EKS-CAF-00216

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00216

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	464.4	1.2E-139	13	297	285

Status

Unreviewed

Ensembl Protein

ENSCAFP00000018871

UniProt Accession

F1PJ61;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000012819	ENSCAFP00000018871	ENSCAFT00000020338

Organism

Canis familiaris

Functional Description

Protein Length

927

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS 240

NPRFHGLRFP AVNHPQTLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ 300

RLLDRSPSRS AKRKPYHVES STLSNRNQAS KSTALQSHHR SNSKDIQNLS VGLPRADEGL 360

PANESFLNGN LAGATLSPMH TKTYQASSQP GSTSKDLTNN NIPHLLSPKE AKSKTEFDFN 420

IDPKPSEGPG TKYLKSSSRS QQNRHSFMES SQSKAGTLQP TEKQSRHSYI DTIPQSSRSP 480

SYRTKAKSHG ALSDSKSVSN LSEARAQIAE SNTSRYFPSS CLDLNSPTSP TPTRHSDTRT 540

LLSPSGRNNR SEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS VGQGMAARAN SLQLLSPQPG EQLPPEMTVA 660

RSSVKESSRE GTSSFHARQK SEGGAYHDPH SDDGAAPKEN RHLYNDPVPR RVGSFYRVPS 720

PRPDNSFHEN NVSTRVSSLP SESSSGTNHS KRQPAFDPWK SPENISHSEQ LKEKEKQGFF 780

RSMKKKKKKS QTVPNSDGPD LLTLQKAIHS ASTPSSRPKE WRPEKISDLQ TQSQPLKSLR 840

KLLHLSSASN HPASSDPRFQ PLTTQQAKNS FSEIRIHPLS QASGGSSNIR QEPTPKGRPA 900

LQLPAVFPAC VRVPVIEDLT SGYCRFL 927

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG AAACACATGA AATTGTGGCA 120

ATCAAGAAAT TCAAGGACAG TGAAGAAAAT GAAGAAGTCA AGGAAACGAC TTTACGAGAG 180

CTTAAAATGC TTCGTACTCT CAAGCAAGAA AACATCGTGG AGCTGAAGGA AGCCTTTCGT 240

CGGAGGGGGA AATTGTACTT GGTGTTTGAG TATGTTGAAA AAAATATGCT TGAATTGCTG 300

GAAGAAATGC CAAATGGGGT TCCACCTGAA AAGGTTAAAA GTTATATCTA TCAGCTAATC 360

AAAGCTATTC ACTGGTGCCA TAAGAATGAT ATTGTCCATA GAGATATAAA GCCAGAAAAT 420

CTCTTAATCA GCCACAATGA TGTTTTGAAA CTGTGTGATT TTGGTTTTGC TCGGAATCTA 480

TCAGAAGGCA ATAATGCTAA TTATACAGAA TATGTGGCCA CCAGGTGGTA TCGGTCCCCA 540

GAACTCTTAC TTGGAGCTCC TTATGGAAAG TCTGTAGATA TGTGGTCAGT GGGCTGTATT 600

CTTGGGGAGC TTAGCGATGG ACAGCCTTTA TTTCCTGGAG AGAGCGAAAT CGACCAACTT 660

TTTACTATTC AGAAGGTGCT AGGACCACTT CCATCTGAAC AGATGAAGCT CTTCTACAGT 720

AATCCTCGAT TCCATGGGCT CCGGTTTCCA GCTGTTAACC ATCCTCAGAC ATTGGAGAGA 780

AGATACCTTG GAATTCTAAA TAGCGTCTTA CTTGACTTAA TGAAGAATTT ACTGAAGTTG 840

GACCCAGCTG ACAGATACTT GACAGAACAG TGTTTGAATC ACCCTACATT TCAAACCCAG 900

AGACTTTTGG ATCGCTCCCC TTCAAGGTCA GCAAAAAGAA AACCTTACCA TGTGGAAAGC 960

AGCACTTTGT CTAATAGAAA CCAAGCCAGC AAAAGTACTG CTTTGCAGTC ACACCACAGA 1020

TCCAACAGCA AGGACATCCA GAACCTAAGT GTGGGTCTGC CTCGGGCTGA CGAAGGTCTG 1080

