EKS-CAF-00059

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00059

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	415.8	9.6E-125	4	287	284

Status

Unreviewed

Ensembl Protein

ENSCAFP00000019027

UniProt Accession

E2RGJ9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK1

Gene Synonyms/Alias

CDK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000012904	ENSCAFP00000039501	ENSCAFT00000046955
ENSCAFG00000012904	ENSCAFP00000019027	ENSCAFT00000020502

Organism

Canis familiaris

Functional Description

Protein Length

297

Protein Sequence
(FASTA)

MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 60

PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQFM DSSLVKSYLY QILQGIVFCH 120

SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 180

YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT 240

FPKWKPGSLA SHVKNLDENG LDLLSKMLVY DPAKRISGKM ALNHPYFNDL DNQIKKM 297

Nucleotide Sequence
(FASTA)

ATGGAAGATT ATACCAAAAT AGAGAAAATT GGAGAAGGTA CCTATGGAGT TGTGTATAAG 60

GGTAGACACA AAACTACAGG TCAAGTGGTA GCCATGAAGA AAATCAGACT AGAAAGTGAA 120

GAGGAAGGGG TTCCTAGTAC TGCAATTCGG GAAATTTCTC TATTAAAAGA ACTTCGTCAT 180

CCAAATATAG TCAGTCTTCA GGATGTGCTT ATGCAAGATT CCAGGTTATA TCTCATCTTT 240

GAATTCCTTT CCATGGATCT CAAGAAATAC TTAGATTCCA TCCCTCCTGG TCAGTTCATG 300

GATTCTTCAC TTGTTAAGAG TTATTTGTAC CAAATCCTAC AAGGGATTGT GTTTTGCCAC 360

TCCAGAAGAG TTCTGCACAG AGACTTAAAA CCTCAAAATC TATTGATTGA TGACAAAGGG 420

ACAATTAAAT TGGCTGATTT TGGCCTTGCC AGAGCTTTTG GAATACCTAT TAGAGTATAC 480

ACACATGAGG TAGTAACACT GTGGTATAGA TCTCCAGAAG TATTGTTGGG GTCAGCTCGC 540

TACTCAACTC CAGTTGACAT TTGGAGTATA GGTACCATAT TTGCAGAGTT AGCAACTAAG 600

AAACCACTTT TCCATGGGGA TTCAGAAATC GATCAACTCT TCAGAATTTT CAGAGCTTTG 660

GGCACCCCCA ATAATGAAGT GTGGCCAGAA GTGGAATCTT TACAGGACTA TAAGAATACA 720

TTTCCCAAGT GGAAACCAGG AAGCCTGGCA TCCCATGTTA AAAACTTGGA TGAAAATGGC 780

TTGGATCTGC TCTCAAAAAT GTTAGTCTAT GATCCTGCCA AACGAATTTC TGGCAAAATG 840

GCATTGAATC ATCCATATTT TAATGATTTG GACAATCAGA TTAAGAAGAT G 891

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y+k+ekigeGtyg+vyk+++k+tg+vvA+Kkirle+e+egvp+ta+rEisllkel+h+ni

Q: 4     YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkk.klsleevkslllqlleglaylHsn  119

         v+L++v++ ++++lyL+fefl++dLkk+l++ +    ++++ vks+l+q+l+g+ ++Hs+

Q: 64    VSLQDVLM-QDSRLYLIFEFLSMDLKKYLDSIPPGqFMDSSLVKSYLYQILQGIVFCHSR  122

         ********.99********************98764789999******************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         ++lHRDlKpqNlLi+++g++klaDfGlaraf+ p + yt+evvTlwYr+Pe+Llg+ +Ys

Q: 123   RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS  182

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         t vDiWs+g i+ael+t+kplf+g+seidql+rif+ lgtp+++vwpev++l++yk++fp

Q: 183   TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP  242

         ************************************************************

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k+k+ +l+++vk+l+e++ldll+k+l +dp+kRis k al+h+yf

Q: 243   KWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALNHPYF  287

         ********************************************9

Domain Sequence
(FASTA)

YTKIEKIGEG TYGVVYKGRH KTTGQVVAMK KIRLESEEEG VPSTAIREIS LLKELRHPNI 60

VSLQDVLMQD SRLYLIFEFL SMDLKKYLDS IPPGQFMDSS LVKSYLYQIL QGIVFCHSRR 120

VLHRDLKPQN LLIDDKGTIK LADFGLARAF GIPIRVYTHE VVTLWYRSPE VLLGSARYST 180

PVDIWSIGTI FAELATKKPL FHGDSEIDQL FRIFRALGTP NNEVWPEVES LQDYKNTFPK 240

WKPGSLASHV KNLDENGLDL LSKMLVYDPA KRISGKMALN HPYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030496	; C:midbody
GO:0005634	; C:nucleus
GO:0005876	; C:spindle microtubule
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0007095	; P:mitotic cell cycle G2/M transition DNA damage checkpoint
GO:0034501	; P:protein localization to kinetochore

KEGG

cfa:100856079

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013