EKS-CAF-00009
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00009
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph502.52.1E-151615874260
StatusUnreviewed
Ensembl ProteinENSCAFP00000020887
UniProt AccessionF1PRQ8;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB4
Gene Synonyms/Alias EPHB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000014162ENSCAFP00000020887ENSCAFT00000022498
OrganismCanis familiaris
Functional Description
Protein Length987
Protein Sequence
(FASTA)
MELRALLCWA SLAAALEETL LNTKLETADL KWVTFPQVDG QWEELSGLDE EQHSVRTYEV 60
CDVQRAPGLA HWLRTGWVPR RGAVHVYATL RFTMLECLSL TRAGRSCKET FTVFYFESDA 120
DTATAFTPAW MENPYIKVDT VAAEHLTRKR PGAEATGKVN IKTLRLGPLT KAGFYLAFQD 180
QGACMALLSL HLFYKKCSQL TVNLTYFPET VPRELVVPVA GSCVADAVPT PGPSPSLYCR 240
EDGQWAEQPV TGCSCAAGFE AAEGNTRCRA CAQGTFKPLS GEGSCQPCPA NSHSNTIGSP 300
MCQCRIGYFR ARTDFRGAPC TTPPSAPRSV VPRLNGSSLR LEWSAPLESG GREDLTYALR 360
CRECRPGGSC TPCGGDLTFD PGPRDLVEPW VAVRGLRPDF TYTFEVTALN GVSSLATGPV 420
PFEAVNVTTD REVPPPVSDI RVTRSSPSSL SLAWAVPRAP SGAVLDYEVK YHEKGTEGPS 480
SVRFLKTSEN RAELRGLKRG ASYLVQVRAR SEAGYGPFGQ EHHSQTQLDE NESWREQLAL 540
IAGTAVVGVV LVLVVIVIAV LCLRKQSNGR EAEYSDKHGQ YLIGHGTKVY IDPFTYEDPN 600
EAVREFAKEI DVSYVKIEEV IGAGEFGEVC RGRLKAPGKK ESCVAIKTLK GGYTERQRRE 660
FLSEASIMGQ FEHPNIIRLE GVVTNSVPVM ILTEFMENGA LDSFLRLNDG QFTVIQLVGM 720
LRGIASGMRY LAEMSYVHRD LAARNILVNS NLVCKVSDFG LSRFLEENSS DPTYTSSLGG 780
KIPIRWTAPE AIAFRKFTSA SDAWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP 840
PPPDCPTSLH QLMLDCWQKD RNARPRFPQV VSALDKMIRN PASLKIVARE NGGASHPLLD 900
QRQPHYSAFG SVGEWLRAIK MGRYEESFAA AGFGSFELVS QISAEDLLRI GVTLAGHQKK 960
ILASVQHMKS QAKPGAPGGS GAPAPQY 987
Nucleotide Sequence
(FASTA)
ATGGAGCTCC GGGCTCTGCT TTGCTGGGCT TCGCTCGCCG CGGCTTTGGA AGAGACCCTA 60
TTGAACACAA AGTTGGAAAC TGCCGATCTG AAGTGGGTCA CGTTCCCTCA GGTGGATGGG 120
CAGTGGGAGG AGCTGAGCGG CCTGGATGAG GAGCAGCACA GCGTTCGGAC CTACGAGGTG 180
TGTGATGTGC AACGGGCACC AGGTCTGGCC CACTGGCTGC GCACTGGCTG GGTCCCGCGC 240
CGTGGAGCTG TCCACGTGTA CGCCACACTC CGCTTCACCA TGCTTGAGTG CCTCTCCCTG 300
ACGCGGGCTG GCCGCTCCTG CAAGGAGACC TTCACCGTCT TCTACTTCGA GAGTGATGCT 360
GACACGGCCA CAGCCTTCAC ACCAGCCTGG ATGGAGAACC CCTATATCAA GGTGGACACC 420
GTGGCTGCTG AGCACCTGAC CCGGAAGCGC CCTGGGGCTG AGGCAACAGG GAAGGTGAAC 480
ATCAAGACAC TGCGTCTGGG CCCACTCACC AAGGCTGGCT TCTACCTGGC CTTCCAGGAC 540
