EKS-CAF-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	558.6	2.3E-168	367	643	277

Status

Unreviewed

Ensembl Protein

ENSCAFP00000018223

UniProt Accession

F1Q2E3;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2IIIC

Gene Synonyms/Alias

FGFR2IIIC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000012374	ENSCAFP00000018243	ENSCAFT00000019669
ENSCAFG00000012374	ENSCAFP00000009051	ENSCAFT00000009748
ENSCAFG00000012374	ENSCAFP00000018223	ENSCAFT00000019648

Organism

Canis familiaris

Functional Description

Protein Length

707

Protein Sequence
(FASTA)

MVSWARFVCL AAVTMATLSL ARPSFNLVED TTLEPEGAPY WTNTEKMEKR LHAVPAANTV 60

KFRCPAGGNP TPTMRWLKNG KEFKQEHRIG GYKVRNQHWS LIMESVVPSD KGNYTCVVEN 120

EYGSINHTYH LDVVERSPHR PILQAGLPAN ASTVVGGDVE FVCKVYSDAQ PHIQWIKHVE 180

KNGSKYGPDG LPYLKVLKHS GINSSNAEVL ALFNVTEEDA GEYICKVSNY IGQANQSAWL 240

TVLPKQQAPV REKEITASPD YLEIAIYCIG VFLIACMVVT VILCRMKTTT KKPDFSSQPA 300

VHKLTKRIPL RRQVTVSAES SSSMNSNTPL VRITTRLSST ADTPMLAGVS EYELPEDPKW 360

EFPRDKLTLG KPLGEGCFGQ VVMAEAVGID KEKPKEAVTV AVKMLKDDAT EKDLSDLVSE 420

MEMMKMIGKH KNIINLLGAC TQDGPLYVIV EYASKGNLRE YLRARRPPGM EYSYDINRVP 480

EEQMTFKDLV SCTYQLARGM EYLASQKCIH RDLAARNVLV TENNVMKIAD FGLARDINNI 540

DYYKKTTNGR LPVKWMAPEA LFDRVYTHQS DVWSFGVLMW EIFTLGGSPY PGIPVEELFK 600

LLKEGHRMDK PANCTNELYM MMRDCWHAVP SQRPTFKQLV EDLDRILTLT TNEEYLDLSQ 660

PLEQYSPSYP DTRSSCSSGD DSVFSPDPMP YEPCLPQYPH VNGSVKT 707

Nucleotide Sequence
(FASTA)

