EKS-CAF-00252

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00252

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	360.0	7.0E-108	20	271	252

Status

Unreviewed

Ensembl Protein

ENSCAFP00000020936

UniProt Accession

E2RCU0;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000014202	ENSCAFP00000020936	ENSCAFT00000022548

Organism

Canis familiaris

Functional Description

Protein Length

918

Protein Sequence
(FASTA)

MVMADGPKHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60

LEKIYREVQI MKMLDHPHII KLYQVMETKN MLYLVTEYAK NGEIFDYLAN HGRLNESEAR 120

RKFWQILSAV DYCHGRKIVH RDLKAENLLL DSNMNIKLAD FGFGNFFKSG ELLATWCGSP 180

PYAAPEVFEG QQYEGPQLDI WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM 240

SEDCEHLIRR MLVLDPSKRL TIAQIKEHKW MLIEVPVQRP VLYPQGQENE PSIGEFNEQV 300

LRLMHSLGID QQKTIESLQN KSYNHFAAIY YLLVERLKSH RSSFPVEQRL DARQRRPSTV 360

AEQTVAKAQT VGLPVTMHSP NVRLMRSALL PQASNMEAFS FPASGCQAEA AFMEEECVDT 420

PKVNGCLLDP VPPVLVRKGC QSLPSNMMET SIDEGLETEG EAEEDPSQAF DAFQSTRSGQ 480

RRHTLSEVTN QLVVVPGSGK IFSMSDNPSL DSVDSEYDMG SVQRDLNFLE DNPSLKDIML 540

ANQPSPRMTS PFISLRPANP AMQALSSQKR EAHNRSPVSF REGRRASDTS LTQGIVAFRQ 600

HLQNLARTKG ILELNKVQLL YEQIGPEADP DLAPATPQLQ DLGGSCPQEE VQQQKTVPAV 660

PNSVRPQLSP RQSLEAQYLQ HRLQKPSLLS KAQNTCQLYC KEPPRSLEQQ LQEHRLQQKR 720

LFLQKQSQLQ AYFNQMQIAE SSYPPGQQLA LPRQEPPAPS SPPPPPFSLA PSLSPVLEPT 780

TAEQMQYSPF LGPFRELQLQ PLPPAPGPRA PPLPPPPPPP PPPQQAGATP APLPFSYQTC 840

ELSGAASPEP DYPPPCQYPM DGTQQGSLAT QDCPQRSSGL QEATSSYDPL TLSEFPGLFD 900

CEMLEAVDPQ HGGYVLVN 918

Nucleotide Sequence
(FASTA)

