EKS-CAF-00376
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00376
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK348.13.6E-104119376258
StatusUnreviewed
Ensembl ProteinENSCAFP00000019767
UniProt AccessionF1PAC5;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K11
Gene Synonyms/Alias MAP3K11;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000013415ENSCAFP00000019767ENSCAFT00000021287
OrganismCanis familiaris
Functional Description
Protein Length630
Protein Sequence
(FASTA)
MEPLKNLFLK SPLGSWNSSG GGGSGGSGGG WPEGSPKTAA YANPVWTALF DYEPNGQDEL 60
ALRKGDRVEV LSRDAAISGD EGWWAGQVGG QVGIFPSNYV SRGGGPPPCE VASFQELRLE 120
EVIGIGGFGK VYRGSWRGEL VAVKAARQDP DEDISVTAES VRQEARLFAM LAHPNIIALK 180
AVCLEEPNLC LVMEYAAGGP LSRALAGRRV PPHVLVNWAV QIARGMHYLH CEALVPVIHR 240
DLKSNNILLL QPIEGDDMDH KTLKITDFGL AREWHKTTQM SAAGTYAWMA PEVIKASTFS 300
KGSDVWSFGV LLWELLTGEV PYRGIDCLAV AYGVAVNKLT LPIPSTCPEP FAQLMADCWA 360
QDPHRRPDFA SILQQLEALE AQVLREMPRD SFHSMQEGWK REIQGLFDEL RAKEKELLSR 420
EEELTRAARE QRSQAEQLRR REHLLAQWEL EVFERELTLL LQQVDRERPH VRRRRGTFKR 480
SKLRARDGGE RISMPLDFKH RITVQASPGL DRRRNVFEVG AGDSPTFPRF RAIQLEPAEP 540
GQAWGRQSPR RLEDSSNGER RACWAWGPSS PKPGEAQNGR RRSRLDEAAW YLDSDDSSSL 600
GSPSTPPMLN GNPPRPRGSP EPEEPRRPGL 630
Nucleotide Sequence
(FASTA)
ATGGAGCCCT TGAAGAACCT CTTTCTCAAG AGCCCGCTGG GGTCATGGAA CAGCAGTGGC 60
GGTGGGGGCA GTGGGGGCAG TGGCGGAGGC TGGCCAGAGG GGTCCCCGAA GACAGCGGCT 120
TATGCCAACC CCGTGTGGAC AGCCCTGTTT GACTATGAGC CCAATGGGCA GGATGAACTG 180
GCCCTGAGAA AGGGCGACCG TGTGGAGGTG CTGTCCCGGG ATGCAGCTAT CTCAGGCGAT 240
GAGGGCTGGT GGGCCGGCCA GGTGGGTGGC CAGGTGGGCA TCTTTCCATC CAACTATGTG 300
TCTCGGGGCG GTGGCCCACC CCCCTGCGAG GTGGCCAGCT TCCAAGAGCT GCGGCTGGAG 360
GAGGTGATCG GCATCGGTGG CTTCGGCAAG GTCTACCGCG GCAGCTGGCG AGGTGAGCTG 420
GTGGCTGTGA AGGCAGCTCG CCAGGACCCC GATGAGGACA TCAGTGTGAC AGCCGAGAGT 480
GTGCGCCAGG AGGCCCGGCT TTTCGCCATG CTGGCACACC CCAACATCAT TGCCCTCAAG 540
GCCGTGTGCC TGGAGGAGCC CAACCTGTGC TTGGTGATGG AGTACGCAGC TGGTGGGCCC 600
CTCAGCCGTG CCCTGGCTGG GCGGCGTGTG CCCCCCCACG TACTGGTCAA CTGGGCTGTG 660
CAGATTGCCC GTGGGATGCA TTACCTGCAC TGTGAGGCCC TGGTGCCTGT CATCCACCGA 720
GACCTCAAGT CCAACAACAT TCTGCTGCTG CAGCCCATTG AAGGTGATGA CATGGACCAC 780
AAGACCTTGA AGATAACGGA CTTTGGCCTG GCCCGAGAGT GGCACAAAAC CACACAAATG 840
AGTGCTGCGG GCACCTATGC CTGGATGGCT CCTGAGGTCA TCAAGGCTTC CACCTTCTCT 900
AAGGGCAGCG ATGTCTGGAG TTTCGGGGTG CTGCTGTGGG AGTTGCTGAC TGGGGAGGTG 960
CCCTACCGTG GTATCGACTG CCTTGCTGTG GCCTACGGAG TAGCCGTCAA CAAGCTCACG 1020
CTGCCCATCC CATCCACCTG CCCTGAGCCC TTCGCACAGC TCATGGCAGA CTGCTGGGCG 1080
CAGGACCCCC ATCGCAGGCC CGACTTTGCC TCCATCCTGC AGCAGCTGGA GGCGCTAGAG 1140
GCGCAAGTCC TGCGGGAAAT GCCGCGGGAC TCCTTCCATT CCATGCAGGA AGGCTGGAAG 1200
CGCGAGATCC AAGGCCTCTT CGACGAGCTG CGGGCCAAGG AAAAGGAACT TCTGAGCCGC 1260
GAGGAGGAGC TGACCCGCGC GGCGCGTGAG CAGCGGTCAC AGGCGGAGCA GCTGCGGCGG 1320
CGCGAGCACC TGCTGGCCCA GTGGGAGTTG GAGGTGTTCG AGCGCGAGCT GACGCTGCTA 1380
