EKS-CAF-00379

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00379

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	320.2	1.2E-95	170	407	238

Status

Unreviewed

Ensembl Protein

ENSCAFP00000019489

UniProt Accession

E2RNS0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K13

Gene Synonyms/Alias

MAP3K13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000013230	ENSCAFP00000019489	ENSCAFT00000020989

Organism

Canis familiaris

Functional Description

Protein Length

966

Protein Sequence
(FASTA)

MANPQEHLSC SSSPHLPLSE NRTFNGLQDE LTPMGSHPSP KLLQDQQEKG VVQTEPNESM 60

NSPITTTVLT SVSEDSRDQF ENSVLQLREQ DESEMAMSQG NSNAVDGEST SGTEDIKIQF 120

SRSGSGSGGF LEGLFGCLRP VWNIIGKAYS TDYKLQQQDT WEVPFEEISE LQWLGSGAQG 180

AVFLGKFRAE EVAIKKVREQ NETDIKHLRK LKHPNIIAFK GVCTQAPCYC IIMEYCAHGQ 240

LYEVLRAGRK ITPRLLVDWS TGIASGMNYL HLHKIIHRDL KSPNVLVTHT DAVKISDFGT 300

SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA 360

IIWGVGSNSL HLPVPSTCPD GFKILMKQTW QSKPRNRPSF RQTLMHLDIA SADVLATPQE 420

TYFKSQAEWR EEVKKHFEKI KSEGTCIHRL DEELIRRRRE ELRHALDIRE HYERKLERAN 480

NLYMELSAIM LQLEMREKEL IKREQAVEKK YPGTYKRHPV RPIIHPNAME KLMKRKGAPH 540

KSGMQTKRPD RLRSEGIPST EVAPAASPLS GSPKMSTSSS KSRYRSKPRH RRGSSRGSHS 600

DFAGILKTQP AQDTSPRPTY LHQAQSQYPS PQHHSTLQQQ YQQGPPATSQ SVHPRLGMHG 660

QDIAACANNL RYFGPAAALR SPLSNHAQRH PPGSSPDLIS TAMAADCWRS SEPDQGPAGP 720

WGCCQADPYD PCLQCRPEPC GSLDIPSAEP VGRSPDLFKS PAHNPLSENT QGSERMEEKD 780

LKGCRSASSL GMPHHTTPTM LPRNTRPLQK SGDDSSEEEE GEVDSEVEFP RRQRPHRCIS 840

SCQSYSTFSS ENFSVSDGEE GNTSDHSNSP DELADKLEDH LAEKLDDLLS QTPEIPIEIS 900

SHSDGLSDKE CAVRRVKTQM SLGKLCAEER GYENPMQFEE SDCDSSDGEC SDATVRTNKH 960

YSSATW 966

Nucleotide Sequence
(FASTA)

