EPS-CAF-00034

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAF-00034

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	196.3	9.3E-58	52	306	255

Status

Unreviewed

Ensembl Protein

ENSCAFP00000036339

UniProt Accession

E2R912;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1F

Gene Synonyms/Alias

PPM1F;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000015440	ENSCAFP00000036339	ENSCAFT00000049586
ENSCAFG00000015440	ENSCAFP00000022735	ENSCAFT00000024489

Organism

Canis familiaris

Functional Description

Protein Length

340

Protein Sequence
(FASTA)

GACAGLCPLS RPSVLDAKGL ARSCFNQLWE VCSQWQKQVP STAQVPQRQW LVSMHAIRNT 60

RRKMEDRHVC LPAFNQLFGL SDPVDRAYFA VFDGHGGVDA AQYAAVHVHT NLARQPELLT 120

DPAGALREAF RHTDEMFLWK AKRERLQSGT TGVCALIVGK TLHIAWLGDS QVILVQQGQV 180

VKLMEPHRPE RQDEKERIEA LGGFVSHMDC WRVNGTLAVS RAIGDVFQKP YVSGEADSAS 240

RELTGSEDYL LLACDGFFDV VPHQEVAGLV HSHLARQQGS GLQVAEELVA AARERGSHDN 300

ITVMVVFLRD PRDLLKGGAQ GTGDVPSGLS QPETSTPQSS 340

Nucleotide Sequence
(FASTA)

GGGGCCTGTG CCGGCCTATG TCCTCTCTCA CGCCCATCAG TGCTGGATGC CAAGGGCCTG 60

GCACGAAGCT GCTTTAACCA GCTCTGGGAA GTATGCAGCC AGTGGCAGAA GCAGGTGCCC 120

TCAACTGCCC AGGTTCCTCA GCGGCAGTGG CTGGTCTCCA TGCATGCCAT CCGGAATACA 180

CGCCGCAAGA TGGAGGACCG GCATGTGTGC CTTCCCGCCT TCAATCAGCT CTTCGGCCTG 240

TCGGACCCCG TGGACCGAGC CTACTTTGCC GTGTTCGATG GTCACGGAGG GGTGGACGCT 300

GCACAGTACG CCGCCGTGCA CGTGCACACC AATCTGGCCC GCCAGCCGGA GCTGCTCACG 360

GACCCCGCGG GAGCCCTCAG AGAAGCCTTC CGGCACACCG ATGAGATGTT TCTCTGGAAA 420

GCCAAGCGAG AGCGGCTGCA GAGCGGCACT ACAGGGGTGT GCGCACTCAT CGTGGGAAAG 480

ACCCTGCACA TCGCCTGGCT TGGGGACTCC CAGGTCATCC TGGTGCAGCA GGGACAGGTG 540

GTGAAGCTGA TGGAGCCTCA CAGGCCTGAG CGACAGGATG AGAAGGAGCG CATTGAGGCG 600

CTGGGCGGCT TCGTGTCCCA CATGGACTGC TGGAGAGTCA ACGGGACCCT GGCCGTGTCC 660

AGAGCCATCG GGGACGTGTT CCAGAAGCCC TACGTGTCAG GGGAGGCGGA CTCGGCCTCT 720

CGGGAGCTGA CGGGCTCCGA GGACTACCTG CTGCTGGCCT GCGACGGCTT CTTCGACGTC 780

GTCCCCCACC AGGAGGTCGC GGGCCTCGTC CACAGCCACC TGGCCCGGCA GCAGGGCAGC 840

GGGCTGCAGG TTGCCGAGGA GCTGGTGGCC GCGGCCCGGG AGCGGGGCTC CCACGACAAC 900

ATCACGGTCA TGGTGGTCTT CCTCAGGGAC CCCCGAGACC TACTGAAGGG CGGGGCCCAG 960

GGGACAGGGG ATGTGCCCTC TGGCCTCTCA CAGCCAGAGA CCAGCACTCC GCAGAGCAGC 1020

TAG 1023

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklhei  60

         v++ ++ + r++med++   p f +  + +d    a+f+v+DGhgg ++a++++ ++h+

Q: 52    VSMHAIRNTRRKMEDRHVCLPAFNQLFGLSDPvdRAYFAVFDGHGGVDAAQYAAVHVHTN  111

         6678999****************999888887778*************************

S: 61    laeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyva  120

         la++ e      ++   al++aF +tde +  l +++ +  +sG+t v+ali +++l++a

Q: 112   LARQPE----LLTDPAGALREAFRHTDEMF--LWKAKRERLQSGTTGVCALIVGKTLHIA  165

         ****77....66777889************..5555568889******************

S: 121   nvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalGd  180

          +GdS+++L ++g++v+l + H+p+r+dE+eRie+ gg v   d+ Rv+G LavsRa+Gd

Q: 166   WLGDSQVILVQQGQVVKLMEPHRPERQDEKERIEALGGFVSHMDCWRVNGTLAVSRAIGD  225

         ********************************************99**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

         ++ kpyv+ e +  s +lt ++++l La+DG +dvv+ +e+  lv+++l  ++ +  ++a

Q: 226   VFQKPYVSGEADSASRELTGSEDYLLLACDGFFDVVPHQEVAGLVHSHLArQQGSGLQVA  285

         ***********************************************9996778899***

S: 240   kkLvklalargskdnvsaivv  260

         ++Lv+ a++rgs+dn++++vv

Q: 286   EELVAAARERGSHDNITVMVV  306

         *****************9997

Domain Sequence
(FASTA)

VSMHAIRNTR RKMEDRHVCL PAFNQLFGLS DPVDRAYFAV FDGHGGVDAA QYAAVHVHTN 60

LARQPELLTD PAGALREAFR HTDEMFLWKA KRERLQSGTT GVCALIVGKT LHIAWLGDSQ 120

VILVQQGQVV KLMEPHRPER QDEKERIEAL GGFVSHMDCW RVNGTLAVSR AIGDVFQKPY 180

VSGEADSASR ELTGSEDYLL LACDGFFDVV PHQEVAGLVH SHLARQQGSG LQVAEELVAA 240

ARERGSHDNI TVMVV 255

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043234	; C:protein complex
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0035690	; P:cellular response to drug
GO:0097193	; P:intrinsic apoptotic signaling pathway
GO:0033137	; P:negative regulation of peptidyl-serine phosphorylation
GO:0044387	; P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0050921	; P:positive regulation of chemotaxis
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0010628	; P:positive regulation of gene expression
GO:0045927	; P:positive regulation of growth
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

cfa:486448

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013