EKS-CAF-00068

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00068

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	350.8	6.5E-105	106	390	285

Status

Unreviewed

Ensembl Protein

ENSCAFP00000018253

UniProt Accession

E2RS72;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK15

Gene Synonyms/Alias

CDK15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000012384	ENSCAFP00000018253	ENSCAFT00000019679

Organism

Canis familiaris

Functional Description

Protein Length

438

Protein Sequence
(FASTA)

MGQELCTRTA RPGCSCHRCG EGGDAHSGRG TVREPGPAAE AAIQLTDLKE ASCSMTSFHP 60

KGLQAVHARK CKSKRPRSNS DSFQEEDLRQ GFQWKKSLPF GAASSYLNLE KLGEGSYATV 120

YKGISRINGQ LVALKVISMN AEEGVPFTAI REASLLKGLK HANIVLLHDI IHTKETLTFV 180

FEYMHTDLAQ YMCQHPGGLH PHNVRLFMFQ LLRGLAYIHH QHVLHRDLKP QNLLISHLGE 240

LKLADFGLAR AKSIPSQTYS SEVVTLWYRP PDALLGATEY SSELDIWGAG CIFIEMFEGQ 300

PLFPGVSNIL EQLEKIWEVL GVPTEDTWPG VSKLPNYNPE WFPLPKPRSL QNVWNRLGRV 360

PEAEDLASQM LKGFPRDRVS AQEALVHDYF SALPSQLHQL PDEESLFTVS GVRLKPEMCD 420

LLVSYRKGHH PAQFSKCW 438

Nucleotide Sequence
(FASTA)

ATGGGTCAGG AGCTGTGTAC AAGGACTGCC CGGCCTGGCT GCAGCTGCCA CCGCTGCGGG 60

GAGGGAGGCG ATGCGCACAG CGGCCGGGGG ACGGTGCGGG AGCCTGGGCC GGCGGCGGAG 120

GCTGCGATCC AGCTAACAGA CCTAAAAGAA GCATCATGTT CCATGACTTC ATTTCACCCC 180

AAGGGACTTC AGGCTGTGCA TGCCCGGAAG TGCAAGAGTA AAAGGCCACG GAGTAACAGT 240

GATTCTTTTC AGGAAGAGGA TCTGAGGCAG GGTTTTCAGT GGAAGAAGAG CCTCCCTTTT 300

GGGGCAGCCT CATCTTACCT GAACTTGGAG AAGCTGGGTG AAGGTTCTTA TGCTACAGTT 360

TACAAGGGGA TTAGCAGGAT AAATGGACAA CTAGTAGCTC TAAAAGTCAT CAGCATGAAT 420

GCAGAGGAAG GAGTCCCATT TACGGCTATT CGGGAAGCTT CTCTCTTGAA GGGTTTGAAA 480

CATGCCAATA TCGTGCTCCT GCATGACATA ATCCACACCA AAGAGACACT GACATTCGTT 540

TTTGAATACA TGCACACAGA CCTGGCCCAG TACATGTGTC AACACCCAGG AGGGCTTCAT 600

CCTCACAATG TCAGGCTTTT CATGTTTCAA CTTTTGCGGG GCCTGGCGTA CATCCACCAC 660

CAACACGTTC TTCACAGGGA CCTGAAACCT CAGAACTTAC TCATCAGTCA CCTGGGAGAG 720

CTCAAACTGG CTGATTTTGG TCTTGCCCGG GCGAAGTCCA TTCCCAGCCA GACATACTCT 780

TCAGAAGTTG TGACCCTCTG GTACCGGCCT CCGGATGCCT TGCTGGGAGC CACTGAATAT 840

TCCTCTGAAC TGGACATATG GGGTGCAGGC TGCATCTTTA TTGAAATGTT CGAGGGTCAA 900

CCTTTGTTTC CTGGGGTTTC CAACATCCTT GAACAGCTGG AGAAGATCTG GGAGGTGTTG 960

GGAGTCCCTA CAGAGGATAC CTGGCCTGGA GTTTCCAAGC TACCTAACTA CAATCCAGAA 1020

TGGTTCCCAT TGCCCAAGCC ACGAAGCCTT CAGAATGTCT GGAACAGGTT GGGCAGGGTT 1080

CCCGAAGCTG AAGACCTGGC CTCCCAAATG CTAAAAGGCT TTCCTAGAGA CCGCGTCTCT 1140

GCCCAGGAAG CACTGGTTCA TGACTACTTC AGTGCCTTGC CATCTCAGCT GCACCAGCTT 1200

CCTGATGAGG AGTCTTTGTT TACAGTTTCA GGAGTGAGGC TAAAGCCAGA GATGTGTGAC 1260

CTTTTGGTCT CCTACCGGAA AGGTCACCAC CCAGCCCAGT TTAGCAAATG CTGGTGA 1317

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y +lek+geG+y++vyk+ ++ +g++vAlK i ++ e egvp+ta+rE sllk lkh+ni

Q: 106   YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANI  164

         6789******************************998.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v L+++++ +k++l++vfe++++dL++++ +++  +l++++v+ +++qll+glay+H+++

Q: 165   VLLHDIIH-TKETLTFVFEYMHTDLAQYMCQHPG-GLHPHNVRLFMFQLLRGLAYIHHQH  222

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLis+ g+lklaDfGlara s p++ty++evvTlwYr+P+ Llga+eYs+

Q: 223   VLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSS  282

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf  238

         ++DiW++gci+ e+++ +plf+g s+  +qle+i+++lg p+e++wp+vsklp+y+ + f

Q: 283   ELDIWGAGCIFIEMFEGQPLFPGVSNiLEQLEKIWEVLGVPTEDTWPGVSKLPNYNpEWF  342

         ***********************99967****************************8889

S: 239   pkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf  284

         p  k+++l++++++l    +a dl +++l+  p++R+sa+eal h+yf

Q: 343   PLPKPRSLQNVWNRLGrvPEAEDLASQMLKGFPRDRVSAQEALVHDYF  390

         999999*******99965679**************************9

Domain Sequence
(FASTA)

YLNLEKLGEG SYATVYKGIS RINGQLVALK VISMNAEEGV PFTAIREASL LKGLKHANIV 60

LLHDIIHTKE TLTFVFEYMH TDLAQYMCQH PGGLHPHNVR LFMFQLLRGL AYIHHQHVLH 120

RDLKPQNLLI SHLGELKLAD FGLARAKSIP SQTYSSEVVT LWYRPPDALL GATEYSSELD 180

IWGAGCIFIE MFEGQPLFPG VSNILEQLEK IWEVLGVPTE DTWPGVSKLP NYNPEWFPLP 240

KPRSLQNVWN RLGRVPEAED LASQMLKGFP RDRVSAQEAL VHDYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

cfa:478873

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013