EKS-CAF-00165

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00165

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.9	9.6E-186	410	688	279

Status

Unreviewed

Ensembl Protein

ENSCAFP00000018459

UniProt Accession

F1PUB2;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000012521	ENSCAFP00000018459	ENSCAFT00000019904
ENSCAFG00000012521	ENSCAFP00000042719	ENSCAFT00000042798

Organism

Canis familiaris

Functional Description

Protein Length

720

Protein Sequence
(FASTA)

GAMDELHSLD PRRQELLEAR FTGVASGSTG STGSCSVGAK ASTNNESSNH SFGSLGSLSD 60

KESETPEKKQ SDSSRGRKRK AENQNESSQG KSIGGRGHKI SDYFEYQGGN GSSPVRGIPP 120

AIRSPQNSHS HSTPSSSVRP NSPSPTALAF GDHPIIQPKQ LSFKITQTDL TMLKLAALES 180

NKNQDLEKKE GRIDDLLRAN CDLRRQIDEQ QKLLEKYKER LNKCISMSKK LLIEKSTQEK 240

LSSREKSMQD RLRLGHFTTV RHGASFTEQW TDGFAFQNLV KQQEWVNQQR EDIERQRKLL 300

AKRKPPTANN SQAPSTNSEP KQRKNKAVNG AENDPFVRPN LPQLLTLAEY HEQEEIFKLR 360

LGHLKKEEAE IQAELERLER VRNLHIRELK RINNEDNSQF KDHPTLNERY LLLHLLGRGG 420

FSEVYKAFDL YEQRYAAVKI HQLNKSWRDE KKENYHKHAC REYRIHKELD HPRIVKLYDY 480

FSLDTDTFCT VLEYCEGNDL DFYLKQHKLM SEKEARSIVM QIVNALRYLN EIKPPIIHYD 540

LKPGNILLVD GTACGEIKIT DFGLSKIMDD DSYGVDGMDL TSQGAGTYWY LPPECFVVGK 600

EPPKISNKVD VWSVGVIFFQ CLYGRKPFGH NQSQQDILQE NTILKATEVQ FPVKPVVSSE 660

AKAFIRRCLA YRKEDRFDVH QLANDPYLLP HMRRSNSSGN LHMAGLTASP TPPSSSIITY 720

Nucleotide Sequence
(FASTA)

