EKS-CAF-00178
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00178
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC459.73.7E-138194453260
StatusUnreviewed
Ensembl ProteinENSCAFP00000037814
UniProt AccessionE2RGU7;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCH
Gene Synonyms/Alias PRKCH;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000015695ENSCAFP00000023082ENSCAFT00000024878
ENSCAFG00000015695ENSCAFP00000037814ENSCAFT00000047128
OrganismCanis familiaris
Functional Description
Protein Length522
Protein Sequence
(FASTA)
MRRRVHQING HKFMATYLRQ PTYCSHCREF IWGVFGKQGY QCQVCTCVVH KRCHHLIVTA 60
CTCQNNINKM DSKIAEQRFG INIPHKFSIH NYKVPTFCDH CGSLLWGIMR QGLQCKICKM 120
NVHIRCQANV APNCGVNAVE LAKTLAGMGL QPGNISPTSK LVSRSTLRRQ GRENTKEGNG 180
VGVNSSSRLG IDNFEFIRVL GKGSFGKVML ARIKETGELY AVKVLKKDVI LQDDDVECTM 240
TEKRILSLAR NHPFLTQLFC CFQTPDRLFF VMEFVNGGDL MFHIQKSRRF DEARARFYAA 300
EIISALMFLH EKGIIYRDLK LDNVLLDHEG HCKLADFGMC KEGICNGVTT ATFCGTPDYI 360
APEILQEMLY GPAVDWWAMG VLLYEMLCGH APFEAENEDD LFEAILNDEV VYPTWLHDDA 420
TGILKSFMTK NPTMRLGSLT QGGEHAILRH PFFKEIDWAQ LNHRQVEPPF RPRIKSREDV 480
SNFDPDFIKE EPVLTPIDEG HLPMINQDEF RNFSFVSPEL QP 522
Nucleotide Sequence
(FASTA)
ATGCGAAGGC GAGTCCACCA GATCAATGGA CACAAGTTTA TGGCCACGTA CCTGAGGCAG 60
CCCACCTACT GCTCTCACTG CAGGGAGTTT ATCTGGGGAG TATTCGGGAA ACAGGGTTAT 120
CAATGTCAAG TGTGCACCTG TGTTGTCCAT AAACGCTGCC ATCATCTAAT TGTTACAGCC 180
TGCACTTGCC AGAACAATAT TAACAAAATG GATTCAAAGA TTGCTGAACA GAGGTTCGGA 240
ATCAACATCC CACACAAGTT CAGTATTCAC AACTACAAAG TACCAACATT CTGCGATCAC 300
TGTGGCTCGC TGCTCTGGGG GATAATGCGA CAAGGACTTC AGTGTAAAAT ATGTAAGATG 360
AATGTCCACA TTCGATGTCA GGCGAACGTG GCACCTAACT GTGGTGTAAA TGCAGTGGAG 420
CTAGCCAAGA CCCTGGCAGG AATGGGCCTC CAGCCCGGAA ATATTTCTCC AACCTCGAAG 480
CTCGTTTCCA GGTCAACTCT AAGACGACAG GGGAGGGAAA ACACCAAAGA GGGAAATGGG 540
GTCGGAGTTA ATTCTTCCAG CCGACTTGGT ATCGACAACT TTGAGTTCAT CCGAGTGTTG 600
GGGAAGGGGA GCTTCGGGAA GGTGATGCTT GCAAGAATAA AAGAAACAGG AGAGCTCTAT 660
GCTGTGAAGG TGCTGAAGAA GGACGTGATC TTGCAGGATG ATGATGTGGA ATGCACGATG 720
ACGGAAAAAA GGATCCTATC TTTGGCTCGC AACCACCCCT TCCTCACACA GTTGTTCTGC 780
TGCTTTCAAA CACCTGATCG TCTGTTTTTT GTGATGGAGT TTGTGAATGG GGGCGACTTG 840
ATGTTTCACA TTCAGAAGTC TCGTCGATTT GATGAAGCAC GAGCTCGTTT CTATGCAGCA 900
GAAATTATTT CAGCGCTCAT GTTCCTACAC GAGAAAGGAA TCATCTATAG AGATCTCAAA 960
CTGGACAATG TACTGTTGGA CCATGAGGGC CACTGTAAGC TGGCAGACTT TGGAATGTGC 1020
AAGGAGGGGA TCTGTAATGG AGTCACCACA GCCACCTTCT GTGGCACACC TGACTATATT 1080
GCTCCAGAGA TCCTCCAGGA AATGCTCTAC GGACCTGCAG TAGATTGGTG GGCCATGGGA 1140
GTTTTGCTCT ACGAGATGCT CTGTGGTCAT GCACCCTTTG AGGCGGAGAA CGAAGATGAC 1200
CTCTTTGAGG CCATACTGAA TGATGAAGTG GTCTACCCTA CATGGCTCCA CGATGATGCC 1260
ACAGGGATCC TGAAATCTTT CATGACCAAG AACCCCACCA TGCGCCTGGG CAGCCTGACT 1320
