EKS-CAF-00007

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00007

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	509.2	1.9E-153	594	853	260

Status

Unreviewed

Ensembl Protein

ENSCAFP00000019263

UniProt Accession

F1P9P1;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB3

Gene Synonyms/Alias

EPHB3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000013005	ENSCAFP00000019263	ENSCAFT00000020750
ENSCAFG00000013005	ENSCAFP00000019282	ENSCAFT00000020769

Organism

Canis familiaris

Functional Description

Protein Length

959

Protein Sequence
(FASTA)

MDTKWVTSEL AWTSHPESGW EEVSGYDEAM NPIRTYQVCN VRESSQNNWL RTGFIWRREV 60

QRVYVELKFT VRDCNSIPNI PGSCKETFNL FYYEADSDVA SASSPFWMEN PYVKVDTIAP 120

DESFSRLDAG RVNTKVRSFG PLSKAGFYLA FQDQGACMSL ISVRAFYKKC ASTTAGFALF 180

PETLTGAEPT SLVIAPGTCI ANAVEVSVPL KLYCNGDGEW MVPVGACTCA TGHEPAAKES 240

QCRPCPPGSY KAKQGEGPCL PCPSNSRTTS PAAGICTCHS NFYRADSDSA DSACTTVPSP 300

PRGVISNVNE TSLILEWSEP RDLGGRDDLL YNVICKKCHG GPGAGGTSAC SRCDDNVEFV 360

PRQLGLTERR VHISHLLAHT RYTFEVQAVN GVSGKSPLPP RYAAVNITTN QAAPSEVPTL 420

HLHSSSGSSL TLSWAPPERP NGVILDYEMK YFEKSEGIAS TVTSQKNSVQ LDGLRPDARY 480

VVQVRARTVA GYGQYSRPAE FETTSERGSG AQQLQEQLPL IVGSATAGLV FVVAVVVIAV 540

VCLRKQRHGS DSEYTEKLQQ YIAPRMKVYI DPFTYEDPNE AVREFAKEID VSCVKIEEVI 600

GAGEFGEVCR GRLKQPGRRE VFVAIKTLKV GYTERQRRDF LSEASIMGQF DHPNIIRLEG 660

VVTKSRPVMI LTEFMENCAL DSFLRLNDGQ FTVIQLVGML RGIAAGMKYL SEMNYVHRDL 720

AARNILVNSN LVCKVSDFGL SRFLEDDPSD PTYTSSLGGK IPIRWTAPEA IAYRKFTSAS 780

DVWSYGIVMW EVMSYGERPY WDMSNQDVIN AVEQDYRLPP PMDCPTALHQ LMLDCWVRDR 840

NLRPKFSQIV NTLDKLIRNA ASLKVIASAQ SGMSQPLLDR TVPDYTTFTT VGDWLDAIKM 900

GRYKESFVSA GFATFDLVAQ MTAEDLLRIG VTLAGHQKKI LSSIQDMRLQ MNQTLPVQV 959

Nucleotide Sequence
(FASTA)

