EKS-CAF-00350

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00350

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	448.3	9.2E-135	127	385	259

Status

Unreviewed

Ensembl Protein

ENSCAFP00000019043

UniProt Accession

E2RFP7;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK2

Gene Synonyms/Alias

TNK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000012918	ENSCAFP00000019043	ENSCAFT00000020518

Organism

Canis familiaris

Functional Description

Protein Length

1041

Protein Sequence
(FASTA)

MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG MGRPGQRRLW 60

EAVKRRKAMC KRKSWMSKVF SGKRLEAEFP PHHSQSTFRK TSPTPGGPAG EGPLQSLTCL 120

IGEKDLHLFE KLGDGSFGVV RRGEWDAPSG KTMSVAVKCL KPDVLSQPEA MDDFIREVNA 180

MHSLDHRNLI RLYGVVLTPP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM 240

GYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE 300

SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDV 360

YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA 420

ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD 480

KIDELYLGNP MDPPDLLSVE LSTPRPTQHL GRLKKPTYDP VSEDQDPLSS DFKRLGLRKP 540

ALTRGLWLAK PSARVPGTKA GRGGGGEVTL IDFGEEPVVP TPRPCAPSLA QLAMDACSLL 600

DKTPPQSPTR ALPRPLHPTP VVDWDARPLP PPPAYDDVAQ DEDDFEVCSI NSTLVGAGVR 660

TGPSQGETNY AFVPEQAQLL PPLEDNLFLP PQGGSKPPNS AQTAEIFQAL QQECMRQLQV 720

PAGSLSPPPG PAPAGEDKPQ VPPRVPIPPR PTRPRGELSP APSGEEEIGR WPGPASPPRV 780

PPREPLSPQG SRTPSPLVPP GGSPLPPRLS SSPGKTMPTT QSFASDPKYA TPQVIQAPGP 840

RAGPCILPIV RDGKKVSSTH YYLLPERPPY LERYQRFLRE AQSPEEPAPL PVPLLLPPPS 900

TPAPAAPTAT VRPMPQAAPD PKANFSTNNS NPGPRPPALR AAARLPQRGC PGDGPEAGRP 960

ADKVQMLQAM VHGVTTEECQ AALQSHSWSV QRAAQYLKVE QLFGLGLRPR SECHKVLEMC 1020

DWNLEQAGCH LLGSCGPAHH K 1041

Nucleotide Sequence
(FASTA)

