EKS-CAF-00324

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00324

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	333.2	1.3E-99	148	404	257

Status

Unreviewed

Ensembl Protein

ENSCAFP00000020961

UniProt Accession

F1PP76;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K2

Gene Synonyms/Alias

MAP4K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000014216	ENSCAFP00000020961	ENSCAFT00000022575

Organism

Canis familiaris

Functional Description

Protein Length

952

Protein Sequence
(FASTA)

MAGGTEGVGP LPPGRRASHL QGAGSGCLAE GPRSARLGSA RLGSAGPRGF PSPQRAGPAG 60

ASSRPGGGAS PPGPAPAASE PPSPAPAVLP RPAPPRPAPR RAAPRRPAPA PRLRGSRPPA 120

RPPSRPPARR RAMALLRDVS LQDPRDRFEL LQRVGAGTYG DVYKARDTVT SELAAVKIVK 180

LDPGDDISSL QQEITILREC RHPNVVAYIG SYLRNDRLWI CMEFCGGGSL QEIYHATGPL 240

EERQIAYVCR EALKGLHHLH SQGKIHRDIK GANLLLTLQG DVKLADFGVS GELTASVAKR 300

RSFIGTPYWM APEVAAVERK GGYNELCDVW ALGITAIELG ELQPPLFHLH PMRALMLMSK 360

SSFQPPRLRD KTRWTQNFHH FLKLALTKNP KKRPTAEKLL QHPFTTQHLP RALLTQLLDK 420

ANDPHLGTLS PEDCDLETYD IFPDTIHSRG QHGPAERTPS EIQFHQVKFG APRRKETDPL 480

NEPWEEEWTL LGKEELSGSL LQSVEEALEE RSLTIRPALE LQELDSPGDT IGTIKRTPFL 540

GPAPPEPPAE DPLSSPLGTS PPPLPGPANP PLLPTAWATM KHKEDPERSS CHGLPPTPKV 600

HMGACFSKVF NGCPLRIHAA VTWIHPVTRD QFLVVGAEEG IYTLNLHELH EDTLEKLISP 660

RCTWLYCVNN VLLSLSGKST HIWAHDLPGL FEQRRLQQQV PLSIPTNRLT QRIIPRRFAL 720

STKIPDTKGC LQCRVVRNPY TGSTFLLAAL PASLLLLQWY EPLQKFLLLK NFSSPLPSPA 780

GMLEPLVLDG KELPQVCVGA EGPEGPGCRV LFHILPLEAG LTPDVLIPPE GLPGTAHQVI 840

QVDRDTVLVC FDRCVRIVNL LGEPTAILAP LLTFDFPIET VVCLQDSVLA FWSHGMQGRS 900

LDTNEVTQEI TDETRIFRVL GAHRDIILES IPTDNPGAHS NLYILTGHQS SY 952

Nucleotide Sequence
(FASTA)