CCTGCCAACG AAAGCTTCCT AAATGGAAAT CTTGCTGGAG CTACTCTTAG TCCCATGCAC 1140

ACCAAAACCT ACCAAGCAAG CAGCCAACCT GGGTCTACCA GCAAAGATCT AACCAACAAT 1200

AACATACCAC ATCTTCTCAG CCCAAAAGAA GCCAAGTCAA AGACAGAGTT TGATTTTAAT 1260

ATTGACCCAA AACCTTCCGA AGGCCCAGGC ACAAAGTACC TCAAGTCAAG CAGCAGATCT 1320

CAGCAGAACC GGCACTCATT TATGGAAAGC TCTCAGAGCA AAGCCGGGAC ACTGCAGCCC 1380

ACTGAGAAGC AGAGTCGGCA TAGCTACATT GACACTATTC CCCAGTCCTC TAGGAGTCCC 1440

TCTTACAGGA CCAAGGCCAA AAGCCACGGG GCGTTGAGTG ACTCCAAGTC TGTGAGCAAC 1500

CTTTCTGAAG CCAGGGCCCA AATTGCAGAG TCCAATACCA GTAGGTACTT CCCATCCAGC 1560

TGCTTGGACT TGAACTCTCC TACCAGCCCA ACCCCTACCA GGCACAGTGA CACAAGAACT 1620

TTGCTCAGCC CCTCCGGGAG AAATAATCGA AGCGAGGGCA CTCTTGACTC ACGCCGAACC 1680

ACAACCAGGC ATTCTAAAAC GATGGAGGAG TTGAAACTGC CCGAGCACAT GGACAGCAGC 1740

CATTCCCATT CTCTGTCTGC ACCTCATGAA TCTTTTTCTT ATGGACTGGG CTATACTAGC 1800

CCCTTCTCTT CCCAGCAGCG TCCACATAGG CATTCCATGT ACGTGACCCG GGACAAAGTG 1860

AGAGCCAAAG GCTTAGACGG AAGCTTGAGC GTAGGGCAAG GAATGGCGGC CAGGGCCAAC 1920

AGCCTGCAGC TCCTATCACC TCAGCCTGGA GAACAGCTCC CTCCAGAGAT GACTGTGGCT 1980

CGATCTTCTG TTAAAGAATC TTCCAGAGAG GGCACCTCTT CGTTCCATGC AAGGCAGAAG 2040

TCTGAGGGTG GAGCATATCA TGACCCTCAC TCTGATGATG GTGCCGCCCC CAAAGAAAAT 2100

CGGCACCTGT ACAATGACCC TGTTCCGAGG AGAGTTGGCA GTTTCTACCG AGTGCCATCT 2160

CCTCGTCCCG ACAATTCTTT CCATGAAAAT AATGTATCAA CCAGAGTTTC TTCCCTACCA 2220

TCAGAGAGCA GTTCCGGAAC TAACCACTCA AAAAGACAAC CAGCATTTGA TCCATGGAAA 2280

AGTCCTGAAA ACATTAGTCA TTCTGAACAA CTCAAGGAAA AGGAGAAACA AGGTTTTTTC 2340

AGGTCAATGA AAAAGAAAAA GAAGAAATCT CAAACAGTGC CCAATTCTGA CGGCCCCGAT 2400

CTTCTAACAT TACAGAAAGC CATTCATTCT GCTAGCACTC CGAGCAGCAG ACCAAAGGAG 2460

TGGCGTCCTG AGAAGATCTC TGATCTACAG ACCCAAAGCC AGCCGTTAAA ATCACTGCGC 2520

AAGCTGTTAC ATCTCTCTTC AGCCTCAAAT CACCCGGCTT CCTCAGACCC CCGCTTCCAG 2580

CCCTTAACAA CTCAACAAGC CAAAAATTCC TTCTCAGAAA TTCGGATCCA CCCCCTGAGC 2640

CAGGCCTCTG GCGGGAGCAG TAACATCCGG CAGGAGCCCA CACCGAAGGG CAGGCCAGCC 2700

CTCCAGCTGC CAGCTGTATT CCCCGCGTGT GTCCGTGTGC CTGTCATAGA GGACCTGACC 2760

TCTGGCTACT GCCGTTTTCT CTGA 2784

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v+++++le++y   ln+vlldl+k++lkldpa+r+++e++l+h++f

Q: 252   VNHPQTLERRYLgILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF  297

         ***********9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYSNP RFHGLRFPAV 240

NHPQTLERRY LGILNSVLLD LMKNLLKLDP ADRYLTEQCL NHPTF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013