ATGGACACAA AATGGGTGAC ATCTGAGTTG GCATGGACAT CTCATCCAGA AAGTGGGTGG 60

GAAGAGGTGA GTGGCTACGA TGAGGCCATG AACCCCATCC GCACGTACCA GGTGTGTAAC 120

GTGCGAGAGT CAAGCCAGAA CAACTGGCTT CGCACGGGGT TCATCTGGCG GCGAGAGGTT 180

CAGCGCGTCT ATGTGGAGCT CAAGTTTACC GTGCGTGACT GCAACAGCAT CCCCAACATC 240

CCTGGCTCCT GTAAAGAGAC TTTCAACCTC TTCTACTATG AGGCTGACAG TGATGTGGCT 300

TCAGCCTCCT CCCCCTTCTG GATGGAGAAC CCCTATGTGA AGGTGGACAC CATCGCGCCC 360

GATGAGAGCT TCTCAAGGCT TGATGCTGGC CGTGTCAACA CCAAGGTGCG AAGCTTTGGG 420

CCACTTTCCA AGGCCGGTTT CTACTTGGCC TTCCAGGACC AGGGTGCCTG CATGTCACTC 480

ATCTCTGTGC GTGCCTTCTA CAAGAAGTGT GCATCTACCA CCGCGGGCTT CGCCCTCTTT 540

CCTGAGACCC TCACGGGGGC TGAGCCCACC TCTCTGGTCA TTGCCCCTGG CACCTGCATT 600

GCTAATGCTG TGGAGGTGTC AGTGCCACTC AAGCTCTACT GCAATGGCGA TGGGGAATGG 660

ATGGTGCCTG TAGGAGCCTG CACCTGTGCC ACCGGCCATG AGCCAGCTGC CAAGGAATCC 720

CAGTGCCGCC CCTGTCCCCC TGGGAGTTAC AAGGCAAAGC AGGGAGAGGG GCCCTGCCTC 780

CCCTGCCCCT CCAACAGCCG CACCACCTCA CCGGCTGCCG GCATCTGCAC CTGCCACAGT 840

AACTTCTATC GTGCAGATTC AGATTCTGCA GACAGTGCCT GTACCACGGT GCCATCTCCT 900

CCTCGGGGCG TGATCTCCAA CGTGAACGAG ACCTCGCTGA TCCTCGAGTG GAGCGAGCCC 960

CGGGACCTGG GTGGCCGGGA CGACCTCCTG TACAATGTCA TCTGCAAGAA GTGCCATGGG 1020

GGCCCTGGGG CCGGGGGCAC CTCAGCCTGC TCTCGCTGTG ACGACAACGT GGAGTTCGTG 1080

CCTCGGCAGC TGGGCCTGAC GGAGCGCCGG GTGCACATCA GCCATCTGCT GGCCCACACA 1140

CGCTATACCT TTGAGGTGCA GGCAGTCAAT GGTGTCTCGG GCAAGAGCCC TCTGCCCCCC 1200

CGCTACGCAG CTGTGAACAT CACCACCAAC CAGGCTGCTC CATCTGAAGT GCCTACACTG 1260

CATCTGCACA GCAGCTCGGG CAGCAGCCTC ACCCTGTCCT GGGCACCCCC AGAGCGGCCC 1320

AATGGAGTCA TCCTGGACTA TGAGATGAAG TACTTTGAGA AGAGTGAGGG CATTGCCTCC 1380

ACGGTGACCA GCCAGAAGAA CTCGGTGCAG CTGGACGGGC TGCGGCCTGA CGCCCGCTAT 1440

GTGGTCCAGG TCCGTGCCCG CACTGTAGCT GGCTACGGAC AGTACAGCCG TCCAGCTGAG 1500

TTTGAGACCA CAAGCGAGAG AGGCTCTGGT GCCCAGCAGC TCCAGGAGCA GCTTCCCCTC 1560

ATTGTGGGCT CTGCCACAGC TGGGCTTGTC TTCGTGGTAG CTGTGGTGGT CATCGCTGTC 1620

GTCTGCCTCA GGAAGCAGCG GCATGGCTCT GATTCGGAAT ACACAGAGAA GCTGCAGCAG 1680

TACATTGCTC CGAGAATGAA GGTGTATATA GACCCTTTTA CCTACGAAGA CCCTAATGAG 1740

GCTGTGCGGG AGTTTGCCAA GGAGATCGAT GTGTCCTGTG TCAAGATCGA GGAGGTGATT 1800

GGAGCTGGGG AATTTGGGGA AGTGTGCCGG GGTCGGCTGA AACAGCCAGG CCGCAGAGAG 1860

GTGTTTGTGG CCATCAAGAC GCTGAAGGTG GGCTACACAG AGAGGCAGCG ACGGGACTTC 1920

CTAAGTGAGG CCTCCATCAT GGGTCAGTTT GACCACCCGA ACATAATCCG ACTAGAGGGT 1980

GTGGTCACTA AAAGTCGGCC GGTCATGATT CTCACCGAGT TCATGGAGAA CTGTGCCCTG 2040

GACTCCTTCC TCCGGCTCAA CGATGGACAG TTCACAGTCA TCCAGCTGGT GGGCATGTTG 2100

CGGGGCATTG CTGCGGGCAT GAAATACCTG TCTGAGATGA ACTATGTGCA CCGAGACCTG 2160

GCTGCCCGCA ACATCCTTGT CAACAGCAAC CTGGTCTGCA AAGTGTCAGA CTTCGGCCTC 2220

TCCCGCTTCC TGGAGGATGA TCCCTCTGAT CCTACTTACA CCAGCTCCCT GGGCGGGAAG 2280

ATCCCCATCC GCTGGACTGC CCCAGAGGCC ATAGCCTATC GGAAGTTCAC CTCTGCAAGT 2340

GATGTCTGGA GCTATGGAAT CGTCATGTGG GAGGTCATGA GCTATGGAGA GCGACCCTAC 2400

TGGGACATGA GCAACCAGGA TGTCATCAAT GCCGTAGAGC AGGATTACCG GCTGCCCCCA 2460

CCCATGGACT GCCCCACAGC ACTGCATCAG CTCATGCTGG ACTGCTGGGT GCGGGACCGG 2520

AACCTCAGGC CCAAATTCTC CCAGATTGTC AACACCCTGG ACAAGCTCAT CCGTAATGCT 2580

GCCAGCCTCA AGGTCATTGC CAGTGCCCAG TCTGGCATGT CACAGCCCCT CCTGGACCGC 2640

ACGGTCCCAG ATTACACGAC TTTCACGACA GTTGGTGACT GGCTAGATGC CATCAAGATG 2700

GGGCGGTACA AGGAGAGCTT CGTCAGTGCG GGGTTTGCAA CCTTTGACCT GGTGGCTCAG 2760

ATGACTGCAG AAGACCTGCT TCGGATCGGG GTCACCTTGG CTGGGCACCA GAAGAAGATC 2820

CTTAGCAGTA TCCAGGACAT GCGGCTGCAG ATGAACCAGA CACTGCCCGT GCAGGTCTGA 2880

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGevc+Grlk+pg+re+ vaiktlk g+te+qrrdflseasi+Gqfdhp

Q: 594   VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHP  653

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvvtks+pvmi+te+men+aldsflr +dgqftviqlvgmlrGia+gmkyls+m

Q: 654   NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM  713

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178

         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt+s ggkipirwtapeaiay

Q: 714   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPsDPTYTSSlGGKIPIRWTAPEAIAY  773

         **********************************99*****999****************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasdvwsyGiv+wev+syGerpywdmsnqdvi+a+e++yrlpppmdcp+al+qlml

Q: 774   RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML  833

         ************************************************************

S: 239   dcwqkdraerpkfeqivsil  258

         dcw +dr+ rpkf+qiv++l

Q: 834   DCWVRDRNLRPKFSQIVNTL  853

         *****************975

Domain Sequence
(FASTA)

VKIEEVIGAG EFGEVCRGRL KQPGRREVFV AIKTLKVGYT ERQRRDFLSE ASIMGQFDHP 60

NIIRLEGVVT KSRPVMILTE FMENCALDSF LRLNDGQFTV IQLVGMLRGI AAGMKYLSEM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDPSDPTY TSSLGGKIPI RWTAPEAIAY 180

RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVINAVE QDYRLPPPMD CPTALHQLML 240

DCWVRDRNLR PKFSQIVNTL 260

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013