ATGGCGGGCG GGACGGAGGG GGTCGGCCCT CTGCCCCCCG GCCGTCGGGC TTCCCACCTG 60

CAGGGCGCGG GGAGCGGCTG TCTGGCTGAA GGGCCGCGCT CGGCTCGGCT CGGCTCGGCT 120

CGGCTCGGCT CCGCCGGGCC TCGGGGCTTC CCCTCCCCGC AGAGGGCCGG TCCCGCCGGC 180

GCCTCCTCCC GGCCGGGCGG CGGGGCATCT CCTCCCGGCC CCGCCCCCGC GGCCTCCGAG 240

CCACCCTCGC CGGCCCCCGC GGTCCTGCCC CGCCCCGCCC CGCCCCGCCC CGCGCCGCGC 300

CGCGCCGCGC CGCGCCGTCC CGCGCCGGCT CCGCGGCTCC GCGGCTCACG ACCGCCCGCC 360

CGCCCGCCCT CCCGCCCTCC CGCCCGGCGC CGGGCAATGG CGCTGCTGCG GGACGTGTCG 420

CTGCAGGACC CGCGGGACCG CTTCGAGCTG CTGCAGCGCG TGGGGGCCGG GACCTATGGC 480

GACGTCTACA AGGCCCGCGA CACGGTCACT TCCGAACTGG CCGCGGTCAA GATAGTCAAG 540

CTAGACCCAG GGGACGACAT CAGCTCCCTC CAGCAGGAAA TCACCATACT GCGTGAGTGC 600

CGTCACCCCA ATGTGGTGGC CTACATTGGC AGCTACCTCA GGAATGACCG CTTGTGGATC 660

TGCATGGAGT TCTGCGGAGG GGGGTCCCTG CAGGAGATTT ACCACGCCAC TGGGCCCCTG 720

GAGGAACGGC AGATCGCCTA TGTCTGCCGA GAGGCACTGA AGGGGCTGCA CCACTTGCAT 780

TCTCAGGGGA AGATCCACAG AGACATCAAG GGAGCCAATC TTCTCCTCAC TCTCCAGGGA 840

GATGTCAAGC TGGCTGACTT TGGGGTGTCA GGCGAGCTGA CGGCGTCCGT GGCTAAGAGG 900

AGGTCTTTCA TTGGGACTCC ATACTGGATG GCCCCAGAGG TGGCTGCTGT GGAGCGCAAA 960

GGAGGCTACA ATGAATTGTG TGACGTCTGG GCCCTGGGCA TCACCGCCAT CGAGCTGGGC 1020

GAGCTGCAGC CCCCTCTGTT CCATCTGCAC CCCATGAGGG CCCTGATGCT CATGTCGAAG 1080

AGTAGCTTCC AGCCGCCTAG GCTGAGAGAC AAGACTCGTT GGACCCAGAA TTTCCACCAT 1140

TTCCTCAAGC TAGCCTTGAC CAAGAACCCC AAGAAGAGGC CCACAGCAGA GAAGCTTCTG 1200

CAGCACCCGT TCACAACCCA GCACCTCCCT CGGGCTCTTC TCACACAGCT GTTGGACAAA 1260

GCCAATGACC CCCACCTGGG AACCCTCTCC CCAGAGGACT GTGACCTAGA GACTTACGAC 1320

ATATTTCCAG ACACCATTCA CTCCCGGGGT CAGCACGGCC CAGCCGAAAG GACCCCCTCG 1380

GAGATCCAGT TTCACCAGGT GAAATTTGGT GCCCCACGCA GGAAGGAAAC AGACCCACTA 1440

AATGAGCCGT GGGAGGAGGA GTGGACACTG CTGGGAAAGG AGGAGCTGAG TGGGAGCCTG 1500

CTACAGTCGG TTGAGGAGGC CCTAGAGGAA AGGAGCCTGA CCATCCGGCC AGCCTTGGAA 1560

CTCCAGGAGC TGGACTCCCC AGGCGACACC ATAGGAACCA TCAAGCGGAC CCCATTCTTG 1620

GGGCCGGCCC CCCCTGAGCC TCCAGCGGAA GACCCTTTAT CCAGCCCTCT GGGAACCTCA 1680

CCTCCACCTC TCCCAGGCCC TGCCAACCCC CCTCTGCTCC CCACTGCCTG GGCTACCATG 1740

AAGCACAAAG AGGATCCAGA GAGATCATCG TGCCACGGGC TCCCCCCAAC CCCCAAGGTG 1800

CACATGGGTG CCTGCTTCTC CAAGGTCTTC AATGGTTGCC CCCTGCGGAT CCATGCTGCT 1860

GTCACCTGGA TTCACCCTGT CACCCGGGAC CAGTTCCTGG TGGTGGGGGC CGAGGAAGGC 1920

ATCTACACCC TCAACCTGCA TGAACTGCAT GAGGATACAC TGGAGAAGCT GATTTCACCC 1980

CGCTGCACCT GGCTCTACTG TGTGAATAAC GTACTGCTGT CACTCTCAGG GAAATCCACG 2040

