EKS-CAF-00460

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00460

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	431.5	1.6E-129	25	313	289

Status

Unreviewed

Ensembl Protein

ENSCAFP00000030998

UniProt Accession

E2R2N2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK1

Gene Synonyms/Alias

MAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000015421	ENSCAFP00000030998	ENSCAFT00000035708

Organism

Canis familiaris

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE 60

HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH 120

LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH 180

TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI 240

LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK 300

RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS 360

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CGGCGGCGGC GGGCGCGGGC CCGGAGATGG TCCGCGGGCA GGTGTTCGAC 60

GTGGGGCCGC GCTACACCAA CCTCTCCTAC ATCGGCGAGG GCGCCTACGG CATGGTGTGC 120

TCTGCTTATG ATAATGTCAA CAAAGTTCGA GTAGCCATCA AGAAAATCAG TCCTTTTGAG 180

CACCAGACCT ACTGCCAGAG AACCCTGAGG GAGATAAAAA TCTTACTGCG CTTCAGACAT 240

GAGAACATCA TTGGAATCAA TGATATTATT CGAGCACCAA CCATCGAGCA AATGAAAGAT 300

GTATATATAG TACAAGACCT CATGGAAACA GATCTTTACA AGCTCTTGAA GACGCAACAC 360

CTCAGCAACG ACCATATCTG CTATTTTCTT TACCAGATCC TCAGAGGGTT AAAATATATC 420

CATTCAGCTA ATGTACTGCA CCGTGACCTC AAACCTTCCA ACCTGCTGCT CAATACCACC 480

TGCGATCTCA AGATCTGTGA CTTTGGCTTG GCCCGTGTTG CAGATCCGGA TCATGATCAC 540

ACAGGGTTCC TGACGGAGTA TGTAGCCACA CGTTGGTACA GGGCTCCAGA AATTATGTTG 600

AATTCCAAGG GCTATACCAA GTCCATTGAT ATTTGGTCTG TAGGCTGCAT TCTGGCAGAG 660

ATGCTGTCCA ACAGGCCCAT CTTCCCGGGG AAGCATTATC TCGACCAGCT GAACCACATT 720

TTGGGTATTC TTGGATCCCC ATCACAGGAA GACCTGAACT GTATAATAAA TTTAAAAGCT 780

AGAAACTACT TGCTTTCTCT TCCACACAAA AATAAGGTGC CATGGAACAG GCTGTTCCCA 840

AATGCTGACT CGAAAGCTCT GGATTTACTG GACAAAATGT TGACATTCAA CCCTCACAAG 900

AGGATTGAAG TAGAACAGGC TCTGGCCCAT CCGTATCTGG AGCAGTATTA TGACCCAAGT 960

GATGAGCCCA TCGCTGAGGC GCCATTCAAG TTTGACATGG AGCTAGATGA CCTGCCCAAG 1020

GAAAAGCTCA AGGAGCTCAT CTTCGAAGAG ACAGCTAGAT TCCAGCCGGG ATACAGATCT 1080

TAA 1083

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+++geGayg+v+sa+d+ ++ rvaikk+s pf+++t ++rtlRE+k+l +++heNi

Q: 25    YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENI  83

         78999***************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++ + +e++kdvY+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hs

Q: 84    IGINDIIRAPT-IEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS  142

         ********999.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad++++++  lteyvatrwYraPei+l++

Q: 143   ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgfLTEYVATRWYRAPEIMLNS  202

         ***********************************999999*******************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arn

Q: 203   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARN  262

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y+ slp+k+k ++++lfp+a+++aldLl+k+L+++p+kRi+ve+aL+hpYl

Q: 263   YLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL  313

         **************************************************7

Domain Sequence
(FASTA)

YTNLSYIGEG AYGMVCSAYD NVNKVRVAIK KISPFEHQTY CQRTLREIKI LLRFRHENII 60

GINDIIRAPT IEQMKDVYIV QDLMETDLYK LLKTQHLSND HICYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLLNTTCDLK ICDFGLARVA DPDHDHTGFL TEYVATRWYR APEIMLNSKG 180

YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQEDLNC IINLKARNYL 240

LSLPHKNKVP WNRLFPNADS KALDLLDKML TFNPHKRIEV EQALAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0031143	; C:pseudopodium
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0050853	; P:B cell receptor signaling pathway
GO:0019858	; P:cytosine metabolic process
GO:0070371	; P:ERK1 and ERK2 cascade
GO:0060716	; P:labyrinthine layer blood vessel development
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0033598	; P:mammary gland epithelial cell proliferation
GO:0045596	; P:negative regulation of cell differentiation
GO:0009887	; P:organ morphogenesis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0010800	; P:positive regulation of peptidyl-threonine phosphorylation
GO:0006974	; P:response to DNA damage stimulus
GO:0043330	; P:response to exogenous dsRNA
GO:0050852	; P:T cell receptor signaling pathway

KEGG

cfa:477575

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013