EKS-CAF-00010
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00010
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph492.32.6E-148614870257
StatusUnreviewed
Ensembl ProteinENSCAFP00000023653
UniProt AccessionF1PX14;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2
Gene Synonyms/Alias EPHA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000016011ENSCAFP00000023602ENSCAFT00000025418
ENSCAFG00000016011ENSCAFP00000023653ENSCAFT00000025475
OrganismCanis familiaris
Functional Description
Protein Length975
Protein Sequence
(FASTA)
MERPGPRACL ALLWGCVLAS AAAAQGKEVV LLDFAAAKGE LGWLTHPYGK GWDLMQNIMD 60
DMPIYMYSVC NVVAGDQDNW LRTNWVYRGE AERIFIELKF TVRDCNSFPG GASSCKETFN 120
LYYAESDVDY GTNFQKRQFT KIDTIAPDEI TVSSDFEARH VKLNVEERSV GPLSRKGFYL 180
AFQDIGACVA LLSVRVYYKK CPELLQGLAR FPETIAGSDA PSLATVAGTC VDHAVVPPGG 240
EEPRMHCAVD GEWLVPIGQC LCQAGYEKVE DACQACSPGF FKSEASESPC LECPVHTVLS 300
SEGATFCDCE EGYFRAPQDL LSMPCTRPPS APHYLTAVGM GAKVELRWTP PQDSGGRDDI 360
VYSVTCEQCW PESGECGPCE ASVRYSEPPH ALTRTSVTVS DLEPHMNYTF AVEARNGVSE 420
LVASRSFRTA SVSINQTEPP KVKLEGRTTT SLSVSWSIPP PQQSRVWKYE VTYRKKGDSN 480
SYNVRRTEGF SVTLDDLAPD TTYLIQVQAL TQEGQGAGSK IHEFQTLSTE ASGNLAVIGG 540
VAVGIVLLLV LAGIGLFIHR RRKSLRTRQS SEDVYFSKSE QLKPLKTYVD PHTYEDPNQA 600
VLKFTTEIHP SCVTRQKVIG AGEFGEVYKG TLKASGKKEV PVAIKTLKAG YTEKQRVDFL 660
SEASIMGQFS HHNIIRLEGV VSKYKPMMII TEYMENGALD KFLREKDGEF SVLQLVGMLR 720
GIAAGMKYLA NMNYVHRDLA ARNILVNSNL VCKVSDFGLS RVLEDDPEAT YTTSGGKIPI 780
RWTAPEAISY RKFTSASDVW SYGIVMWEVM TYGERPYWEL SNHEVMKAIN DGFRLPTPMD 840
CPSAIYQLMM QCWQQERARR PKFADIVSIL DKLIRAPDSL KTLADFDPRV SIRLPSTSGS 900
EGVPFRTVSE WLESIKMQQY TEHFLAAGYT AIEKVVQMTN DDIKRIGVRL PGHQKRIAYS 960
LLGLKDQVNT VGIPI 975
Nucleotide Sequence
(FASTA)
ATGGAGCGGC CGGGGCCCCG CGCCTGCCTG GCCCTGCTGT GGGGCTGCGT GCTGGCCTCG 60
GCCGCCGCGG CGCAGGGCAA GGAAGTTGTA CTGTTGGACT TTGCTGCAGC TAAAGGGGAA 120
CTCGGCTGGC TCACGCACCC ATATGGCAAA GGGTGGGACC TGATGCAGAA CATCATGGAC 180
GACATGCCCA TCTACATGTA CTCCGTGTGC AATGTGGTGG CCGGAGACCA GGACAACTGG 240
CTTCGCACCA ACTGGGTGTA CCGCGGCGAG GCCGAGCGGA TCTTCATCGA GCTCAAGTTC 300
ACCGTGCGTG ACTGCAACAG CTTCCCCGGT GGCGCCAGCT CCTGCAAGGA GACGTTCAAC 360
CTCTACTACG CCGAGTCGGA CGTGGACTAC GGCACCAACT TCCAGAAGCG CCAGTTCACC 420
AAGATCGACA CCATCGCGCC CGACGAGATC ACGGTCAGCA GCGACTTCGA GGCGCGCCAC 480
GTGAAGCTGA ACGTGGAGGA GCGCTCCGTG GGGCCGCTCA GCCGCAAGGG CTTCTACCTG 540
GCGTTCCAGG ACATTGGCGC CTGCGTGGCC CTCCTCTCCG TCCGCGTCTA CTACAAGAAG 600
