EKS-CAF-00389

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00389

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	364.7	4.0E-109	647	901	255

Status

Unreviewed

Ensembl Protein

ENSCAFP00000019241

UniProt Accession

F1PAG1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K15

Gene Synonyms/Alias

MAP3K15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000013057	ENSCAFP00000019241	ENSCAFT00000020727

Organism

Canis familiaris

Functional Description

Protein Length

1305

Protein Sequence
(FASTA)

MESGGGAPPA GALGAAAESV RGPLPPGAEG AAGPAEPDGA AEGAGGAGGP RRALRAVYVR 60

SESPPGGAAG GPEAGARQCL LRACEAEGAQ FTSVPFGQLD FGETAVLDAF YDADVAVVDM 120

SEISRQPSLF YHLGVRESFD MANNVILYHD TDADTALSLK DMVTQKNTAS SGNYYFIPYI 180

VTPCADYFCC ESDAQRRASE YMQPNWDTIL GPLCVPLVDR FISLLKDIHV TSCAYYKETL 240

LNDIRRAREK YQGDELAKEL ARIRLRLDNT EVLTSDVIIN LLLSYRDIQD YDAMVKLVET 300

LEMLPTCDLT DQHNIKFHYA FALNRRNRAG DREKALQVML QVLQSCDHPA PDMFCLCGRI 360

YKDIFLDSDC KDDTSRDNAI EWYRKGFELQ SSLYSGINLA VLLIVAGQQF ETSMELRKIG 420

VRLNSLLGRK GSLEKMSNYW DVGQFVTVGV LANDIGKAVQ AAERLFKLRP PVWYLRSLVQ 480

NLLLIQRFKK SITEHSPRQE RLNFWLDMIF EATNEAPNGL RFPVLVIEPT KVYQPSYVSI 540

NNEAEEKTVS LWHVSPTEMK QIHEWNFTAS SIRGISISKF DERCCFLYVL DNSDDFQIYF 600

STEDQCSRFC SLVKEMISNA ARSTMELEGD TDGDTLEYAY EHDANGDRVV LGKGTYGIVY 660

AGRDLSNQVR IAIKEIPERD SRYSQPLHEE IALHKYLKHR NIVQYLGSVS EDGYIKIFME 720

QVPGGSLSAL LRSKWGPIKE PTIKFYTRQI LEGLKYLHEN QIVHRDIKGD NVLVNTYSGM 780

VKISDFGTSK RLAGVNPCTE TFTGTLQYMA PEIIDQGPRG YGAPADIWSL GCTIIEMATS 840

RPPFHELGEP QAAMFKVGMF KIHPEIPEAL STDARAFILS CFEPDPHKRA TAAELLKEGF 900

LRQVNKGKKN RIAFKPAENT RGTALALPSS GEPMGSSSSE HGSVSPDSDA QLDAFFEKAQ 960

APQHQLGHLL SVPDESAAPS PEDRDPGFFL LRKDSERRAI LYKILWEEQN QVASNLQECV 1020

VQSSEDLHLS VVHIKQIIGI LREFIRSPEH RVMASTISKL KVDLDFDSSS INQIHLVLFG 1080

FQDAVNKILR NHLIRPHWMF AMDNIIRRAV QAAVTILIPE LRAHFEPASE TEGLEKDTDE 1140

VEEDRPPADG PRSGAQPQQL QHQHLSLQLG ELRQETNRLL EHLVQKEREY QNLLRQTLER 1200

KTQELYHLQL QFKSNDTTEN SASPPGSQEQ KTDKELVDWL QLQGADSSTI EKIVEEGYTL 1260

SDILNDITRE DLRHLRLRGG CLCRLWTAVC QYRRAQGSPA ARDEA 1305

Nucleotide Sequence
(FASTA)

