EKS-CAF-00353

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00353

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NEK	356.8	8.6E-107	8	270	263

Status

Unreviewed

Ensembl Protein

ENSCAFP00000032514

UniProt Accession

E2RSC1;

Protein Name

Protein Synonyms/Alias

Gene Name

NEK2

Gene Synonyms/Alias

NEK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000012136	ENSCAFP00000032514	ENSCAFT00000037067

Organism

Canis familiaris

Functional Description

Protein Length

444

Protein Sequence
(FASTA)

MPTRAEDYEV LHTIGTGSYG RCQKIRRKSD GKVLVWKELD YGSMTEAEKQ MLVSEVNLLR 60

ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASLITK GTKERQYLEE EFVLRVMTQL 120

TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP 180

YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFN QKELAGKIRE GKFRRIPYRY 240

SDELNDIITR MLNLKDYHRP SVEEILDNPL IANLVAEEQR RNPERRGRRL EPEKLQDSSP 300

VLGELKLKEL QLQERERALK AREERLEQKE RELCVRERLA EDKLARAENL LKNYSLLKEQ 360

KFLCLASDPE LFDLPSSIIK KKVHFSGESK ENVMRSKNSE SLLTSKSKCK DLKKRLHAAQ 420

LRAQALSDIE KNYQLKSRQI LGMR 444

Nucleotide Sequence
(FASTA)

ATGCCGACGC GGGCGGAGGA CTACGAGGTG CTGCACACCA TTGGCACGGG CTCCTACGGC 60

CGCTGCCAGA AGATCCGGAG GAAGAGCGAC GGCAAGGTAT TAGTTTGGAA AGAACTTGAC 120

TATGGCTCCA TGACAGAAGC CGAGAAACAG ATGCTTGTTT CTGAAGTGAA TTTGCTCCGT 180

GAACTGAAGC ATCCAAACAT TGTCCGTTAC TATGATCGAA TTATTGACCG AACCAACACA 240

ACACTGTACA TTGTAATGGA ATATTGTGAA GGAGGGGACC TGGCTAGTCT AATTACAAAG 300

GGAACAAAGG AAAGACAATA TTTAGAGGAA GAGTTTGTTC TTCGAGTGAT GACTCAGCTG 360

ACTCTGGCCC TAAAGGAATG TCACAGACGA AGCGATGGTG GTCATACTGT GCTGCATCGT 420

GATCTGAAAC CAGCCAACGT TTTCCTGGAT GGCAAGCAAA ACGTTAAGCT TGGGGACTTT 480

GGGCTAGCGA GGATATTAAA CCATGATACA AGTTTTGCAA AAACATTTGT TGGCACACCC 540

TATTACATGT CTCCTGAACA AATGAATCGG ATGTCCTACA ATGAAAAATC GGATATCTGG 600

TCACTAGGTT GTTTGCTGTA TGAATTGTGT GCATTAATGC CTCCATTTAC AGCTTTCAAC 660

CAGAAAGAAC TAGCAGGGAA GATTAGAGAA GGCAAATTCA GGCGAATTCC ATACCGTTAC 720

TCTGATGAAT TGAATGATAT TATTACAAGG ATGTTAAATT TAAAGGATTA CCACCGACCT 780

TCTGTGGAAG AAATTCTTGA CAATCCCTTG ATAGCAAACT TGGTTGCAGA AGAGCAAAGA 840

AGAAATCCCG AGAGGAGAGG GCGGCGATTA GAACCAGAGA AGTTGCAGGA TTCCAGCCCT 900

GTCTTGGGAG AGCTGAAACT AAAGGAACTG CAGCTACAGG AGAGAGAGCG AGCCCTCAAA 960

GCTCGTGAAG AAAGGCTGGA GCAGAAGGAA CGAGAGCTTT GTGTTCGTGA GAGACTGGCA 1020

GAGGACAAGC TGGCTAGGGC AGAAAATCTG TTGAAGAATT ACAGCCTGCT GAAGGAGCAG 1080

AAGTTCCTGT GTCTGGCAAG TGATCCAGAA CTTTTTGACC TTCCATCCTC GATAATTAAG 1140

AAGAAAGTTC ATTTCAGTGG GGAAAGCAAA GAGAACGTCA TGAGGAGTAA GAATTCTGAG 1200

AGTCTGCTCA CCTCCAAATC CAAGTGCAAA GACCTGAAGA AAAGGCTTCA CGCTGCTCAG 1260

CTCCGCGCTC AAGCCTTGTC AGATATCGAA AAAAATTACC AGCTGAAAAG CAGACAGATT 1320

CTGGGCATGC GCTAG 1335

Domain Profile

S: 1     yevlkkiGrGsfgevlkvrkksdkkllvlKeikleeldekerqklvkevsllkqlkHpni  60

         yevl++iG+Gs+g+++k+r+ksd+k lv+Ke+++++++e+e+q+lv+ev+ll++lkHpni

Q: 8     YEVLHTIGTGSYGRCQKIRRKSDGKVLVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI  67

         99**********************************************************

S: 61    veyyesfe..eneelyivmeyceggdLsqlikeqkekkklleEktvlkilvqlllalkkl  118

         v+yy++++  +n++lyivmeyceggdL++li++ ++++++leE+ vl++++ql+lalk++

Q: 68    VRYYDRIIdrTNTTLYIVMEYCEGGDLASLITKGTKERQYLEEEFVLRVMTQLTLALKEC  127

         ******5548999***********************************************

S: 119   Hek.....kilHRDlkpaNifltkkevvklgDfGlaklleskielaktlvGtpyYlsPEv  173

         H++     ++lHRDlkpaN+fl+ k++vklgDfGla++l++++++akt+vGtpyY+sPE+

Q: 128   HRRsdgghTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQ  187

         *65555559***************************************************

S: 174   leekpYneksDiWslgCvlyelcaLkkpFeaknllelvlkivegklepvpekyseelkel  233

         +++ +YneksDiWslgC+lyelcaL++pF+a n +el+ ki egk++++p +ys+el+++

Q: 188   MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGKFRRIPYRYSDELNDI  247

         ************************************************************

S: 234   iesllkvdpekrpsveeilkkpl  256

         i+++l+ ++ +rpsveeil++pl

Q: 248   ITRMLNLKDYHRPSVEEILDNPL  270

         *******************9986

Domain Sequence
(FASTA)

YEVLHTIGTG SYGRCQKIRR KSDGKVLVWK ELDYGSMTEA EKQMLVSEVN LLRELKHPNI 60

VRYYDRIIDR TNTTLYIVME YCEGGDLASL ITKGTKERQY LEEEFVLRVM TQLTLALKEC 120

HRRSDGGHTV LHRDLKPANV FLDGKQNVKL GDFGLARILN HDTSFAKTFV GTPYYMSPEQ 180

MNRMSYNEKS DIWSLGCLLY ELCALMPPFT AFNQKELAGK IREGKFRRIP YRYSDELNDI 240

ITRMLNLKDY HRPSVEEILD NPL 263

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>