TGCCCCGAGC TGCTGCAGGG CCTGGCCCGC TTCCCCGAGA CCATCGCGGG CTCCGACGCG 660
CCCTCCCTGG CCACCGTGGC CGGCACGTGT GTGGACCACG CGGTGGTGCC GCCCGGGGGC 720
GAGGAGCCCC GCATGCACTG CGCGGTGGAC GGCGAGTGGC TGGTGCCCAT CGGTCAGTGC 780
CTGTGCCAGG CGGGCTACGA GAAGGTGGAG GACGCCTGCC AGGCCTGCTC GCCTGGATTC 840
TTCAAGTCCG AGGCATCCGA AAGCCCCTGT TTGGAGTGCC CCGTGCACAC GGTGCTGTCC 900
TCCGAGGGGG CCACCTTCTG TGACTGTGAG GAAGGCTACT TCCGAGCCCC CCAGGACCTG 960
CTGTCCATGC CCTGCACTCG CCCGCCCTCC GCCCCGCACT ACCTCACGGC TGTGGGCATG 1020
GGCGCCAAAG TCGAGCTGCG CTGGACGCCT CCCCAGGACA GCGGGGGCCG GGACGACATT 1080
GTCTACAGTG TCACCTGCGA GCAGTGCTGG CCCGAGTCGG GCGAGTGCGG ACCCTGCGAG 1140
GCCAGCGTGC GCTACTCCGA GCCGCCGCAC GCGCTGACCC GCACCAGCGT GACGGTCAGT 1200
GACCTGGAGC CGCACATGAA CTACACCTTT GCGGTGGAGG CCCGCAACGG GGTGTCGGAG 1260
CTGGTGGCCA GCCGCAGCTT CCGCACCGCC AGCGTCAGCA TCAACCAGAC AGAGCCCCCA 1320
AAGGTCAAGC TGGAGGGCCG CACCACCACC TCGCTGAGTG TCTCCTGGAG TATCCCCCCA 1380
CCACAGCAGA GCCGTGTGTG GAAGTACGAG GTCACCTACC GCAAGAAGGG GGACTCCAAC 1440
AGCTACAACG TGCGCCGCAC TGAGGGCTTC TCCGTGACCC TGGACGACCT GGCTCCGGAT 1500
ACCACCTACC TGATCCAGGT GCAGGCGCTG ACGCAGGAGG GCCAGGGTGC CGGCAGCAAG 1560
ATTCACGAGT TCCAGACGTT GTCCACGGAA GCATCTGGCA ACTTGGCAGT GATTGGCGGT 1620
GTGGCCGTTG GCATCGTCCT GCTTCTGGTG CTGGCAGGAA TCGGCCTCTT CATCCATCGC 1680
AGGAGGAAGA GCCTGCGGAC CCGCCAGTCC TCGGAGGACG TTTACTTCTC CAAGTCAGAG 1740
CAACTGAAGC CCCTGAAGAC ATACGTGGAC CCCCACACAT ATGAGGACCC CAACCAGGCT 1800
GTGCTTAAGT TCACCACTGA GATCCACCCG TCCTGTGTCA CGCGGCAGAA GGTCATTGGG 1860
GCAGGAGAGT TCGGGGAGGT GTATAAGGGA ACACTGAAGG CGTCGGGGAA GAAGGAGGTG 1920
CCCGTGGCCA TCAAGACGCT GAAAGCCGGC TACACCGAGA AGCAGCGGGT GGACTTCCTC 1980
AGCGAGGCCA GCATCATGGG CCAGTTCAGC CACCACAACA TCATCCGCCT GGAGGGTGTC 2040
GTCTCCAAAT ACAAACCCAT GATGATCATC ACCGAGTACA TGGAGAACGG GGCCCTGGAC 2100
AAGTTCCTTC GGGAGAAGGA CGGCGAGTTC AGCGTGCTGC AGCTGGTGGG CATGCTGCGG 2160
GGCATCGCGG CCGGCATGAA GTACCTGGCC AACATGAACT ACGTTCACCG CGACCTGGCC 2220
GCTCGCAACA TCCTTGTCAA CAGCAACCTG GTCTGCAAGG TGTCGGACTT CGGCCTGTCC 2280
CGTGTGCTGG AGGATGACCC CGAGGCCACC TACACCACCA GTGGTGGCAA GATTCCGATC 2340
CGCTGGACAG CTCCGGAGGC CATTTCCTAC CGCAAGTTCA CCTCAGCCAG CGACGTGTGG 2400
AGCTATGGCA TCGTCATGTG GGAGGTGATG ACGTACGGCG AGCGGCCCTA CTGGGAGCTG 2460
TCGAACCATG AGGTGATGAA AGCCATCAAC GACGGCTTCC GGCTCCCCAC GCCCATGGAC 2520
TGCCCCTCCG CCATCTACCA GCTTATGATG CAGTGCTGGC AGCAGGAGCG CGCCCGCCGC 2580
CCCAAGTTCG CCGACATCGT CAGCATCCTC GACAAGCTCA TCCGCGCCCC CGACTCCCTC 2640
AAGACCCTGG CTGACTTTGA CCCCCGGGTG TCCATCCGGC TGCCCAGCAC CAGTGGCTCC 2700
