EKS-CAF-00391
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00391
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11347.85.9E-104510766257
StatusUnreviewed
Ensembl ProteinENSCAFP00000017922
UniProt AccessionF1P6H0;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K6
Gene Synonyms/Alias MAP3K6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000012144ENSCAFP00000017922ENSCAFT00000019323
OrganismCanis familiaris
Functional Description
Protein Length1154
Protein Sequence
(FASTA)
MTNNVLLCSQ ADLPDLQALR EDVFQKNSDC VGSYTLIPYV VTASGRVLCG DAGLLRGLAD 60
GLVQAGVGSE ALLTPLVGRL ARLLETTPTD SCGYFRETIR QDIRRARERF SGQQLRQELA 120
RLQRRLDSVE LLSPDIIMNL LLSYRDVQDY SAIIELVETL QALPTCDVAE QHNICFHYTF 180
ALNRRNRPGD REKALAVLLP LVQGEGSVAP DLYCMCGRVY KDMFFSSGFQ DAGHREQAYH 240
WYRKAFDVEP SLHSGINAAV LLIAAGQRFE DSEELRLIGM KLGCLLARKG CVEKMQYYWD 300
VGFYLGAQIL ANDLAQVALA AEQLYKLNAP IWYLVSMMET FLLYQHFRPM LELPEGPPHR 360
AHFWLHFLLQ SCQPFKMACP QGDQCLVLVL EMNKVLLPGR LEIQGTDPVS AVTLSLLEPE 420
TQDVPSSWTF PVASICGVSS SKRDERCCFL YALPPAQDVQ LCFPSAGHCR WFCGLIQALV 480
TNPDSTAPSE EAEGVKEVLE FDYEYTETGQ RLVLGKGTYG VVYAGRERHT RVRIAIKEIP 540
ERDSRFSQPL HEEIALHKRL RHKNIVRYLG STSQGGYLKI FMEEVPGGSL SSLLRSVWGP 600
LQDNESTISF YTRQILQGLS YLHDNRIVHR DIKGDNVLIN TFSGLLKISD FGTSKRLAGI 660
TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI EMATGRPPFH ELGSPQAAMF 720
QVGMYKVHPP MPPSLSAEAQ AFLLRTFEPD PRLRASAQAL LGDPFLQPGK RSRSPGSPRH 780
ALRPSDAPSA SPTPSADLTT QSQTFPRPQA PFQHPSSPPK RCLSYGDTSQ LRVPEEPGAE 840
EPTSPEESSG LSLLHQESKR RAMLAAVLEQ ELPTLADSLC LKQEQGPGAG RNHVEQLLRC 900
LGAHIHTPNR RQLAQELRAL QAQLRAQGLG PALLHGPLFA FPDAVKQILR RRHIRPHWMF 960
VLDSLLSRAV RVALAVLGPE VETEAIPPRS EESSKEEEPQ PKRQETLVQL SQLPEEAEKA 1020
PPPRMVQLDL LRAETDRLRD VLAEKERECQ ALVQQALQRV NGEARICALA SEPPAVPTWD 1080
QGLVEWLQEL NVDPGTIQML LNHSFTLRTL LTCATRDDLI YTRIRGGMVC RIWRAILAQR 1140
AGSTPVTPGR QEAE 1154
Nucleotide Sequence
(FASTA)
ATGACCAACA ACGTGCTCCT CTGCTCCCAG GCTGACCTCC CTGACCTGCA GGCCCTTCGG 60
GAAGACGTTT TCCAGAAGAA TTCGGACTGT GTTGGCAGCT ACACACTGAT CCCCTATGTG 120
GTGACAGCCA GTGGCCGGGT GCTGTGCGGT GATGCGGGCC TCCTGAGAGG CCTGGCTGAT 180
GGGCTAGTCC AGGCAGGGGT GGGCAGCGAG GCCCTGCTAA CGCCCCTGGT GGGCCGGCTC 240
GCCCGCCTGC TGGAGACCAC ACCCACGGAC TCTTGTGGCT ACTTCCGAGA GACCATTCGG 300
CAGGACATCC GGCGGGCCCG GGAGCGGTTC TCCGGGCAGC AGCTGCGGCA GGAGCTGGCT 360
CGCCTGCAGC GGAGGCTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCAT CATGAACCTG 420
CTGCTCTCCT ACCGTGACGT GCAGGACTAC TCAGCCATCA TTGAGCTGGT GGAGACACTG 480
CAGGCCTTGC CCACCTGTGA CGTGGCCGAG CAGCACAACA TCTGCTTCCA CTACACGTTT 540
