EKS-CAF-00338

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00338

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	313.6	1.2E-93	14	280	267

Status

Unreviewed

Ensembl Protein

ENSCAFP00000031628

UniProt Accession

F1P7H3;

Protein Name

Protein Synonyms/Alias

Gene Name

MYO3B

Gene Synonyms/Alias

MYO3B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000012487	ENSCAFP00000031628	ENSCAFT00000036270
ENSCAFG00000012487	ENSCAFP00000018396	ENSCAFT00000019832

Organism

Canis familiaris

Functional Description

Protein Length

913

Protein Sequence
(FASTA)

MLGLESLPDP TDTWEIIETI GKGTYGKVYK VTNKKDGSLA AVKILDPVSD MDEEIEAEYN 60

ILQFLPNHPN VVKFYGMFYK ADHCVGGQLW LVLELCNGGS VTELVKGLLR CGQRLDEAMI 120

SYILYGALLG LQHLHNNRII HRDVKGNNIL LTTEGGVKLV DFGVSAQLTS TRLRRNTSVG 180

TPFWMAPEVI ACEQQYDSSY DARCDVWSLG ITAIELGDGD PPLFDMHPVK TLFKIPRNPP 240

PTLLHPEEWC EEFNHFISRC LIKDFEKRPS VTHLLDHPFI KGAHGKVLFL QKQLAKVLQD 300

QKHQNTVVKT RHERMHTRRP YHVENAEKYC LEDDLVNLEV LDEDTIIRQL QKRYVDLLIY 360

TYVGDILIAL NPFQNLSIYS PQFSRLYHGV RRASNPPHIF ASADAAYQCM VTFSKDQCIV 420

ISGESGSGKT ESAHLIVQHL TFLGKANNQT LREKILQVNS LVEAFGNACT AINDNSSRFG 480

KYLEMMFTPT GAVMGARISE YLLEKSRVIK QAVGEKNFHI FYYIYAGLYH QRKLSEFRLP 540

EEKPPRYIAD GTGRVIHNIT SKESYRRQFE AIQHCFRTIG FTDKEVHSVY RILAGILNIG 600

NIEFAAISSQ HQTDKSEVPN AEALENAASV LCISPEELQE ALISHCVVTR GETIIRANTV 660

DRAADVRDAM SKALYGRLFS WIVNRINTLL QPDKNICSAD DGMNVGILDI FGFENFGRNS 720

FEQLCINIAN EQIQYYFNQH VFALEQMEYQ NEGIDATLVM YEDNRPLLDM FLQKPLGLLA 780

LLDEESRFPQ ATNQTLVDKF EDNLRCKYFW RPKGVELCFG ILHYAGKVLY DASGVLEKNK 840

DTLPADVVVV LRTSENKLLQ QLFSIPLTKT DTERERQRHR QKEKQAPCRE PDVGLHPWTS 900

GSHPKLKAVQ KWV 913

Nucleotide Sequence
(FASTA)

