EKS-CAF-00198

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00198

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	474.6	9.6E-143	331	600	270

Status

Unreviewed

Ensembl Protein

ENSCAFP00000019243

UniProt Accession

F1PAG0;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000013044	ENSCAFP00000019243	ENSCAFT00000020729
ENSCAFG00000013044	ENSCAFP00000019249	ENSCAFT00000020735

Organism

Canis familiaris

Functional Description

Protein Length

637

Protein Sequence
(FASTA)

MAAQAGEDTW RCRGCGDHVA PSQRWYRTVN EAWHSSCFRC SECQDSLTNW YYEKDGKLYC 60

HKDYWGKFGE FCHGCSLMMT GPVMVAGEFK YHPECFACMS CKVIIEDGDA YALVQHTTLY 120

CGKCHNEVVL APMFERLSTE SVQDQLPYSV THISMPATAE GRRGFSVSVE SACSNYATTV 180

QVKEVNRLHI SPNNRNAIHP GDRILEINGT PVRTLRVEEV EDAISQTSQT LQLLIEHDPV 240

SQRLDQLRLD ARLSPHMQNA GHSHSLSTLD TKENLEGTLR RRSLRRSNSI SKSPGPSSPK 300

EPLLFSRDIS RSESLRCSSS NSQQIFRPCD LIHGEVLGKG FFGQAIKVTH KATGKVMVMK 360

ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV 420

DPFPWQQKVR FAKGIASGMA YLHSMCIIHR DLNSHNCLIK LDKTVVVADF GLSRLIVEER 480

KKPPTEKATS KKRTLRKNDR KKRYTVVGNP YWMAPEMLNG KSYDETVDVF SFGIVLCEII 540

GQVYADPDCL PRTLDFGLNV KLFWEKFVPT DCPPAFFPLA AICCKLEPES RPAFSKLEDS 600

FEALSLYLGE LGIPLPAELE ELDHTTPICS REQTHPT 637

Nucleotide Sequence
(FASTA)