ATGGTCATGG CGGATGGCCC GAAGCACTTG CAGCGCGGGC CGGTCCGGGT GGGGTTCTAC 60

GACATCGAGG GCACGCTGGG CAAGGGTAAC TTCGCTGTGG TGAAGCTGGG GCGGCACCGG 120

ATCACCAAGA CGGAGGTGGC GATAAAAATA ATTGATAAAT CTCAGCTGGA TGCAGTGAAC 180

CTTGAGAAAA TCTACCGAGA AGTACAAATA ATGAAAATGT TAGACCACCC ACACATCATC 240

AAACTTTATC AGGTAATGGA GACCAAAAAT ATGTTGTACC TTGTGACAGA ATATGCCAAA 300

AATGGAGAAA TTTTTGACTA CCTTGCTAAC CATGGCCGGT TAAATGAGTC TGAGGCCAGG 360

CGCAAATTCT GGCAAATCCT GTCTGCTGTT GATTATTGTC ATGGTCGGAA GATTGTGCAC 420

CGTGATCTCA AGGCTGAAAA TCTCCTGCTG GATAGCAACA TGAACATCAA GCTAGCAGAT 480

TTCGGTTTTG GAAATTTCTT TAAAAGTGGT GAACTGCTGG CAACATGGTG TGGCAGCCCC 540

CCTTATGCAG CCCCAGAAGT CTTTGAAGGG CAGCAGTATG AAGGACCACA GCTGGATATT 600

TGGAGCATGG GAGTTGTTCT TTACGTCCTT GTCTGTGGAG CTCTGCCTTT TGATGGACCG 660

ACTCTTCCAA TTTTGAGGCA GAGAGTTTTA GAGGGAAGAT TCCGGATTCC GTATTTCATG 720

TCAGAAGATT GTGAGCACCT TATTCGAAGG ATGTTGGTCC TAGATCCGTC CAAACGGCTA 780

ACTATAGCTC AAATCAAGGA GCATAAATGG ATGCTCATAG AAGTTCCTGT ACAGAGACCT 840

GTTCTCTATC CACAAGGGCA AGAAAACGAG CCATCCATTG GGGAATTTAA TGAACAGGTT 900

CTGCGATTGA TGCACAGCCT TGGAATAGAT CAGCAAAAAA CCATTGAGTC TTTGCAGAAC 960

AAGAGCTATA ACCACTTTGC TGCCATTTAT TACTTGTTGG TGGAGCGCCT GAAATCACAT 1020

CGGAGCAGTT TTCCTGTGGA GCAGAGACTC GATGCCCGCC AGCGGCGGCC TAGCACCGTG 1080

GCTGAACAAA CAGTTGCCAA GGCTCAAACT GTGGGGCTCC CCGTGACCAT GCATTCACCG 1140

AACGTGCGGC TGATGCGATC TGCCCTCCTC CCACAGGCGT CCAATATGGA GGCCTTTTCA 1200

TTCCCGGCAT CCGGCTGCCA GGCAGAAGCA GCATTTATGG AAGAAGAGTG TGTCGACACA 1260

CCAAAGGTAA ATGGCTGTCT GCTGGACCCC GTGCCTCCTG TCCTAGTGAG GAAGGGGTGC 1320

CAGTCGTTGC CCAGCAACAT GATGGAGACC TCCATCGATG AGGGGCTGGA GACAGAGGGA 1380

GAGGCCGAGG AAGACCCCAG CCAGGCCTTT GATGCGTTCC AGTCCACACG CAGTGGGCAG 1440

AGACGGCACA CTCTGTCGGA AGTCACCAAC CAGCTAGTCG TGGTGCCTGG TTCAGGGAAA 1500

ATTTTCTCCA TGAGTGACAA CCCCTCCCTT GACAGTGTGG ACTCTGAGTA TGATATGGGG 1560

TCTGTTCAGA GGGACCTGAA CTTTCTGGAA GACAACCCTT CCCTGAAGGA CATCATGTTA 1620

GCCAACCAGC CCTCCCCACG CATGACATCT CCCTTCATCA GTCTGAGACC TGCCAACCCG 1680

GCCATGCAGG CTTTGAGCTC CCAGAAGCGA GAGGCCCACA ACAGGTCACC AGTGAGCTTC 1740

AGAGAGGGCC GCAGGGCGTC AGATACCTCC CTCACCCAAG GAATTGTGGC ATTTAGACAA 1800

CATCTTCAGA ATCTGGCTAG AACCAAAGGA ATCCTAGAGT TGAACAAAGT GCAGCTGCTC 1860

TACGAACAAA TAGGACCAGA GGCAGACCCT GACTTGGCCC CAGCCACTCC TCAACTCCAG 1920

GACCTTGGTG GCAGTTGTCC TCAGGAGGAA GTTCAGCAGC AGAAAACGGT CCCCGCTGTG 1980

CCCAACAGTG TGCGTCCTCA GCTTTCGCCA CGGCAGAGCC TTGAGGCCCA GTATCTCCAG 2040

CACAGACTCC AGAAGCCCAG CCTTCTGTCA AAAGCACAGA ACACCTGTCA GCTTTATTGT 2100

AAAGAACCAC CACGGAGCCT TGAGCAGCAA CTGCAGGAAC ACAGACTCCA ACAGAAGCGC 2160

CTCTTCCTGC AGAAGCAGTC TCAGCTGCAG GCGTACTTCA ATCAGATGCA GATCGCCGAG 2220

AGCTCATACC CGCCGGGCCA GCAGCTGGCC CTGCCCCGCC AGGAGCCGCC CGCACCATCT 2280

TCACCACCAC CCCCCCCTTT CAGCCTGGCC CCGTCCCTGA GCCCTGTCCT GGAGCCTACC 2340

ACCGCCGAGC AGATGCAGTA CAGCCCCTTC CTTGGCCCCT TCCGAGAGCT GCAGCTGCAG 2400

CCCCTGCCTC CGGCCCCTGG CCCCCGAGCC CCTCCACTGC CGCCACCGCC CCCACCACCG 2460

CCCCCTCCCC AGCAGGCAGG GGCCACCCCG GCACCCCTCC CGTTCTCCTA CCAGACTTGC 2520

GAGCTGTCCG GGGCAGCATC CCCTGAGCCA GACTACCCAC CTCCCTGCCA GTACCCAATG 2580

GACGGAACCC AACAGGGCAG CCTGGCCACA CAGGACTGTC CACAGCGGAG CTCAGGACTG 2640

CAGGAGGCCA CCTCCAGCTA TGACCCACTC ACCCTCTCCG AGTTCCCTGG ACTCTTTGAT 2700

TGTGAGATGC TGGAGGCTGT GGACCCACAG CATGGCGGCT ACGTCCTGGT GAATTAG 2757

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++  tlG+g+f+ Vkl +h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 20    YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI  79

         89999*******************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e+ear+ f q++sav+Y+h ++iv

Q: 80    IKLYQVMETKNMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nik+aDFG++n+fk+g+ll t+cGsppYaaPe+++g++Yegp++D

Q: 140   HRDLKAENLLLDSNMNIKLADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +s+++e+L+r++Lv dp+kR

Q: 200   IWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

         +ti +i++h+w+

Q: 260   LTIAQIKEHKWM  271

         ***********8

Domain Sequence
(FASTA)

YDIEGTLGKG NFAVVKLGRH RITKTEVAIK IIDKSQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK NMLYLVTEYA KNGEIFDYLA NHGRLNESEA RRKFWQILSA VDYCHGRKIV 120

HRDLKAENLL LDSNMNIKLA DFGFGNFFKS GELLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PTLPILRQRV LEGRFRIPYF MSEDCEHLIR RMLVLDPSKR 240

LTIAQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008286	; P:insulin receptor signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017090	; Ser/Thr_kinase_SIK1/2.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013