EKS-CAF-00155

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00155

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	557.0	6.8E-168	314	590	277

Status

Unreviewed

Ensembl Protein

ENSCAFP00000022066

UniProt Accession

F1P9Z7;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000014993	ENSCAFP00000022066	ENSCAFT00000023773
ENSCAFG00000014993	ENSCAFP00000024312	ENSCAFT00000026184

Organism

Canis familiaris

Functional Description

Protein Length

648

Protein Sequence
(FASTA)

MDKKLLAVPA ANTVRFRCPA AGNPTPSISW LKNGKEFRGE HRIGGIKLRH QQWSLVMESV 60

VPSDRGNYTC VVENKFGSIR QTYTLDVLER SPHRPILQAG LPANQTAVLG SDVEFHCKVY 120

SDAQPHIQWL KHVEVNGSKV GPDGTPYVTV LKTAGANTTD KELEVLSLRN VTFEDAGEYT 180

CLAGNSIGFS HHSAWLVVLP AEEELVEAGE AGSVYAGVLS YGVGFLLFIL VVAAVTLCRL 240

RTPPKKGLGS PTVHKVSRFP LKRQVSLESN SSMNSNTPLV RIARLSSGEG PALANVSELE 300

LPADPKWELS RARLTLGKPL GEGCFGQVVM AEAIGIDKDR AAKPVTVAVK MLKDDATDKD 360

LSDLVSEMEM MKMIGRHKNI INLLGACTQG GPLYVLVEYA AKGNLREYLR ARRPPGMDYS 420

FDTCKLPEEQ LTCKDLVSCA YQVARGMEYL ASQKCIHRDL AARNVLVTED NVMKIADFGL 480

ARDVHNLDYY KKTTNGRLPV KWMAPEALFD RVYTHQSDVW SFGVLLWEIF TLGGSPYPGI 540

PVEELFKLLK EGHRMDKPAN CTHDLYMIMR ECWHAVPSQR PTFKQLVEDL DRILTVTSTD 600

EYLDLSVPFE QYSPGGQDTP SSSSSGDDSV FAHDLLPPAP PGGGGPRT 648

Nucleotide Sequence
(FASTA)