ATGCTTGGAC TTGAATCACT TCCAGATCCT ACTGATACCT GGGAAATTAT AGAGACCATA 60

GGTAAAGGCA CCTATGGCAA GGTCTATAAA GTAACTAACA AGAAAGATGG GAGCCTGGCT 120

GCAGTAAAAA TTTTGGATCC AGTCAGTGAT ATGGATGAAG AAATTGAAGC AGAATACAAC 180

ATTTTGCAGT TTCTTCCTAA TCATCCCAAC GTTGTAAAGT TTTATGGGAT GTTTTACAAA 240

GCGGATCACT GTGTGGGAGG ACAGCTGTGG CTGGTCCTGG AGTTGTGTAA TGGGGGCTCA 300

GTCACGGAGC TTGTCAAAGG TCTACTCAGG TGTGGCCAGC GATTGGATGA AGCAATGATC 360

TCCTACATCT TATATGGGGC CCTCTTGGGT CTTCAGCATT TGCACAATAA CCGAATCATC 420

CACCGTGATG TCAAGGGGAA TAACATTCTT CTGACAACAG AAGGAGGAGT TAAGCTCGTT 480

GACTTTGGTG TCTCAGCTCA ACTCACCAGT ACACGTCTAC GGAGAAACAC ATCTGTTGGT 540

ACCCCGTTCT GGATGGCTCC TGAGGTCATT GCTTGTGAGC AGCAGTATGA CTCTTCCTAT 600

GACGCTCGCT GTGACGTCTG GTCCTTGGGG ATCACAGCTA TTGAACTGGG GGACGGAGAC 660

CCTCCCCTCT TTGACATGCA TCCTGTGAAA ACGCTTTTTA AGATTCCAAG AAATCCTCCA 720

CCTACTTTAC TCCATCCAGA AGAATGGTGT GAGGAATTCA ACCACTTTAT TTCACGGTGT 780

CTTATTAAGG ATTTTGAAAA GCGGCCTTCT GTCACACATC TCCTTGACCA CCCATTTATT 840

AAAGGAGCCC ACGGGAAGGT TTTATTTCTG CAAAAACAGC TGGCCAAGGT CCTCCAAGAC 900

CAGAAGCATC AAAACACTGT TGTTAAAACA AGGCATGAAA GAATGCATAC CAGAAGACCC 960

TATCACGTGG AAAATGCTGA AAAATACTGC CTTGAGGATG ATTTGGTGAA TTTAGAGGTT 1020

CTGGATGAGG ATACAATTAT TCGTCAGTTG CAAAAGCGTT ATGTGGACTT GCTCATTTAC 1080

ACCTATGTTG GAGACATCTT AATTGCCTTA AACCCCTTCC AGAATCTAAG CATATATTCT 1140

CCACAGTTTT CCAGACTTTA TCATGGGGTG AGACGTGCCT CCAATCCCCC CCACATATTT 1200

GCATCAGCAG ATGCTGCTTA CCAATGTATG GTTACTTTCA GCAAAGACCA GTGCATTGTC 1260

ATCAGTGGAG AAAGTGGCTC TGGGAAGACA GAGAGTGCCC ACCTGATTGT TCAGCATTTG 1320

ACTTTCTTGG GAAAGGCCAA TAATCAGACC TTGAGAGAGA AAATTCTGCA AGTCAACTCT 1380

CTGGTGGAAG CCTTTGGAAA TGCATGCACT GCCATCAATG ACAATTCGAG CCGTTTTGGA 1440

AAATATCTGG AAATGATGTT TACACCAACC GGAGCTGTGA TGGGGGCAAG AATATCTGAA 1500

TATCTCCTTG AAAAATCCAG AGTTATAAAA CAGGCAGTGG GAGAGAAAAA TTTTCACATA 1560

TTTTACTATA TTTATGCTGG TCTTTATCAC CAGAGGAAAC TTTCTGAGTT TAGACTTCCT 1620

GAGGAAAAAC CTCCTAGGTA TATAGCTGAT GGAACTGGAA GGGTGATACA CAACATAACT 1680

TCCAAGGAGT CTTACAGAAG ACAATTTGAA GCAATTCAGC ATTGCTTCAG GACTATAGGG 1740

TTCACTGACA AGGAGGTGCA CTCAGTGTAT AGAATTTTGG CTGGAATTTT GAATATTGGA 1800

AACATTGAGT TTGCAGCTAT TTCCTCTCAG CATCAAACTG ACAAAAGTGA GGTCCCCAAT 1860

GCTGAAGCTT TGGAAAATGC TGCCTCTGTT CTCTGCATCA GCCCCGAAGA ACTCCAAGAG 1920

GCCCTTATCT CACACTGTGT GGTCACCCGC GGTGAAACCA TCATCCGTGC CAATACTGTC 1980

GACAGGGCTG CGGATGTCCG AGATGCCATG TCCAAAGCCC TGTATGGGAG GCTCTTCAGT 2040

TGGATTGTAA ATCGCATCAA TACACTCCTG CAGCCAGACA AAAACATATG TAGTGCAGAT 2100

