EKS-CAF-00001

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00001

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	520.4	7.1E-157	591	848	258

Status

Unreviewed

Ensembl Protein

ENSCAFP00000023565

UniProt Accession

F1PYW2;

Protein Name

Protein Synonyms/Alias

Gene Name

Cfa.39442

Gene Synonyms/Alias

Cfa.39442;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000015936	ENSCAFP00000023565	ENSCAFT00000025379

Organism

Canis familiaris

Functional Description

Protein Length

956

Protein Sequence
(FASTA)

VTLLDSRSVQ GELGWIASPL EGGWEEVSIM DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIT 60

REGAQRVYIE IKFTLRDCNS LPGVMGTCKE TFNLYYYESD NDKERFIRES QFAKIDTIAA 120

DESFTQVDIG DRIMKLNTEI RDVGPLSKKG FYLAFQDVGA CIALVSVRVF YKKCPLTVRN 180

LAQFPDTITG ADTSSLVEVR GSCVNNSEEK DVPKMYCGAD GEWLVPIGNC LCNAGHEERN 240

GECQACKIGY YKALSTDAAC AKCPPHSYSV WEGATSCTCD RGFFRADNDA ASMPCTRPPS 300

APLNLISNVN ETSVNLEWSS PQNTGGRQDI SYNVVCKKCG AGDSSKCRPC GSGVHYTPQQ 360

NGLKTTKVSI TDLLAHTNYT FEIWAVNGVS KYNPSPDQSV SVTVTTNQAA PSSIALVQAK 420

EVTRYSVALA WLEPDRPNGV ILEYEVKYYE KDQNERSYRI VRTAARNTDI KGLNPLTSYV 480

FHVRARTAAG YGDFSEPLEV TTNTVPSRII GDGANSTVLL VSVSGSVVLV VILIAAFVIS 540

RRRSKYSKAK QEADEEKHLN QGVRTYVDPF TYEDPNQAVR EFAKEIDASC IKIEKVIGVG 600

EFGEVCSGRL KVPGKREICV AIKTLKAGYT DKQRRDFLSE ASIMGQFDHP NIIHLEGVVT 660

KCKPVMIITE YMENGSLDAF LRKNDGRFTV IQLVGMLRGI GSGMKYLSDM SYVHRDLAAR 720

NILVNSNLVC KVSDFGMSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK FTSASDVWSY 780

GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMDCP IALHQLMLDC WQKERSDRPK 840

FGQIVNMLDK LIRNPNSLKR TGTESSRPNT ALLDPSSPEF SAVVSVGDWL QAIKMDRYKD 900

NFTAAGYTTL EAVVHMNQED LARIGITAVT HQNKILSSVQ AMRTQMQQIH GRMVPV 956

Nucleotide Sequence
(FASTA)

