EKS-CAF-00221

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00221

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NKF2	549.1	4.4E-165	1	336	336

Status

Unreviewed

Ensembl Protein

ENSCAFP00000022173

UniProt Accession

E2RCD1;

Protein Name

Protein Synonyms/Alias

Gene Name

PINK1

Gene Synonyms/Alias

PINK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000015045	ENSCAFP00000022173	ENSCAFT00000023885

Organism

Canis familiaris

Functional Description

Protein Length

405

Protein Sequence
(FASTA)

MPVLPQNREV VKSIRPLPGR GPDVDAREEE PASQAPTFPL AIKMMWNISA GSSSEAIFST 60

MSQELVPASR VALAGEYGAV TYRKSKGGPK QLAPHPNIIR VFRAFTSSVP LLPGALVDYP 120

DVLPPRLHPE GLGHGRTLFL VMKNYPCTLR QYLRENTPSP RLATVMILQL LEAVDHLVQQ 180

GVAHRDLKSD NILVELDADG CPWLVIADFG CCLADERTGL QLPFTSWYVD RGGNGCLMAP 240

EVSTACPGPR AVIDYSKADA WAVGTLAYEI FGLPNPFYGQ GRAHLESRSY QEAQLPAMPE 300

SVPLDARQLV RSLLQREASK RPSARVAANV LHLSLWGEHT LALKNLKLDK MIGWLLQQSA 360

ATLLADRLTE KSCVETKMKM LFLANLEYEA LCQAALLLYS WRAAP 405

Nucleotide Sequence
(FASTA)

