EKS-CAF-00164

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00164

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.6	4.6E-188	440	719	280

Status

Unreviewed

Ensembl Protein

ENSCAFP00000019369

UniProt Accession

F1P773;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000013137	ENSCAFP00000019369	ENSCAFT00000020861

Organism

Canis familiaris

Functional Description

Protein Length

750

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 60

RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSGPGTSP GRSVPPVARS SPQHSLSNPL 120

PRRVEQPLYG LDGSAAKEVS EEQSALPTLM SVMLAKPRLD TEQLAQRGAG LCFTFVSAQQ 180

NSPSSTGSGN TEHSGSSQKQ ISIQHRQTQS DLTIEKISAL ENSKNSDLEK KEGRIDDLLR 240

ANCDLRRQID EQQKMLEKYK ERLNRCVTMS KKLLIEKSKQ EKMACRDKSM QDRLRLGHFT 300

TVRHGASFTE QWTDGYAFQN LIKQQERINS QREEIERQRK MLAKRKPPAM GQAPPATNEQ 360

KQRKSKTNGA ENETLTLAEY HEQEEIFKLR LGHLKKEEAE IQAELERLER VRNLHIRELK 420

RIHNEDNSQF KDHPTLNDRY LLLHLLGRGG FSEVYKAFDL TEQRYVAVKI HQLNKNWRDE 480

KKENYHKHAC REYRIHKELD HPRIVKLYDY FSLDTDSFCT VLEYCEGNDL DFYLKQHKLM 540

SEKEARSIIM QIVNALKYLN EIKPPIIHYD LKPGNILLVN GTACGEIKIT DFGLSKIMDD 600

DSYNSVDGME LTSQGAGTYW YLPPECFVVG KEPPKISNKV DVWSVGVIFY QCLYGRKPFG 660

HNQSQQDILQ ENTILKATEV QFPPKPVVTP EAKAFIRRCL AYRKEDRIDV QQLACDPYLL 720

PHIRKSVSTS SPAGAAIAST SGASNNSSSN 750

Nucleotide Sequence
(FASTA)

ATGATGGAAG AATTGCATAG CCTGGACCCT CGACGGCAGG AATTATTAGA GGCCAGGTTT 60

ACAGGAGTTG GTGTTAGTAA GGGGCCACTC AACAGTGAGT CTTCCAACCA GAGCTTGTGC 120

AGCGTGGGGT CCTTGAGTGA TAAAGAAGTA GAGACTCCTG AGAAAAAACA GAATGACCAG 180

CGAAACCGGA AAAGAAAAGC TGAACCATAT GAAACTAGCC AAGGGAAAGG CACTCCTAGG 240

GGACATAAAA TTAGTGATTA CTTTGAGTTT GCTGGGGGAA GCGGGCCAGG AACCAGCCCT 300

GGCAGAAGTG TTCCACCAGT TGCACGATCC TCACCGCAAC ATTCCTTATC CAATCCCTTA 360

CCGCGGCGAG TAGAACAGCC CCTCTATGGC TTAGATGGCA GCGCTGCAAA GGAGGTGTCA 420

GAGGAGCAAT CTGCTCTGCC CACCCTGATG TCAGTGATGC TAGCAAAACC TCGGCTTGAC 480

ACGGAGCAGC TGGCACAGAG GGGAGCTGGC CTCTGCTTCA CTTTTGTTTC AGCTCAGCAA 540

AACAGTCCCT CTTCTACAGG ATCTGGCAAC ACAGAGCATT CCGGCAGCTC CCAAAAACAG 600

ATCTCCATCC AACACAGACA GACCCAGTCT GACCTCACAA TAGAAAAAAT ATCTGCACTA 660

GAAAACAGTA AGAATTCTGA CTTAGAAAAG AAGGAGGGAA GAATAGATGA TTTGTTAAGA 720

GCCAACTGTG ATTTGAGGCG GCAGATTGAC GAGCAGCAAA AGATGCTAGA GAAGTACAAA 780

GAACGATTGA ATCGATGTGT GACAATGAGC AAGAAACTTC TCATAGAAAA GTCAAAACAG 840

GAAAAGATGG CATGTAGAGA TAAGAGCATG CAAGACCGCT TGAGATTGGG CCACTTTACC 900

ACTGTTCGAC ATGGGGCCTC TTTTACTGAA CAATGGACAG ATGGTTATGC TTTTCAGAAC 960

CTTATCAAGC AACAGGAAAG GATAAATTCA CAGAGGGAAG AGATAGAAAG ACAACGGAAA 1020

ATGTTAGCAA AGCGGAAACC TCCTGCCATG GGACAGGCCC CTCCAGCAAC CAATGAGCAG 1080

AAACAGCGGA AAAGCAAGAC CAATGGAGCT GAAAATGAAA CGTTAACATT AGCAGAATAC 1140

CATGAACAAG AAGAAATTTT CAAACTCAGA TTAGGTCATC TTAAAAAGGA GGAAGCAGAG 1200

ATCCAGGCAG AGCTGGAAAG GCTAGAAAGG GTTAGAAATC TACATATCAG GGAACTAAAA 1260

AGGATACATA ATGAAGATAA TTCACAATTT AAAGATCATC CAACGCTAAA TGACAGATAT 1320

TTGTTATTAC ATCTTTTGGG TAGAGGAGGT TTCAGTGAAG TTTACAAGGC ATTTGATCTA 1380

ACAGAACAAA GATACGTAGC TGTGAAAATT CACCAGTTAA ACAAAAACTG GAGAGATGAG 1440

AAAAAGGAGA ATTACCACAA GCATGCATGT AGGGAATACC GGATTCACAA AGAACTGGAT 1500

CATCCCAGGA TAGTTAAGCT GTATGATTAC TTTTCACTGG ACACTGACTC GTTTTGTACA 1560

GTATTAGAAT ACTGTGAGGG AAATGATCTG GACTTCTACC TGAAACAGCA CAAATTAATG 1620

TCGGAGAAAG AGGCCCGATC CATTATCATG CAGATTGTGA ATGCTTTAAA GTACTTAAAT 1680

GAAATCAAAC CTCCCATCAT ACACTATGAC CTCAAACCAG GTAATATTCT TTTAGTAAAT 1740

GGTACAGCAT GTGGAGAGAT AAAAATCACA GATTTTGGTC TTTCCAAGAT CATGGATGAT 1800

GATAGCTACA ATTCAGTGGA TGGCATGGAG CTAACGTCAC AAGGTGCTGG TACTTATTGG 1860

TATTTACCAC CAGAGTGTTT TGTGGTTGGG AAAGAGCCAC CAAAGATCTC AAATAAAGTT 1920

GATGTCTGGT CAGTGGGTGT GATATTCTAC CAGTGTCTCT ATGGAAGGAA GCCTTTTGGC 1980

CACAACCAGT CCCAGCAAGA TATTCTACAA GAAAATACGA TTCTTAAAGC TACTGAAGTG 2040

CAGTTCCCGC CAAAGCCAGT AGTAACACCA GAAGCAAAGG CGTTTATTCG ACGATGCTTA 2100

GCCTACCGAA AGGAGGACCG AATCGACGTT CAGCAGCTGG CCTGTGACCC CTACTTGCTG 2160

CCTCACATCC GAAAGTCGGT CTCCACGAGT AGCCCTGCTG GAGCTGCTAT CGCATCAACA 2220

TCAGGGGCGT CCAATAATAG TTCTTCAAAT TGA 2253

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 440   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  499

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 500   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  559

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 560   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  619

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 620   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  679

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 680   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  719

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013