EPS-CAF-00014

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAF-00014

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	152.9	6.3E-45	94	239	146

Status

Unreviewed

Ensembl Protein

ENSCAFP00000039066

UniProt Accession

E2QXG3;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000015574	ENSCAFP00000022900	ENSCAFT00000024682
ENSCAFG00000015574	ENSCAFP00000039066	ENSCAFT00000043550

Organism

Canis familiaris

Functional Description

Protein Length

1126

Protein Sequence
(FASTA)

MVSDAETESI FMEPIHLSSS VAAKQIINEE FKPRGIRAEA ECPGMLESAE QLLVEDLYNR 60

VREKMDDTSL YNTPCVLDLQ RALVQDRQEA PWNEVDEVWP NVFIAEKSVA VNKGRLKRLG 120

ITHILNAAHG TGVYTGPEFY TGLEIQYLGV EVDDFPEVDI SQHFRKAAEF LDEALLTYRG 180

KVLVSSEMGI SRSAVLVVAY LMIFHNMAIL EALMTVRRKR AIYPNDGFLK QLRELNEKLM 240

EEREEDYSQE GVTDEAEEGE DRESKVGARV HSLTVQEEED TVSHLSGSSW GRASQASKPL 300

SLIDEDEEEK LYEEWKKEQG LPAGQAPPAG SAQRRPASGQ GTEEPEDEED VERMIREWQS 360

RNERYQAEGH QWWGREEEEQ VQEEEEGEGG SFVRRSRRRL LSESSTSESV SSHDIRVLKQ 420

QLQVSSLSRA GRRRSDSVST ESTWDTWNQR LQEIEKEAAR RYRSRSRREE AAAGSSSEAG 480

SRGRQDDEES VSSEASSFYN FCSRHKDKLT ALERWKIKRI QFGFHKKDLG AEESGGEPGA 540

QEEAEGEKSA DVSLTAYQAW KLQHQKKVGG ENTEEVLELS KADAAASAKK RQRRLELLER 600

SRQTLEESQS LGSWEAAGSA TGGSIPLSAF WAAGSSVGAE EDAASVLSTQ SHSSRASQAG 660

SNAGGCLASL PGTAVPSLPV GPGDTISIAS IQNWIANVVS ETLAQKQNEM LLLPRSPSVA 720

SAKAAPAAGC PGDDQVSLLS GHSGSSLGGR LLPQSQPGPG SGSAALLASR AAGGPRPESQ 780

GGKVRGTSKP IYSLFADNVD LKELGRKERE MQMELREKMS EYKMEKLASD NKRSSLFKKK 840

KVKEDEDDDV GDRDEDTDSA IGSFRYSSRS NSQKPETDTS SSLAISDRNG SGSRAGKEMD 900

GSITKWLSGL RTEEKSSPQS DWSGSSRGKY TRSSLLRETE SKSSSYKFSK SQSEEQDTSS 960

YHEANGNSVR STSRISSSST REGREMHKLS RSMFSETSSS REESPEPYFF RRSPEPSEGD 1020

ASPEPRRPNW ARPRDWEDVE ESSNSDFSEF GAKRKFTQSF MRSEEEGEKE RMENREEGRF 1080

ASGRRSQYRR STDREEEEEM DDEAIIAAWR RRQEETRTKL QRRRED 1126

Nucleotide Sequence
(FASTA)

