EKS-CAF-00471

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00471

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	335.0	4.2E-100	22	312	291

Status

Unreviewed

Ensembl Protein

ENSCAFP00000019572

UniProt Accession

E2RIY9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000013287	ENSCAFP00000019572	ENSCAFT00000021077

Organism

Canis familiaris

Functional Description

Protein Length

584

Protein Sequence
(FASTA)

MAEKGDCIAS VYGYDLGGRF VDFQPLGFGV NGLVLSAVDS RARRKVAVKK IILSDARSMK 60

HALREIKIIR RLDHDNIVKV YEVLGPQGAD LQGELFKLSV AYIVQEYMET DLARLLEQGT 120

LTEEHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIVDQHYS 180

HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GAHELEQMQL 240

ILETIPVIRE EDKDELLRVM PSFISSTWEV KRPLRKLLPE VNSEAIDFLE KILTFNPMDR 300

LTAEMGLQHP YMSPYSCPED EPTSQHPFRI EDEIDDILLM AANQSQLSNW DRYPVSLSSD 360

LEWRPDRGQD ASEVQRDPRA GSGSAALAED VQVDPRKDSQ GSSERFLERS PSSMERAFEA 420

DCGRSCDYKV GSPSYLDKLL WRDSKPHHYS EPKLILDLSH WKQAAGPPPS ARVAADPGPR 480

EDEPASLFLE IAQWVQSTRG GPEPASPAPG SPERRPAASP PSRAAPEDGA SPQFDLDVFI 540

SRALKLCTKP EDLPDSKLGD LNGACIPEHP GDLVQTEAFS KERW 584

Nucleotide Sequence
(FASTA)

