EKS-CAF-00248

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00248

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.7	2.6E-116	20	271	252

Status

Unreviewed

Ensembl Protein

ENSCAFP00000022179

UniProt Accession

F1PVU3;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000014976	ENSCAFP00000022179	ENSCAFT00000023891
ENSCAFG00000014976	ENSCAFP00000022164	ENSCAFT00000023875

Organism

Canis familiaris

Functional Description

Protein Length

611

Protein Sequence
(FASTA)

MLRGRNSAAS ADEQPHIGNY RLLKTIGKGN FAKVKLARHI LTGKEVAVKI IDKTQLNSSS 60

LQKLFREVRI MKVLNHPNIV KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR 120

AKFRQIVSAV QYCHQKFIVH RDLKAENLLL DADMNIKIAD FGFSNEFTFG NKLDTFCGSP 180

PYAAPELFQG KKYDGPEVDV WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM 240

STDCENLLKK FLILNPSKRG TLEQIMKDRW MNVGHEDDEL KPYVEPLPDY KDPRRTELMV 300

SMGYTREEIQ DSLVGQRYNE VMATYLLLGY KSSELEGDTI TLKPRPSADL TNSSAPSPSH 360

KVQRSVSANP KQRRFSDQAG PAIPTSNSYS KKTQSNNAEN KRPEEDRESG RKASSTAKVP 420

ASPLPGLERK KTTPTPSTNS VLSTSTNRSR NSPLLERASL GQASIQNGKD STAPQRVPVA 480

SPSAHNISSS GGAPDRTNFP RGVSSRSTFH AGQLRQVRDQ QNLPYGVTPA SPSGNSQGRR 540

GASGSIFSKF TSKFVRRNLN EPESKDRVER THTSRGGRWR QRQRKGRVSG GQTALTTLHV 600

EYEDHQLHGA Q 611

Nucleotide Sequence
(FASTA)

ATGCTGCGGG GCCGCAACTC AGCCGCCTCT GCTGACGAGC AGCCCCATAT CGGCAACTAC 60

CGACTCCTTA AGACCATCGG CAAGGGCAAC TTCGCCAAGG TGAAGCTGGC CCGGCACATC 120

CTGACTGGGA AAGAGGTAGC TGTGAAGATC ATTGACAAGA CTCAACTGAA CTCCTCCAGT 180

CTCCAGAAAC TATTCCGCGA AGTAAGAATA ATGAAGGTTT TGAATCATCC CAACATAGTT 240

AAGTTATTTG AAGTGATTGA GACTGAGAAA ACTCTATACC TTGTCATGGA GTATGCCAGT 300

GGAGGAGAGG TGTTTGACTA CCTGGTGGCT CATGGCAGGA TGAAAGAAAA AGAGGCTCGA 360

GCCAAATTCC GCCAGATAGT GTCTGCTGTG CAGTACTGCC ACCAGAAGTT CATTGTTCAT 420

AGAGACTTAA AGGCAGAAAA CCTGCTCTTG GATGCTGATA TGAACATCAA GATAGCAGAC 480

TTTGGCTTCA GCAACGAATT CACCTTTGGG AACAAGCTGG ATACCTTCTG TGGCAGTCCC 540

CCTTATGCTG CCCCAGAGCT CTTCCAGGGC AAAAAATATG ATGGACCTGA GGTAGATGTG 600

TGGAGCCTGG GAGTTATCCT GTATACACTG GTCAGTGGAT CCCTGCCTTT TGATGGACAG 660

AACCTCAAGG AGCTACGGGA GCGGGTCCTG AGGGGCAAAT ACCGCATTCC GTTCTACATG 720

TCCACGGACT GTGAAAACCT GCTTAAGAAA TTTCTCATTC TCAACCCCAG CAAGAGAGGC 780

ACTTTAGAGC AAATCATGAA AGATCGATGG ATGAATGTGG GTCATGAAGA TGATGAATTA 840

AAGCCTTATG TGGAGCCACT CCCTGACTAC AAGGACCCCC GGCGGACAGA ATTGATGGTC 900

TCCATGGGTT ACACACGGGA AGAGATCCAA GACTCACTGG TGGGCCAGAG GTACAACGAG 960

GTGATGGCTA CTTACCTGCT CCTGGGCTAC AAGAGCTCTG AGTTGGAAGG CGACACCATC 1020

ACCTTGAAGC CCCGGCCTTC AGCTGATCTG ACCAATAGCA GTGCCCCTTC CCCCTCCCAC 1080

AAGGTACAGC GTAGTGTCTC AGCCAACCCC AAGCAACGAC GCTTCAGTGA CCAGGCTGGT 1140

CCTGCCATTC CCACATCTAA TTCCTACTCT AAGAAGACGC AGAGTAACAA CGCAGAAAAT 1200

AAGCGGCCTG AGGAAGACCG GGAGTCAGGG CGGAAGGCCA GTAGCACAGC CAAAGTGCCT 1260

GCCAGCCCGC TGCCCGGCCT GGAGAGGAAG AAGACCACCC CTACCCCCTC CACGAACAGC 1320

GTCCTCTCCA CCAGCACAAA TCGAAGCAGG AATTCCCCAC TTTTGGAGAG GGCCAGCCTT 1380

GGCCAGGCCT CCATCCAGAA TGGCAAAGAC AGCACAGCCC CTCAACGCGT CCCTGTCGCC 1440

TCCCCCTCCG CCCACAACAT CAGCAGCAGC GGTGGAGCCC CCGACCGAAC TAATTTCCCC 1500

CGGGGTGTGT CCAGTCGAAG CACCTTCCAT GCTGGGCAGC TCCGGCAGGT GCGGGACCAG 1560

CAGAATTTGC CCTATGGTGT GACCCCAGCC TCTCCCTCTG GCAACAGCCA GGGCCGGCGG 1620

GGGGCCTCAG GGAGCATCTT CAGCAAATTT ACTTCCAAGT TTGTACGCAG GAACCTGAAT 1680

GAACCTGAAA GCAAAGACCG AGTGGAGAGG ACTCATACCT CACGTGGTGG GCGGTGGAGG 1740

CAACGACAAA GAAAAGGAAG AGTTTCGGGA GGCCAAACCG CGCTCACTAC GCTTCACGTG 1800

GAGTATGAAG ACCACCAGCT CCATGGAGCC CAATGA 1836

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 20    YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI  79

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 80    VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 140   HRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 200   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 260   GTLEQIMKDRWM  271

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKVLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKFIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTF GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240

GTLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013