ATGGTCTCAG ATGCAGAAAC AGAAAGCATT TTCATGGAGC CCATTCACCT GTCTTCGTCG 60

GTTGCAGCTA AACAGATCAT CAACGAAGAA TTCAAGCCAC GGGGGATCAG AGCCGAGGCA 120

GAGTGTCCAG GCATGCTGGA GTCGGCCGAG CAGCTGCTGG TGGAGGACCT GTACAACCGT 180

GTCAGGGAGA AGATGGATGA CACCAGCCTA TACAATACCC CCTGCGTCCT GGATTTACAG 240

CGGGCCTTGG TCCAAGACCG CCAGGAGGCG CCCTGGAATG AGGTGGATGA GGTCTGGCCC 300

AATGTCTTCA TAGCAGAGAA GAGCGTAGCT GTGAACAAAG GGAGGCTGAA GAGGCTGGGA 360

ATCACGCACA TCCTGAATGC TGCTCATGGC ACCGGCGTCT ATACTGGGCC CGAATTCTAC 420

ACTGGCCTGG AGATTCAGTA CTTGGGCGTG GAGGTGGATG ACTTTCCCGA GGTAGACATC 480

TCCCAGCATT TCCGGAAGGC TGCTGAGTTC CTTGATGAAG CCCTGCTGAC CTACAGAGGG 540

AAAGTCCTGG TCAGCAGTGA GATGGGCATC AGCCGGTCAG CAGTGCTGGT GGTGGCCTAC 600

CTGATGATCT TCCACAACAT GGCCATCCTG GAGGCCTTGA TGACGGTGCG CCGGAAGCGG 660

GCCATCTACC CCAATGACGG CTTCCTGAAG CAGCTCCGGG AGCTCAACGA GAAGTTGATG 720

GAGGAGAGAG AAGAGGACTA CAGCCAGGAA GGGGTGACAG ATGAGGCTGA GGAGGGCGAG 780

GATAGGGAGA GCAAGGTGGG GGCCAGAGTG CACAGCCTCA CGGTGCAGGA GGAGGAGGAC 840

ACGGTCAGCC ACCTGAGCGG CTCCTCCTGG GGCCGGGCCA GCCAGGCCTC CAAGCCCCTC 900

AGCCTCATTG ACGAAGATGA GGAGGAGAAG CTGTACGAGG AGTGGAAGAA GGAGCAGGGC 960

CTCCCGGCGG GCCAGGCCCC CCCGGCTGGA AGTGCCCAGA GACGGCCGGC CTCTGGCCAG 1020

GGTACGGAGG AGCCAGAAGA CGAAGAGGAC GTGGAGAGGA TGATTCGGGA GTGGCAGAGC 1080

CGAAATGAGA GGTACCAGGC AGAAGGGCAT CAGTGGTGGG GGAGGGAGGA GGAGGAGCAG 1140

GTGCAGGAGG AGGAGGAGGG CGAGGGGGGC TCCTTCGTGA GGAGGAGCCG GAGGCGCTTG 1200

CTGAGCGAGA GCAGCACTTC GGAGAGTGTG AGCAGCCACG ACATCCGGGT CCTGAAGCAG 1260

CAGCTGCAGG TGAGCAGCCT GAGCCGGGCT GGGAGGCGCC GCTCGGACTC GGTGTCCACG 1320

GAGAGCACCT GGGACACGTG GAACCAGAGG CTGCAGGAGA TTGAGAAGGA GGCCGCCCGG 1380

CGGTATCGCT CTCGGAGCAG GAGGGAGGAG GCGGCCGCGG GCTCGAGCTC GGAGGCGGGG 1440

AGCAGGGGGC GCCAAGACGA CGAGGAGAGC GTGTCTTCCG AGGCCAGCTC GTTCTACAAC 1500

TTCTGCAGCA GGCACAAGGA CAAGCTCACT GCCCTCGAAA GGTGGAAGAT CAAGAGAATC 1560

CAATTTGGGT TTCACAAGAA GGACCTGGGG GCTGAAGAGA GCGGCGGCGA GCCGGGCGCC 1620

CAGGAGGAGG CCGAGGGCGA GAAGAGCGCC GACGTCAGCC TGACGGCCTA CCAGGCCTGG 1680

AAGCTGCAGC ACCAGAAGAA GGTGGGCGGC GAGAACACGG AGGAGGTGCT GGAGCTCAGC 1740

AAGGCGGACG CCGCCGCCTC GGCCAAGAAG AGGCAGCGGA GGCTGGAGCT GCTGGAGAGA 1800

AGCCGGCAGA CGTTGGAGGA GAGCCAGTCC CTGGGCAGCT GGGAGGCCGC CGGCTCGGCC 1860

ACCGGCGGGA GCATCCCCCT GTCTGCCTTC TGGGCAGCGG GCTCCTCGGT GGGCGCTGAG 1920

GAGGACGCGG CCTCGGTGCT CAGCACCCAG AGCCACAGCT CCCGCGCCTC GCAGGCGGGG 1980