ATGGCTGAGA AGGGGGACTG CATCGCCAGT GTCTACGGGT ACGACCTTGG TGGCCGCTTT 60

GTTGACTTCC AGCCCCTGGG CTTTGGCGTC AACGGGCTGG TGCTATCGGC CGTGGACAGC 120

AGGGCCCGCC GGAAGGTGGC CGTGAAGAAG ATCATCCTGA GTGATGCCCG CAGCATGAAG 180

CACGCGCTCC GAGAGATCAA GATCATCCGG CGCCTGGACC ACGACAACAT CGTGAAGGTG 240

TACGAGGTGC TGGGACCCCA GGGTGCGGAC CTGCAGGGCG AGCTGTTCAA GCTCAGCGTG 300

GCCTACATCG TCCAGGAGTA CATGGAGACC GACCTGGCAC GGCTGCTGGA GCAGGGCACG 360

CTGACAGAGG AGCACGCCAA GCTGTTCATG TACCAGCTGC TCCGCGGCCT CAAGTACATC 420

CACTCGGCCA ATGTGTTGCA CAGGGACCTG AAGCCCGCCA ACATCTTCAT CAGCACAGAG 480

GACCTTGTGC TCAAGATTGG GGACTTCGGG TTGGCTCGCA TCGTTGACCA GCATTATTCA 540

CACAAGGGTT ATCTGTCGGA AGGGCTGGTA ACTAAGTGGT ACCGCTCACC CCGCCTGCTC 600

CTGTCCCCTA ACAACTACAC CAAAGCCATC GACATGTGGG CCGCCGGCTG CATCCTGGCC 660

GAGATGCTCA CGGGCAGAAT GCTCTTTGCT GGGGCTCACG AGCTGGAGCA GATGCAGCTG 720

ATCCTAGAGA CCATCCCTGT GATCCGGGAG GAGGACAAAG ACGAGCTGCT CAGGGTGATG 780

CCGTCCTTCA TCAGCAGCAC CTGGGAAGTG AAGCGGCCGC TGCGCAAGCT GCTCCCTGAA 840

GTGAACAGTG AAGCCATAGA CTTTCTAGAG AAGATCCTGA CCTTCAACCC CATGGATCGC 900

CTAACAGCAG AGATGGGGCT GCAGCACCCC TACATGAGCC CATACTCGTG CCCTGAGGAT 960

GAGCCCACCT CGCAGCACCC CTTCCGCATT GAAGACGAGA TCGATGACAT CCTGCTGATG 1020

GCCGCCAACC AGAGCCAGCT CTCCAACTGG GACAGGTACC CCGTGAGCCT GTCATCCGAC 1080

CTGGAGTGGA GGCCGGACCG CGGCCAGGAC GCCAGCGAGG TGCAGCGCGA CCCCCGCGCG 1140

GGCTCGGGCT CGGCGGCGCT GGCGGAGGAC GTGCAGGTGG ACCCGCGCAA GGACTCGCAG 1200

GGCAGCTCGG AGCGCTTCCT GGAGCGCTCG CCCTCGTCCA TGGAGCGCGC CTTCGAGGCC 1260

GACTGCGGGC GCTCCTGCGA CTACAAGGTG GGCTCGCCCT CCTACCTGGA CAAGCTGCTG 1320

TGGCGCGACA GCAAGCCACA CCACTACTCG GAGCCCAAGC TCATCCTGGA CCTGTCGCAC 1380

TGGAAGCAGG CGGCCGGGCC GCCCCCCAGC GCCAGGGTGG CCGCGGACCC CGGGCCGCGC 1440

GAGGACGAGC CGGCCAGCCT CTTCCTGGAG ATCGCGCAGT GGGTGCAGAG CACGCGGGGC 1500

GGCCCCGAGC CTGCCAGCCC GGCCCCCGGC AGCCCCGAGC GCCGCCCCGC CGCCTCCCCG 1560

CCCAGCCGCG CGGCCCCGGA GGACGGCGCC AGCCCCCAGT TCGACCTGGA CGTGTTCATC 1620

TCCCGCGCCC TGAAGCTCTG CACCAAGCCG GAGGACCTGC CCGACAGCAA GCTGGGTGAC 1680

CTGAACGGCG CGTGCATCCC CGAGCACCCC GGCGACCTGG TGCAGACCGA GGCCTTCTCC 1740

AAAGAAAGGT GGTGA 1755

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + +plg G +g+v+savd+r++++va+kk+   ++++ s+k++lRE+k++++l+h+Ni+k

Q: 22    DFQPLGFGVNGLVLSAVDSRARRKVAVKKII--LSDARSMKHALREIKIIRRLDHDNIVK  79

         6799**************************9..9**************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         +++v+ p+      el +l+  Y+v+e+metdL++++++ +l++eh+kl++yq+lrglky

Q: 80    VYEVLGPQGadlqgELFKLSVAYIVQEYMETDLARLLEQGTLTEEHAKLFMYQLLRGLKY  139

         *******998888889999*****************************************

S: 118   lHsanviHrDlKPsNllvnedc.elkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hsanv+HrDlKP+N++++++   lki dFGlar+ d+++++k  l+e ++t+wYr+P++

Q: 140   IHSANVLHRDLKPANIFISTEDlVLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYRSPRL  199

         ******************8765169**************999999***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltg++lf+g++e++q+++ile+++  +ee+ +++ +

Q: 200   LLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRV  259

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          + ++i+s+++ k+ ++++l+p+ ++ea+d+lek+L+++p++R+++e+ L+hpY+

Q: 260   -MPSFISSTWEVKR-PLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM  312

         .9*******99988.9**************************************7

Domain Sequence
(FASTA)

DFQPLGFGVN GLVLSAVDSR ARRKVAVKKI ILSDARSMKH ALREIKIIRR LDHDNIVKVY 60

EVLGPQGADL QGELFKLSVA YIVQEYMETD LARLLEQGTL TEEHAKLFMY QLLRGLKYIH 120

SANVLHRDLK PANIFISTED LVLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYRSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGRMLFAG AHELEQMQLI LETIPVIREE DKDELLRVMP 240

SFISSTWEVK RPLRKLLPEV NSEAIDFLEK ILTFNPMDRL TAEMGLQHPY M 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013