GAGGGGGTGC CTTTCCGCAC GGTGTCCGAG TGGCTTGAGT CCATCAAGAT GCAGCAGTAC 2760
ACAGAGCACT TCCTGGCGGC TGGCTACACT GCCATCGAGA AGGTGGTGCA GATGACCAAC 2820
GACGACATCA AGAGGATTGG GGTGCGGCTG CCCGGCCACC AGAAACGCAT CGCCTACAGC 2880
CTGCTGGGAC TCAAGGACCA GGTGAACACA GTGGGGATCC CCATCTGA 2928
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
         + +kviGaGefGev++G+lk++gk+e++vaiktlkag+tekqr+dflseasi+Gqf+h+n
Q: 614   TRQKVIGAGEFGEVYKGTLKASGKKEVPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHN  673
         6789********************************************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         iirleGvv+k kp+mi+teymengald+flr+kdg+f+v+qlvgmlrGia+gmkyl++m+
Q: 674   IIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMN  733
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yrkf
Q: 734   YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKF  793
         ************************************************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         tsasdvwsyGiv+wev++yGerpyw++sn++v+kai++g+rlp+pmdcp+a+yqlm++cw
Q: 794   TSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCW  853
         ************************************************************
S: 242   qkdraerpkfeqivsil  258
         q++ra+rpkf++ivsil
Q: 854   QQERARRPKFADIVSIL  870
         **************985
Domain Sequence
(FASTA)
TRQKVIGAGE FGEVYKGTLK ASGKKEVPVA IKTLKAGYTE KQRVDFLSEA SIMGQFSHHN 60
IIRLEGVVSK YKPMMIITEY MENGALDKFL REKDGEFSVL QLVGMLRGIA AGMKYLANMN 120
YVHRDLAARN ILVNSNLVCK VSDFGLSRVL EDDPEATYTT SGGKIPIRWT APEAISYRKF 180
TSASDVWSYG IVMWEVMTYG ERPYWELSNH EVMKAINDGF RLPTPMDCPS AIYQLMMQCW 240
QQERARRPKF ADIVSIL 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00009
EKS-ANC-00009
EKS-BOT-00008
EKS-CAJ-00009
EKS-CAP-00007
EKS-DAR-00015
EKS-EQC-00010
EKS-FEC-00007
EKS-GAM-00004
EKS-GAA-00015
EKS-GOG-00009
EKS-HOS-00011
EKS-ICT-00009
EKS-LAC-00010
EKS-LOA-00010
EKS-MAM-00009
EKS-MAE-00001
EKS-MEG-00012
EKS-MUM-00010
EKS-MUP-00010
EKS-MYL-00011
EKS-NOL-00009
EKS-OCP-00002
EKS-ORN-00018
EKS-ORA-00008
EKS-ORC-00009
EKS-ORL-00015
EKS-OTG-00010
EKS-PAT-00012
EKS-PES-00008
EKS-POA-00010
EKS-RAN-00009
EKS-SAH-00008
EKS-SUS-00007
EKS-TAR-00014
EKS-TEN-00014
EKS-XIM-00015
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR019931; LPXTG-motif_cell_wall_anchor.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS50847; GRAM_POS_ANCHORING; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013