EKS-CAF-00305
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00305
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR494.66.8E-149720977258
StatusUnreviewed
Ensembl ProteinENSCAFP00000024079
UniProt AccessionF1PIQ9;
Protein Name
Protein Synonyms/Alias
Gene NameCfa.3747
Gene Synonyms/Alias Cfa.3747;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000016351ENSCAFP00000024079ENSCAFT00000025936
OrganismCanis familiaris
Functional Description
Protein Length1260
Protein Sequence
(FASTA)
MELAAWCRWG LLLALLPSGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 60
ELTYLPANAS LSFLQDIQEV QGYVLIAHSQ VRQIPLQRLR IVRGTQLFED NYALAVLDNG 120
DPLEGGIPAP GAAPGGLREL QLRSLTEILK GGVLIQRSPQ LCHQDTILWK DVFHKNNQLA 180
LTLIDTNRSR ACPPCSPACK DAHCWGASSG DCQSLTRTVC AGGCARCKGP QPTDCCHEQC 240
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTSCP 300
YNYLSTDVGS CTLVCPLNNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN 360
IQEFAGCKKI FGSLAFLPES FEGDPASNTA PLQPEQLRVF EALEEITGYL YISAWPDSLP 420
NLSVFQNLRV IRGRVLHDGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHR NARLCFVHTV 480
PWDQLFRNPH QALLHSANRP EEECVGEGLA CYPLCAHGHC WGPGPTQCVN CSQFLRGQEC 540
VEECRVLQGL PREYVKDRYC LPCHSECQPQ NGSVTCFGSE ADQCVACAHY KDPPFCVARC 600
PSGVKPDLSF MPIWKFADEE GTCQPCPINC THSCADLDEK GCPAEQRASP VTSIIAAVVG 660
ILLAVVVGLV LGILIKRRRQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL 720
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP 780
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV REHRGRLGSQ DLLNWCVQIA KGMSYLEDVR 840
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESLLRRRFT 900
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM 960
IDSECRPRFR ELVAEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA 1020
EEYLVPQQGF FCPEPTPGAG GTAHRRHRSS STRSGGGELT LGLEPSEEEP PKSPLAPSEG 1080
AGSDVFDGDL GMGAAKGLQS LPSQDPSPLQ RYSEDPTVPL PPETDGYVAP LTCSPQPEYV 1140
NQPEVWPQPP SPLEGPLPPS RPAGATLERP KTLSPKTLSP GKNGVVKDVF AFGSAVENPE 1200
YLAPRGRAAP QPHPPPAFSP AFDNLYYWDQ DPSERGSPPS TFEGTPTAEN PEYLGLDVPV 1260
Nucleotide Sequence
(FASTA)
ATGGAGCTGG CGGCCTGGTG CCGCTGGGGG CTCCTTCTCG CCCTCCTGCC CTCCGGAGCC 60
GCGGGCACCC AAGTGTGCAC CGGCACAGAC ATGAAGCTCC GGCTCCCGGC CAGTCCCGAG 120
ACCCACCTGG ATATGCTCCG CCACCTGTAC CAGGGCTGTC AAGTGGTACA GGGGAACCTG 180
GAGCTCACTT ACCTGCCTGC CAATGCCAGC CTGTCCTTCC TGCAGGATAT CCAGGAGGTG 240
CAGGGCTATG TGCTCATTGC TCACAGCCAA GTGAGGCAGA TCCCACTGCA GAGGCTACGA 300
ATTGTGCGAG GCACCCAGCT CTTTGAGGAC AACTACGCCC TGGCCGTGCT GGACAATGGA 360
GACCCGCTGG AGGGTGGCAT CCCTGCACCA GGGGCGGCCC CAGGAGGGCT GCGGGAGCTG 420
CAGCTTCGAA GCCTCACAGA GATCCTGAAG GGAGGGGTCT TGATTCAGCG GAGCCCGCAG 480
CTCTGCCACC AGGACACGAT TTTATGGAAG GACGTCTTCC ATAAGAACAA CCAGCTGGCC 540
CTCACGCTGA TAGACACCAA CCGCTCTCGG GCCTGCCCAC CCTGTTCTCC AGCTTGTAAA 600