ATGGCCAACC CTCAGGAGCA CCTGAGCTGC TCCTCTTCCC CACACTTACC CTTGAGTGAA 60

AACAGAACCT TCAATGGACT ACAAGATGAA CTCACACCTA TGGGGAGCCA CCCCTCACCC 120

AAGCTCCTTC AGGACCAGCA GGAAAAGGGG GTGGTACAAA CAGAGCCAAA TGAGAGCATG 180

AACAGCCCCA TCACCACAAC AGTGTTGACC AGTGTGAGTG AGGATTCCAG GGACCAGTTT 240

GAGAACAGCG TGCTTCAGCT GAGGGAACAA GATGAATCAG AGATGGCCAT GTCTCAGGGG 300

AACAGCAATG CCGTGGATGG AGAGAGCACA AGTGGAACTG AAGACATCAA GATTCAGTTC 360

AGCAGGTCGG GCAGTGGCAG TGGTGGGTTT CTGGAAGGAC TATTTGGATG CTTAAGGCCT 420

GTATGGAATA TCATTGGGAA GGCATATTCT ACTGATTACA AATTGCAGCA GCAAGATACT 480

TGGGAAGTGC CATTTGAGGA GATCTCAGAG CTGCAGTGGC TGGGTAGTGG AGCCCAAGGA 540

GCTGTCTTCT TGGGCAAGTT CCGAGCGGAA GAGGTGGCCA TCAAGAAAGT GAGAGAACAG 600

AATGAGACGG ATATCAAGCA TTTGAGGAAG TTGAAGCACC CTAACATCAT CGCTTTCAAG 660

GGCGTTTGTA CTCAGGCCCC CTGTTACTGC ATCATCATGG AATACTGTGC CCATGGACAA 720

CTCTATGAGG TTTTGCGAGC TGGCAGGAAG ATCACACCAC GGTTGCTAGT GGACTGGTCC 780

ACGGGAATTG CAAGTGGAAT GAATTATTTG CACCTCCATA AAATTATTCA TCGTGATCTC 840

AAATCACCTA ATGTTTTGGT GACTCATACA GATGCGGTAA AGATTTCAGA TTTTGGAACG 900

TCTAAGGAAC TCAGTGACAA AAGCACGAAG ATGTCCTTTG CTGGCACAGT CGCGTGGATG 960

GCACCAGAGG TGATACGCAA TGAACCTGTC TCTGAAAAAG TTGATATATG GTCTTTTGGA 1020

GTGGTGCTTT GGGAGCTGCT GACAGGAGAG ATTCCTTACA AAGATGTAGA CTCTTCAGCC 1080

ATTATTTGGG GTGTTGGAAG CAATAGTCTA CACCTTCCAG TTCCTTCCAC TTGCCCCGAT 1140

GGATTCAAAA TCCTTATGAA ACAGACCTGG CAGAGCAAAC CTCGCAACCG CCCTTCCTTC 1200

CGGCAGACAC TCATGCACTT AGACATCGCT TCTGCAGATG TTCTTGCCAC CCCACAAGAA 1260

ACCTACTTCA AGTCTCAGGC TGAATGGAGA GAAGAGGTGA AAAAACACTT TGAGAAGATC 1320

AAAAGTGAGG GGACTTGTAT ACACCGATTA GATGAAGAAC TGATTCGGAG GCGCAGAGAA 1380

GAGCTCAGGC ATGCTTTGGA TATTCGTGAA CACTATGAGA GAAAACTTGA GCGAGCTAAT 1440

AATTTATACA TGGAACTGAG TGCCATCATG CTGCAGCTAG AAATGCGGGA GAAGGAGCTC 1500

ATTAAGCGTG AGCAAGCAGT GGAAAAGAAG TATCCTGGAA CCTACAAACG ACACCCTGTC 1560

CGTCCAATAA TCCACCCTAA TGCCATGGAG AAACTCATGA AGAGGAAAGG TGCGCCTCAT 1620

AAATCTGGGA TGCAGACCAA ACGGCCAGAT CGGTTGAGGT CTGAAGGTAT CCCCAGTACA 1680

GAGGTGGCTC CCGCGGCATC CCCTTTGTCC GGAAGCCCCA AAATGTCCAC CTCGAGCAGC 1740

AAGAGCCGAT ATAGGAGCAA ACCACGCCAC CGCCGAGGGA GTAGCCGCGG CAGCCACAGT 1800

GACTTTGCAG GGATCTTGAA AACCCAGCCA GCCCAGGACA CTTCACCCCG TCCCACTTAC 1860

CTACACCAAG CTCAGTCCCA GTACCCTTCC CCCCAGCACC ACAGTACTCT GCAGCAGCAG 1920

TACCAGCAAG GCCCTCCTGC CACCTCTCAG AGCGTCCATC CCCGACTGGG TATGCATGGA 1980

CAGGACATTG CCGCCTGCGC CAACAACCTG CGGTACTTCG GCCCCGCCGC GGCCCTGCGG 2040

AGCCCACTCA GCAACCACGC TCAAAGGCAC CCGCCCGGCT CCAGCCCCGA CCTCATCTCC 2100

ACAGCCATGG CGGCAGACTG CTGGAGAAGC TCTGAGCCTG ACCAGGGCCC AGCCGGCCCC 2160

TGGGGCTGTT GTCAGGCTGA CCCATATGAC CCCTGCCTCC AGTGCAGGCC GGAACCCTGT 2220