GTAACCTTAT TGGATTCCAG ATCTGTTCAG GGAGAACTTG GGTGGATAGC GAGCCCTCTG 60

GAAGGAGGGT GGGAGGAAGT GAGTATCATG GATGAAAAAA ACACACCAAT CCGAACCTAC 120

CAAGTGTGCA ACGTGATGGA ACCCAGCCAG AATAACTGGC TCCGAACTGA TTGGATCACC 180

CGAGAAGGGG CGCAGAGGGT GTACATTGAA ATCAAGTTCA CATTGAGAGA CTGCAACAGC 240

CTTCCAGGTG TCATGGGCAC TTGCAAGGAG ACGTTCAACC TCTACTACTA TGAATCAGAC 300

AACGACAAAG AGCGTTTTAT CCGAGAGAGC CAGTTTGCCA AGATTGACAC CATCGCTGCT 360

GACGAGAGCT TCACCCAGGT GGACATTGGT GACAGGATCA TGAAGCTGAA CACCGAGATC 420

CGGGATGTAG GGCCGTTGAG CAAAAAGGGG TTTTATCTGG CTTTTCAGGA TGTGGGGGCT 480

TGCATCGCCC TGGTGTCAGT CCGTGTGTTC TATAAGAAGT GTCCGCTCAC CGTCCGCAAT 540

CTGGCCCAGT TTCCAGACAC CATCACGGGG GCTGATACGT CTTCCCTGGT GGAGGTTCGA 600

GGCTCCTGTG TCAACAACTC AGAAGAGAAG GATGTGCCAA AAATGTACTG TGGGGCAGAT 660

GGTGAATGGC TGGTACCCAT TGGCAACTGC CTATGCAATG CTGGGCACGA AGAGCGAAAT 720

GGAGAATGCC AAGCCTGCAA AATTGGGTAT TACAAGGCCC TCTCCACGGA TGCGGCCTGT 780

GCCAAGTGCC CGCCCCACAG CTATTCGGTC TGGGAAGGAG CCACATCGTG TACCTGTGAC 840

CGAGGCTTTT TCAGAGCCGA CAACGACGCC GCCTCCATGC CCTGCACCCG CCCACCGTCT 900

GCTCCCCTCA ACCTGATTTC AAATGTCAAC GAGACTTCGG TGAATTTGGA ATGGAGCAGT 960

CCCCAGAACA CAGGTGGCCG CCAGGATATT TCCTACAATG TGGTGTGCAA GAAATGTGGA 1020

GCTGGTGATT CCAGCAAGTG CCGACCCTGT GGAAGTGGGG TCCACTATAC CCCACAGCAG 1080

AATGGCCTGA AGACCACCAA AGTTTCCATC ACTGACCTCC TGGCTCACAC CAATTACACC 1140

TTCGAAATCT GGGCGGTGAA TGGAGTGTCC AAGTACAACC CCAGCCCAGA CCAATCAGTG 1200

TCCGTCACTG TGACGACCAA CCAAGCAGCA CCATCATCCA TTGCCTTGGT CCAGGCGAAA 1260

GAAGTTACAA GATACAGTGT TGCTCTGGCT TGGCTGGAAC CAGATCGGCC CAATGGGGTG 1320

ATCTTGGAGT ATGAAGTCAA GTATTATGAG AAGGATCAGA ATGAGCGAAG CTACCGGATT 1380

GTCCGGACGG CCGCCAGGAA CACAGATATC AAAGGCCTGA ATCCTCTGAC TTCCTACGTG 1440

TTCCATGTCC GAGCCAGGAC AGCAGCTGGC TACGGCGACT TCAGCGAGCC CCTGGAGGTC 1500

ACAACCAACA CAGTGCCTTC CCGGATCATC GGAGATGGGG CCAACTCCAC GGTCCTTCTG 1560

GTCTCAGTCT CAGGCAGTGT GGTGCTGGTG GTCATTCTCA TCGCGGCCTT TGTCATCAGC 1620

AGGAGACGGA GTAAATACAG TAAAGCTAAA CAAGAAGCAG ATGAAGAGAA ACATTTGAAT 1680

CAAGGTGTTA GAACTTATGT GGATCCCTTT ACATATGAAG ATCCCAACCA AGCAGTTCGA 1740

GAATTTGCCA AAGAAATCGA CGCCTCCTGC ATTAAGATTG AAAAAGTCAT AGGAGTTGGT 1800

GAATTTGGCG AAGTATGCAG CGGGCGTCTC AAAGTGCCTG GCAAGAGAGA GATCTGTGTA 1860

GCCATCAAGA CACTGAAAGC TGGTTATACA GACAAACAGA GGAGAGACTT CCTGAGTGAG 1920

GCCAGCATCA TGGGACAGTT TGACCACCCG AACATAATTC ACTTGGAAGG CGTTGTCACC 1980

AAATGTAAAC CAGTAATGAT CATAACAGAG TACATGGAGA ATGGCTCCTT GGATGCATTC 2040

CTCAGGAAGA ATGATGGCAG ATTTACTGTC ATTCAGCTGG TGGGCATGCT TCGTGGCATC 2100

GGGTCTGGGA TGAAGTACTT ATCTGATATG AGCTATGTGC ATCGAGATCT AGCTGCACGG 2160

AACATTCTGG TCAATAGCAA CTTGGTCTGC AAAGTGTCTG ATTTTGGCAT GTCGCGAGTG 2220

CTTGAGGATG ATCCGGAAGC AGCTTACACC ACCAGGGGTG GCAAGATTCC TATCCGGTGG 2280

ACCGCGCCAG AAGCAATTGC CTATCGTAAA TTCACATCAG CGAGTGATGT ATGGAGCTAT 2340

GGAATCGTTA TGTGGGAAGT GATGTCGTAT GGAGAGAGAC CCTATTGGGA TATGTCCAAT 2400

CAAGACGTGA TTAAAGCCAT TGAGGAAGGC TATCGGCTCC CCCCTCCAAT GGACTGCCCC 2460

ATCGCCCTCC ATCAGCTGAT GCTAGACTGC TGGCAGAAGG AGAGAAGTGA CAGGCCGAAA 2520

TTCGGGCAGA TTGTCAACAT GTTGGACAAA CTCATCCGCA ACCCCAACAG CTTGAAGAGG 2580

ACGGGAACTG AGAGCTCCAG ACCTAACACT GCCTTGTTGG ACCCAAGCTC CCCTGAATTC 2640

TCCGCCGTGG TATCAGTGGG CGATTGGCTC CAGGCCATTA AAATGGACCG ATATAAGGAT 2700

AACTTCACGG CTGCTGGTTA TACCACACTA GAGGCTGTAG TGCACATGAA CCAGGAGGAC 2760

CTGGCGAGGA TCGGCATCAC GGCCGTCACA CACCAGAACA AGATTTTGAG CAGCGTCCAG 2820

GCGATGAGAA CCCAAATGCA ACAGATCCAC GGCAGGATGG TTCCCGTCTG A 2871

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         +kiekviG GefGevcsGrlk+pgkrei+vaiktlkag+t+kqrrdflseasi+Gqfdhp

Q: 591   IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP  650

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         nii+leGvvtk+kpvmi+teymeng+ld+flrk+dg+ftviqlvgmlrGi+sgmkylsdm

Q: 651   NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM  710

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         +yvhrdlaarnilvnsnlvckvsdfG+srvledd+eaaytt+ggkipirwtapeaiayrk

Q: 711   SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  770

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlpppmdcp al+qlmldc

Q: 771   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDC  830

         ************************************************************

S: 241   wqkdraerpkfeqivsil  258

         wqk+r++rpkf qiv++l

Q: 831   WQKERSDRPKFGQIVNML  848

         ***************985

Domain Sequence
(FASTA)

IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT DKQRRDFLSE ASIMGQFDHP 60

NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV IQLVGMLRGI GSGMKYLSDM 120

SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180

FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMDCP IALHQLMLDC 240

WQKERSDRPK FGQIVNML 258

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR011510	; SAM_2.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF07647	; SAM_2; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013