CAGGGTGGTG AGCATGCCAT CTTGAGACAT CCTTTCTTTA AGGAAATCGA CTGGGCCCAG 1380
CTGAACCATC GCCAAGTAGA ACCACCTTTC AGACCCAGAA TCAAATCTCG AGAAGATGTC 1440
AGTAATTTTG ACCCTGACTT CATTAAGGAA GAGCCAGTTT TAACCCCAAT TGATGAAGGA 1500
CATCTTCCTA TGATTAACCA GGATGAATTT AGAAACTTTT CCTTTGTGTC TCCAGAATTG 1560
CAACCTTAG 1569
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         fe+++vlGkGsfgkv+la+ k+t elya+kvlkkdv+lqdddve+t++ekr+l+la+++p
Q: 194   FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHP  253
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+qlf+cfqt drlffv+e+vnGGdlmfhiqk+r+++e+rarfyaaeii+al+flhekg
Q: 254   FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKG  313
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvlld+eGh+kladfG+cke+i++g tt+tfcGtPdyiaPeil+e+ yg +
Q: 314   IIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPA  373
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyeml+g++Pfe+e+ed+lfe+il++ev+yP++l+ +a+ ilk+++tk+p+
Q: 374   VDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHDDATGILKSFMTKNPT  433
         ************************************************************
S: 241   krlGvk.eegeedikehaff  259
         +rlG+  + ge++i +h+ff
Q: 434   MRLGSLtQGGEHAILRHPFF  453
         *****65999*********9
Domain Sequence
(FASTA)
FEFIRVLGKG SFGKVMLARI KETGELYAVK VLKKDVILQD DDVECTMTEK RILSLARNHP 60
FLTQLFCCFQ TPDRLFFVME FVNGGDLMFH IQKSRRFDEA RARFYAAEII SALMFLHEKG 120
IIYRDLKLDN VLLDHEGHCK LADFGMCKEG ICNGVTTATF CGTPDYIAPE ILQEMLYGPA 180
VDWWAMGVLL YEMLCGHAPF EAENEDDLFE AILNDEVVYP TWLHDDATGI LKSFMTKNPT 240
MRLGSLTQGG EHAILRHPFF 260
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00163
EKS-BOT-00171
EKS-CAJ-00175
EKS-CAP-00171
EKS-EQC-00168
EKS-FEC-00161
EKS-GAM-00092
EKS-GAG-00147
EKS-GOG-00169
EKS-HOS-00177
EKS-ICT-00166
EKS-LOA-00175
EKS-MAM-00169
EKS-MEG-00136
EKS-MOD-00169
EKS-MUM-00176
EKS-MUP-00175
EKS-MYL-00180
EKS-NOL-00164
EKS-ORA-00153
EKS-ORC-00158
EKS-OTG-00177
EKS-PAT-00162
EKS-PES-00151
EKS-PTV-00149
EKS-RAN-00166
EKS-SAH-00168
EKS-SUS-00148
EKS-TAG-00199
EKS-TUT-00153
EKS-XIM-00211
Gene Ontology
GO:0005829; C:cytosol
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0035556; P:intracellular signal transduction
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0050861; P:positive regulation of B cell receptor signaling pathway
GO:0060252; P:positive regulation of glial cell proliferation
GO:0045618; P:positive regulation of keratinocyte differentiation
GO:0010744; P:positive regulation of macrophage derived foam cell differentiation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:2000810; P:regulation of tight junction assembly
KEGG
cfa:490722;
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013