GACGCCCACT GCTGGGGGGC CAGCTCCGGG GACTGTCAGA GCTTGACGCG GACTGTCTGT 660
GCGGGGGGCT GTGCCCGCTG CAAGGGCCCA CAACCCACCG ACTGCTGCCA CGAGCAGTGT 720
GCTGCTGGCT GCACGGGCCC CAAGCACTCT GACTGCCTGG CCTGCCTTCA CTTCAACCAC 780
AGTGGCATCT GTGAGCTGCA CTGCCCAGCC CTGGTCACCT ACAACACGGA CACCTTCGAA 840
TCCATGCCCA ACCCTGAGGG CCGATATACC TTCGGGGCCA GCTGTGTGAC CTCCTGTCCC 900
TACAACTACC TGTCTACGGA TGTGGGATCC TGCACCCTGG TCTGTCCCCT GAACAACCAA 960
GAGGTGACGG CTGAGGATGG GACACAGCGG TGCGAGAAAT GCAGCAAGCC CTGTGCCCGA 1020
GTGTGCTACG GTCTGGGCAT GGAGCACCTG CGGGAGGTGA GAGCGGTCAC CAGTGCGAAC 1080
ATCCAGGAGT TTGCCGGCTG CAAGAAGATC TTTGGAAGCC TGGCATTTTT GCCAGAGAGC 1140
TTTGAGGGGG ACCCAGCCTC CAACACTGCC CCCCTACAGC CTGAGCAGCT CAGAGTGTTT 1200
GAGGCTCTGG AGGAGATCAC AGGTTACCTG TACATCTCAG CGTGGCCAGA CAGCCTGCCT 1260
AACCTCAGTG TCTTCCAGAA CCTGCGAGTA ATCCGGGGAC GAGTTCTGCA TGATGGTGCC 1320
TACTCGCTGA CCCTGCAAGG GCTGGGCATC AGCTGGCTGG GGCTGCGCTC GCTGCGGGAA 1380
CTGGGCAGTG GGCTGGCCCT CATCCACCGC AACGCCCGCC TTTGCTTCGT GCACACGGTG 1440
CCCTGGGACC AGCTCTTCCG GAACCCCCAC CAGGCCCTGC TCCATAGTGC CAACCGGCCA 1500
GAGGAGGAGT GCGTGGGCGA GGGCCTGGCC TGCTACCCGC TGTGCGCCCA TGGGCACTGC 1560
TGGGGTCCAG GGCCGACCCA GTGCGTCAAC TGCAGCCAAT TCCTTCGGGG CCAGGAGTGC 1620
GTGGAAGAAT GCCGAGTACT GCAGGGGCTG CCCCGAGAGT ATGTGAAGGA CAGGTACTGT 1680
CTGCCGTGCC ACTCAGAGTG TCAGCCCCAG AATGGCTCAG TGACCTGCTT CGGATCGGAG 1740
GCTGACCAGT GTGTGGCCTG CGCCCACTAC AAGGACCCTC CCTTCTGTGT GGCTCGCTGC 1800
CCCAGTGGTG TGAAACCTGA CCTGTCCTTC ATGCCCATCT GGAAGTTCGC AGATGAGGAG 1860
GGCACTTGCC AGCCGTGCCC CATCAACTGC ACCCACTCCT GTGCGGACCT GGACGAGAAG 1920
GGCTGTCCCG CCGAGCAGAG AGCCAGCCCT GTGACATCCA TCATTGCCGC TGTGGTGGGC 1980
ATTCTGCTGG CTGTGGTCGT GGGGCTGGTC CTCGGCATCC TGATCAAGCG AAGGCGGCAG 2040
AAGATCCGGA AGTACACTAT GCGGAGGCTG CTGCAGGAAA CCGAGCTGGT GGAGCCGCTG 2100
ACGCCTAGTG GAGCGATGCC CAACCAGGCT CAGATGCGGA TCCTGAAAGA GACAGAGCTG 2160
AGGAAGGTGA AGGTGCTTGG ATCCGGAGCT TTTGGCACAG TCTACAAGGG CATCTGGATC 2220
CCTGATGGGG AAAATGTGAA AATCCCAGTG GCCATCAAAG TGTTGAGGGA AAACACATCT 2280
CCCAAAGCCA ACAAAGAAAT CTTGGACGAA GCATATGTGA TGGCTGGAGT GGGCTCCCCG 2340
TATGTGTCCC GCCTCCTGGG CATCTGCCTG ACATCCACGG TGCAGCTGGT GACACAGCTT 2400
ATGCCCTACG GCTGCCTCTT AGACCATGTC CGAGAACACC GTGGGCGCCT GGGCTCCCAG 2460
GACTTGCTGA ACTGGTGTGT GCAGATTGCC AAGGGGATGA GCTACTTGGA GGATGTCCGG 2520
CTGGTGCACA GGGACCTGGC TGCCCGGAAT GTGCTGGTCA AGAGTCCCAA CCATGTCAAG 2580
ATTACAGATT TCGGGCTGGC TCGGTTGCTG GACATCGACG AGACAGAGTA CCATGCGGAT 2640
GGGGGCAAGG TGCCCATCAA GTGGATGGCG CTGGAGTCCC TTCTCCGCCG GCGGTTCACC 2700
CACCAGAGTG ATGTGTGGAG CTATGGTGTG ACTGTGTGGG AACTGATGAC TTTTGGGGCC 2760
AAACCTTATG ATGGGATCCC AGCCCGGGAG ATCCCTGACC TGCTGGAGAA GGGGGAACGG 2820
CTGCCCCAGC CCCCCATCTG CACCATTGAT GTCTACATGA TCATGGTCAA GTGCTGGATG 2880
ATAGACTCTG AATGCCGACC CCGGTTCCGG GAGTTGGTGG CCGAATTCTC ACGTATGGCC 2940
