EKS-CAF-00321

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00321

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	345.0	3.4E-103	20	277	258

Status

Unreviewed

Ensembl Protein

ENSCAFP00000021311

UniProt Accession

E2RGP4;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K5

Gene Synonyms/Alias

MAP4K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000014383	ENSCAFP00000021311	ENSCAFT00000022944
ENSCAFG00000014383	ENSCAFP00000039561	ENSCAFT00000045392

Organism

Canis familiaris

Functional Description

Protein Length

846

Protein Sequence
(FASTA)

MEAPLRPAAD ILRRNPQQDY ELVQRVGSGT YGDVYKARNI HTGELAAVKI IKLEPGDDFS 60

LIQQEIFMVK ECKHCNIVAY FGSYLSREKL WICMEYCGGG SLQDIYHVTG PLSELQIAYV 120

CRETLQGLAY LHTKGKMHRD IKGANILLTD HGDVKLADFG VAAKITATIA KRKSFIGTPY 180

WMAPEVAAVE KNGGYNQLCD IWAVGITAIE LGELQPPMFD LHPMRALFLM SKSNFQPPKL 240

KDKTKWSSTF HNFVKIALTK NPKKRPTAER LLTHTFVGQP GLSRALAVEL LDKVNNPDNH 300

AHYTEGDDDD FEPHAIIRHT IRSTNRNARA ERTASEINFD KLQFEPPLRK ETEARDEMGV 360

SSDPNFVLQW NPFVDGANTG KSTSKRAIPP PLPPKPRINS YPEDNLLDEE KSSTVKRCPD 420

SENRAPQFLR RQSSPSCGPV AETSSIGNGD GISKLISENT EGSAQAPQLP RKKDKRDFPK 480

PAINGLPPTP KVLMGACFSK VFDGCPLKIN CATSWIHPDT KDQYIIFGTE DGIYTLNLNE 540

LHEATMEQLF PRKCTWLYVI NNTLMSLSEG KTFQLYSHNL IALFEQAKKP GLAAHIQTHR 600

FPDRILPRKF ALTTKIPDTK GCHKCCIVRN PYTGHKYLCG ALQSGIVLLQ WYEPMQKFML 660

IKHFDFPLPS PLNVFEMLVI PEQEYPMVCV AISKGTESNQ VVQFETINLN SASSWFTEIG 720

AGSQQLDSIH VTQLERDTVL VCLDKFVKIV NLQGKLKSSK KLASELSFDF RIESVVCLQD 780

SVLAFWKHGM QGKSFKSDEV TQEISDETRV FRLLGSDRVV VLESRPTENP TAHSNLYILA 840

GHENSY 846

Nucleotide Sequence
(FASTA)