CACATCTGGG CCCATGACCT TCCAGGCCTG TTTGAGCAGC GAAGACTTCA GCAACAGGTT 2100

CCCCTCTCCA TCCCCACCAA CCGCCTCACG CAGCGCATCA TTCCCAGGCG CTTTGCCTTG 2160

TCCACCAAGA TTCCAGACAC CAAAGGCTGC CTGCAGTGTC GTGTGGTGCG GAACCCCTAC 2220

ACTGGCAGCA CCTTCCTACT GGCTGCCCTG CCTGCCAGCC TGCTCCTGCT ACAGTGGTAC 2280

GAGCCTCTCC AGAAGTTCCT GCTGCTGAAG AACTTCTCCA GCCCCTTGCC CAGCCCAGCA 2340

GGGATGCTGG AGCCACTGGT GCTGGATGGG AAGGAGTTAC CGCAGGTGTG TGTCGGGGCT 2400

GAGGGCCCCG AGGGGCCTGG CTGCCGAGTT CTCTTCCACA TCCTGCCCCT GGAGGCCGGT 2460

TTGACGCCTG ATGTCCTCAT ACCACCTGAG GGGCTCCCGG GCACAGCCCA CCAGGTGATC 2520

CAGGTGGACA GGGACACAGT CCTGGTCTGC TTTGACCGCT GCGTGAGGAT CGTCAACCTG 2580

CTGGGCGAGC CCACGGCCAT CCTAGCACCC CTGCTGACTT TTGACTTCCC CATCGAGACT 2640

GTGGTGTGTC TGCAAGACAG CGTGCTGGCC TTCTGGAGCC ATGGAATGCA AGGCCGTAGC 2700

CTGGACACCA ACGAGGTGAC CCAGGAGATC ACAGATGAGA CAAGGATCTT CCGAGTGCTT 2760

GGGGCCCACA GAGATATCAT CCTTGAGAGC ATTCCCACTG ACAACCCTGG GGCTCACAGC 2820

AACCTGTACA TTCTAACGGG CCACCAGAGC AGTTACTGA 2859

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +ell+++g G++g+vy+ar++ t+el+a+k+++l+  +++++lq+ei++l++++hpn+v+

Q: 148   FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVA  207

         899*********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l++++lw++me++ gGsl+++++   + +l+E+qiay++re+lk+L++lHs+++i

Q: 208   YIGSYLRNDRLWICMEFCGGGSLQEIYH--ATGPLEERQIAYVCREALKGLHHLHSQGKI  265

         ****************************..9*****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++n+Llt +g+VkL+dfgv+ +l+++++kr++++gtpywmAPEv a+e + gY+e

Q: 266   HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVErKGGYNE  325

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +D+w+lGItaiel e +pP+++l+p++al++++k++  pp+l++k++++++f++f++ +

Q: 326   LCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSfqPPRLRDKTRWTQNFHHFLKLA  385

         **********************************99988*********************

S: 238   lqknpekRpsasellkhkF  256

         l+knp+kRp+a++ll+h+F

Q: 386   LTKNPKKRPTAEKLLQHPF  404

         ******************9

Domain Sequence
(FASTA)

FELLQRVGAG TYGDVYKARD TVTSELAAVK IVKLDPGDDI SSLQQEITIL RECRHPNVVA 60

YIGSYLRNDR LWICMEFCGG GSLQEIYHAT GPLEERQIAY VCREALKGLH HLHSQGKIHR 120

DIKGANLLLT LQGDVKLADF GVSGELTASV AKRRSFIGTP YWMAPEVAAV ERKGGYNELC 180

DVWALGITAI ELGELQPPLF HLHPMRALML MSKSSFQPPR LRDKTRWTQN FHHFLKLALT 240

KNPKKRPTAE KLLQHPF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013