GGTGCAATGG ATGAGCTTCA TAGTCTGGAT CCGAGAAGGC AAGAATTATT GGAAGCTAGA 60

TTTACAGGAG TTGCAAGTGG GAGTACGGGG AGCACAGGCA GTTGCAGTGT TGGAGCAAAA 120

GCCTCAACAA ATAATGAAAG TTCTAATCAT AGTTTTGGAA GCTTGGGATC TCTAAGTGAC 180

AAAGAATCTG AGACACCAGA GAAGAAACAA TCGGACTCAT CCAGAGGAAG AAAGAGAAAA 240

GCAGAAAACC AGAATGAAAG TAGTCAGGGA AAAAGTATTG GCGGACGTGG CCATAAAATT 300

AGTGACTATT TTGAATACCA AGGTGGGAAT GGCTCAAGTC CAGTAAGAGG CATACCTCCT 360

GCTATCCGTT CTCCTCAAAA TTCACATTCA CATTCCACTC CTTCCTCATC TGTTCGACCG 420

AATAGCCCTT CTCCTACTGC ATTAGCTTTT GGGGACCACC CTATTATACA ACCAAAGCAG 480

TTATCCTTTA AAATTACTCA GACTGATCTC ACAATGCTGA AATTAGCAGC ATTAGAAAGT 540

AATAAAAACC AGGACCTGGA AAAGAAGGAA GGTCGTATAG ATGACTTGCT CAGGGCTAAC 600

TGTGATCTCA GACGGCAAAT AGATGAACAA CAAAAGTTAC TTGAAAAATA CAAAGAACGA 660

TTAAATAAGT GCATATCAAT GAGCAAGAAG CTGCTTATTG AAAAGAGTAC ACAAGAAAAA 720

CTGTCAAGCC GAGAGAAGAG TATGCAAGAC CGATTACGCC TTGGGCACTT CACAACAGTT 780

AGACATGGTG CTTCATTTAC TGAACAATGG ACAGATGGTT TTGCATTTCA GAATCTTGTG 840

AAGCAACAAG AATGGGTGAA TCAGCAAAGG GAAGATATTG AAAGGCAAAG GAAACTTCTA 900

GCCAAACGCA AACCTCCTAC AGCTAATAAT TCTCAGGCAC CCTCTACCAA TTCTGAACCA 960

AAACAAAGGA AAAACAAAGC AGTCAATGGA GCAGAGAATG ATCCCTTTGT TAGACCAAAT 1020

TTACCACAAC TGTTGACTTT GGCAGAATAT CATGAACAGG AAGAAATTTT CAAACTTAGA 1080

CTAGGACATC TCAAAAAGGA AGAGGCAGAA ATCCAGGCAG AACTTGAACG TTTGGAAAGA 1140

GTCAGAAATC TTCACATTCG AGAGCTCAAA AGAATAAATA ATGAAGATAA TTCGCAGTTC 1200

AAAGATCACC CAACGTTAAA TGAAAGATAT TTATTACTTC ATCTGCTTGG TAGAGGTGGC 1260

TTTAGTGAAG TGTATAAGGC TTTTGATCTT TATGAACAAA GATATGCTGC TGTGAAGATC 1320

CACCAGCTTA ATAAAAGCTG GAGGGATGAG AAGAAGGAAA ACTACCACAA ACATGCCTGC 1380

AGAGAGTATA GAATACACAA AGAACTGGAT CACCCTAGGA TAGTTAAACT CTATGATTAT 1440

TTCTCGTTGG ATACAGATAC GTTTTGTACA GTGTTAGAGT ACTGTGAAGG CAATGACTTG 1500

GATTTCTATC TGAAGCAACA TAAATTAATG TCAGAGAAGG AAGCTAGGTC TATTGTAATG 1560

CAAATTGTAA ATGCACTAAG ATATCTCAAT GAAATCAAAC CCCCTATTAT ACATTATGAT 1620

CTTAAGCCAG GAAACATCCT TCTGGTAGAT GGCACAGCAT GTGGAGAAAT CAAAATCACT 1680

GATTTCGGTC TATCCAAGAT CATGGATGAT GATAGCTATG GTGTAGATGG AATGGATCTA 1740

ACTTCTCAAG GGGCAGGCAC TTACTGGTAT TTACCTCCTG AGTGTTTTGT AGTTGGAAAA 1800

GAACCACCAA AGATTTCCAA CAAGGTTGAT GTGTGGTCAG TCGGCGTCAT TTTCTTTCAG 1860

TGTCTTTATG GAAGAAAGCC ATTTGGTCAC AATCAATCTC AACAAGACAT TCTTCAAGAA 1920

AATACAATAT TAAAAGCCAC AGAAGTCCAG TTCCCTGTAA AACCAGTTGT AAGCAGTGAA 1980

GCAAAGGCCT TTATAAGACG CTGTCTGGCC TACCGAAAAG AAGATCGGTT TGATGTGCAC 2040

CAACTGGCAA ATGACCCGTA CCTTCTTCCA CATATGAGAA GATCAAATTC TTCAGGAAAC 2100

TTACACATGG CTGGGCTTAC AGCATCCCCT ACACCCCCTT CTTCAAGCAT AATTACTTAC 2160

TGA 2163

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 410   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  469

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 470   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  529

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 530   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  588

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 589   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  648

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvsseakafirrclayrkedr+dv+qla+d+yl

Q: 649   VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL  688

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPVKPVVSS EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013