AGGGACCCCC AGCGCTTTGT GGTCATTCAG AATGAAGACT TGGGCCCCGC CAGCCCCTTG 3000
GACAGCACCT TCTACCGTTC ACTACTGGAA GATGATGACA TGGGGGACCT GGTGGATGCT 3060
GAGGAGTACC TGGTACCCCA GCAGGGTTTC TTCTGCCCAG AACCTACCCC AGGGGCTGGG 3120
GGCACTGCCC ACCGACGGCA CCGCAGCTCA TCCACCAGGA GTGGCGGTGG TGAGCTGACT 3180
CTAGGACTGG AGCCCTCCGA GGAGGAGCCC CCCAAGTCTC CACTGGCACC CTCAGAGGGC 3240
GCTGGCTCTG ACGTGTTTGA TGGTGACTTG GGAATGGGGG CAGCCAAGGG GCTGCAGAGC 3300
CTTCCCTCAC AGGACCCCAG CCCTCTCCAG CGGTACAGTG AGGACCCTAC GGTACCCTTG 3360
CCCCCTGAGA CTGATGGCTA CGTCGCCCCC CTGACCTGCA GCCCCCAGCC TGAATATGTG 3420
AACCAGCCAG AAGTTTGGCC GCAGCCCCCC TCGCCCCTAG AAGGCCCTCT GCCTCCTTCC 3480
CGACCGGCTG GTGCCACTCT GGAAAGGCCC AAGACTCTGT CCCCCAAGAC TCTCTCCCCT 3540
GGCAAGAATG GGGTTGTCAA AGACGTTTTT GCCTTTGGGA GTGCTGTGGA GAATCCGGAG 3600
TACCTGGCAC CCCGGGGCAG AGCTGCCCCT CAGCCCCACC CTCCTCCAGC CTTCAGCCCA 3660
GCCTTTGACA ACCTGTATTA CTGGGACCAG GATCCATCAG AGCGGGGCTC TCCACCCAGC 3720
ACCTTTGAAG GGACCCCTAC AGCAGAGAAC CCGGAGTACC TGGGGCTGGA CGTGCCAGTG 3780
TGA 3783
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 720   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  779
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+ 
Q: 780   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  839
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+ales+l+r++
Q: 840   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESLLRRRF  899
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 900   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  959
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+e+rp+f+el++efs
Q: 960   MIDSECRPRFRELVAEFS  977
         ****************96
Domain Sequence
(FASTA)
LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESLLRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDSECRPRF RELVAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAJ-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0010008; C:endosome membrane
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007507; P:heart development
GO:0008045; P:motor neuron axon guidance
GO:0042552; P:myelination
GO:0033088; P:negative regulation of immature T cell proliferation in thymus
GO:0007528; P:neuromuscular junction development
GO:0007422; P:peripheral nervous system development
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0045785; P:positive regulation of cell adhesion
GO:0030307; P:positive regulation of cell growth
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0032321; P:positive regulation of Rho GTPase activity
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727; P:positive regulation of translation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0032886; P:regulation of microtubule-based process
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013