ATGGCCGCGC AGGCGGGTGA AGATACCTGG AGGTGTCGGG GCTGTGGGGA CCATGTTGCT 60

CCAAGCCAGA GGTGGTACAG GACTGTCAAC GAAGCCTGGC ATAGCTCCTG CTTCCGGTGT 120

TCAGAATGCC AGGATTCCCT CACGAACTGG TACTATGAGA AGGATGGGAA GCTTTACTGC 180

CACAAGGACT ACTGGGGGAA ATTTGGGGAG TTCTGCCATG GGTGTTCTCT GATGATGACA 240

GGGCCCGTCA TGGTGGCCGG GGAGTTCAAG TACCACCCAG AGTGCTTTGC CTGTATGAGC 300

TGCAAGGTGA TCATTGAGGA TGGGGATGCA TATGCCCTGG TGCAGCACAC CACCCTCTAC 360

TGCGGAAAGT GCCATAATGA GGTGGTGCTG GCCCCCATGT TTGAGAGGCT CTCCACAGAG 420

TCTGTGCAGG ACCAGCTGCC ATATTCTGTC ACACACATCT CCATGCCAGC CACCGCCGAG 480

GGCAGACGGG GCTTCTCGGT GTCCGTGGAA AGCGCCTGCT CCAACTATGC CACCACTGTG 540

CAAGTAAAAG AGGTCAACCG GTTGCACATC AGTCCCAACA ACCGCAATGC CATCCACCCT 600

GGGGACCGCA TCCTAGAGAT CAATGGGACC CCTGTCCGCA CACTCCGAGT GGAAGAGGTG 660

GAGGATGCGA TTAGCCAGAC AAGCCAGACG CTTCAGCTCT TGATTGAACA CGATCCTGTC 720

TCCCAGCGCC TGGATCAGCT GCGGCTGGAT GCACGGCTCT CTCCCCACAT GCAGAATGCC 780

GGACACTCCC ATAGCCTCAG CACCCTGGAC ACCAAGGAAA ATCTGGAAGG GACATTAAGG 840

AGACGCTCCC TGAGGCGCAG TAACAGCATC TCCAAGTCCC CTGGCCCCAG CTCCCCAAAG 900

GAGCCCCTAC TCTTTAGCCG TGACATCAGC CGCTCAGAAT CCCTCCGCTG TTCCAGCAGC 960

AACTCACAGC AGATTTTCCG GCCATGTGAC CTGATCCACG GGGAGGTCCT GGGGAAGGGC 1020

TTCTTTGGGC AGGCCATAAA GGTAACACAC AAAGCCACGG GCAAAGTGAT GGTCATGAAG 1080

GAGTTAATTC GGTGTGATGA GGAAACACAG AAGACTTTTC TGACTGAGGT GAAGGTGATG 1140

CGCAGCCTGG ACCACCCCAA TGTGCTCAAG TTCATTGGTG TGCTTTACAA GGACAAGAAG 1200

CTGAACCTGT TGACAGAGTA CATCGAGGGG GGCACACTGA AGGACTTCCT GCGCAGTGTG 1260

GACCCGTTTC CCTGGCAGCA GAAGGTCAGA TTTGCCAAAG GCATCGCCTC TGGAATGGCC 1320

TATTTGCACT CCATGTGCAT CATCCACCGG GATCTGAACT CACACAACTG CCTTATCAAG 1380

CTGGACAAGA CTGTGGTGGT GGCAGACTTT GGGCTGTCAA GGCTCATAGT TGAGGAGAGG 1440

AAAAAGCCCC CAACGGAAAA AGCCACCAGC AAGAAACGCA CCTTGCGTAA GAATGACCGC 1500

AAGAAGCGCT ATACAGTGGT GGGAAACCCC TACTGGATGG CCCCTGAGAT GCTGAACGGA 1560

AAGAGCTACG ATGAGACGGT GGATGTCTTC TCTTTTGGGA TCGTTCTTTG CGAGATCATT 1620

GGGCAGGTAT ATGCAGATCC TGACTGCCTG CCCCGAACAC TGGACTTTGG CCTCAACGTG 1680

AAGCTTTTCT GGGAGAAGTT TGTCCCTACA GACTGCCCCC CCGCCTTCTT TCCCCTGGCC 1740

GCCATCTGCT GCAAACTGGA GCCTGAGAGC AGACCTGCAT TCTCAAAACT GGAGGACTCC 1800

TTTGAGGCTC TCTCCCTGTA CCTGGGGGAG CTGGGCATCC CGCTGCCTGC AGAGCTGGAG 1860

GAGCTGGACC ACACTACACC AATCTGCTCC AGAGAACAAA CACATCCCAC CTGA 1914

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r+l+hpnvlk

Q: 331   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK  390

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdkkl+llteyiegGtlk++l+s +++pw+q+vr+ak+iasG++ylhs++iihr

Q: 391   FIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPFPWQQKVRFAKGIASGMAYLHSMCIIHR  450

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+ncl++ dk+vvvadfGl+rl+veerkk+      +k+r+l+k+drkkr+tvvG+P

Q: 451   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPptekatSKKRTLRKNDRKKRYTVVGNP  510

         *******************************9999999999*******************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+gksyde+vdvfsfGivlceii++v+adPd+lPrt dfgl+vk f+ek+v++

Q: 511   YWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPT  570

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekk  264

         dcP+af++la++cc+l+pesrp+f++le++

Q: 571   DCPPAFFPLAAICCKLEPESRPAFSKLEDS  600

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV DPFPWQQKVR FAKGIASGMA YLHSMCIIHR 120

DLNSHNCLIK LDKTVVVADF GLSRLIVEER KKPPTEKATS KKRTLRKNDR KKRYTVVGNP 180

YWMAPEMLNG KSYDETVDVF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPT 240

DCPPAFFPLA AICCKLEPES RPAFSKLEDS 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 2.
PS50023	; LIM_DOMAIN_2; 2.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013