EKS-CAF-00375

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00375

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	379.9	6.4E-114	221	469	249

Status

Unreviewed

Ensembl Protein

ENSCAFP00000019074

UniProt Accession

F1PEM3;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000012942	ENSCAFP00000019074	ENSCAFT00000020551

Organism

Canis familiaris

Functional Description

Protein Length

482

Protein Sequence
(FASTA)

APSGPKPGRG DAGGMEPFLR KRLTFLSFFW DKIWPVAAPD DGLPGLPERT ADFSARGAGE 60

LSVRRGDRPC ALREDGDYLL ARRLSGPPSP GPVPLSHLAR AAPEPEPERS WYFSGISRAR 120

AQQLLLSPAN APGAFLVRPS ESSHGDYSLS VRAQAKVRHY RISAAADGLY LQKGRLFPSL 180

EELLAYYAAN WKLIRNPLLQ PCVAQKLPQQ DEWERPRSEF ALRRKLGEGH FGEVWEGLWL 240

GSTPVAVKVI KSAYMKLADL AKEIQTLKSL RHERLIRLHA VCSAGEPVYI VTELMRKGNL 300

QAFLGGPEGR ALGLPVLLSF ACQVAEGMSY LEERRIVHRD LAARNVLVGD DLACKVADFG 360

LARLLKEDIY SPSSGCKIPV KWTAPEAANY RIYSPKSDVW SFGVLLYEVF THGQCPYEGL 420

SNHEALQQVT RGYRLPRPAA CPAEVYTLML ECWKGSPARR PAFATLQDRL SAAHGRLRPA 480

HT 482

Nucleotide Sequence
(FASTA)

GCCCCATCCG GCCCGAAGCC CGGCCGCGGC GACGCCGGGG GCATGGAGCC CTTCCTCAGG 60

AAGCGGCTGA CCTTCCTGTC CTTCTTCTGG GACAAGATCT GGCCGGTGGC GGCGCCGGAC 120

GACGGGCTCC CCGGGCTCCC CGAGCGCACG GCGGACTTCA GCGCGCGGGG CGCGGGGGAG 180

CTGAGCGTCC GCCGCGGGGA CCGGCCGTGC GCCCTCAGGG AGGACGGCGA CTACCTCTTG 240

GCGCGCAGGC TCTCGGGCCC GCCCAGCCCC GGGCCGGTAC CGCTCAGCCA CCTGGCCAGG 300

GCCGCCCCGG AGCCGGAGCC GGAGCGCAGC TGGTACTTCA GCGGCATCAG CCGCGCCCGC 360

GCACAGCAGC TGCTCCTGTC TCCCGCCAAC GCGCCCGGGG CCTTCCTCGT TCGGCCCAGC 420

GAGAGCAGCC ACGGGGACTA CTCGCTCTCA GTCCGGGCCC AGGCCAAGGT TCGCCACTAC 480

CGCATCTCCG CGGCCGCCGA CGGTCTCTAC CTGCAGAAGG GCCGGCTCTT CCCCAGCCTG 540

GAGGAGCTGC TCGCCTACTA CGCGGCCAAC TGGAAGCTGA TCCGGAACCC GCTGCTGCAG 600

CCCTGTGTGG CCCAGAAGCT CCCCCAGCAG GATGAGTGGG AGCGGCCTCG CTCAGAGTTT 660

GCCCTGCGGA GGAAGCTGGG AGAAGGCCAC TTCGGGGAGG TGTGGGAAGG CCTGTGGCTT 720

GGCTCCACGC CGGTGGCCGT CAAGGTCATT AAATCAGCCT ACATGAAGCT GGCGGACCTC 780

GCCAAGGAGA TCCAGACACT CAAGAGCCTG AGGCACGAGC GTCTCATCCG GCTGCACGCC 840

GTGTGCTCGG CTGGCGAGCC CGTGTACATC GTCACCGAGC TCATGCGCAA GGGCAACCTG 900

CAGGCCTTCC TGGGCGGCCC CGAGGGACGG GCCCTGGGCC TGCCCGTCCT GCTGAGCTTT 960

GCGTGCCAGG TGGCTGAGGG CATGAGCTAC CTGGAGGAGC GGCGCATCGT GCACCGGGAC 1020

CTGGCGGCCA GGAACGTGCT TGTGGGCGAC GACCTGGCCT GCAAGGTGGC TGACTTCGGC 1080

CTGGCCCGGC TGCTCAAGGA GGACATCTAC TCCCCAAGCA GTGGCTGCAA GATCCCTGTC 1140

AAGTGGACGG CGCCCGAGGC AGCCAACTAT CGCATCTACT CCCCGAAGTC AGACGTCTGG 1200

TCCTTCGGGG TCCTGCTCTA CGAGGTCTTC ACCCACGGCC AGTGTCCCTA CGAAGGGCTG 1260

AGCAACCACG AGGCCCTGCA GCAGGTGACT CGAGGCTACC GGCTGCCGCG GCCCGCCGCC 1320

TGCCCGGCCG AGGTCTACAC GCTCATGCTG GAGTGCTGGA AGGGCAGCCC CGCGCGGCGG 1380

CCGGCCTTCG CCACGCTGCA GGACAGGCTG AGCGCGGCCC ACGGGCGCCT CCGCCCTGCT 1440

CACACGTGA 1449

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

          l +klGeG+fGevw+g+w gs++vavk++k++ ++ +++ +e+q+lk+lrhe+l++l+a

Q: 221   ALRRKLGEGHFGEVWEGLWLGSTPVAVKVIKSAYMKLADLAKEIQTLKSLRHERLIRLHA  280

         688*********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s++eP+yivtelm+kG+l++fl   eg++l lp l+ +a+qvaeGm+ylee++++hrd

Q: 281   VCSAGEPVYIVTELMRKGNLQAFLGGPEGRALGLPVLLSFACQVAEGMSYLEERRIVHRD  340

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarnvlvg++l++kvadfGlarl+++d+y++++g k+P+kWtaPea++++ ++ ksdvW

Q: 341   LAARNVLVGDDLACKVADFGLARLLKEDIYSPSSGCKIPVKWTAPEAANYRIYSPKSDVW  400

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfG+ll+e++t+G++Py+G++n+e+l+qv+rgyrlprp++cp+e+y+l+lecwk +p +r

Q: 401   SFGVLLYEVFTHGQCPYEGLSNHEALQQVTRGYRLPRPAACPAEVYTLMLECWKGSPARR  460

         ************************************************************

S: 242   Ptfetlqev  250

         P+f tlq

Q: 461   PAFATLQDR  469

         ******976

Domain Sequence
(FASTA)

ALRRKLGEGH FGEVWEGLWL GSTPVAVKVI KSAYMKLADL AKEIQTLKSL RHERLIRLHA 60

VCSAGEPVYI VTELMRKGNL QAFLGGPEGR ALGLPVLLSF ACQVAEGMSY LEERRIVHRD 120

LAARNVLVGD DLACKVADFG LARLLKEDIY SPSSGCKIPV KWTAPEAANY RIYSPKSDVW 180

SFGVLLYEVF THGQCPYEGL SNHEALQQVT RGYRLPRPAA CPAEVYTLML ECWKGSPARR 240

PAFATLQDR 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013