ATGGACAAGA AGCTGCTGGC TGTGCCGGCC GCCAACACTG TGCGCTTCCG CTGCCCGGCC 60

GCTGGCAACC CCACGCCGTC CATCTCGTGG CTGAAGAACG GCAAGGAGTT CCGAGGCGAG 120

CATCGCATTG GTGGCATCAA GCTGCGACAT CAGCAGTGGA GCCTGGTCAT GGAGAGCGTG 180

GTGCCCTCGG ACCGTGGGAA CTACACATGC GTTGTGGAGA ACAAGTTTGG CAGCATCCGG 240

CAGACGTACA CTCTGGACGT GCTGGAGCGC TCCCCGCACC GGCCCATCCT GCAGGCCGGG 300

CTGCCGGCCA ACCAGACGGC CGTGCTGGGC AGTGATGTGG AGTTCCACTG CAAGGTGTAC 360

AGCGACGCCC AGCCCCACAT CCAGTGGCTC AAGCATGTGG AGGTGAACGG CAGCAAAGTG 420

GGGCCCGACG GTACGCCCTA CGTCACTGTG CTCAAGACGG CGGGCGCTAA CACCACCGAC 480

AAGGAGCTAG AGGTTCTGTC CTTACGCAAT GTCACCTTTG AGGACGCGGG GGAGTACACG 540

TGTCTGGCGG GCAATTCTAT CGGGTTTTCC CATCACTCTG CGTGGCTGGT GGTGCTGCCA 600

GCCGAGGAGG AGCTGGTGGA GGCTGGTGAG GCTGGCAGCG TGTACGCAGG TGTCCTCAGC 660

TACGGGGTGG GCTTCCTCCT CTTCATCCTG GTGGTGGCAG CTGTGACACT GTGCCGTCTG 720

CGCACTCCCC CGAAGAAGGG CCTGGGCTCG CCTACCGTGC ACAAGGTCTC CCGCTTTCCA 780

CTCAAGCGAC AGGTGTCCTT GGAGTCCAAC TCGTCCATGA ACTCTAACAC GCCACTGGTG 840

CGTATCGCCC GGCTGTCTTC TGGGGAGGGC CCTGCACTGG CCAACGTCTC TGAGCTGGAG 900

CTGCCTGCTG ACCCCAAGTG GGAGCTGTCC AGGGCCCGGC TGACCCTAGG CAAGCCTCTT 960

GGGGAAGGCT GCTTTGGCCA GGTGGTCATG GCAGAGGCCA TCGGTATTGA CAAGGACCGG 1020

GCTGCCAAGC CTGTCACTGT GGCTGTGAAG ATGCTAAAAG ATGATGCCAC GGACAAGGAC 1080

CTCTCAGACC TGGTGTCTGA GATGGAGATG ATGAAGATGA TCGGCAGGCA CAAGAACATC 1140

ATCAATCTTC TGGGAGCCTG CACCCAGGGT GGACCCCTGT ACGTGCTGGT GGAGTATGCA 1200

GCCAAGGGCA ACCTGCGGGA ATACCTGCGG GCAAGGAGGC CCCCGGGCAT GGACTACTCC 1260

TTCGACACCT GCAAGCTGCC TGAGGAGCAG CTCACCTGCA AGGACCTGGT GTCCTGTGCC 1320

TATCAGGTGG CACGGGGCAT GGAGTACCTG GCTTCCCAGA AGTGCATCCA CAGGGACCTG 1380

GCAGCCCGTA ACGTGCTGGT GACCGAGGAC AATGTGATGA AGATTGCAGA CTTCGGCCTG 1440

GCTCGGGACG TGCACAACCT CGACTATTAC AAGAAGACCA CCAACGGCCG GCTGCCTGTG 1500

AAGTGGATGG CACCCGAGGC CCTGTTTGAC CGAGTCTACA CCCACCAGAG TGATGTCTGG 1560

TCCTTTGGGG TGCTGCTCTG GGAGATCTTT ACCCTGGGGG GCTCCCCATA CCCTGGCATC 1620

CCAGTGGAGG AGCTCTTCAA GCTGCTGAAG GAGGGCCACC GCATGGACAA GCCAGCCAAC 1680

TGCACACACG ACCTGTACAT GATCATGCGG GAGTGCTGGC ATGCCGTGCC TTCCCAGAGG 1740

CCCACGTTCA AGCAGCTAGT GGAGGATCTG GACCGCATCC TCACTGTGAC GTCCACTGAT 1800

GAGTATCTGG ACCTGTCGGT GCCTTTTGAG CAGTACTCAC CAGGCGGCCA GGACACTCCC 1860

AGCTCCAGCT CCTCGGGGGA TGATTCCGTG TTTGCCCATG ACCTGCTGCC TCCAGCCCCA 1920

CCCGGCGGTG GGGGTCCTCG GACGTGA 1947

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aeaig+dkd+++k vtvavkmlk+datdkdl+dlvseme++k+

Q: 314   LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  373

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iG+hkniinllGactq+Gplyv+veyaakGnlre+lrarrp+g+++s d++k +eeqlt+

Q: 374   IGRHKNIINLLGACTQGGPLYVLVEYAAKGNLREYLRARRPPGMDYSFDTCKLPEEQLTC  433

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++dyykkt

Q: 434   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT  493

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh

Q: 494   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  553

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl

Q: 554   RMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDL  590

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA IGIDKDRAAK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60

IGRHKNIINL LGACTQGGPL YVLVEYAAKG NLREYLRARR PPGMDYSFDT CKLPEEQLTC 120

KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNLDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTH DLYMIMRECW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013