ATGGAGAGCG GCGGCGGGGC GCCCCCGGCC GGGGCGCTCG GGGCGGCGGC CGAGTCAGTG 60

CGGGGCCCGC TGCCGCCGGG AGCCGAGGGC GCGGCGGGGC CGGCGGAGCC CGACGGGGCG 120

GCCGAGGGCG CGGGGGGCGC GGGCGGGCCG CGGCGGGCCC TGCGGGCCGT GTACGTGCGC 180

AGCGAGAGCC CCCCGGGCGG CGCGGCCGGC GGCCCCGAGG CGGGCGCGCG TCAGTGCCTG 240

CTGCGAGCCT GCGAGGCCGA GGGCGCCCAG TTCACCTCCG TGCCCTTCGG GCAGCTCGAC 300

TTCGGGGAGA CCGCTGTGCT CGACGCCTTC TACGACGCAG ATGTTGCTGT GGTGGACATG 360

AGTGAGATCT CCAGACAGCC TTCCCTCTTT TACCATCTGG GGGTCCGCGA AAGCTTTGAC 420

ATGGCCAACA ATGTGATCCT GTACCATGAC ACCGATGCGG ACACTGCTCT TTCATTGAAG 480

GATATGGTAA CCCAGAAAAA CACAGCATCT AGTGGAAATT ATTATTTCAT CCCATACATT 540

GTGACACCGT GTGCTGATTA TTTTTGCTGC GAGAGTGATG CGCAGAGGCG TGCCTCAGAG 600

TACATGCAGC CCAACTGGGA CACCATCCTG GGTCCACTGT GCGTGCCCCT GGTGGACAGG 660

TTTATTAGCC TCCTCAAGGA CATCCACGTG ACCTCCTGTG CTTATTACAA AGAAACCTTG 720

TTAAATGACA TCCGGAGAGC CCGAGAGAAA TACCAGGGTG ATGAACTGGC AAAGGAGCTG 780

GCTCGGATCA GACTTCGCTT GGACAACACT GAAGTTCTGA CCTCGGACGT CATCATTAAT 840

TTGCTGCTGT CCTACCGTGA CATCCAGGAC TATGACGCCA TGGTGAAGCT GGTGGAGACA 900

CTGGAAATGC TGCCTACGTG TGACTTGACG GACCAGCATA ATATTAAATT CCATTATGCC 960

TTTGCACTGA ATAGGAGAAA CCGTGCAGGT GACCGAGAAA AGGCTCTGCA GGTCATGCTC 1020

CAGGTTCTGC AGAGCTGTGA CCACCCAGCC CCCGACATGT TCTGCCTGTG TGGGAGGATC 1080

TACAAGGACA TCTTCTTGGA TTCAGACTGC AAAGATGACA CCAGCCGAGA CAACGCCATT 1140

GAGTGGTACC GCAAAGGCTT TGAGCTCCAG TCATCTCTCT ATTCAGGAAT TAACCTGGCA 1200

GTTCTGCTGA TAGTTGCTGG ACAACAATTT GAAACTTCCA TGGAACTAAG GAAGATAGGT 1260

GTCCGGCTGA ACAGTTTGTT GGGAAGGAAA GGGAGCTTGG AGAAAATGAG CAATTACTGG 1320

GATGTGGGTC AGTTTGTCAC CGTCGGTGTG TTGGCCAATG ATATCGGGAA GGCGGTCCAG 1380

GCGGCAGAGA GGTTGTTCAA ACTGAGACCT CCAGTTTGGT ACCTCAGGTC ATTAGTTCAG 1440

AACTTGTTAT TAATTCAGCG CTTCAAGAAA TCCATTACTG AACATTCACC CAGGCAAGAA 1500

CGGCTTAACT TCTGGTTAGA TATGATTTTC GAGGCAACAA ATGAAGCTCC TAATGGACTC 1560

AGATTTCCAG TGCTGGTGAT AGAACCAACC AAAGTCTACC AGCCTTCGTA TGTCTCTATA 1620

AATAATGAGG CTGAGGAGAA GACAGTTTCT CTGTGGCATG TCTCACCCAC AGAAATGAAA 1680

CAAATTCATG AATGGAATTT TACAGCTTCT TCCATTAGGG GAATAAGCAT ATCCAAGTTT 1740

GATGAACGGT GTTGTTTTCT TTATGTCCTT GATAATTCTG ATGACTTTCA AATCTACTTT 1800

TCCACTGAAG ACCAGTGTAG TAGGTTTTGC TCTTTGGTTA AAGAGATGAT AAGCAATGCA 1860

GCGCGCAGTA CAATGGAGCT GGAGGGGGAC ACCGATGGAG ACACCTTAGA GTATGCGTAT 1920

GAGCATGATG CGAACGGCGA TAGGGTCGTG CTGGGGAAAG GCACGTACGG GATCGTGTAT 1980

GCCGGAAGAG ACCTGAGCAA CCAAGTGCGA ATCGCCATCA AGGAAATCCC AGAGAGAGAC 2040

AGCAGGTACT CGCAGCCTCT GCATGAGGAG ATAGCCCTGC ACAAGTACCT TAAGCACCGC 2100

AATATTGTTC AGTACCTGGG CTCCGTTTCT GAGGACGGCT ACATTAAGAT ATTTATGGAG 2160

CAGGTGCCTG GGGGAAGCCT CTCTGCCCTT TTGCGATCAA AGTGGGGGCC AATAAAGGAG 2220

CCCACCATCA AGTTCTACAC CAGGCAGATC CTGGAAGGCC TTAAGTATCT CCATGAAAAC 2280

CAGATCGTTC ACAGAGACAT AAAGGGTGAC AACGTTCTGG TGAATACCTA CAGTGGCATG 2340

GTGAAGATTT CTGATTTTGG AACCTCCAAA CGTCTCGCAG GAGTGAATCC ATGCACTGAA 2400

ACTTTTACTG GCACGCTGCA GTACATGGCA CCTGAGATTA TCGATCAGGG ACCTCGCGGG 2460

TACGGTGCCC CAGCTGATAT CTGGTCCCTG GGCTGCACCA TCATCGAGAT GGCCACCAGC 2520

