EKS-CAF-00470

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00470

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	348.1	4.4E-104	20	316	297

Status

Unreviewed

Ensembl Protein

ENSCAFP00000022989

UniProt Accession

E2QVF3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000015640	ENSCAFP00000033397	ENSCAFT00000037788
ENSCAFG00000015640	ENSCAFP00000022989	ENSCAFT00000024780

Organism

Canis familiaris

Functional Description

Protein Length

460

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAIKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNSVYIVQEY METDLANVLE 120

QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL SVIPVYIRND MTEPHKPLTQ LLPGISREAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC 360

QFSEHDWPIH NNFDIDEVQL DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTNYS 420

TDPCWQYPDH HENKYCDLEC SHTCNYKTSS YDTYQWHMIY 460

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AATTTGAAAG TCTCATGAAC ATTCATGGTT TTGATCTGGG CTCTAGATAT 60

ATGGACTTAA AACCATTGGG TTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 120

GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTTA CTGATCCCCA GAGTGTCAAA 180

CATGCTCTAC GTGAAATCAA AATTATTAGA AGACTTGACC ATGATAACAT TGTGAAAGTG 240

TTTGAAATTC TTGGTCCTAG CGGAAGCCAG TTAACAGACG ATGTGGGCTC TCTTACTGAA 300

CTGAACAGTG TTTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCTAA TGTGCTGGAG 360

CAGGGCCCTT TACTGGAAGA GCATGCCAGG CTTTTCATGT ATCAGCTGCT ACGTGGGCTC 420

AAATATATTC ACTCTGCAAA CGTACTGCAC AGAGATCTCA AACCAGCTAA TCTTTTCATT 480

AATACTGAAG ACTTGGTGCT GAAGATAGGT GACTTCGGTC TTGCACGGAT CATGGATCCC 540

CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CTAAATGGTA CAGGTCTCCA 600

CGTCTTTTAC TGTCTCCTAA TAATTATACT AAAGCCATTG ATATGTGGGC TGCAGGCTGC 660

ATCTTTGCTG AAATGCTGAC TGGTAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGCTGA TTTTAGAATC TATTCCTGTT GTACATGAGG AAGATCGTCA GGAGCTTCTC 780

AGCGTAATTC CAGTTTACAT TAGAAATGAC ATGACTGAGC CACACAAACC TTTAACTCAG 840

CTGCTTCCAG GAATTAGTCG AGAAGCACTG GATTTCCTGG AACAAATTTT GACATTTAGC 900

CCAATGGATA GGTTGACAGC AGAAGAAGCG CTTTCCCATC CTTACATGAG CATATATTCT 960

TTTCCAATGG ATGAGCCAAT TTCAAGTCAT CCTTTTCATA TTGAAGATGA AGTTGATGAT 1020

ATTTTACTTA TGGATGAAAC TCATAGTCAC ATTTATAACT GGGAAAGGTA CCATGATTGT 1080

CAATTTTCAG AGCATGATTG GCCTATACAT AACAACTTTG ATATTGATGA AGTTCAGCTT 1140

GACCCAAGAG CTCTGTCTGA TGTCACTGAT GAAGAAGAAG TACAGGTTGA TCCTCGAAAA 1200

TATTTGGATG GAGATCGTGA AAAGTATTTG GAGGATCCTG CTTTTGATAC CAATTATTCT 1260

ACTGATCCTT GTTGGCAGTA CCCAGATCAT CATGAAAACA AATACTGTGA TCTGGAGTGT 1320

AGCCATACGT GTAACTACAA AACAAGCTCA TATGATACTT ATCAGTGGCA CATGATCTAC 1380

TGA 1383

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rvaikk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el++vY+v+e+metdL++v+++  l +eh++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ s  +  yi++ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAIK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELNSVYIVQE YMETDLANVL EQGPLLEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LSVIPVYIRN DMTEPHKPLT QLLPGISREA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013