GCCCTCAACC GGAGGAACAG GCCTGGGGAC CGGGAGAAGG CACTGGCTGT GCTGCTGCCA 600
CTGGTGCAGG GGGAGGGGTC TGTGGCCCCT GACCTATACT GCATGTGTGG CCGTGTCTAC 660
AAGGACATGT TCTTTAGCTC TGGCTTCCAG GATGCTGGGC ATCGGGAGCA GGCGTATCAC 720
TGGTATCGCA AGGCTTTTGA CGTAGAGCCC AGCCTCCACT CGGGGATCAA CGCAGCTGTG 780
CTGCTCATTG CTGCTGGGCA GCGCTTTGAA GACTCTGAGG AGCTCCGGCT AATAGGCATG 840
AAGCTGGGCT GCCTGCTGGC CCGAAAAGGC TGCGTGGAGA AGATGCAGTA TTACTGGGAC 900
GTAGGCTTCT ACCTGGGAGC TCAGATCCTC GCCAATGACC TCGCCCAGGT GGCTCTGGCT 960
GCAGAGCAGC TGTACAAGCT CAATGCTCCC ATATGGTACC TGGTGTCCAT GATGGAAACC 1020
TTCCTGCTGT ACCAGCACTT CAGACCGATG CTAGAGCTTC CGGAAGGACC CCCACACCGT 1080
GCCCACTTTT GGCTCCACTT CTTGCTGCAG TCCTGTCAGC CATTCAAGAT GGCCTGTCCC 1140
CAGGGGGACC AGTGCTTGGT GCTGGTCCTG GAGATGAACA AGGTGCTGCT GCCTGGGAGG 1200
CTTGAGATTC AGGGTACTGA TCCCGTTAGC GCGGTGACCC TGAGTCTGCT GGAGCCAGAA 1260
ACCCAGGACG TTCCCTCCAG CTGGACCTTC CCGGTGGCCT CCATCTGCGG GGTCAGTTCC 1320
TCCAAGAGGG ACGAGCGCTG CTGCTTCCTC TACGCGCTTC CCCCGGCTCA GGACGTCCAG 1380
CTGTGCTTCC CCAGCGCCGG GCACTGCCGG TGGTTCTGCG GCCTGATCCA AGCCTTGGTG 1440
ACGAATCCGG ATTCCACGGC GCCCTCGGAG GAGGCGGAGG GCGTGAAGGA GGTGCTGGAG 1500
TTTGATTATG AGTACACGGA GACGGGCCAG CGGCTGGTGC TGGGCAAGGG CACGTACGGG 1560
GTGGTGTACG CGGGCCGCGA GCGGCACACG CGGGTGCGCA TCGCCATTAA GGAGATCCCC 1620
GAGCGTGACA GCAGGTTCTC GCAGCCCCTG CACGAAGAGA TTGCTCTGCA CAAACGCCTT 1680
CGCCACAAGA ACATCGTGCG CTACCTGGGC TCGACCAGCC AGGGCGGCTA CCTCAAGATC 1740
TTCATGGAGG AAGTGCCCGG AGGCAGCCTG TCCTCCTTGC TGCGCTCCGT GTGGGGACCC 1800
CTGCAGGACA ACGAGAGCAC CATCAGTTTC TACACCCGCC AGATCCTGCA GGGACTCAGC 1860
TACCTGCACG ACAACCGCAT AGTGCATCGA GACATCAAGG GGGACAATGT ACTGATCAAC 1920
ACCTTCAGTG GGCTGCTCAA GATTTCTGAC TTTGGCACCT CCAAGAGGCT GGCAGGCATC 1980
ACACCCTGCA CTGAGACCTT CACAGGGACC CTACAGTATA TGGCACCAGA AATCATTGAC 2040
CAGGGCCCAC GAGGGTATGG GAAGGCAGCT GACATCTGGT CACTGGGCTG CACTGTCATC 2100
GAGATGGCCA CAGGTCGCCC ACCCTTCCAT GAGCTAGGGA GCCCACAGGC TGCCATGTTT 2160
CAGGTGGGCA TGTACAAGGT GCATCCGCCA ATGCCCCCTT CTCTGTCAGC GGAGGCGCAA 2220
GCCTTTCTTC TCCGAACTTT TGAGCCAGAC CCCCGTCTCC GAGCCAGTGC TCAAGCATTG 2280
CTGGGGGACC CCTTCCTGCA GCCCGGGAAG AGGAGCCGCA GCCCTGGCTC CCCCCGCCAT 2340
GCACTGCGGC CCTCAGATGC CCCTTCAGCC AGCCCCACTC CTTCAGCTGA CCTGACCACC 2400
CAGTCCCAGA CATTCCCACG CCCTCAGGCA CCCTTTCAGC ACCCATCCAG TCCCCCGAAG 2460
CGCTGCCTCA GTTATGGAGA CACCAGCCAG CTCCGGGTGC CCGAGGAACC GGGAGCCGAG 2520
GAGCCCACGT CCCCTGAGGA GAGTTCTGGG CTGAGCCTGC TGCATCAAGA GAGCAAGCGC 2580
CGGGCCATGC TGGCGGCTGT ACTGGAGCAG GAGCTGCCCA CGCTGGCGGA CAGTCTGTGC 2640
CTGAAGCAGG AACAGGGTCC CGGGGCCGGC AGGAATCACG TGGAACAGCT CCTGCGCTGC 2700