CTGCAGCAGG TGGACCGCGA GCGGCCGCAC GTACGCCGCC GGCGCGGCAC CTTCAAGCGC 1440
AGCAAGCTCC GCGCGCGGGA CGGCGGCGAG CGCATCAGCA TGCCCCTCGA TTTCAAACAC 1500
CGCATCACTG TGCAGGCCTC ACCTGGCCTG GACCGGAGGA GAAATGTCTT CGAGGTCGGA 1560
GCTGGGGATT CGCCCACCTT CCCCCGGTTC CGGGCGATCC AGTTGGAGCC TGCAGAACCA 1620
GGCCAGGCAT GGGGCCGCCA ATCCCCCCGG CGTCTGGAGG ACTCCAGCAA TGGAGAGCGG 1680
CGAGCATGCT GGGCCTGGGG TCCCAGTTCC CCCAAGCCTG GGGAAGCCCA GAATGGGAGG 1740
AGAAGGTCCC GCTTGGATGA AGCCGCGTGG TACCTGGATT CAGATGACTC ATCGTCCTTG 1800
GGATCTCCTT CTACACCCCC GATGCTCAAT GGTAACCCCC CGCGGCCGAG GGGGAGCCCG 1860
GAGCCTGAGG AGCCTCGGCG CCCAGGCCTG TAG 1893
Domain Profile
S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60
         lee+ig g fgkvy+++wr++ vavK++r++  e  + ++e++++ea+l+++l+hpnii+
Q: 119   LEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEdiSVTAESVRQEARLFAMLAHPNIIA  178
         789****************************99988999*********************
S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120
         l++vcleepnl+lvmey++gg Ls++l++   r+++++vlv+wa+qiArGm+YLh ea +
Q: 179   LKAVCLEEPNLCLVMEYAAGGPLSRALAG---RRVPPHVLVNWAVQIARGMHYLHCEALV  235
         *****************************...9***************************
S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173
         ++ihrdLks+n+Ll       ++++ktlki+dFG are++k+t+msaagt+awmaPEv+k
Q: 236   PVIHRDLKSNNILLlqpiegdDMDHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIK  295
         ********************999*************************************
S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233
         ++++s+ sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++Lm
Q: 296   ASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLM  355
         ************************************************************
S: 234   kecwnedpekRpsfseivksl  254
          +cw++dp++Rp+f++i+++l
Q: 356   ADCWAQDPHRRPDFASILQQL  376
         *****************9986
Domain Sequence
(FASTA)
LEEVIGIGGF GKVYRGSWRG ELVAVKAARQ DPDEDISVTA ESVRQEARLF AMLAHPNIIA 60
LKAVCLEEPN LCLVMEYAAG GPLSRALAGR RVPPHVLVNW AVQIARGMHY LHCEALVPVI 120
HRDLKSNNIL LLQPIEGDDM DHKTLKITDF GLAREWHKTT QMSAAGTYAW MAPEVIKAST 180
FSKGSDVWSF GVLLWELLTG EVPYRGIDCL AVAYGVAVNK LTLPIPSTCP EPFAQLMADC 240
WAQDPHRRPD FASILQQL 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00376
EKS-CAJ-00383
EKS-CAP-00409
EKS-DIO-00059
EKS-DRM-00176
EKS-EQC-00374
EKS-FEC-00364
EKS-GAA-00460
EKS-GOG-00367
EKS-HOS-00383
EKS-ICT-00356
EKS-LAC-00397
EKS-LOA-00385
EKS-MAM-00375
EKS-MOD-00366
EKS-MUM-00408
EKS-MUP-00370
EKS-MYL-00374
EKS-NOL-00344
EKS-ORN-00483
EKS-ORC-00352
EKS-ORL-00446
EKS-OTG-00378
EKS-PAT-00356
EKS-PES-00335
EKS-POA-00366
EKS-PTV-00099
EKS-RAN-00391
EKS-SAH-00352
EKS-TAR-00479
EKS-TEN-00477
EKS-XIM-00473
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR011511; SH3_2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF07653; SH3_2; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013