EKS-CAF-00061

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00061

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	387.8	3.4E-116	239	520	282

Status

Unreviewed

Ensembl Protein

ENSCAFP00000022118

UniProt Accession

E2RDF8;

Protein Name

Protein Synonyms/Alias

Gene Name

CFA.8047

Gene Synonyms/Alias

CFA.8047;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000015003	ENSCAFP00000022118	ENSCAFT00000023826

Organism

Canis familiaris

Functional Description

Protein Length

570

Protein Sequence
(FASTA)

MPFYGHARGR IGGPSVLGEP LAPSTAGSII AAAPEKACCG GLCSHSEAAP IEANTSPVGP 60

LPSASHPSLN TQVAMDRMKK IKRQLSMTLR GGRSADKTNG APEQIGLDES GGGGGTDLGE 120

VPTRAAPGEP RSGRGPLSSA PEIVHEDLKM GSDGESDQAS ATSSDEVQSP VRVRMRNHPP 180

RKISTEDINK RLSLPADIRL PEGYLEKLTL NSPIFDKPLS RRLRRVSLSE IGFGKLETYI 240

KLDKLGEGTY ATVYKGKSKL TDNLVALKEI RLEHEEGAPC TAIREVSLLK DLKHANIVTL 300

HDIIHTEKSL TLVFEYLDKD LKQYLDDCGN VINMHNVKLF LFQLLRGLAY CHRQKVLHRD 360

LKPQNLLINE RGELKLADFG LARAKSIPTK TYSNEVVTLW YRPPDILLGS TDYSTQIDMW 420

GVGCIFYEMA TGRPLFPGST VEEQLHFIFR ILGTPTEETW PGILSNEEFK TYNYPKYRAE 480

ALLSHAPRLD SDGADLLTKL LQFEGRNRIS AEDAMKHPFF LSLGERIHKL PDTTSIFALK 540

EIQLQKEASL RSSSMPDSGR PAFRVVDTEF 570

Nucleotide Sequence
(FASTA)

ATGCCATTCT ATGGGCATGC CCGGGGCCGT ATTGGTGGCC CTTCGGTCCT GGGCGAGCCT 60

CTCGCCCCAT CCACAGCTGG GTCCATCATT GCCGCTGCAC CTGAGAAGGC CTGCTGTGGA 120

GGCCTCTGCT CCCACAGTGA GGCTGCCCCC ATAGAGGCCA ACACTTCACC GGTTGGGCCC 180

TTACCCTCAG CCAGCCACCC AAGCCTCAAT ACCCAGGTCG CCATGGATCG GATGAAGAAG 240

ATCAAGCGGC AGCTGTCGAT GACACTCCGA GGGGGCCGAA GTGCGGACAA GACCAATGGT 300

GCCCCTGAAC AGATAGGCCT GGATGAAAGT GGGGGTGGCG GTGGCACTGA CCTTGGAGAG 360

GTACCCACTC GTGCCGCTCC TGGGGAACCT CGCTCTGGAC GGGGCCCACT CAGCTCTGCA 420

CCAGAGATTG TACATGAGGA CTTGAAGATG GGGTCTGATG GGGAAAGTGA CCAGGCTTCA 480

GCCACGTCCT CGGATGAGGT GCAGTCGCCA GTGAGGGTGC GCATGCGCAA CCATCCCCCA 540

CGCAAGATCT CCACTGAGGA CATCAACAAG CGCCTGTCAC TACCAGCCGA CATCCGGCTG 600

CCTGAGGGCT ACCTTGAGAA GCTGACCCTC AATAGCCCCA TCTTCGACAA GCCCCTTAGC 660

CGCCGCCTCC GCCGCGTCAG CCTATCTGAG ATTGGCTTTG GGAAACTGGA GACCTACATC 720

AAGCTGGACA AGCTGGGCGA GGGTACCTAT GCCACCGTCT ACAAAGGCAA AAGCAAGCTC 780

ACAGACAACC TTGTAGCACT CAAGGAGATC AGACTGGAAC ACGAAGAGGG GGCACCCTGC 840

ACCGCCATCC GGGAAGTGTC CCTGCTCAAG GACCTCAAAC ACGCCAACAT CGTCACACTA 900

CATGACATCA TCCACACGGA GAAGTCCCTC ACCCTTGTCT TTGAGTACCT GGACAAGGAC 960

CTGAAGCAGT ACCTGGATGA CTGTGGGAAC GTCATCAACA TGCACAACGT GAAACTGTTC 1020

CTGTTCCAGC TGCTCCGTGG CCTGGCCTAC TGCCACCGGC AGAAGGTGCT ACACCGAGAC 1080

CTCAAGCCCC AAAACCTGCT TATCAATGAG AGAGGAGAGC TGAAGCTGGC GGATTTCGGC 1140

CTGGCCCGAG CTAAGTCAAT TCCAACGAAG ACCTACTCCA ACGAGGTGGT GACACTGTGG 1200

TACCGGCCCC CCGACATCCT GCTTGGCTCC ACAGACTACT CTACCCAGAT TGACATGTGG 1260

GGTGTGGGCT GCATCTTCTA TGAGATGGCC ACGGGCCGGC CCCTCTTCCC AGGCTCCACA 1320

GTGGAGGAAC AGCTGCACTT CATCTTCCGC ATCTTGGGAA CCCCAACTGA AGAGACGTGG 1380

CCAGGCATTC TGTCCAACGA AGAGTTCAAG ACATACAACT ACCCCAAGTA TCGAGCCGAG 1440

GCCCTTTTGA GCCATGCACC CCGACTTGAC AGTGATGGGG CTGACCTCCT TACCAAGCTG 1500

CTGCAGTTTG AAGGTCGCAA TCGGATCTCC GCGGAGGATG CCATGAAACA TCCATTCTTC 1560

CTCAGTCTGG GGGAGCGGAT CCACAAACTT CCTGACACTA CTTCCATATT TGCACTAAAG 1620

GAGATCCAGC TACAAAAGGA GGCCAGCCTT CGGTCTTCGT CAATGCCTGA CTCGGGCAGG 1680

CCAGCTTTCC GCGTGGTGGA CACCGAGTTC TAA 1713

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++vyk+k+k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 239   YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANI  297

         7799********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++k+l+Lvfe+l++dLk++l+++ +  +++++vk +l+qll+glay+H++k

Q: 298   VTLHDIIH-TEKSLTLVFEYLDKDLKQYLDDCGN-VINMHNVKLFLFQLLRGLAYCHRQK  355

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g+lklaDfGlara s p+kty++evvTlwYr+P++Llg+++Yst

Q: 356   VLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYST  415

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

         ++D+W+vgci+ e++t +plf+g++  +ql+ if++lgtp+e++wp++ + +e+k +++p

Q: 416   QIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKtYNYP  475

         *******************************************************88***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k++++ l ++ ++l++++ dll+kll+++ ++Risa++a++h++f

Q: 476   KYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF  520

         *******************************************98

Domain Sequence
(FASTA)

YIKLDKLGEG TYATVYKGKS KLTDNLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV 60

TLHDIIHTEK SLTLVFEYLD KDLKQYLDDC GNVINMHNVK LFLFQLLRGL AYCHRQKVLH 120

RDLKPQNLLI NERGELKLAD FGLARAKSIP TKTYSNEVVT LWYRPPDILL GSTDYSTQID 180

MWGVGCIFYE MATGRPLFPG STVEEQLHFI FRILGTPTEE TWPGILSNEE FKTYNYPKYR 240

AEALLSHAPR LDSDGADLLT KLLQFEGRNR ISAEDAMKHP FF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

cfa:480897

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013