ATGGAGGCCC CGCTGCGGCC TGCCGCGGAC ATCCTGAGGC GGAACCCGCA GCAGGACTAC 60

GAGCTCGTCC AGAGGGTCGG CAGTGGCACC TACGGGGACG TCTACAAGGC TAGAAATATT 120

CATACAGGAG AGTTGGCTGC AGTAAAAATT ATCAAATTGG AGCCTGGAGA TGATTTTTCT 180

TTGATTCAAC AAGAAATATT TATGGTTAAA GAATGTAAAC ATTGTAACAT CGTTGCCTAC 240

TTTGGGAGCT ATCTCAGTCG AGAAAAACTA TGGATTTGTA TGGAATACTG TGGTGGTGGA 300

TCACTTCAAG ATATTTACCA TGTTACTGGG CCATTATCAG AATTGCAAAT AGCCTATGTA 360

TGCAGAGAAA CTTTACAGGG TCTTGCCTAT TTGCATACTA AAGGCAAAAT GCATAGAGAT 420

ATCAAAGGTG CAAATATTTT ATTGACAGAT CATGGTGATG TAAAATTAGC TGACTTTGGC 480

GTGGCTGCAA AAATAACAGC TACCATTGCA AAGAGAAAAT CTTTCATTGG CACTCCCTAC 540

TGGATGGCCC CAGAAGTTGC AGCAGTAGAA AAAAATGGTG GCTACAACCA GCTCTGTGAT 600

ATCTGGGCAG TGGGAATAAC TGCGATTGAA CTTGGAGAAC TTCAACCGCC TATGTTTGAT 660

CTTCATCCAA TGAGGGCCCT CTTCTTAATG TCAAAAAGTA ATTTTCAGCC TCCAAAACTA 720

AAGGACAAAA CAAAATGGTC ATCAACATTC CATAATTTTG TCAAAATAGC ACTAACCAAA 780

AACCCCAAAA AAAGACCAAC TGCTGAAAGA CTTCTGACTC ATACATTTGT AGGGCAGCCA 840

GGTCTCTCTA GGGCCCTGGC AGTTGAGCTG TTGGACAAAG TGAATAATCC AGACAACCAT 900

GCACATTACA CTGAGGGAGA TGACGATGAC TTTGAGCCCC ATGCAATCAT TCGTCATACC 960

ATTAGATCTA CAAACAGGAA TGCCAGAGCT GAACGGACAG CTTCAGAAAT AAATTTTGAC 1020

AAATTACAGT TCGAACCTCC TCTGAGAAAA GAAACAGAAG CACGGGATGA AATGGGAGTG 1080

TCATCAGACC CAAACTTTGT ATTACAGTGG AATCCTTTTG TTGATGGTGC AAATACTGGC 1140

AAATCAACCT CAAAACGCGC AATACCACCT CCCTTACCTC CTAAGCCAAG GATAAACAGC 1200

TACCCTGAAG ACAACCTCCT AGATGAAGAA AAATCATCAA CTGTAAAACG TTGTCCTGAT 1260

TCAGAGAATA GAGCTCCCCA GTTTCTCCGA AGACAGAGTA GCCCAAGTTG TGGTCCTGTA 1320

GCTGAGACTT CCTCTATTGG AAATGGTGAT GGTATTTCAA AACTGATTAG TGAAAATACA 1380

GAAGGATCAG CACAAGCACC ACAGTTACCA CGGAAAAAGG ACAAACGAGA TTTCCCAAAA 1440

CCAGCCATCA ATGGCCTTCC ACCCACCCCA AAAGTGCTGA TGGGAGCATG TTTTTCCAAA 1500

GTTTTTGATG GCTGCCCTTT GAAAATTAAT TGTGCAACAT CCTGGATACA TCCTGATACA 1560

AAAGATCAGT ACATTATTTT TGGAACTGAA GATGGTATTT ACACACTGAA TCTCAATGAG 1620

CTACATGAGG CAACGATGGA ACAGTTATTT CCACGGAAAT GTACTTGGCT ATATGTTATC 1680

AATAATACTT TAATGTCATT ATCAGAAGGA AAAACCTTTC AGCTCTACTC TCATAATCTT 1740

ATAGCTTTGT TTGAACAAGC CAAAAAACCA GGATTGGCTG CCCATATTCA AACCCATAGG 1800

TTTCCAGACC GTATACTACC AAGAAAGTTT GCTTTAACAA CAAAGATTCC TGATACTAAA 1860

GGCTGCCACA AATGTTGTAT AGTCAGAAAC CCTTACACAG GACATAAATA CCTCTGTGGA 1920

GCTTTACAGT CTGGAATTGT TTTACTTCAA TGGTATGAGC CAATGCAGAA ATTCATGTTG 1980

ATAAAGCACT TTGATTTTCC TTTGCCAAGT CCTTTGAATG TTTTTGAAAT GCTGGTAATA 2040

CCAGAACAGG AATATCCTAT GGTCTGTGTA GCTATTAGCA AGGGCACCGA ATCAAATCAG 2100

GTTGTTCAGT TTGAGACAAT CAATTTGAAC TCTGCATCTT CATGGTTTAC AGAAATTGGT 2160

GCAGGCAGCC AACAGTTAGA TTCCATCCAC GTAACACAGT TGGAGAGAGA TACCGTTTTA 2220

GTGTGTTTAG ATAAATTTGT AAAAATTGTA AATCTACAAG GAAAACTAAA ATCAAGTAAG 2280

AAACTGGCCT CTGAGCTAAG TTTTGATTTT CGCATTGAAT CTGTAGTATG CCTTCAAGAT 2340

AGTGTTTTGG CTTTCTGGAA ACATGGAATG CAGGGTAAAA GCTTCAAATC AGATGAGGTT 2400

ACCCAGGAGA TCTCAGATGA AACAAGAGTG TTCCGCTTAT TGGGATCAGA CAGGGTTGTC 2460

GTTTTGGAAA GTAGGCCAAC AGAAAATCCT ACTGCACACA GCAATCTTTA CATCTTGGCT 2520

GGACATGAAA ATAGTTACTA A 2541

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         yel++++g+G++g+vy+ar+++tgel+a+k+i+le  ++ +++q+ei ++k++kh niv+

Q: 20    YELVQRVGSGTYGDVYKARNIHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVA  79

         99**********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l +e+lw++mey+ gGsl+d+++  ++ +l+E qiay++re+l++L+ylH+k+++

Q: 80    YFGSYLSREKLWICMEYCGGGSLQDIYH--VTGPLSELQIAYVCRETLQGLAYLHTKGKM  137

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgvaa++++t +krk+++gtpywmAPEv a+e + gY++

Q: 138   HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEkNGGYNQ  197

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +Diw++GItaiel e +pP++dl+p++al++++k++  ppklk+k+k+s++f++fv+ +

Q: 198   LCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFVKIA  257

         ********************************9999988*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h+F+

Q: 258   LTKNPKKRPTAERLLTHTFV  277

         *******************7

Domain Sequence
(FASTA)

YELVQRVGSG TYGDVYKARN IHTGELAAVK IIKLEPGDDF SLIQQEIFMV KECKHCNIVA 60

YFGSYLSREK LWICMEYCGG GSLQDIYHVT GPLSELQIAY VCRETLQGLA YLHTKGKMHR 120

DIKGANILLT DHGDVKLADF GVAAKITATI AKRKSFIGTP YWMAPEVAAV EKNGGYNQLC 180

DIWAVGITAI ELGELQPPMF DLHPMRALFL MSKSNFQPPK LKDKTKWSST FHNFVKIALT 240

KNPKKRPTAE RLLTHTFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

cfa:490685

;

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013