AGCAACGCAG GGGGGTGCCT GGCCTCGCTC CCCGGCACAG CTGTGCCCAG CCTGCCCGTG 2040

GGGCCCGGGG ACACCATTTC CATTGCCAGT ATTCAGAACT GGATTGCCAA CGTGGTCAGT 2100

GAAACTCTGG CCCAGAAGCA AAACGAGATG CTGCTCTTGC CCCGCTCGCC GTCCGTGGCG 2160

AGCGCGAAGG CGGCGCCAGC AGCCGGCTGC CCGGGGGACG ACCAGGTGTC CCTTCTCAGC 2220

GGACACAGCG GCTCCTCCCT GGGCGGCCGC CTGCTGCCGC AGAGCCAGCC CGGGCCCGGC 2280

TCCGGCTCAG CAGCCCTGCT GGCCTCCCGC GCTGCGGGGG GTCCGAGGCC CGAAAGTCAG 2340

GGGGGCAAAG TCAGGGGGAC CAGCAAGCCT ATCTACAGCC TCTTCGCTGA CAACGTGGAT 2400

CTGAAAGAGC TTGGCCGGAA GGAAAGGGAG ATGCAGATGG AGCTGAGGGA GAAGATGTCT 2460

GAGTACAAGA TGGAGAAGCT GGCCTCCGAC AACAAACGGA GCTCCCTTTT CAAGAAGAAG 2520

AAGGTCAAGG AAGATGAGGA CGATGATGTG GGTGACAGGG ATGAGGACAC TGACAGCGCC 2580

ATCGGGAGCT TCCGGTATTC TTCCCGCAGT AATTCCCAAA AACCTGAAAC AGACACCTCC 2640

TCCTCCCTGG CCATTTCTGA TCGCAATGGA AGTGGTAGCA GGGCTGGCAA AGAGATGGAC 2700

GGCAGTATCA CTAAGTGGCT CAGTGGCCTC CGGACAGAGG AAAAATCTTC TCCCCAGAGT 2760

GATTGGTCGG GAAGCTCCAG GGGGAAGTAC ACCAGATCTT CCCTGCTCCG GGAGACTGAG 2820

TCCAAGTCCT CCAGCTACAA GTTCTCCAAA TCCCAGTCGG AGGAGCAGGA CACCTCCTCC 2880

TACCATGAGG CCAATGGCAA CTCTGTAAGG AGCACTTCAC GGATCTCTTC TTCCTCTACC 2940

AGGGAGGGCA GGGAGATGCA CAAGTTATCC AGGTCGATGT TCAGCGAGAC CTCCAGCTCC 3000

CGGGAGGAGA GCCCAGAGCC CTACTTCTTC CGCCGGAGCC CTGAGCCCTC TGAAGGGGAT 3060

GCATCCCCGG AACCACGGCG TCCAAACTGG GCCAGGCCCA GGGACTGGGA AGACGTGGAA 3120

GAGTCATCTA ACTCAGACTT TTCTGAATTT GGAGCCAAGA GGAAATTCAC CCAAAGCTTC 3180

ATGAGGTCTG AAGAGGAGGG AGAAAAAGAG AGAATGGAAA ACAGAGAAGA AGGGAGGTTT 3240

GCTTCAGGGA GGCGGTCTCA GTATCGGAGA AGCACTGACA GGGAGGAGGA GGAAGAAATG 3300

GACGATGAAG CCATCATTGC TGCCTGGAGA CGTCGGCAGG AAGAAACCAG GACGAAGCTG 3360

CAGAGAAGGA GGGAGGATTA A 3381

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 94    EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  152

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++G+sRSa+lv+aYLm+++++++ +A

Q: 153   DDFPEVDISQHFRKAAEFLDEAlLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEA  212

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v+rkr +i+pn+gfl+QL+el++kl

Q: 213   LMTVRRKR-AIYPNDGFLKQLRELNEKL  239

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKVL VSSEMGISRS AVLVVAYLMI FHNMAILEAL 120

MTVRRKRAIY PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

cfa:490361

;

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013