EKS-CAF-00286

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00286

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	447.1	3.2E-134	234	521	288

Status

Unreviewed

Ensembl Protein

ENSCAFP00000023698

UniProt Accession

E2QW66;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1A

Gene Synonyms/Alias

BMPR1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000016077	ENSCAFP00000023698	ENSCAFT00000025524

Organism

Canis familiaris

Functional Description

Protein Length

532

Protein Sequence
(FASTA)

MTQLYIYIKL LGAYLFIISY VQGQNLDSML HGTGMKSDSD QKKSENGVTL APEDTLPFLK 60

CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR 120

TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVVLISM AVCIIAMIIF SSCFCYKHYC 180

KSISSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240

GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300

SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360

RDLKSKNILI KRNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN 420

HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPNDPSYEDM REVVCVKRLR 480

PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532

Nucleotide Sequence
(FASTA)

ATGACTCAGC TGTATATTTA CATCAAATTA TTGGGAGCCT ATCTCTTCAT CATTTCTTAT 60

GTTCAAGGGC AGAACCTAGA CAGTATGCTC CACGGTACTG GGATGAAATC GGACTCTGAC 120

CAGAAAAAAT CGGAAAATGG AGTAACCTTA GCACCAGAGG ATACCTTGCC TTTTTTGAAG 180

TGCTATTGCT CAGGACACTG CCCGGATGAT GCTATTAATA ACACATGCAT AACTAATGGG 240

CATTGCTTTG CCATCATAGA AGAAGATGAC CAGGGAGAAA CCACATTAGC TTCAGGGTGT 300

ATGAAATATG AAGGATCTGA TTTTCAGTGC AAGGATTCAC CAAAAGCCCA GCTACGCCGG 360

ACGATAGAAT GTTGTCGGAC CAATTTATGT AACCAGTATT TACAACCTAC ACTGCCCCCT 420

GTTGTTATAG GTCCATTTTT TGATGGCAGC ATTCGATGGC TGGTCGTGCT CATTTCTATG 480

GCTGTCTGCA TAATTGCTAT GATCATCTTC TCCAGCTGCT TTTGTTACAA ACATTATTGT 540

AAGAGCATCT CAAGCAGACG TCGTTACAAT CGTGATTTGG AACAAGATGA AGCATTTATT 600

CCAGTTGGAG AATCATTAAA AGACCTCATT GACCAGTCAC AGAGCTCTGG TAGTGGATCC 660

GGACTACCTT TATTGGTTCA GCGAACTATC GCCAAGCAGA TTCAGATGGT TCGGCAAGTG 720

GGGAAAGGCC GGTACGGAGA AGTGTGGATG GGTAAATGGC GTGGGGAGAA GGTGGCGGTC 780

AAGGTGTTCT TCACCACGGA GGAGGCCAGC TGGTTTCGGG AGACGGAAAT CTACCAGACT 840

GTGCTGATGC GCCACGAGAA CATTCTTGGT TTCATAGCAG CAGACATTAA AGGGACAGGC 900

TCCTGGACTC AGCTCTATTT GATTACTGAT TACCATGAAA ACGGATCTCT CTATGATTTC 960

CTGAAATGCG CTACGCTGGA CACCAGAGCC CTGCTCAAGT TGGCTTATTC AGCTGCCTGT 1020

GGTCTGTGCC ATCTCCACAC AGAAATTTAT GGCACCCAAG GAAAGCCTGC AATTGCTCAT 1080

CGAGACCTAA AAAGCAAAAA CATCCTCATT AAGAGAAATG GAAGTTGCTG TATTGCTGAC 1140

CTGGGTCTTG CTGTTAAATT CAATAGCGAC ACAAATGAAG TTGACGTGCC CCTGAATACC 1200

CGGGTGGGTA CCAAACGCTA TATGGCTCCA GAAGTGCTGG ATGAGAGCTT GAATAAAAAC 1260

CATTTCCAGC CCTACATAAT GGCCGACATC TACAGCTTTG GCCTGATCAT TTGGGAAATG 1320

GCTCGTCGTT GTATCACAGG AGGGATCGTG GAAGAGTACC AGTTGCCATA TTACAATATG 1380

GTGCCCAACG ATCCATCATA CGAAGATATG CGTGAGGTCG TGTGTGTCAA ACGTTTGCGG 1440

CCAATTGTGT CCAATAGATG GAACAGCGAT GAATGTCTCC GAGCAGTTCT GAAGCTCATG 1500

TCGGAATGCT GGGCGCACAA CCCGGCCTCC AGACTCACGG CTCTGAGGAT CAAGAAGACC 1560

CTTGCCAAGA TGGTTGAGTC CCAGGATGTC AAGATTTGA 1599

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         +++++++gkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 234   IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  293

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+d+Lk  tld++ ll+la+s+a+Gl+hLH+ei gt+

Q: 294   ADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQ  353

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNil+k++++cciaDlGLa+k++++++e+d+  n++vGtkRYmaPE

Q: 354   G--KPAIAHRDLKSKNILIKRNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPE  411

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+ + +aD+Ys+gL++WE+a+Rc + +++veey+lp++++v++dPs+e+m

Q: 412   VLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT-GGIVEEYQLPYYNMVPNDPSYEDM  470

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv++k+lrP ++++w+++e+l+++ kl++ecW+++p++Rltalr+kk+l

Q: 471   REVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL  521

         *************************************************97

Domain Sequence
(FASTA)

IQMVRQVGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDFLKC ATLDTRALLK LAYSAACGLC HLHTEIYGTQ 120

GKPAIAHRDL KSKNILIKRN GSCCIADLGL AVKFNSDTNE VDVPLNTRVG TKRYMAPEVL 180

DESLNKNHFQ PYIMADIYSF GLIIWEMARR CITGGIVEEY QLPYYNMVPN DPSYEDMREV 240

VCVKRLRPIV SNRWNSDECL RAVLKLMSEC WAHNPASRLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005524	; F:ATP binding
GO:0000981	; F:sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0051216	; P:cartilage development
GO:0048589	; P:developmental growth
GO:0009950	; P:dorsal/ventral axis specification
GO:0007398	; P:ectoderm development
GO:0042733	; P:embryonic digit morphogenesis
GO:0048568	; P:embryonic organ development
GO:0003272	; P:endocardial cushion formation
GO:0060914	; P:heart formation
GO:0035137	; P:hindlimb morphogenesis
GO:0006955	; P:immune response
GO:0001701	; P:in utero embryonic development
GO:0048368	; P:lateral mesoderm development
GO:0030324	; P:lung development
GO:0048382	; P:mesendoderm development
GO:0001707	; P:mesoderm formation
GO:0001880	; P:Mullerian duct regression
GO:0050768	; P:negative regulation of neurogenesis
GO:0014032	; P:neural crest cell development
GO:0021998	; P:neural plate mediolateral regionalization
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0060021	; P:palate development
GO:0048352	; P:paraxial mesoderm structural organization
GO:0021983	; P:pituitary gland development
GO:0030501	; P:positive regulation of bone mineralization
GO:0050679	; P:positive regulation of epithelial cell proliferation
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0001756	; P:somitogenesis
GO:0019827	; P:stem cell maintenance

KEGG

cfa:489077

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013