CAGGGTGCCT GCATGGCCCT GCTCTCCCTG CACCTCTTCT ATAAGAAGTG CTCCCAACTG 600
ACTGTGAACC TCACATACTT CCCGGAGACG GTGCCTCGGG AGCTTGTGGT GCCTGTGGCA 660
GGGAGCTGTG TGGCCGACGC CGTCCCCACT CCTGGCCCCA GCCCCAGCCT CTACTGCCGG 720
GAGGATGGCC AGTGGGCTGA GCAGCCGGTC ACGGGCTGCA GCTGTGCTGC TGGCTTCGAG 780
GCCGCAGAGG GGAATACCAG GTGCCGAGCC TGTGCCCAAG GCACCTTCAA GCCCTTGTCC 840
GGGGAGGGGT CCTGTCAGCC GTGTCCAGCC AACAGCCACT CCAACACCAT CGGCTCACCC 900
ATGTGCCAGT GCCGCATTGG GTACTTCAGG GCCCGCACAG ATTTCCGGGG AGCACCCTGT 960
ACCACGCCAC CCTCTGCTCC CAGAAGTGTG GTTCCCCGCC TGAATGGCTC CTCCCTGCGC 1020
CTGGAGTGGA GCGCCCCCCT GGAGTCCGGG GGCCGAGAGG ATCTCACCTA TGCTCTGCGC 1080
TGCCGGGAGT GCCGCCCTGG GGGGTCCTGT ACACCCTGCG GAGGAGACCT GACTTTTGAC 1140
CCTGGCCCCC GGGACCTTGT GGAACCCTGG GTGGCAGTTC GTGGGCTGCG TCCAGATTTC 1200
ACCTACACCT TCGAGGTCAC CGCCTTGAAC GGGGTGTCCT CTCTGGCCAC TGGACCTGTC 1260
CCATTTGAGG CTGTGAATGT CACCACTGAC CGTGAGGTAC CACCCCCAGT GTCCGACATC 1320
CGGGTGACAC GGTCATCGCC CAGCAGCTTG AGCCTGGCCT GGGCTGTTCC CCGGGCCCCC 1380
AGCGGAGCTG TGCTGGACTA TGAGGTCAAG TATCATGAGA AGGGCACAGA GGGCCCCAGC 1440
AGCGTGCGGT TCCTGAAGAC GTCGGAAAAC CGGGCAGAGC TGCGGGGGCT GAAACGGGGA 1500
GCCAGCTACC TGGTCCAGGT GCGGGCACGC TCTGAAGCCG GCTATGGGCC CTTTGGCCAG 1560
GAGCACCACA GCCAGACCCA GCTGGACGAG AACGAGAGCT GGCGGGAGCA GCTGGCCCTG 1620
ATCGCGGGCA CAGCTGTCGT GGGTGTGGTG CTGGTCCTGG TGGTCATTGT CATTGCTGTT 1680
CTCTGCCTCA GGAAGCAGAG CAACGGGAGA GAAGCTGAGT ACTCGGACAA GCATGGACAG 1740
TACCTCATCG GGCACGGTAC TAAGGTCTAT ATTGACCCCT TCACTTATGA AGACCCCAAT 1800
GAGGCTGTGA GGGAATTTGC GAAAGAGATT GACGTTTCCT ATGTCAAGAT TGAGGAGGTG 1860
ATCGGCGCAG GTGAGTTTGG CGAGGTGTGC CGGGGGCGGC TCAAGGCCCC AGGGAAGAAA 1920
GAGAGCTGTG TGGCTATCAA GACCCTGAAA GGGGGCTACA CAGAGCGGCA GCGGCGGGAG 1980
TTCCTGAGTG AGGCCTCCAT CATGGGCCAG TTCGAGCATC CTAACATCAT CCGCCTGGAG 2040
GGCGTGGTCA CCAACAGCGT GCCTGTCATG ATCCTCACCG AGTTCATGGA GAATGGCGCT 2100
CTGGACTCCT TCCTGCGGCT CAATGATGGG CAGTTCACTG TCATCCAGCT GGTGGGCATG 2160
CTTCGGGGCA TTGCCTCTGG CATGCGGTAC CTTGCTGAAA TGAGCTATGT CCATCGAGAC 2220
CTGGCTGCCC GCAACATCCT GGTCAACAGC AATCTTGTCT GCAAGGTGTC TGACTTTGGG 2280
CTTTCCCGGT TCCTGGAGGA GAACTCTTCT GATCCCACCT ATACAAGCTC TCTGGGTGGA 2340
AAGATTCCCA TCCGATGGAC AGCCCCCGAG GCCATTGCCT TCCGGAAGTT CACATCTGCT 2400
AGTGATGCGT GGAGCTACGG AATTGTGATG TGGGAGGTCA TGTCCTTTGG AGAACGGCCA 2460
TACTGGGACA TGAGCAATCA GGATGTGATC AATGCCATTG AACAGGACTA CCGGCTGCCC 2520