CTGGGGGCGC ACATCCACAC TCCCAACCGC CGCCAGCTGG CCCAGGAGCT TCGGGCGCTG 2760
CAGGCGCAGC TGCGGGCCCA AGGCCTCGGG CCTGCGCTTC TGCACGGACC GCTCTTCGCC 2820
TTCCCGGATG CGGTGAAGCA GATCCTCCGC AGGCGCCACA TCCGCCCACA CTGGATGTTC 2880
GTGCTGGACT CGCTGCTCAG CCGAGCCGTC CGGGTAGCCC TGGCTGTGTT GGGCCCAGAA 2940
GTGGAGACGG AGGCCATCCC ACCGAGGTCA GAGGAGTCGA GTAAAGAAGA GGAACCCCAG 3000
CCCAAGCGGC AGGAGACCTT GGTCCAGCTC AGCCAGCTCC CCGAGGAAGC AGAGAAGGCA 3060
CCCCCGCCCC GGATGGTGCA GCTGGACCTC TTGCGAGCCG AGACTGACAG GCTTCGGGAT 3120
GTCCTGGCTG AGAAAGAACG GGAGTGCCAG GCCCTGGTGC AACAAGCTCT ACAGCGGGTG 3180
AATGGGGAGG CCCGGATCTG CGCCCTGGCC TCCGAGCCCC CAGCTGTTCC CACCTGGGAC 3240
CAGGGCCTGG TAGAGTGGCT ACAGGAACTG AACGTGGATC CAGGCACCAT CCAGATGCTG 3300
CTGAACCACA GCTTCACCCT CCGTACCCTA CTGACCTGTG CCACTCGAGA TGACCTCATC 3360
TACACCCGCA TCAGGGGAGG GATGGTATGC CGCATCTGGA GAGCCATCCT GGCACAGCGA 3420
GCAGGATCCA CACCAGTTAC CCCTGGCCGA CAGGAGGCCG AATGA 3465
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya+++ +t+ ++a+Ke+   pe++s+   +++l+eEi+l+k+l+H+n
Q: 510   QRLVLGKGTYGVVYAGRERHTRVRIAIKEI---PERDSR--FSQPLHEEIALHKRLRHKN  564
         5779**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl+yLH+
Q: 565   IVRYLGSTSQGGYLKIFMEEVPGGSLSSLLRsVWGPLQdnESTISFYTRQILQGLSYLHD  624
         *******************************99****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++
Q: 625   NRIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  681
         *****************9*********************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc+viem+tg++Pf+el++++a+mf+vg+ k++P++p +ls+e+++
Q: 682   GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPPSLSAEAQA  741
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         fl +++e dp+ r+sa+ LL ++fl
Q: 742   FLLRTFEPDPRLRASAQALLGDPFL  766
         **********************996
Domain Sequence
(FASTA)
QRLVLGKGTY GVVYAGRERH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL 60
GSTSQGGYLK IFMEEVPGGS LSSLLRSVWG PLQDNESTIS FYTRQILQGL SYLHDNRIVH 120
RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180
ADIWSLGCTV IEMATGRPPF HELGSPQAAM FQVGMYKVHP PMPPSLSAEA QAFLLRTFEP 240
DPRLRASAQA LLGDPFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00364
EKS-BOT-00391
EKS-CAJ-00392
EKS-CAP-00420
EKS-EQC-00382
EKS-FEC-00381
EKS-HOS-00398
EKS-ICT-00368
EKS-LOA-00400
EKS-MAM-00388
EKS-MAE-00046
EKS-MIM-00057
EKS-MOD-00378
EKS-MUM-00422
EKS-MUP-00384
EKS-MYL-00387
EKS-ORC-00368
EKS-OTG-00392
EKS-PAT-00368
EKS-POA-00382
EKS-RAN-00404
EKS-SUS-00342
EKS-TUT-00109
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013