EKS-CAF-00145

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00145

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	504.8	6.3E-152	148	405	258

Status

Unreviewed

Ensembl Protein

ENSCAFP00000023241

UniProt Accession

F1Q4F8;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT3

Gene Synonyms/Alias

AKT3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000015806	ENSCAFP00000023241	ENSCAFT00000025041

Organism

Canis familiaris

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MSDVTVVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 60

LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 120

PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 180

KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 240

RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 300

ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 360

EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFSGVNW QDVYDKKLVP 420

PFKPQVTSET DTRYFDEEFT AQTITITPPE KYDEDGMDCV DNERRPHFPQ FSYSASGRE 479

Nucleotide Sequence
(FASTA)

ATGAGCGATG TTACCGTTGT GAAAGAAGGC TGGGTTCAGA AGAGGGGAGA ATATATAAAA 60

AACTGGAGGC CAAGATATTT CCTTTTGAAG ACAGATGGCT CATTCATAGG ATATAAAGAG 120

AAACCTCAAG ATGTGGATTT ACCTTATCCC CTCAACAACT TTTCAGTGGC AAAATGCCAG 180

TTAATGAAAA CAGAACGACC AAAGCCAAAC ACATTTATTA TCAGATGTCT CCAGTGGACC 240

ACTGTTATAG AGAGAACATT TCATGTAGAT ACTCCAGAGG AAAGGGAAGA GTGGACAGAA 300

GCTATTCAGG CGGTAGCAGA CAGACTTCAG AGACAAGAAG AGGAGAGAAT GAATTGTAGT 360

CCAACTTCAC AAATTGATAA TATAGGGGAG GAAGAGATGG ATGCTTCCAC AACCCATCAT 420

AAAAGAAAGA CAATGAATGA TTTTGACTAT TTGAAACTAC TAGGTAAAGG CACTTTTGGG 480

AAAGTTATTT TGGTTCGAGA GAAGGCAAGT GGGAAATACT ATGCTATGAA GATTCTGAAG 540

AAAGAAGTGA TTATTGCAAA GGATGAAGTG GCACATACTC TAACGGAAAG CAGAGTGTTA 600

AAGAACACTC GACACCCCTT TTTAACATCC TTGAAATATT CCTTCCAGAC AAAAGACCGT 660

TTGTGTTTTG TGATGGAATA TGTTAATGGG GGAGAGCTGT TTTTCCATTT GTCGAGAGAG 720

CGGGTGTTCT CCGAGGACCG CACACGTTTC TATGGTGCAG AAATTGTCTC TGCCTTGGAC 780

TATCTACATT CCGGAAAGAT TGTGTACCGT GATCTCAAGT TGGAGAATTT GATGCTGGAT 840

AAAGATGGCC ACATAAAAAT TACAGATTTT GGACTTTGCA AAGAAGGGAT TACAGATGCA 900

GCCACCATGA AGACATTCTG TGGCACACCA GAGTATCTGG CACCAGAGGT GTTAGAAGAC 960

AATGACTATG GCCGAGCCGT GGATTGGTGG GGACTGGGGG TCGTCATGTA TGAAATGATG 1020

TGTGGGAGGT TACCTTTCTA CAATCAGGAT CATGAGAAGC TTTTTGAACT AATACTAATG 1080

GAAGACATTA AATTCCCTCG AACACTCTCT TCAGATGCAA AATCATTGCT TTCGGGGCTC 1140

TTGATAAAGG ATCCAAATAA ACGCCTTGGC GGGGGCCCAG ATGATGCAAA AGAAATTATG 1200

AGGCACAGTT TCTTCTCTGG AGTCAATTGG CAAGATGTAT ACGATAAAAA GCTTGTACCT 1260

CCTTTTAAGC CTCAAGTAAC ATCTGAGACA GATACCAGAT ATTTCGATGA AGAATTTACA 1320

GCGCAGACTA TTACAATAAC ACCACCTGAA AAGTATGACG AGGACGGTAT GGACTGCGTG 1380

GACAACGAGC GGCGGCCGCA CTTCCCTCAG TTCTCCTACT CCGCCAGCGG CCGGGAGTAA 1440

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 148   FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  207

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGelffhls+ervfsedr+rfygaeivsaldylhs ++

Q: 208   LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI  267

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 268   VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  327

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dheklfelil+e++kfpr+ls++aksllsGll kdp+k

Q: 328   DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNK  387

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 388   RLGGGPDDAKEIMRHSFF  405

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEDR TRFYGAEIVS ALDYLHSGKI 120

VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEDIKFPR TLSSDAKSLL SGLLIKDPNK 240

RLGGGPDDAK EIMRHSFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013