CCGCCCCCAG ACTGCCCCAC TTCCCTGCAC CAGCTCATGC TGGACTGTTG GCAGAAGGAC 2580
CGGAATGCAC GGCCCCGCTT CCCCCAGGTG GTCAGCGCCC TTGACAAGAT GATCCGGAAC 2640
CCGGCCAGTC TCAAAATTGT GGCCAGGGAG AATGGCGGCG CCTCACACCC ACTCCTGGAT 2700
CAGCGGCAGC CTCACTACTC AGCTTTTGGC TCCGTGGGTG AGTGGCTTCG AGCCATCAAG 2760
ATGGGACGAT ACGAAGAAAG TTTTGCAGCT GCTGGCTTTG GCTCCTTCGA ACTGGTCAGC 2820
CAGATCTCTG CTGAGGACCT GCTCCGAATT GGAGTCACTC TGGCGGGACA CCAGAAGAAA 2880
ATCCTGGCCA GCGTCCAGCA CATGAAGTCC CAGGCCAAGC CTGGAGCCCC AGGCGGGTCG 2940
GGAGCACCAG CCCCCCAGTA CTGA 2964
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pgk+e++vaiktlk+g+te+qrr+flseasi+Gqf+hp
Q: 615   VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHP  674
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+s pvmi+te+mengaldsflr +dgqftviqlvgmlrGiasgm+yl++m
Q: 675   NIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEM  734
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+le++s +++yt+s ggkipirwtapeaia+
Q: 735   SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSsDPTYTSSlGGKIPIRWTAPEAIAF  794
         *******************************99988*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasd+wsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlppp dcp++l+qlml
Q: 795   RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLML  854
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f q+vs+l
Q: 855   DCWQKDRNARPRFPQVVSAL  874
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KAPGKKESCV AIKTLKGGYT ERQRREFLSE ASIMGQFEHP 60
NIIRLEGVVT NSVPVMILTE FMENGALDSF LRLNDGQFTV IQLVGMLRGI ASGMRYLAEM 120
SYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEENSSDPTY TSSLGGKIPI RWTAPEAIAF 180
RKFTSASDAW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPPD CPTSLHQLML 240
DCWQKDRNAR PRFPQVVSAL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00008
EKS-BOT-00007
EKS-CAJ-00008
EKS-CAP-00006
EKS-DAR-00013
EKS-EQC-00009
EKS-FEC-00006
EKS-GAA-00011
EKS-GOG-00008
EKS-HOS-00009
EKS-ICT-00008
EKS-LAC-00014
EKS-LOA-00009
EKS-MAM-00007
EKS-MOD-00008
EKS-MUM-00009
EKS-MUP-00009
EKS-MYL-00010
EKS-NOL-00008
EKS-ORN-00012
EKS-ORA-00007
EKS-ORC-00008
EKS-ORL-00012
EKS-OTG-00009
EKS-PAT-00009
EKS-POA-00006
EKS-PRC-00003
EKS-RAN-00008
EKS-SAH-00007
EKS-SUS-00006
EKS-TEN-00011
EKS-TUT-00005
EKS-XIM-00010
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013