AGGCCTCCGT TCCATGAGCT CGGTGAACCA CAGGCAGCAA TGTTCAAAGT GGGGATGTTT 2580

AAGATCCACC CGGAGATTCC AGAAGCCCTT TCAACTGATG CCAGAGCCTT CATTTTATCC 2640

TGTTTTGAGC CTGACCCCCA CAAACGTGCC ACTGCCGCCG AGCTGCTCAA AGAGGGTTTC 2700

TTAAGGCAGG TGAACAAGGG CAAGAAGAAC CGAATTGCTT TCAAGCCGGC AGAGAACACC 2760

CGGGGCACCG CCCTGGCCCT GCCTTCGTCT GGGGAGCCCA TGGGCAGCAG CAGCAGCGAG 2820

CACGGCTCTG TGTCCCCGGA CTCTGATGCC CAGCTGGATG CGTTCTTTGA GAAGGCCCAG 2880

GCACCCCAGC ACCAGCTCGG CCACCTGCTC AGCGTGCCCG ACGAGAGCGC AGCCCCATCC 2940

CCGGAGGACA GGGACCCAGG ATTCTTCCTG CTGCGCAAGG ACAGCGAGCG CCGCGCCATC 3000

CTGTACAAAA TCCTCTGGGA GGAGCAGAAC CAGGTGGCCT CCAACCTGCA GGAGTGCGTG 3060

GTCCAGAGTT CAGAAGACTT GCACCTCTCG GTCGTCCACA TCAAGCAAAT AATTGGGATC 3120

CTGAGAGAGT TCATCCGCTC CCCGGAACAC AGAGTGATGG CATCCACGAT ATCTAAGCTA 3180

AAGGTGGACC TGGACTTTGA CAGCTCATCC ATCAATCAGA TTCATCTGGT ACTGTTTGGA 3240

TTTCAGGATG CTGTAAATAA AATTTTGAGG AACCACTTAA TTAGGCCCCA CTGGATGTTT 3300

GCGATGGACA ACATAATCCG TCGAGCGGTG CAGGCCGCGG TCACCATTCT CATCCCCGAG 3360

CTCCGAGCCC ACTTTGAGCC TGCATCAGAG ACTGAAGGGC TGGAGAAGGA CACGGACGAG 3420

GTAGAAGAGG ACCGTCCCCC AGCAGACGGG CCTCGAAGTG GGGCCCAGCC CCAGCAGCTC 3480

CAGCACCAGC ACCTGAGCCT CCAGCTGGGC GAGCTCAGAC AGGAGACCAA CAGACTTTTG 3540

GAACACCTAG TTCAGAAAGA AAGAGAGTAC CAGAATCTTC TACGGCAAAC CCTGGAGCGG 3600

AAAACTCAGG AATTGTATCA TCTTCAGTTA CAATTCAAAT CTAATGATAC TACAGAGAAT 3660

TCAGCATCCC CTCCTGGGTC TCAGGAGCAG AAAACTGATA AAGAGCTTGT GGACTGGTTA 3720

CAACTGCAAG GAGCAGATTC GAGTACAATA GAAAAGATTG TTGAAGAAGG TTATACCCTT 3780

TCTGATATTC TTAATGACAT CACTAGGGAA GATCTAAGAC ACCTTAGACT ACGTGGTGGT 3840

TGCCTCTGCC GGCTCTGGAC AGCAGTCTGC CAGTACAGAA GGGCTCAGGG GTCTCCAGCC 3900

GCCCGAGATG AGGCT 3915

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k lkH+n

Q: 647   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKYLKHRN  701

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         iv+y+G+ +e++++kif+E+v+gGsls+ll+ k+g+++e +ik+yt+qilegl+yLHe++

Q: 702   IVQYLGSVSEDGYIKIFMEQVPGGSLSALLRsKWGPIKEPTIKFYTRQILEGLKYLHENQ  761

         *******************************9****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sg+vk+sDFG+skrla +n++   +e++tGtl+ymaPE+i+++

Q: 762   IVHRDIKGDNVLVNTySGMVKISDFGTSKRLAGVNPC---TETFTGTLQYMAPEIIDQGP  818

         *************************************...8*******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+t+++Pf+el+e++a+mfkvg+ k++Peipe+ls+++++f+

Q: 819   RGYGAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSTDARAFI  878

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhefl  263

          +c+e dp+kr++a+eLLk+ fl

Q: 879   LSCFEPDPHKRATAAELLKEGFL  901

         *******************9985

Domain Sequence
(FASTA)

DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKY LKHRNIVQYL 60

GSVSEDGYIK IFMEQVPGGS LSALLRSKWG PIKEPTIKFY TRQILEGLKY LHENQIVHRD 120

IKGDNVLVNT YSGMVKISDF GTSKRLAGVN PCTETFTGTL QYMAPEIIDQ GPRGYGAPAD 180

IWSLGCTIIE MATSRPPFHE LGEPQAAMFK VGMFKIHPEI PEALSTDARA FILSCFEPDP 240

HKRATAAELL KEGFL 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013