ATGGTCAGCT GGGCCCGCTT CGTCTGCCTG GCCGCGGTCA CCATGGCAAC CTTGTCCCTG 60

GCCCGGCCCT CCTTCAATTT AGTGGAGGAC ACCACGTTAG AGCCGGAAGG GGCGCCTTAC 120

TGGACCAACA CAGAAAAGAT GGAAAAGCGT CTGCACGCTG TCCCTGCGGC CAATACTGTC 180

AAGTTTCGCT GTCCAGCTGG GGGGAATCCA ACACCAACTA TGAGGTGGCT GAAGAACGGA 240

AAGGAGTTTA AGCAGGAACA TCGCATTGGA GGCTATAAGG TACGAAACCA GCACTGGAGC 300

CTTATTATGG AGAGCGTGGT CCCATCCGAC AAAGGAAATT ACACCTGTGT GGTAGAGAAT 360

GAGTATGGCT CCATTAATCA CACGTACCAC CTCGACGTCG TCGAGCGATC GCCACACCGG 420

CCCATCCTCC AAGCTGGGCT GCCGGCAAAC GCCTCCACCG TGGTCGGAGG CGACGTGGAG 480

TTTGTCTGCA AAGTTTACAG CGATGCCCAG CCCCACATTC AGTGGATCAA ACACGTAGAA 540

AAGAACGGGA GCAAATACGG GCCCGATGGG TTGCCGTACC TCAAGGTTCT CAAGCACTCG 600

GGAATAAATA GTTCCAATGC AGAAGTGCTG GCTCTGTTCA ATGTGACTGA GGAGGATGCT 660

GGGGAGTATA TATGTAAGGT CTCCAATTAT ATAGGGCAGG CCAACCAGTC TGCCTGGCTC 720

ACTGTCCTGC CAAAACAGCA AGCTCCTGTA AGAGAAAAGG AGATTACGGC TTCCCCAGAC 780

TACCTGGAGA TAGCCATTTA CTGCATAGGG GTCTTCCTAA TTGCCTGTAT GGTGGTGACA 840

GTCATCCTGT GCCGAATGAA GACCACAACC AAGAAGCCAG ACTTCAGCAG CCAGCCAGCT 900

GTGCACAAGC TGACCAAGCG CATCCCCTTG CGGAGACAGG TAACAGTGTC TGCTGAGTCC 960

AGCTCCTCTA TGAACTCCAA CACTCCGCTG GTGAGGATAA CCACGCGCCT CTCCTCAACA 1020

GCAGACACCC CCATGCTGGC AGGGGTCTCC GAGTATGAAC TGCCGGAAGA TCCAAAGTGG 1080

GAGTTTCCCA GAGATAAGCT GACGCTGGGC AAACCTCTGG GGGAAGGTTG CTTTGGGCAA 1140

GTGGTCATGG CCGAAGCGGT GGGAATTGAC AAAGAGAAGC CCAAGGAAGC AGTCACGGTG 1200

GCGGTGAAGA TGTTGAAAGA CGATGCCACA GAGAAAGATC TTTCTGATCT AGTGTCAGAG 1260

ATGGAGATGA TGAAGATGAT TGGAAAACAC AAAAATATCA TAAATCTCCT TGGAGCCTGT 1320

ACTCAGGATG GCCCACTCTA CGTCATTGTG GAGTATGCCT CGAAAGGCAA CCTCCGTGAA 1380

TACCTCCGAG CCCGGAGGCC GCCTGGGATG GAGTATTCCT ATGACATTAA CCGCGTTCCT 1440

GAGGAGCAGA TGACCTTTAA GGACTTGGTG TCGTGTACCT ACCAGCTGGC GAGAGGCATG 1500

GAGTACTTGG CTTCCCAGAA ATGTATTCAT CGGGATTTAG CAGCCAGAAA TGTTTTGGTA 1560

ACAGAAAACA ATGTGATGAA AATAGCAGAC TTTGGACTGG CCAGAGATAT CAACAATATA 1620

GACTATTACA AAAAGACCAC AAATGGGCGA CTTCCGGTCA AGTGGATGGC TCCAGAAGCC 1680

CTTTTCGATC GAGTGTACAC CCATCAGAGT GACGTTTGGT CCTTCGGGGT GTTAATGTGG 1740

GAGATCTTCA CGCTGGGGGG CTCACCATAC CCAGGGATTC CGGTGGAGGA ACTATTTAAG 1800

CTGCTCAAGG AGGGGCACAG GATGGACAAG CCAGCAAACT GCACCAATGA ACTGTATATG 1860

ATGATGAGGG ACTGTTGGCA TGCTGTGCCC TCACAGAGGC CGACGTTCAA GCAGTTGGTA 1920

GAGGACTTGG ATCGGATTCT CACTCTCACA ACCAATGAGG AATACTTGGA CCTCAGTCAG 1980

CCTCTCGAAC AGTATTCACC TAGTTATCCT GACACAAGGA GTTCGTGTTC TTCAGGAGAC 2040

GATTCTGTTT TCTCTCCAGA CCCCATGCCT TACGAACCAT GCCTTCCTCA GTATCCACAT 2100

GTAAACGGCA GTGTTAAAAC ATGA 2124

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dk+k+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 367   LTLGKPLGEGCFGQVVMAEAVGIDKEKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  426

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+

Q: 427   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  486

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt

Q: 487   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  546

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 547   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  606

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 607   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  643

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKEKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120

KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013