GGGTCCTTAG ACATACCCTC TGCTGAGCCA GTGGGGAGGA GCCCCGACCT TTTCAAGTCA 2280

CCAGCACACA ATCCCCTCTC GGAAAATACC CAAGGTTCTG AGAGAATGGA AGAAAAGGAC 2340

CTCAAAGGCT GTAGGTCTGC ATCATCCCTT GGCATGCCTC ATCACACCAC CCCCACCATG 2400

CTACCTCGAA ACACAAGGCC CCTGCAAAAG AGTGGAGATG ACTCCTCAGA AGAGGAAGAA 2460

GGGGAAGTAG ATAGTGAAGT TGAATTTCCA CGAAGACAGA GGCCCCATCG CTGTATCAGC 2520

AGCTGCCAGT CGTATTCAAC CTTTAGCTCT GAGAATTTCT CTGTGTCTGA TGGAGAGGAG 2580

GGAAATACCA GTGACCACTC CAACAGTCCT GATGAGTTAG CGGATAAACT TGAAGACCAC 2640

CTGGCAGAGA AGCTAGATGA CCTGCTGTCC CAGACGCCAG AGATCCCCAT TGAGATATCC 2700

TCGCATTCAG ATGGGCTCTC TGATAAGGAG TGCGCTGTTC GCCGCGTGAA GACACAGATG 2760

TCCCTGGGCA AGCTGTGTGC GGAGGAACGT GGCTACGAGA ATCCTATGCA GTTTGAAGAA 2820

TCGGACTGTG ACTCTTCTGA TGGAGAGTGT TCTGATGCCA CAGTTAGGAC CAATAAACAC 2880

TACAGTTCTG CTACTTGGTA A 2901

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         + +++gsga+g+v+ +k+r++eva+Kk+re++e+         ++k+l+kl+hpnii+++

Q: 170   ELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------DIKHLRKLKHPNIIAFK  220

         6789**************************9999.........*****************

S: 63    GvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkki  122

         Gvc++ p+++++mey+++g+L++vl++   r+i+++ lv+w++ iA+Gm+YLh +   ki

Q: 221   GVCTQAPCYCIIMEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLH---KI  275

         ***************************..99************************...9*

S: 123   ihrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseks  181

         ihrdLks+nvL+ ++++ +ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+

Q: 276   IHRDLKSPNVLV-THTDAVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKV  334

         ************.999***************99***************************

S: 182   DvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedp  241

         D+wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+ps+cp+ +k Lmk++w+++p

Q: 335   DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP  394

         ************************************************************

S: 242   ekRpsfseivksl  254

         ++Rpsf++ +++l

Q: 395   RNRPSFRQTLMHL  407

         *******998775

Domain Sequence
(FASTA)

ELQWLGSGAQ GAVFLGKFRA EEVAIKKVRE QNETDIKHLR KLKHPNIIAF KGVCTQAPCY 60

CIIMEYCAHG QLYEVLRAGR KITPRLLVDW STGIASGMNY LHLHKIIHRD LKSPNVLVTH 120

TDAVKISDFG TSKELSDKST KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVVLWELLTG 180

EIPYKDVDSS AIIWGVGSNS LHLPVPSTCP DGFKILMKQT WQSKPRNRPS FRQTLMHL 238

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008385	; C:IkappaB kinase complex
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007254	; P:JNK cascade
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013