ATGCAGCCGG AGGAGGGCAC AGGCTGGCTG CTGGAGCTGC TGTCCGAGGT GCAGCTGCAA 60

CAGTACTTCC TGCGGCTCCG CGATGACCTC AATGTTACCC GCCTGTCCCA CTTTGAGTAT 120

GTCAAGAATG AGGACCTGGA GAAGATTGGC ATGGGCCGGC CTGGTCAGCG GCGGTTGTGG 180

GAGGCTGTGA AGAGGAGAAA GGCCATGTGC AAACGCAAGT CTTGGATGAG CAAGGTGTTC 240

AGTGGAAAGC GACTGGAGGC TGAGTTCCCC CCTCATCACT CTCAGAGCAC CTTCCGGAAG 300

ACCTCACCCA CCCCGGGGGG CCCAGCAGGG GAGGGGCCCC TACAGAGCCT CACCTGCCTC 360

ATTGGGGAAA AGGACCTGCA TCTATTCGAG AAGCTAGGAG ATGGCTCCTT TGGCGTGGTG 420

CGCCGGGGCG AGTGGGATGC CCCCTCGGGG AAGACGATGA GTGTGGCTGT GAAGTGCCTG 480

AAGCCTGACG TGCTGAGCCA GCCAGAGGCC ATGGACGACT TCATCCGGGA GGTCAACGCC 540

ATGCACTCGC TTGACCATCG CAACCTCATT CGCCTCTATG GGGTGGTGCT CACGCCGCCC 600

ATGAAGATGG TGACGGAGCT GGCGCCGCTA GGATCGTTGT TGGACCGGCT GCGCAAGCAC 660

CAGGGCCACT TCCTCCTGGG CACTCTGAGC CGCTACGCTG TGCAGGTGGC GGAGGGCATG 720

GGCTACCTGG AGTCCAAGCG CTTTATTCAC CGTGACCTGG CTGCCCGAAA TCTGCTGTTG 780

GCCACCCGTG ACCTGGTCAA GATCGGGGAC TTCGGGTTGA TGCGTGCGCT ACCCCAGAAT 840

GACGACCACT ATGTCATGCA AGAGCATCGC AAGGTGCCCT TTGCCTGGTG TGCCCCTGAG 900

AGCCTGAAGA CGCGCACCTT CTCCCACGCC AGTGACACCT GGATGTTTGG AGTGACGTTG 960

TGGGAGATGT TCACCTACGG CCAGGAGCCC TGGATCGGCC TCAATGGCAG TCAGATTCTG 1020

CATAAGATTG ACAAGGAGGG GGAGCGTCTC CCGCGGCCGG AGGACTGCCC CCAGGATGTC 1080

TACAACGTCA TGGTCCAGTG CTGGGCCCAC AAGCCAGAGG ACAGACCCAC GTTCGTGGCT 1140

CTGCGGGACT TCCTGCTGGA GGCCCAGCCC ACCGACATGC GTGCCCTTCA GGACTTTGAG 1200

GAACCAGACA AGCTGCACAT CCAGATGAAC GACGTCATCA CCGTCATCGA GGGAAGGGCG 1260

GAGAACTACT GGTGGCGCGG CCAGAACACG CGGACGCTGT GTGTGGGGCC CTTCCCTCGC 1320

AACGTGGTGA CCTCCGTGGC TGGCCTGTCG GCCCAGGACA TCAGTCAGCC GCTGCAGAAC 1380

AGCTTCATCC ACACGGGACA TGGCGACAGC GACCCCCGCC ACTGCTGGGG CTTCCCCGAC 1440

AAGATTGACG AACTGTATCT GGGAAACCCC ATGGATCCTC CTGACCTGCT GAGCGTGGAA 1500

CTGAGCACCC CCCGGCCCAC CCAGCATCTA GGAAGGCTGA AAAAGCCAAC CTATGACCCT 1560

GTGAGTGAGG ACCAGGACCC CCTGTCCAGC GACTTCAAGA GGCTGGGCCT CCGGAAACCA 1620

GCCCTGACCC GTGGGCTGTG GCTCGCGAAG CCCTCCGCTC GGGTGCCCGG CACCAAGGCG 1680

GGTCGTGGCG GTGGGGGCGA GGTCACGCTC ATTGACTTTG GCGAGGAGCC CGTCGTCCCC 1740

ACCCCCCGGC CCTGCGCGCC CTCACTGGCG CAGCTGGCCA TGGATGCCTG TTCCTTACTG 1800

GACAAGACCC CGCCGCAGAG CCCCACGCGG GCCCTGCCCC GGCCCCTGCA CCCCACGCCC 1860

GTGGTGGACT GGGACGCCCG CCCGCTGCCC CCGCCTCCTG CCTACGACGA TGTGGCCCAG 1920

GACGAGGATG ACTTCGAGGT CTGCTCCATC AACAGCACCC TGGTGGGTGC AGGGGTCCGC 1980

ACTGGGCCCA GCCAGGGCGA AACCAATTAC GCCTTTGTGC CTGAGCAGGC ACAGCTGCTC 2040

CCTCCCCTGG AGGACAATCT GTTCCTCCCA CCCCAGGGTG GGAGCAAGCC GCCCAACTCG 2100

GCCCAGACCG CAGAGATCTT CCAGGCGCTG CAGCAGGAGT GCATGCGGCA GCTGCAGGTC 2160

CCGGCTGGCT CCCTGAGCCC TCCTCCTGGC CCGGCCCCAG CGGGTGAGGA CAAGCCCCAG 2220

GTGCCCCCCC GCGTGCCCAT CCCCCCGAGG CCCACCCGCC CACGGGGCGA GCTGTCTCCA 2280

GCCCCCTCAG GCGAGGAGGA GATAGGGCGG TGGCCTGGAC CCGCCTCCCC TCCCCGGGTG 2340

CCTCCCCGGG AGCCCCTGTC CCCTCAAGGC TCACGGACCC CTAGCCCCCT GGTTCCACCC 2400

GGCGGCTCCC CGCTGCCACC TCGGCTCTCC AGCTCACCTG GGAAGACCAT GCCCACCACC 2460