GATGGTATGA ATGTGGGGAT TTTGGATATT TTTGGATTTG AGAACTTTGG GAGAAATTCA 2160

TTTGAACAGC TCTGCATAAA CATCGCCAAT GAGCAAATCC AGTACTATTT CAACCAGCAT 2220

GTTTTCGCTC TTGAGCAGAT GGAATATCAG AATGAGGGCA TTGATGCTAC ACTTGTGATG 2280

TATGAGGACA ATCGCCCACT CTTGGACATG TTCCTCCAGA AACCTCTGGG ACTGCTTGCG 2340

CTTTTGGATG AGGAAAGTCG ATTTCCCCAA GCAACTAATC AGACCCTGGT TGATAAATTT 2400

GAAGATAATC TACGATGCAA ATACTTCTGG AGGCCCAAAG GGGTGGAGCT ATGCTTTGGC 2460

ATTCTGCACT ATGCTGGAAA GGTATTATAC GATGCTTCTG GGGTTCTTGA GAAAAACAAA 2520

GACACTCTCC CTGCTGATGT GGTTGTAGTC CTGAGAACGT CAGAAAACAA GCTTCTGCAG 2580

CAACTCTTCT CAATTCCCTT GACCAAAACA GACACAGAGA GAGAGAGGCA GAGACACAGA 2640

CAGAAGGAGA AGCAGGCTCC ATGCAGGGAG CCTGATGTGG GACTCCATCC CTGGACTTCA 2700

GGATCACACC CTAAGCTGAA GGCAGTTCAG AAATGGGTCT AG 2742

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkkl.khpniv  59

         +e++e+igkG++gkvy+ ++kk g+l+a+k+++  + ++ ee++ e+++l+ l +hpn+v

Q: 14    WEIIETIGKGTYGKVYKVTNKKDGSLAAVKILDPVS-DMDEEIEAEYNILQFLpNHPNVV  72

         799******************************998.9*************98356****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         +++++f+k       +lwlv+e+++gGs+++lvk    + ++l+E  i+yil ++l +L+

Q: 73    KFYGMFYKadhcvGGQLWLVLELCNGGSVTELVKglLRCGQRLDEAMISYILYGALLGLQ  132

         *******99888889*******************777899********************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lH++++iHrd+k++niLlt+eg VkL+dfgv+aql++tr +r+t vgtp+wmAPEvia+

Q: 133   HLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIAC  192

         ************************************************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D+wslGItaiel +g+pP++d++p+k l+ki++n+pp+l +++++++e

Q: 193   EqqyDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEEWCEE  252

         9888899*****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         f++f+++cl k++ekRps+++ll+h+F+

Q: 253   FNHFISRCLIKDFEKRPSVTHLLDHPFI  280

         ***************************7

Domain Sequence
(FASTA)

WEIIETIGKG TYGKVYKVTN KKDGSLAAVK ILDPVSDMDE EIEAEYNILQ FLPNHPNVVK 60

FYGMFYKADH CVGGQLWLVL ELCNGGSVTE LVKGLLRCGQ RLDEAMISYI LYGALLGLQH 120

LHNNRIIHRD VKGNNILLTT EGGVKLVDFG VSAQLTSTRL RRNTSVGTPF WMAPEVIACE 180

QQYDSSYDAR CDVWSLGITA IELGDGDPPL FDMHPVKTLF KIPRNPPPTL LHPEEWCEEF 240

NHFISRCLIK DFEKRPSVTH LLDHPFI 267

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016459	; C:myosin complex
GO:0005524	; F:ATP binding
GO:0003774	; F:motor activity
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013