ATGCCTGTGT TGCCCCAGAA CCGGGAGGTG GTGAAGAGCA TCAGACCTCT TCCAGGCCGA 60

GGCCCAGATG TCGATGCACG AGAAGAGGAG CCAGCTTCAC AGGCCCCTAC CTTTCCCTTA 120

GCCATCAAGA TGATGTGGAA TATCTCGGCG GGCTCCTCCA GTGAAGCCAT CTTTAGCACA 180

ATGAGCCAGG AACTCGTCCC AGCTAGTCGA GTGGCCTTGG CTGGGGAGTA CGGAGCGGTC 240

ACTTACAGAA AATCCAAGGG TGGTCCCAAG CAGCTGGCCC CTCACCCCAA CATCATCCGG 300

GTCTTTCGTG CCTTCACCTC TTCTGTACCA CTGCTGCCAG GAGCCCTGGT TGACTACCCT 360

GATGTGCTGC CCCCACGTCT TCACCCCGAA GGCCTGGGCC ACGGGCGGAC GCTCTTCCTC 420

GTTATGAAGA ACTACCCCTG TACGCTGCGC CAGTACCTCC GCGAGAACAC CCCAAGTCCC 480

CGCCTCGCCA CCGTGATGAT CTTACAGCTG CTGGAGGCAG TGGATCATCT GGTTCAACAG 540

GGCGTCGCGC ACAGAGACTT AAAATCTGAC AACATTCTCG TGGAGTTGGA TGCAGATGGC 600

TGCCCCTGGC TGGTGATCGC AGACTTTGGC TGCTGCCTGG CTGACGAGCG CACCGGCCTG 660

CAGCTGCCTT TCACCAGCTG GTATGTGGAT CGGGGCGGAA ACGGCTGCCT GATGGCTCCA 720

GAGGTGTCTA CTGCCTGCCC AGGCCCCAGG GCAGTGATCG ACTACAGTAA GGCTGATGCC 780

TGGGCCGTGG GTACGCTTGC CTATGAAATC TTCGGGCTCC CCAATCCCTT TTATGGCCAG 840

GGCAGGGCCC ACCTTGAAAG CCGCAGTTAC CAGGAGGCTC AGCTGCCCGC GATGCCCGAG 900

TCAGTCCCTC TGGATGCAAG ACAGCTGGTG AGGTCACTGC TCCAGCGAGA GGCCAGCAAG 960

AGACCATCTG CCCGAGTAGC TGCTAATGTG CTTCATTTAA GCCTCTGGGG TGAACATACT 1020

CTCGCCCTGA AGAATCTAAA ACTAGACAAG ATGATTGGCT GGCTCCTCCA GCAGTCAGCT 1080

GCCACTCTGC TGGCTGACCG GCTCACGGAG AAGAGCTGCG TGGAAACCAA GATGAAGATG 1140

TTATTTCTAG CCAACCTGGA GTACGAAGCG CTGTGCCAGG CAGCCCTGCT CCTCTACTCC 1200

TGGAGAGCAG CCCCGTGA 1218

Domain Profile

S: 20    latldqelekakhlgll.gkevtvvlaeidqesavaakkfplaiklmfnieadssseall  78

         ++ l+q+ e+ k++  l g++++v ++e+++   + a++fplaik+m+ni+a+sssea++

Q: 1     MPVLPQNREVVKSIRPLpGRGPDVDAREEEPA--SQAPTFPLAIKMMWNISAGSSSEAIF  58

         78899*****99998666*****999887765..5689**********************

S: 79    ksmsqelvpasrvaldgeygav........pkllakhPnivrvlrafidsvkllPdalld  130

         ++msqelvpasrval+geygav        pk+la+hPni+rv+raf++sv+llP+al+d

Q: 59    STMSQELVPASRVALAGEYGAVtyrkskggPKQLAPHPNIIRVFRAFTSSVPLLPGALVD  118

         ************************************************************

S: 131   yPdalparlypeglgegktlylvmkrydqtlreylesqdrstrlaalllaqlleavdhlv  190

         yPd+lp+rl+peglg+g+tl+lvmk+y++tlr+yl ++++s+rla+++++qlleavdhlv

Q: 119   YPDVLPPRLHPEGLGHGRTLFLVMKNYPCTLRQYLRENTPSPRLATVMILQLLEAVDHLV  178

         ************************************************************

S: 191   khgvahrdlksdnilveldddeiPvlviadfGCcladkvdglrlpyessevdkGGnaalm  250

         ++gvahrdlksdnilveld d++P+lviadfGCclad+ +gl+lp++s++vd+GGn++lm

Q: 179   QQGVAHRDLKSDNILVELDADGCPWLVIADFGCCLADERTGLQLPFTSWYVDRGGNGCLM  238

         ************************************************************

S: 251   aPeistavpGpsavinyekadtWavGalayeifglsnPfygegkaslesasyqeaqlPal  310

         aPe+sta pGp+avi+y+kad+WavG+layeifgl nPfyg+g+a+les+syqeaqlPa+

Q: 239   APEVSTACPGPRAVIDYSKADAWAVGTLAYEIFGLPNPFYGQGRAHLESRSYQEAQLPAM  298

         ************************************************************

S: 311   pesvppelrqlvydllkreaskrvsadiaanvlqlslf  348

         pesvp ++rqlv++ll+reaskr+sa++aanvl+lsl+

Q: 299   PESVPLDARQLVRSLLQREASKRPSARVAANVLHLSLW  336

         *************************************9

Domain Sequence
(FASTA)

MPVLPQNREV VKSIRPLPGR GPDVDAREEE PASQAPTFPL AIKMMWNISA GSSSEAIFST 60

MSQELVPASR VALAGEYGAV TYRKSKGGPK QLAPHPNIIR VFRAFTSSVP LLPGALVDYP 120

DVLPPRLHPE GLGHGRTLFL VMKNYPCTLR QYLRENTPSP RLATVMILQL LEAVDHLVQQ 180

GVAHRDLKSD NILVELDADG CPWLVIADFG CCLADERTGL QLPFTSWYVD RGGNGCLMAP 240

EVSTACPGPR AVIDYSKADA WAVGTLAYEI FGLPNPFYGQ GRAHLESRSY QEAQLPAMPE 300

SVPLDARQLV RSLLQREASK RPSARVAANV LHLSLW 336

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0010857	; F:calcium-dependent protein kinase activity
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0000422	; P:mitochondrion degradation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0033603	; P:positive regulation of dopamine secretion
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200	; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226	; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254	; P:regulation of protein complex assembly
GO:0031396	; P:regulation of protein ubiquitination
GO:0006950	; P:response to stress

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013