ccdldpe+rpsf +le++l
Q: 579   FFPITVRCCDLDPEKRPSFMKLEQWL  604
         ************************97
Domain Sequence
(FASTA)
LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDEETQ RTFLKEVKVM RCLEHPNVLK 60
FIGVLYKDKR LNFITEYIKG GTLRDIIKSM DSQYPWTQRV SFAKDIASGM AYLHSMNIIH 120
RDLNSHNCLV RENKNVVVAD FGLARLMVEE KTQPGGLRSI KKSDRKKRYT VVGNPYWMAP 180
EMINGRSYDE KVDVFSFGIV LCEIIGRVNA DPDYLPRTMD FGLNVRGFLD RYCPPNCPPS 240
FFPITVRCCD LDPEKRPSFM KLEQWL 266
KeywordComplete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00180
EKS-ANC-00185
EKS-BOT-00191
EKS-CAP-00216
EKS-CIS-00229
EKS-DAR-00492
EKS-DIO-00098
EKS-DRM-00101
EKS-EQC-00186
EKS-FEC-00179
EKS-GAM-00108
EKS-GAG-00164
EKS-GAA-00234
EKS-GOG-00189
EKS-HOS-00197
EKS-ICT-00183
EKS-LAC-00202
EKS-LOA-00189
EKS-MAM-00192
EKS-MAE-00074
EKS-MEG-00151
EKS-MIM-00089
EKS-MOD-00190
EKS-MUM-00194
EKS-MUP-00195
EKS-MYL-00196
EKS-OCP-00125
EKS-ORN-00242
EKS-ORA-00170
EKS-ORC-00174
EKS-ORL-00227
EKS-OTG-00197
EKS-PAT-00182
EKS-PES-00169
EKS-POA-00188
EKS-RAN-00185
EKS-SAH-00188
EKS-SUS-00165
EKS-TAG-00217
EKS-TAR-00248
EKS-TEN-00242
EKS-TUT-00179
EKS-XET-00223
EKS-XIM-00238
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005925; C:focal adhesion
GO:0043005; C:neuron projection
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0008270; F:zinc ion binding
GO:0051444; P:negative regulation of ubiquitin-protein ligase activity
GO:0032233; P:positive regulation of actin filament bundle assembly
GO:0045773; P:positive regulation of axon extension
KEGG
cfa:489800;
InterPros
IPR011009; Kinase-like_dom.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781; Znf_LIM.
Pfam
PF00412; LIM; 2.
PF00595; PDZ; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00132; LIM; 2.
SM00228; PDZ; 1.
Prosites
PS00478; LIM_DOMAIN_1; 1.
PS50023; LIM_DOMAIN_2; 2.
PS50106; PDZ; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013