CAGAGCTTCG CCTCAGACCC CAAGTACGCC ACACCCCAAG TGATCCAGGC ACCCGGCCCA 2520

CGGGCTGGTC CCTGCATCCT GCCCATTGTC CGCGACGGCA AGAAGGTCAG CAGCACCCAC 2580

TACTACCTGC TGCCCGAGCG CCCACCCTAC CTGGAACGCT ATCAGCGCTT CCTGCGTGAG 2640

GCTCAGAGCC CTGAAGAGCC GGCCCCCCTG CCCGTGCCCC TGCTGCTGCC CCCGCCCAGC 2700

ACCCCGGCTC CTGCTGCCCC CACTGCCACC GTTCGACCGA TGCCCCAGGC CGCCCCCGAT 2760

CCCAAGGCCA ACTTCTCCAC CAACAACAGT AATCCAGGGC CCCGGCCACC AGCCCTGCGG 2820

GCCGCTGCTC GGCTGCCACA GAGGGGCTGC CCTGGGGACG GGCCGGAGGC TGGACGGCCG 2880

GCAGACAAGG TCCAGATGCT GCAGGCCATG GTGCATGGGG TGACCACAGA GGAGTGCCAG 2940

GCGGCCCTGC AGAGCCACAG CTGGAGCGTG CAGAGGGCTG CACAGTATCT GAAGGTGGAG 3000

CAGCTCTTTG GGTTGGGTCT GCGGCCGCGA AGCGAGTGCC ACAAAGTGCT GGAGATGTGC 3060

GACTGGAACT TGGAGCAGGC TGGCTGCCAC CTGCTGGGCT CCTGCGGCCC TGCCCACCAC 3120

AAGTGA 3126

Domain Profile

S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllkleh  60

         +l eklG+Gsfgvv+rgeW+apsgk+++vavk+lk+d+l+++e+ ddf+rev+++++l+h

Q: 127   HLFEKLGDGSFGVVRRGEWDAPSGKTMSVAVKCLKPDVLSQPEAmDDFIREVNAMHSLDH  186

         5789***************************************99***************

S: 61    enlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayle  120

         +nl+rlyGvvlt p+k+vtela+lgslldrlrk++   ++l+ +l++yavq+aeg+ yle

Q: 187   RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG--HFLLGTLSRYAVQVAEGMGYLE  244

         ***********************************9..9*********************

S: 121   skrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrt  180

         skr++hrdlaarnllla+++lvki+dfGl+ral++++d+yv++e++kvPfaWcaPesl+t

Q: 245   SKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKT  304

         ************************************************************

S: 181   rkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysll  240

         r+fs+asd+W+fGvtlWemf+yG+ePW+gl+g+qil+kidke+erl++Pe+cp+d+y+++

Q: 305   RTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDVYNVM  364

         ************************************************************

S: 241   lkcWakkpadrpkfsalkekl  261

         ++cWa+kp+drp+f+al+++l

Q: 365   VQCWAHKPEDRPTFVALRDFL  385

         ******************986

Domain Sequence
(FASTA)

HLFEKLGDGS FGVVRRGEWD APSGKTMSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH 60

RNLIRLYGVV LTPPMKMVTE LAPLGSLLDR LRKHQGHFLL GTLSRYAVQV AEGMGYLESK 120

RFIHRDLAAR NLLLATRDLV KIGDFGLMRA LPQNDDHYVM QEHRKVPFAW CAPESLKTRT 180

FSHASDTWMF GVTLWEMFTY GQEPWIGLNG SQILHKIDKE GERLPRPEDC PQDVYNVMVQ 240

CWAHKPEDRP TFVALRDFL 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR021619	; Inhibitor_Mig-6.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF09027	; GTPase_binding; 1.
PF11555	; Inhibitor_Mig-6; 1.
PF07714	; Pkinase_Tyr; 1.
PF00627	; UBA; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.
SM00165	; UBA; 2.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50002	; SH3; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013